CH95148A - Process for the preparation of the sodium salt of benzylphthalamic acid. - Google Patents

Process for the preparation of the sodium salt of benzylphthalamic acid.

Info

Publication number
CH95148A
CH95148A CH95148DA CH95148A CH 95148 A CH95148 A CH 95148A CH 95148D A CH95148D A CH 95148DA CH 95148 A CH95148 A CH 95148A
Authority
CH
Switzerland
Prior art keywords
benzylphthalamic
acid
sodium salt
preparation
water
Prior art date
Application number
Other languages
German (de)
Inventor
F Hoffmann- Aktiengesellschaft
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CH95148A publication Critical patent/CH95148A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

  

  Verfahren zur. Darstellung des     Natriumsalzes    der     Benzylphtalamidsäure.       Das     Natriumsalz    der     Benzylphtalamid-          säure    ist bis jetzt nur in seiner wässerigen  Lösung bekannt geworden. Versucht man es  durch Eindampfen derselben zu gewinnen, so  erhält man ein mehr oder weniger verun  reinigtes Präparat, da sich aus diesem Salz  in wässeriger Lösung namentlich     in    der  Wärme leicht wieder     Benzylphtalimid    bildet.  



  Nach dem Verfahren des Hauptpatentes  Nr. 94948 begegnet man der Zersetzung des       Natriumsalzes    der     Benzylphtalamidsäure     beim Eindampfen dadurch, dass der einzu  dampfenden Lösung eine geringe Menge Na  triumhydroxyd zugegeben wird.    Es wurde nun gefunden, dass die Zerset  zung des     Natriumsalzes    der     Benzylphtalamid-          säure    auch dadurch vermieden werden. kann,       wenn    das Eindampfen der wässerigen Lö  sung in genügend hohem Vakuum vorgenom  men .wird.  



  Das an     feuchter    Luft leicht     zerfliess-          liehe        Natriumsalz    der     Benzylphtalamidsäure,     welches in verfilzten Nadeln kristallisiert,  löst sich leicht in Wasser und verdünntem  Alkohol. Es hat die Eigenschaft, trotz seiner    Wasserlöslichkeit     spasmolytisch    zu wirken  und ist durch eine äusserst geringe     Toxizität     ausgezeichnet; daher soll es in der Therapie  Verwendung finden.

      <I>Beispiel:</I>    255 Teile     Benzylphtalamidsäure    (Berichte  der deutschen chemischen     Gesellschaft    81,  1898, S. 2740) werden mit Wasser verrührt  und durch allmählichen Zusatz von 144 Tei  len     Kristallsoda    in eine neutral reagierende  Lösung übergeführt. Die filtrierte Lösung  wird im Vakuum zur Trockne eingedampft  und der Trockenrückstand aus absolutem Al  kohol umkristallisiert.



  Procedure for. Preparation of the sodium salt of benzylphthalamic acid. The sodium salt of benzylphthalamic acid has hitherto only been known in its aqueous solution. If one tries to obtain it by evaporating it, one obtains a more or less uncleaned preparation, since benzylphthalimide is easily formed again from this salt in aqueous solution, especially when heated.



  According to the method of main patent no. 94948, the decomposition of the sodium salt of benzylphthalamic acid is countered during evaporation by adding a small amount of sodium hydroxide to the solution to be evaporated. It has now been found that the decomposition of the sodium salt of benzylphthalamic acid can also be avoided in this way. can if the aqueous solution is evaporated in a sufficiently high vacuum.



  The sodium salt of benzylphthalamic acid which dissolves easily in moist air and which crystallizes in matted needles dissolves easily in water and dilute alcohol. It has the property of having a spasmolytic effect despite its solubility in water and is distinguished by its extremely low toxicity; therefore it should be used in therapy.

      <I> Example: </I> 255 parts of benzylphthalamic acid (reports from the German Chemical Society 81, 1898, p. 2740) are mixed with water and converted into a neutral solution by gradually adding 144 parts of crystal soda. The filtered solution is evaporated to dryness in vacuo and the dry residue is recrystallized from absolute alcohol.

Claims (1)

PATENTANSPRUCH Verfahren zur Darstellung des Natrium salzes der. Benzylphtalamidsäure, dadurch gekennzeichnet, dass man seine wässerige Lö sung im Vakuum zur Trockne eindampft. Das an feuchter Luft leicht zerfliessliche Natriumsalz der Benzylphtalamidsäure, wel ches in verfilzten Nadeln kristallisiert, löst sich leicht in Wasser und verdünntem Alko- hol. Es hat die Eigenschaft, trotz seiner Wasserlöslichkeit spasmolytisch zu wirken und ist durch eine äusserst geringe Toxizität ausgezeichnet; daher soll es in der Therapie Verwendung finden. PATENT CLAIM Process for the preparation of the sodium salt of. Benzylphthalamic acid, characterized in that its aqueous solution is evaporated to dryness in vacuo. The sodium salt of benzylphthalamic acid, which dissolves easily in moist air and which crystallizes in matted needles, dissolves easily in water and dilute alcohol. It has the property of having a spasmolytic effect despite its solubility in water and is distinguished by its extremely low toxicity; therefore it should be used in therapy.
CH95148D 1921-03-05 1921-03-05 Process for the preparation of the sodium salt of benzylphthalamic acid. CH95148A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH95148T 1921-03-05

Publications (1)

Publication Number Publication Date
CH95148A true CH95148A (en) 1922-06-16

Family

ID=4352794

Family Applications (1)

Application Number Title Priority Date Filing Date
CH95148D CH95148A (en) 1921-03-05 1921-03-05 Process for the preparation of the sodium salt of benzylphthalamic acid.

Country Status (1)

Country Link
CH (1) CH95148A (en)

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