DE504183C - Process for the preparation of therapeutically valuable, sterile and durable solutions of p-dialkylaminoarylphosphinous acid salts suitable for injections - Google Patents

Process for the preparation of therapeutically valuable, sterile and durable solutions of p-dialkylaminoarylphosphinous acid salts suitable for injections

Info

Publication number
DE504183C
DE504183C DEI33982D DEI0033982D DE504183C DE 504183 C DE504183 C DE 504183C DE I33982 D DEI33982 D DE I33982D DE I0033982 D DEI0033982 D DE I0033982D DE 504183 C DE504183 C DE 504183C
Authority
DE
Germany
Prior art keywords
dialkylaminoarylphosphinous
sterile
injections
solutions
acid salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DEI33982D
Other languages
German (de)
Inventor
Dr Louis Benda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
IG Farbenindustrie AG
Original Assignee
IG Farbenindustrie AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by IG Farbenindustrie AG filed Critical IG Farbenindustrie AG
Priority to DEI33982D priority Critical patent/DE504183C/en
Application granted granted Critical
Publication of DE504183C publication Critical patent/DE504183C/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Description

Verfahren zur Darstellung therapeutisch wertvoller, steriler und haltbarer, zu Injektionen geeigneter Lösungen von p-dialkyiaminoarylphosphinigsauren Salzen Lösungen von dialkylaminoarylphosphinigsauren Salzen sind nicht haltbar. Besonders unangenehm tritt diese Unbeständigkeit in Erscheinung bei dem Versuch, solche Lösungen zu sterilisieren. In vielen Fällen tritt schon nach kurzem Erhitzen auf Sterilisationstemperatur Zersetzung ein unter Abscheidung des betreffenden Arylamins, in anderen Fällen färben sich die sterilisierten Lösungen nach kurzem Lagern und scheiden einen blauvioletten Niederschlag aus.Process for the preparation of therapeutically valuable, sterile and durable, for injections of suitable solutions of p-dialkyiaminoarylphosphinous acid salts Solutions of dialkylaminoarylphosphinous acid salts are not stable. Particularly This instability becomes unpleasant when trying to find such solutions to sterilize. In many cases, sterilization temperature occurs after a short period of heating Decomposition one with deposition of the arylamine in question, in other cases color the sterilized solutions after a short storage and excrete a blue-violet Precipitation from.

Es wurde nun gefunden, daß man durch Zusatz säurebindender Substanzen zu den neutral reagierenden Lösungen vollkommen beständige und sterilisierbare Lösungen erhält, die - in Form von subkutanen, intravenösen oder intramuskulären Injektionen angewandt -sich als hervorragende, völlig ungiftige und reizlose Roborantia, Stoffwechsel-Stimulantia und Antirachitica erwiesen haben.It has now been found that by adding acid-binding substances Completely stable and sterilizable solutions in addition to the neutral reacting solutions receives that - in the form of subcutaneous, intravenous or intramuscular injections Applied as an excellent, completely non-toxic and irritant-free Roborantia, metabolic stimulant and Antirachitica have proven.

Die Ausführung des Verfahrens kann in der Weise geschehen, da.ß man die gelösten Komponenten zusammenbringt und dann sterilisiert oder daß man sie in festem Zustande mischt, die Mischung löst und hierauf sterilisiert.The procedure can be carried out in such a way that one the dissolved components are brought together and then sterilized or that they are in solid state mixes, the mixture dissolves and then sterilized.

Als Lösungsmittel dient reines Wasser; es können aber auch in manchen Fällen mit Vorteil sogenannte physiologische Lösungen, wie physiologische Kochsalzlösung, Ringer-L östing u. dgl., verwendet werden. Beispiel 1,25 kg i-dimethylamino-3-methylbenzol-4-phosphinigsaures Natrium (vgl. Patentschrift 397 813 der Klasse i2q, Beispiel 2) werden in ioo 1 Wasser gelöst. Man fügt 4o g Natrium carbonicum siccum (D. A. B. 6) zu und sterilisiert bei ioo° G i Stunde lang in strömendem Wasserdampf. Die Lösung bleibt vollkommen klar und wasserhell und ist unbegrenzte Zeit haltbar, während eine ohne Zusatz von Natrium carbonicum siccum, aber sonst in gleicher Weise bereitete Lösung nach dem Sterilisieren zersetzt ist unter Abscheidung von Öltropfen, die im wesentlichen aus Dimethylm-toluidin bestehen.Pure water is used as the solvent; In some cases, however, so-called physiological solutions, such as physiological saline solution, Ringer's dissolving and the like, can also be used with advantage. Example 1.25 kg of i-dimethylamino-3-methylbenzene-4-phosphinous acid sodium (cf. patent specification 397 813 of class i2q, example 2) are dissolved in 100 l of water. 40 g of sodium carbonicum siccum (DAB 6) are added and sterilized at 100 ° G for 1 hour in flowing steam. The solution remains completely clear and water-white and can be kept indefinitely, while a solution prepared without the addition of sodium carbonicum siccum, but otherwise prepared in the same way, is decomposed after sterilization with the separation of oil droplets, which essentially consist of dimethylm-toluidine.

Claims (1)

PATENTANSPRUCH: Verfahren zur Darstellung therapeutisch wertvoller, steriler und. haltbarer, zu Injektionen geeigneter Lösungen von p-dialkylaminoarylphosphinigsauren Salzen, darin bestehend, daß man Lösungen dieser Salze nach Zusatz säurebindender Stoffe sterilisiert oder die festen Komponenten mischt und die Lösung der Mischung sterilisiert. PATENT CLAIM: Process for the presentation of therapeutically valuable, sterile and. Durable, injectable solutions of p-dialkylaminoarylphosphinous acid salts, consisting in that solutions of these salts are sterilized after the addition of acid-binding substances or the solid components are mixed and the solution of the mixture is sterilized.
DEI33982D 1928-03-30 1928-03-30 Process for the preparation of therapeutically valuable, sterile and durable solutions of p-dialkylaminoarylphosphinous acid salts suitable for injections Expired DE504183C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DEI33982D DE504183C (en) 1928-03-30 1928-03-30 Process for the preparation of therapeutically valuable, sterile and durable solutions of p-dialkylaminoarylphosphinous acid salts suitable for injections

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEI33982D DE504183C (en) 1928-03-30 1928-03-30 Process for the preparation of therapeutically valuable, sterile and durable solutions of p-dialkylaminoarylphosphinous acid salts suitable for injections

Publications (1)

Publication Number Publication Date
DE504183C true DE504183C (en) 1930-08-07

Family

ID=7188581

Family Applications (1)

Application Number Title Priority Date Filing Date
DEI33982D Expired DE504183C (en) 1928-03-30 1928-03-30 Process for the preparation of therapeutically valuable, sterile and durable solutions of p-dialkylaminoarylphosphinous acid salts suitable for injections

Country Status (1)

Country Link
DE (1) DE504183C (en)

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