DE463805C - Process for the preparation of durable, sterilizable solutions which contain phosphorus in organic bonds and bound gold - Google Patents

Process for the preparation of durable, sterilizable solutions which contain phosphorus in organic bonds and bound gold

Info

Publication number
DE463805C
DE463805C DEC36851D DEC0036851D DE463805C DE 463805 C DE463805 C DE 463805C DE C36851 D DEC36851 D DE C36851D DE C0036851 D DEC0036851 D DE C0036851D DE 463805 C DE463805 C DE 463805C
Authority
DE
Germany
Prior art keywords
durable
preparation
solutions
contain phosphorus
organic bonds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DEC36851D
Other languages
German (de)
Inventor
Dr Louis Benda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
Original Assignee
Leopold Cassella et Cie GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leopold Cassella et Cie GmbH filed Critical Leopold Cassella et Cie GmbH
Priority to DEC36851D priority Critical patent/DE463805C/en
Application granted granted Critical
Publication of DE463805C publication Critical patent/DE463805C/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/242—Gold; Compounds thereof

Description

Verfahren zur Darstellung haltbarer, sterilisierbarer Lösungen, die Phosphor in organischer Bindung sowie gebundenes Gold enthalten Die in der Patentschrift 397 813 beschriebenen Salze der diallcylaminoarylphosphinigen Säure zersetzen sich beim Erhitzen ihrer wässerigen Lösungen unter Abspaltung der entsprechenden aromatischen Basen.Process for the preparation of durable, sterilizable solutions that Phosphorus in organic bonds and bound gold are contained in the patent 397 813 described salts of dialcylaminoarylphosphinous acid decompose when their aqueous solutions are heated, the corresponding aromatic ones are split off Bases.

Es wurde nun die überraschende Beobachtung gemacht, daß man vollkommen haltbare und sterilisierbare Lösungen gewinnen kann, wenn man Lösungen der obenerwähnten dialkylaminoarylphosphinigsauren Salze und die in der Patentschrift .462 187 beschriebenen Goldlösungen aufeinander einwirken läßt. Vermutlich handelt es sich um- die Bildung komplexer Anlagerungen.It has now made the surprising observation that one can gain durable and perfectly sterilizable solutions when solutions of the aforementioned salts dialkylaminoarylphosphinigsauren and the gold solutions described in the patent .462 187 can interact. Presumably it is about the formation of complex deposits.

Man erhält auf diese Weise Lösungen von hohem therapeutischen Wert, die ohne jede Reizwirkung eingespritzt werden können und die sowohl im Tierexperiment als auch in ausgedehnten klinischen Versuchen keine schädlichen Nebenwirkungen - selbst bei Verwendung hoher Dosen -, dagegen eine vorzügliche Heilwirkung bei der Behandlung tuberkulöser Prozesse gezeigt haben.In this way, solutions of high therapeutic value are obtained, which can be injected without any irritation and which are used in animal experiments as well as in extensive clinical trials no harmful side effects - even when using high doses -, on the other hand, an excellent healing effect with the Have shown treatment of tubercular processes.

Dieses günstige Ergebnis ist zum Teil der Gold-, zürn anderen Teil zweifellos der Phoshhorkornponente zuzuschreiben; denn klinische Versuche haben gezeigt, daß Phosphor in Form der diallzylaminoarylphosphinigen Säuren ein wertvolles Unterstützungsmittel bei der Heilung tuberkulöser Erkrankungen darstellt, und pharmakologisch sowohl wie klinisch wurden außerdem die analeptischen Eigenschaften dieser Phosphorverbindungen nachgewiesen, die namentlich bei der Goldbehandlung, die oft große Anforderungen an den Herzmuskel stellt, von Bedeutung sind. Beispiel.This favorable result is partly the gold, partly the other undoubtedly attributable to the phosphorus component; because clinical trials have showed that phosphorus in the form of the dialzylaminoarylphosphinous acids is a valuable Aids in curing tuberculous diseases, and pharmacologically The analeptic properties of these phosphorus compounds have also been shown both clinically and in the same way proven that, especially in gold treatment, the often great demands to the heart muscle are important. Example.

I oo g Goldnatriumthiosulfat und 25 g reines 1N atriumthiosulfat werden zusammen in 5 1 Wasser gelöst; man fügt eine Lösung von 50 g p-dimethylaminotolylphosphinigsauren Natriums in 5 1 Wasser hinzu und sterilisiert in der üblichen Weise in strömendem Wasserdampf; die Lösung bleibt vollkommen klar.10 g of gold sodium thiosulphate and 25 g of pure 1N atrium thiosulphate are dissolved together in 5 l of water; a solution of 50 g of sodium p-dimethylaminotolylphosphinous acid in 5 l of water is added and sterilized in the usual way in flowing steam; the solution remains perfectly clear.

Das Mischungsverhältnis der Komponenten kann in weiten Grenzen variiert werden. Auch kann man zurErreichung des gewünschten Effektes entweder die Lösungen zusammenbringen und sterilisieren oder aber die festen Substanzen mischen, dann lösen und hierauf sterilisieren.The mixing ratio of the components can vary within wide limits will. Either of the solutions can also be used to achieve the desired effect bring together and sterilize or mix the solid substances, then loosen and then sterilize.

Claims (1)

PATENTANSPRUCH: Verfahren zur Darstellung haltbarer, sterilisierbarer Lösungen, die Phosphor in organischer Bindung sowie gebundenes Gold enthalten, darin bestehend, daß man die gemäß Verfahren der Patentschrift 462 187 erhaltene komplexe Goldnatriumthiosulfatlösung auf Lösungen von dialkylaminoarylphosphinigsauren Salzen einwirken läßt oder die festen Ausgangsstoffe mischt und dann das Gemenge löst. PATENT CLAIM: Process for the preparation of durable, sterilizable solutions which contain phosphorus in organic bonds and bound gold, consisting in that the complex sodium gold thiosulfate solution obtained according to the process of patent specification 462 187 is allowed to act on solutions of dialkylaminoarylphosphinous acid salts or the solid starting materials are mixed and then the Mixture dissolves.
DEC36851D 1925-06-23 1925-06-23 Process for the preparation of durable, sterilizable solutions which contain phosphorus in organic bonds and bound gold Expired DE463805C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DEC36851D DE463805C (en) 1925-06-23 1925-06-23 Process for the preparation of durable, sterilizable solutions which contain phosphorus in organic bonds and bound gold

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEC36851D DE463805C (en) 1925-06-23 1925-06-23 Process for the preparation of durable, sterilizable solutions which contain phosphorus in organic bonds and bound gold

Publications (1)

Publication Number Publication Date
DE463805C true DE463805C (en) 1928-08-03

Family

ID=7022499

Family Applications (1)

Application Number Title Priority Date Filing Date
DEC36851D Expired DE463805C (en) 1925-06-23 1925-06-23 Process for the preparation of durable, sterilizable solutions which contain phosphorus in organic bonds and bound gold

Country Status (1)

Country Link
DE (1) DE463805C (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0054997A1 (en) * 1980-12-22 1982-06-30 THE PROCTER & GAMBLE COMPANY Anti-arthritic compositions containing gold salts and organophosphonates

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0054997A1 (en) * 1980-12-22 1982-06-30 THE PROCTER & GAMBLE COMPANY Anti-arthritic compositions containing gold salts and organophosphonates

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