DE614337C - Process for the preparation of a calcium salt solution suitable for injection - Google Patents
Process for the preparation of a calcium salt solution suitable for injectionInfo
- Publication number
- DE614337C DE614337C DEC48646D DEC0048646D DE614337C DE 614337 C DE614337 C DE 614337C DE C48646 D DEC48646 D DE C48646D DE C0048646 D DEC0048646 D DE C0048646D DE 614337 C DE614337 C DE 614337C
- Authority
- DE
- Germany
- Prior art keywords
- calcium
- preparation
- injection
- salt solution
- calcium salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
Verfahren zur Herstellung einer zur Injektion geeigneten Caleiumsalzlösung Gegenstand des Patents 602 7 i i ist 'ein Verfahren zur Herstellung haltbarer, zur Injektion geeigneter Lösungen von a-(3-dioxypropionsaurem Calcium, das darin besteht, daß man glycerinsaures Calcium in Gegenwart von Natriumthiosulfat in Lösung bringt.Process for the preparation of a calcium salt solution suitable for injection The subject of patent 602 7 ii is' a process for the preparation of stable, suitable for injection solutions of a- (3-dioxypropionic acid calcium, which consists in bringing glyceric acid calcium into solution in the presence of sodium thiosulphate .
Es wurde nun gefunden, daß nicht nur glycerinsaures Calcium, sondern auch Calciumgluconat in Gegenwart von N.atriumthiosulfat haltbare Lösungen gibt; auch wird die Löslichkeit des 'gluconsauren Calciums in Wasser stark erhöht.It has now been found that not only calcium glycerate, but Calcium gluconate also gives durable solutions in the presence of sodium thiosulphate; the solubility of calcium gluconic acid in water is also greatly increased.
Es ist bekannt, daß man übersättigte, lange Zeit klarbleibende konzentrierte Calciumgluconatlösungen herstellen kann, jedoch muß nach dem Verfahren der Patentschrift q.723¢6 das Abfüllen von Calciumgluconat unter ganz besonderen Verhältnissen durchgeführt werden.It is known that over-saturated, long-lasting clear concentrates were concentrated Calcium gluconate solutions can produce, but must by the method of the patent q.723 ¢ 6 the filling of calcium gluconate is carried out under very special conditions will.
Man erhält nach dem vorliegenden Verfahren haltbare Lösungen von hoher Konzentration ohne Anwendung irgendwelcher besonderer Vorrichtungen, nur durch Auflösen des Calciumgluconats in Wasser in Gegenwart von N.atriumthiosulfat.The present process gives long-lasting solutions of high Concentration without the use of any special devices, just by dissolving of calcium gluconate in water in the presence of sodium thiosulphate.
Beispiel I a) 2o g gluconsauZes Calcium- werden in i oo g destilliertem Wasser in der Wärme gelöst. Nach Abkühlen nach 2¢ Stunden habet sich 18 g Calciumgluconat aus der Lösung abgeschieden.Example I a) 20 g of calcium gluconic acid are distilled in 10 g Water dissolved in the heat. After cooling down after 2 ¢ hours, you have 18 g of calcium gluconate deposited from the solution.
b) Versetzt man jedoch i-oo ccm Wasser z. B. mit q.,o g Natriumthiosülfat und lös nunmehr 2o g Calciumgluconat, so fallet nach 2¢ Stunden nach Abkühlen, unter genas denselben Bedingungen wie bei a), nur o,6 f gluconsaures Calcium aus.b) However, if one adds i-oo ccm of water z. B. with q., O g sodium thiosulfate and if 20 g of calcium gluconate now dissolve, it falls under after 2 [hours] after cooling Recovered the same conditions as in a), only o.6 f gluconic acid calcium.
Beispiel II io g gluconsaures Calcium werden mit 2 g gatriumthiosulfat verrieben und in 5o ccir. Wasser aufgelöst. Man erhält eine klare Lösung, die auch nach 24 Stunden nur einer. ganz geringen Niederschlag von Calciumgluconat aufweist. Die Lösung von 2 g Calciumgluconat ohne Natriumthiosulfat ergibt einen reichlichen Niederschlag von gluconsaurem Calcium.Example II 10 g of calcium gluconic acid are mixed with 2 g of sodium thiosulphate rubbed in and in 5o ccir. Dissolved in water. You get a clear solution, that too after 24 hours only one. has very little precipitation of calcium gluconate. The solution of 2 g of calcium gluconate without sodium thiosulfate gives an abundant one Precipitation of calcium gluconic acid.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEC48646D DE614337C (en) | 1933-12-19 | 1933-12-19 | Process for the preparation of a calcium salt solution suitable for injection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEC48646D DE614337C (en) | 1933-12-19 | 1933-12-19 | Process for the preparation of a calcium salt solution suitable for injection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE614337C true DE614337C (en) | 1935-06-07 |
Family
ID=7026803
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DEC48646D Expired DE614337C (en) | 1933-12-19 | 1933-12-19 | Process for the preparation of a calcium salt solution suitable for injection |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE614337C (en) |
-
1933
- 1933-12-19 DE DEC48646D patent/DE614337C/en not_active Expired
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