DE458837C - Process for the preparation of an aqueous solution of hexamethylenetetramine silver nitrate suitable for injections - Google Patents

Process for the preparation of an aqueous solution of hexamethylenetetramine silver nitrate suitable for injections

Info

Publication number
DE458837C
DE458837C DEZ15496D DEZ0015496D DE458837C DE 458837 C DE458837 C DE 458837C DE Z15496 D DEZ15496 D DE Z15496D DE Z0015496 D DEZ0015496 D DE Z0015496D DE 458837 C DE458837 C DE 458837C
Authority
DE
Germany
Prior art keywords
silver nitrate
aqueous solution
hexamethylenetetramine
injections
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DEZ15496D
Other languages
German (de)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to DEZ15496D priority Critical patent/DE458837C/en
Application granted granted Critical
Publication of DE458837C publication Critical patent/DE458837C/en
Expired legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Description

Verfahren zur Darstellung einer zu Injektionen geeigneten wässerigen Lösung von Hexamethylentetramin-Silbernitrat. Die Wirksamkeit von Silberlösungen als ein Desinfiziens ist bekannt. Jedoch verursachen Lösungen von z. B. Silbernitrat große Schmerzen, weshalb die Anwendung dieser Lösungen trotz ihrer hohen antibakteriellen Wirkung eine beschränkte ist. Es hat sich nun herausgestellt, daß man Silberlösungen Tierstellen kann, welche trotz einer im Vergleich zu Silbernitrat und anderen löslichen Silbersalzen erhöhten bakteriziden Kraft in der Anwendung fast schmerzlos sind. So ist eine Doppelverbindung von Silbernitrat und Hexamethy lentetramin bekannt. Sie kann aber keine Verwendung finden, weil die Löslichkeit in Wasser zu gering ist. Überraschendenveise hat es sich herausgestellt, daß man diese Doppelverbindung leicht in wässerige Lösung bringen kann, wenn man dem Lösungswasser organische Amine, wie z. B. Diäthylendiamin,_ zusetzt. Beispiel r.Method for preparing an aqueous solution suitable for injections Solution of hexamethylenetetramine silver nitrate. The effectiveness of silver solutions is known as a disinfectant. However, solutions of e.g. B. Silver Nitrate great pain, which is why the application of these solutions despite their high antibacterial properties Effect is limited. It has now been found that one can use silver solutions Animal bodies can, which despite one in comparison to silver nitrate and others soluble Silver salts have increased bactericidal power and are almost painless to use. A double compound of silver nitrate and Hexamethy lentetramin is known. But it cannot be used because its solubility in water is too low is. Surprisingly, it has been found that this double compound can easily be brought into aqueous solution if organic amines, such as B. diethylenediamine, _ adds. Example r.

Teile der Verbindung C@H"N4 - AgN O;, «-erden mit der gleichen Menge kristall. Diätlivlendiamin verrieben. Das Gemisch löst sich leicht in Wasser.Parts of the compound C @ H "N4 - AgN O ;,« -erden with the same amount crystal. Dietary livlenediamine triturated. The mixture dissolves easily in water.

Beispiele. 2 Teile Diäthylendiamin werden in roo Teilen Wasser aufgelöst; a Teile des obigen Doppelsalzes lösen sich glatt in dieser Lösung.Examples. 2 parts of diethylenediamine are dissolved in 100 parts of water; a Parts of the above double salt dissolve smoothly in this solution.

Claims (1)

PATE:hTTANSPRUCH erfahren zur Darstellung einer zu Injektionen geeigneten wässerigen Lösung von Hexamethylentetramin-Silbernitrat, dadurch gekennzeichnet, daß man Hexamethvlentetramin-Silbernitrat in wässerigen Lösungen von organischen Aminen auflöst.PATE: hTTANSPRUCH learn to present a suitable for injections aqueous solution of hexamethylenetetramine silver nitrate, characterized in that that one hexamethylene tetramine silver nitrate in aqueous solutions of organic Dissolves amines.
DEZ15496D 1925-08-13 1925-08-13 Process for the preparation of an aqueous solution of hexamethylenetetramine silver nitrate suitable for injections Expired DE458837C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DEZ15496D DE458837C (en) 1925-08-13 1925-08-13 Process for the preparation of an aqueous solution of hexamethylenetetramine silver nitrate suitable for injections

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEZ15496D DE458837C (en) 1925-08-13 1925-08-13 Process for the preparation of an aqueous solution of hexamethylenetetramine silver nitrate suitable for injections

Publications (1)

Publication Number Publication Date
DE458837C true DE458837C (en) 1928-04-19

Family

ID=7623803

Family Applications (1)

Application Number Title Priority Date Filing Date
DEZ15496D Expired DE458837C (en) 1925-08-13 1925-08-13 Process for the preparation of an aqueous solution of hexamethylenetetramine silver nitrate suitable for injections

Country Status (1)

Country Link
DE (1) DE458837C (en)

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