DE726635C - Process for the production of rich, durable solutions of calcium gluconate or lactate - Google Patents

Process for the production of rich, durable solutions of calcium gluconate or lactate

Info

Publication number
DE726635C
DE726635C DEI62952D DEI0062952D DE726635C DE 726635 C DE726635 C DE 726635C DE I62952 D DEI62952 D DE I62952D DE I0062952 D DEI0062952 D DE I0062952D DE 726635 C DE726635 C DE 726635C
Authority
DE
Germany
Prior art keywords
solutions
lactate
rich
calcium
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DEI62952D
Other languages
German (de)
Inventor
Dr Hans Schmidt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
IG Farbenindustrie AG
Original Assignee
IG Farbenindustrie AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by IG Farbenindustrie AG filed Critical IG Farbenindustrie AG
Priority to DEI62952D priority Critical patent/DE726635C/en
Application granted granted Critical
Publication of DE726635C publication Critical patent/DE726635C/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

Verfahren zur Herstellung gehaltreicher. haltbarer Lösungen von Calciumgluconat oder -lactat Es wurde gefunden, daß man zu haltbaren, für Injektionszwecke brauchbaren Lösungen von Calciumgluconat oder -lactat mit einem hohen Calciumgehalt gelangt, wenn man die Lösungen unter Zusatz von Calciumhypophosphit herstellt. Es lassen sich so leicht neutrale, für die Injektion geeignete, haltbare Lösungen mit einem Calciumgehalt von 10, 20, 30, 40 und mehr Milligramm Calcium im Kubikzentimeter herstellen, d. h. weit höhere Konzentrationen erreichten, als sie mit den Einzelkomponenten allein möglich sind.Process for the production of rich. more stable solutions of calcium gluconate or lactate It has been found that one can use too long-lasting, usable for injection purposes Calcium gluconate or lactate solutions with a high calcium content get in, if the solutions are prepared with the addition of calcium hypophosphite. Leave it This makes it easy to find neutral, stable solutions suitable for injection with one Calcium content of 10, 20, 30, 40 and more milligrams of calcium per cubic centimeter manufacture, d. H. far higher concentrations than they achieved with the individual components alone are possible.

Es muß daher die Bildung von Doppelverbindungen in der Lösung angenommen merden.The formation of double compounds in the solution must therefore be assumed merden.

Äfan kann den Lösungen auch einen fiir medizinische Zwecke erwünschten Gehalt an Magnesium durch Zusatz von Magnesiumhypophosphit geben, ohne daß eine Kristallisation eintritt, während ein entsprechender Zusatz von z. B. Magnesiumgluconat reichliche Kristallisation zur Folge hat. The solutions can also be used for medical purposes Giving magnesium content by adding magnesium hypophosphite without a Crystallization occurs, while an appropriate addition of z. B. Magnesium gluconate results in copious crystallization.

Die gemäß dem vorliegenden Verfahren erhältlichen Lösungen haben sich als gut verträglich erwiesen. Die NIöglichkeit, hohe Konzentrationen herzustellen, ist für gewisse pharmazeutische Zwecke zur Vermeidung hoher Volumina der Injektionslösungen von Bedeutung. außerdem ist auch der Gehalt der Lösungen an Hypophospbit therapeutisch wertvoll. Have the solutions obtainable according to the present process proved to be well tolerated. The ability to produce high concentrations is for certain pharmaceutical purposes to avoid high volumes of injection solutions significant. in addition, the hypophosphite content of the solutions is also therapeutic valuable.

Die Herstellung der Lösungen erfolgt in der Weise, daß man die Komponenten unter Erwärmen in Wasser löst und die Lösung auf das gewünschte Volumen bringt. So erhält man z.B. Lösungen mit nachstehendem Gehalt an Calcium bzw. Calcium und Magnesium, wenn man folgende Mengen der Salze unter Erwärmen in Wasser löst und die Lösung auf 100 ccm auffüllt bzw. einengt: Calcium- 1 ccm enthält Magnesium- gluconat lactat Ca Mg phit 12 g 12,8 g - - 40 mg - 15,2 g 10,8 g - 10 g 40 mg 9,2 mg 12 g 12,8 g - 10 g 40 mg 9,2 mg - 11,4 g 10 g - 40 mg - - 11,4 g 10 g 10 g 40 mg 9,2 mg In gleicher Weise kann man mit anderen Mengenverhältnissen zu haltbaren, konzentrierten Calciumlösungen gelangen.The solutions are prepared in such a way that the components are dissolved in water with heating and the solution is brought to the desired volume. For example, solutions with the following content of calcium or calcium and magnesium are obtained if the following amounts of the salts are dissolved in water while warming and the solution is made up to 100 ccm or reduced: Calcium contains 1 cc Magnesium- gluconate lactate Ca Mg phit 12 g 12.8 g - - 40 mg - 15.2 g 10.8 g - 10 g 40 mg 9.2 mg 12 g 12.8 g - 10 g 40 mg 9.2 mg - 11.4 g 10 g - 40 mg - - 11.4 g 10 g 10 g 40 mg 9.2 mg In the same way, you can get stable, concentrated calcium solutions with other proportions.

Claims (2)

P A T E N T A N S P R Ü C H E : 1. Verfahren zur Herstellung gehaltreicher, haltbarer Lösungen von Calciumgluconat oder -lactat, dadurch gekennzeichnet, daß man die Lösungen unter Zusatz von Calciumhypophosphit herstellt. P A T E N T A N S P R Ü C H E: 1. Process for the production of rich, Durable solutions of calcium gluconate or lactate, characterized in that the solutions are prepared with the addition of calcium hypophosphite. 2. Ausführungsform des Verfahrens nach Auspruch 1, dadurch gekennzeichnet, daß die Lösungen außer den genannten Bestandteilen Magnesiumhypophosphit enthalten. 2. Embodiment of the method according to claim 1, characterized in that that the solutions contain magnesium hypophosphite in addition to the components mentioned.
DEI62952D 1938-11-23 1938-11-23 Process for the production of rich, durable solutions of calcium gluconate or lactate Expired DE726635C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DEI62952D DE726635C (en) 1938-11-23 1938-11-23 Process for the production of rich, durable solutions of calcium gluconate or lactate

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEI62952D DE726635C (en) 1938-11-23 1938-11-23 Process for the production of rich, durable solutions of calcium gluconate or lactate

Publications (1)

Publication Number Publication Date
DE726635C true DE726635C (en) 1942-10-17

Family

ID=7195792

Family Applications (1)

Application Number Title Priority Date Filing Date
DEI62952D Expired DE726635C (en) 1938-11-23 1938-11-23 Process for the production of rich, durable solutions of calcium gluconate or lactate

Country Status (1)

Country Link
DE (1) DE726635C (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1287254B (en) * 1964-01-20 1969-01-16 Astra Ab Process for the production of an aqueous solution with a high calcium content for veterinary medicine

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1287254B (en) * 1964-01-20 1969-01-16 Astra Ab Process for the production of an aqueous solution with a high calcium content for veterinary medicine

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