DE861906C - Process for the production of durable solutions of o-dioxyphenyl-ethanolamine - Google Patents

Process for the production of durable solutions of o-dioxyphenyl-ethanolamine

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Publication number
DE861906C
DE861906C DEC4084A DEC0004084A DE861906C DE 861906 C DE861906 C DE 861906C DE C4084 A DEC4084 A DE C4084A DE C0004084 A DEC0004084 A DE C0004084A DE 861906 C DE861906 C DE 861906C
Authority
DE
Germany
Prior art keywords
dioxyphenyl
ethanolamine
production
solution
sulfate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DEC4084A
Other languages
German (de)
Inventor
Paul Dr-Ing Herrmann
Hans Dr Med Zaubitzer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Curta & Co U S Administration
Original Assignee
Curta & Co U S Administration
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Curta & Co U S Administration filed Critical Curta & Co U S Administration
Priority to DEC4084A priority Critical patent/DE861906C/en
Application granted granted Critical
Publication of DE861906C publication Critical patent/DE861906C/en
Expired legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

Verfahren zur Herstellung haltbarer Lösungen von o-Dioxyphenyl-äthanolamin ` Es ist bekannt, daß man Lösungen von o-Dioxyphenyl-äthanolmethylamin dadurch herstellen kann, daß man diese Base mittels verdünnter Mineralsäuren oder auch organischer Säuren auflöst. So hat sich die Lösung i : iooo in verdünnter Salzsäure als maximal beständig in der Pharmazie eingeführt und es ist bekannt, die Beständigkeit dieser Lösung durch einen Säureüberschuß zu erhöhen. Aber auch dieser Säureübcrschuß kann die Lösung nicht vollständig vor der Zersetzung durch Oxydation schützen und hat außerdem den Nachteil, bei Injektionen reizend zu wirken, so daß die allgemeine Verwendungsmöglichkeit darunter leiden muß.Process for the preparation of durable solutions of o-dioxyphenyl-ethanolamine `It is known that solutions of o-dioxyphenyl-ethanolmethylamine can be produced in this way can that this base by means of dilute mineral acids or organic Dissolves acids. The solution i: iooo in dilute hydrochloric acid has thus proven to be the maximum consistently introduced in pharmacy and it is known the persistence of this Increase solution by an excess of acid. But this excess acid can also does not protect the solution completely from decomposition by oxidation and has also the disadvantage of being irritating to injections, so that the general Possible use must suffer from it.

Es wurde nun gefunden, daß man o-Dioxyphenyläthanolmethylamin auch mit organischen Salzen wie Sparteinsulfat an Stelle von Säuren in Lösung bringen kann, wodurch die Verwendungsmöglichkeit vergrößert wird. Auch zeigen diese Lösungen große Haltbarkeit, trotzdem sie annähernd neutral sind, je nach der angewandten Menge Sparteinsulfat. Die Umsetzung der Base mit dem Salz erfolgt im molekularen Verhältnis, und zwar setzt sich i Mol o-Dioxyphenyläthanolmethylamin mit i Mol Spartcinsulfat zu einem Doppelsalz um, das an i Mol Schwefelsäure gebunden ist. Der Endpunkt dieser Reaktion ist angezeigt durch die genaue Neutralisation grgcnüber Methylrot als Indikator. Eine größere Haltbarkeit der Lösung gegenüber Oxydationen läßt sich durch Anwendung eines Überschusses an Sparteinsulfat erzielen.It has now been found that o-dioxyphenylethanolmethylamine can also be used Dissolve with organic salts such as sparteine sulfate instead of acids can, whereby the possibility of use is increased. Also show these solutions great durability, although they are approximately neutral, depending on the one used Amount of sparteine sulfate. The reaction of the base with the salt takes place in the molecular Ratio, namely one mole of o-dioxyphenylethanolmethylamine is set with one mole of spartcinol sulfate to a double salt that is bound to 1 mole of sulfuric acid. The end point of this The reaction is indicated by the exact neutralization green using methyl red as an indicator. A greater durability of the solution against oxidation can be achieved through use achieve an excess of sparteine sulfate.

