DE678115C - Process for the preparation of solutions of medicinal substances which are difficult to dissolve or insoluble in water - Google Patents

Process for the preparation of solutions of medicinal substances which are difficult to dissolve or insoluble in water

Info

Publication number
DE678115C
DE678115C DEH154300D DEH0154300D DE678115C DE 678115 C DE678115 C DE 678115C DE H154300 D DEH154300 D DE H154300D DE H0154300 D DEH0154300 D DE H0154300D DE 678115 C DE678115 C DE 678115C
Authority
DE
Germany
Prior art keywords
water
parts
insoluble
solutions
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DEH154300D
Other languages
German (de)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Priority to DEH154300D priority Critical patent/DE678115C/en
Application granted granted Critical
Publication of DE678115C publication Critical patent/DE678115C/en
Expired legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Description

Verfahren zur Herstellung von Lösungen von in Wasser schwer oder unlöslichen Arzneistoffen Es wunde gefunden, daß man zur Herstellung von konzentrierten wasserhaltigen Lösungen von in Wasser schwer oder unlöslichen Arzneistoffen mit Vorteil 3, 4-Dimethoxybenzylalkohol (Veratrylalkohol) als Lösungsvermattler anwenden kann. Veratrylalkohol ist mit Wasser in jedem Verhältnis m'ischhar und besitzt sowohl in reiner Form wie in wä. sseriNger Lösung ein auffallendes Lösungsvermögen für in Wasser schwer oder nicht lösliche Verbindungen.Process for the preparation of solutions of sparingly or insoluble in water Medicinal substances It was found that one can produce concentrated hydrous Solutions of medicinal substances which are sparingly soluble or insoluble in water with advantage 3,4-dimethoxybenzyl alcohol (Veratryl alcohol) can use as a dissolving agent. Veratryl alcohol is with water m'ischhar in every proportion and possesses both in pure form and in wä. sseriNger Solution a noticeable solvent power for those that are sparingly or insoluble in water Links.

Veratrylalkohol ist schon als' Fixateur für Riechstoffe benutzt worden (Patentschrift 5I5 332). Diese Verwendung ließ jedoch keineswegs voraussehen, daß Veratrylalkohol zur Herstellung von wasserhaltigen Lösungen in Wasser nicht oder schwerlöslicher Arzneistoffe dienen kann. Veratryl alcohol has been used as a fixative for fragrances (Patent 5I5,332). However, this use by no means indicated that Veratryl alcohol for the preparation of aqueous solutions in water not or can serve poorly soluble drugs.

Der Veratrylalkohol ist ausgezeichnet durch geringe Giftigkeit und geringe Reizwirkung, weshalb mit seiner Hilfe Lösungen hergestellt werden können, die für perorale, percutane oder intravenöse Anwendung geeignet sind. Veratryl alcohol is distinguished by its low toxicity and low irritant effect, which is why solutions can be produced with its help, which are suitable for oral, percutaneous or intravenous use.

Beispiele 1. 5 Teile Chininhydrochlorid werden in 5 Teilen Veratrylalkohol durch Erwärmen auf dem Wasserbad gelöst. Man fügt nach dem Abkühlen 2 Teile Wasser zu und erhält eine klare Lösung. Examples 1. 5 parts of quinine hydrochloride are added to 5 parts of veratryl alcohol dissolved by heating on a water bath. After cooling, 2 parts of water are added to and receives a clear solution.

2. 10 Teile Chininbase werden unter Erwärmen auf dem Wasserbad gelöst in 50 Teilen Veratrylalkohol. Durch Zugabe von 10 Teilen Wasser erhält man eine klare Lösung. 2. 10 parts of quinine base are dissolved while warming on a water bath in 50 parts of veratryl alcohol. Adding 10 parts of water gives one clear solution.

3. 2 Teile Allylisopropylbarbitursäure werden mit 8 Teilen Veratrylalkohol bis zur Lösung erwärmt. Durch Zufügen von 3 Teilen Wasser entsteht eine farblose Lösung. 3. 2 parts of allylisopropylbarbituric acid are mixed with 8 parts of veratryl alcohol warmed to solution. Adding 3 parts of water creates a colorless one Solution.

4. 5 Teile p-Amidobenzolsulfamid werden durch Erwärmen in 50 Teilen Veratrylalkohol gelöst. Die Lösung wird mit 40 Teilen Wasser versetzt. Man erhält eine leichtflüssige Lösung. 4. 5 parts of p-amidobenzenesulfamide are added by heating in 50 parts Veratryl alcohol dissolved. 40 parts of water are added to the solution. You get a liquid solution.

5. Durch Lösen. von 2 Teilen Oestrin in IOOO Teilen Veratrylalkohol und Zugabe von goooTeilen Wasser erhält man eine sterilisierbare Lösung, die für Injektionen geeignet ist. 5. By loosening. of 2 parts of oestrin in 10000 parts of veratryl alcohol and adding gooo parts of water, a sterilizable solution is obtained that is suitable for Injections is suitable.

6. 2 Teile Oestrin werden gelöst in 500 Teilen Veratrylalkohol. Man fügt nach dem Abkühlen 450 Teile Wasser zu und erhält eine klare Lösung. 6. 2 parts of oestrin are dissolved in 500 parts of veratryl alcohol. Man after cooling, add 450 parts of water and obtain a clear solution.

Claims (1)

PATENTANSPRUCH : Verfahren zur Herstellung von konzentrierten wasserhaltigen Lösungen von in Wasser schwer oder unlöslichen Arzneistoffen, dadurch gekennzeichnet, daß man 3, 4-Dimethoxybenzylalkohol als Lösungsvermittler verwendet. PATENT CLAIM: Process for the production of concentrated hydrous Solutions of medicinal substances which are sparingly soluble or insoluble in water, characterized in that that one uses 3, 4-dimethoxybenzyl alcohol as a solubilizer.
DEH154300D 1938-01-11 1938-01-11 Process for the preparation of solutions of medicinal substances which are difficult to dissolve or insoluble in water Expired DE678115C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DEH154300D DE678115C (en) 1938-01-11 1938-01-11 Process for the preparation of solutions of medicinal substances which are difficult to dissolve or insoluble in water

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEH154300D DE678115C (en) 1938-01-11 1938-01-11 Process for the preparation of solutions of medicinal substances which are difficult to dissolve or insoluble in water

Publications (1)

Publication Number Publication Date
DE678115C true DE678115C (en) 1939-07-08

Family

ID=7181873

Family Applications (1)

Application Number Title Priority Date Filing Date
DEH154300D Expired DE678115C (en) 1938-01-11 1938-01-11 Process for the preparation of solutions of medicinal substances which are difficult to dissolve or insoluble in water

Country Status (1)

Country Link
DE (1) DE678115C (en)

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