DE374097C - Process for the production of double compounds from caffeine which are easily soluble in water - Google Patents

Process for the production of double compounds from caffeine which are easily soluble in water

Info

Publication number
DE374097C
DE374097C DEA32881D DEA0032881D DE374097C DE 374097 C DE374097 C DE 374097C DE A32881 D DEA32881 D DE A32881D DE A0032881 D DEA0032881 D DE A0032881D DE 374097 C DE374097 C DE 374097C
Authority
DE
Germany
Prior art keywords
caffeine
water
easily soluble
production
double compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DEA32881D
Other languages
German (de)
Inventor
Dr Marcell Bachstez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Agfa Gevaert NV
Original Assignee
Aktiengesellschaft fuer Anilinfabrikation GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aktiengesellschaft fuer Anilinfabrikation GmbH filed Critical Aktiengesellschaft fuer Anilinfabrikation GmbH
Priority to DEA32881D priority Critical patent/DE374097C/en
Application granted granted Critical
Publication of DE374097C publication Critical patent/DE374097C/en
Expired legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/12—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1, 3, and 7, e.g. caffeine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

Verfahren zur Herstellung von in Wasser leicht löslichen Doppelverbindungen aus Coffein. Es ist bekannt, daß Coffein mit den Alkalisalzen aliphatischer und aromatischer Säuren in leichtlösliche Doppelverbindungen übergeführt werden kann.Process for the production of double compounds which are readily soluble in water made from caffeine. It is known that caffeine is aliphatic and aliphatic with the alkali salts aromatic acids can be converted into easily soluble double compounds.

Es wurde nun gefunden, daß Coffein mit den Alkalisalzen der nach dem Verfahren des Patents 371692, K1. i2o, erhältlichen 4-Äthoxyphenylmalonamidsäureebenfallsleicht lösliche Doppelverbindungen bildet, wenn man die Komponenten im molekularen Verhältnis in Wasser löst und die Lösung zur Trockne eindampft. Daß diese kompliziert zusammengesetzte Säure gleichfalls leichtlösliche Doppelsalze bilden würde, war nicht zu erwarten.It has now been found that caffeine with the alkali salts of the after Procedure of patent 371692, K1. i2o, available 4-ethoxyphenylmalonamic acid also easily Soluble double compounds are formed when the components are in a molecular ratio dissolves in water and the solution evaporates to dryness. That this complex compound Acid would also form readily soluble double salts was not to be expected.

Die bisher angewandten Alkalisalze organischer Säuren dienten nur dazu, das Coffein leichtlöslich zu machen und so seine physiologische Wirkung zu erhöhen; dagegen verbinden sich bei den neuen Doppelverbindungen die den Alkalisalzen der 4-Äthoxyphenylmalonamidsäure eigenen antifebrilen und nervinen Eigenschaften mit der Wirkung des Coffeins in wertvoller Weise. Beispiel i. 245g 4-äthoxyphenylmalonamidsaures Natrium werden mit 2r2 g Coffein in wenig Wasser gelöst und die klare Lösung auf dem Wasserbade eingedampft. Es hinterbleibt ein weißes, kristallinisches Pulver, das in Wasser leichtlöslich ist. Bei.spie12. 229 g 4-äthoxyphenylmalonamidsaures Lithium werden mit 212 g Coffein in wenig Wasser gelöst und die klare Lösung auf dem Wasserbade eingedampft. Es hinterbleibt ein weißes, kristallinisches Pulver, das in Wasser leichtlöslich ist.The previously used alkali salts of organic acids were only used to make the caffeine easily soluble and thus its physiological effect raise; on the other hand, in the case of the new double compounds, the alkali salts combine 4-ethoxyphenylmalonamic acid has its own antifebrile and nervous properties with the effect of caffeine in a valuable way. Example i. 245g 4-ethoxyphenylmalonamic acid Sodium is dissolved in a little water with 2r2 g of caffeine and the clear solution is dissolved evaporated in the water bath. A white, crystalline powder remains, which is easily soluble in water. Bei.spie12. 229 g of 4-ethoxyphenylmalonamic acid Lithium are dissolved in a little water with 212 g of caffeine and the clear solution is dissolved evaporated in the water bath. A white, crystalline powder remains, which is easily soluble in water.

Claims (1)

PATENT-ANSPRUcH: Verfahren zur Herstellung von in Wasser leichtlöslichen Doppelverbindungen aus Coffein, darin bestehend, daß man Coffein und ein Alkalisalz der 4-Äthoxyphenylmalonamidsäure im molekularen Verhältnis in Wasser löst und die Lösung zur Trockne eindampft.PATENT CLAIM: Process for the production of readily soluble in water Double compounds of caffeine, consisting in that one caffeine and an alkali salt the 4-ethoxyphenylmalonamic acid dissolves in the molecular ratio in water and the Solution evaporated to dryness.
DEA32881D 1920-01-28 1920-01-28 Process for the production of double compounds from caffeine which are easily soluble in water Expired DE374097C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DEA32881D DE374097C (en) 1920-01-28 1920-01-28 Process for the production of double compounds from caffeine which are easily soluble in water

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEA32881D DE374097C (en) 1920-01-28 1920-01-28 Process for the production of double compounds from caffeine which are easily soluble in water

Publications (1)

Publication Number Publication Date
DE374097C true DE374097C (en) 1923-04-19

Family

ID=6927948

Family Applications (1)

Application Number Title Priority Date Filing Date
DEA32881D Expired DE374097C (en) 1920-01-28 1920-01-28 Process for the production of double compounds from caffeine which are easily soluble in water

Country Status (1)

Country Link
DE (1) DE374097C (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE944518C (en) * 1950-08-20 1956-06-14 Byk Gulden Lomberg Chem Fab Process for the preparation of solutions of xanthines substituted in the 1,3-position

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE944518C (en) * 1950-08-20 1956-06-14 Byk Gulden Lomberg Chem Fab Process for the preparation of solutions of xanthines substituted in the 1,3-position

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