Beispiel i i Mol Sparteinsulfat = q.22 g werden in 2 1 Wasser gelöst und in diese Lösung allmählich i Mol o-Dioxyphenyl -äthanolmethylamin - 183 g in pulverisierter Form unter Rühren eingetragen. Die Lösung erfolgt sehr schnell ohne Wärmezufuhr.Example i i mole of sparteine sulfate = 22 g are dissolved in 2 l of water and gradually adding 1 mole of o-dioxyphenyl to this solution -ethanolmethylamine - 183 g entered in powdered form with stirring. The solution is done very much quickly without heat.

Beispiel 2 In eine Aufschlämmung von x Mol o-Dioxyphenyläthanohnethylamin in 11 Wasser gibt man festes oder in Lösung befindliches,Sparteinsulfat, bis vollständige Lösung erfolgt ist. Das tritt nach dem Verbrauch von x Mol Sparteinsulfat ein. Nach Belieben kann man dieser Lösung weitere Mengen Sparteinsulfat zugeben. Beispiel 3 x Mol Sparteinsulfat wird in fester Form mit x Mol o-Dioxyphenyl-äthanohuethylamin vermengt und im Gebrauchsfalle mit einer beliebigen- Menge Wasser zu einer klaren und haltbaren- Lösung des Doppelsalzes verarbeitet. - ' ` - 'Example 2 To a slurry of x moles o-Dioxyphenyläthanohnethylamin in 1 1 of water is one solid or in solution, Sparteinsulfat is carried out until complete dissolution. This occurs after x moles of sparteine sulfate have been consumed. If desired, you can add additional amounts of sparteine sulfate to this solution. EXAMPLE 3 x moles of sparteine sulfate are mixed in solid form with x moles of o-dioxyphenyl-ethanohuethylamine and, if necessary, processed with any amount of water to give a clear and durable solution of the double salt. - '`` -'

Claims (3)

PATENTANSPRÜCHE: x. Verfahren .zur Herstellung eines in Wasser löslichen Doppelsalzes aus o-Dioxyphenyl-äthanolmethylamin und Sparteinsulfat, dadurch gekennzeichnet, daß man Sparteinsulfat in wäßriger Lösung im molekularen Verhältnis auf o-Dioxyphenyläthanolmethylamin einwirken läßt. PATENT CLAIMS: x. Process for the preparation of a water-soluble double salt from o-dioxyphenylethanolmethylamine and sparteine sulfate, characterized in that sparteine sulfate is allowed to act on o-dioxyphenylethanolmethylamine in an aqueous solution in a molecular ratio. 2. Verfahren wie in Anspruch x, dadurch gekennzeichnet, daß man diese Reaktion im Überschuß von Sparteinsulfat erfolgen läßt. 2. Method as in claim x, characterized in that this reaction is carried out in excess of sparteine sulfate can be done. 3. Verfahren nach Anspruch x und 2, dadurch gekennzeichnet, daß man eine fertige Mischung beider fester Körper in Wasser miteinander reagieren lä.ßt.3. The method according to claim x and 2, characterized in that one a finished mixture of the two solid bodies in water reacts with one another.
DEC4084A 1951-04-19 1951-04-19 Process for the production of durable solutions of o-dioxyphenyl-ethanolamine Expired DE861906C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DEC4084A DE861906C (en) 1951-04-19 1951-04-19 Process for the production of durable solutions of o-dioxyphenyl-ethanolamine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEC4084A DE861906C (en) 1951-04-19 1951-04-19 Process for the production of durable solutions of o-dioxyphenyl-ethanolamine

Publications (1)

Publication Number Publication Date
DE861906C true DE861906C (en) 1953-01-08

Family

ID=7013267

Family Applications (1)

Application Number Title Priority Date Filing Date
DEC4084A Expired DE861906C (en) 1951-04-19 1951-04-19 Process for the production of durable solutions of o-dioxyphenyl-ethanolamine

Country Status (1)

Country Link
DE (1) DE861906C (en)

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