DE731086C - Process for the preparation of durable solutions of calcium gluconate or lactate - Google Patents

Process for the preparation of durable solutions of calcium gluconate or lactate

Info

Publication number
DE731086C
DE731086C DEI64233D DEI0064233D DE731086C DE 731086 C DE731086 C DE 731086C DE I64233 D DEI64233 D DE I64233D DE I0064233 D DEI0064233 D DE I0064233D DE 731086 C DE731086 C DE 731086C
Authority
DE
Germany
Prior art keywords
calcium
solutions
magnesium
lactate
gluconate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DEI64233D
Other languages
German (de)
Inventor
Dr Hans Schmidt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
IG Farbenindustrie AG
Original Assignee
IG Farbenindustrie AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by IG Farbenindustrie AG filed Critical IG Farbenindustrie AG
Priority to DEI64233D priority Critical patent/DE731086C/en
Application granted granted Critical
Publication of DE731086C publication Critical patent/DE731086C/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Description

Verfahren zur Herstellung haltbarer Lösungen von Calciumgluconat oder -lactat Durch das Patent 726 635 wird ein Verfahren zur Herstellung von haltbaren, für Injektionszwecke brauchbaren Lösungen mit einem hohen Calciumgehalt geschützt. Das Verfahren besteht darin, daß man Lösungen von Calcimnsalzen der Gluconsäure oder Milchsäure unter Mitverwendung von Calciumhypophosphit herstellt. Diesen Lösungen kann man einen für medizinische Zwecke erwünschten Gehalt an Magnesium durch Zusatz von Magnesiumhypophosphit geben.Process for making durable solutions of calcium gluconate or -lactate Patent 726 635 describes a process for the production of durable, solutions with a high calcium content suitable for injection purposes. The method consists in making solutions of the calcium salts of gluconic acid or lactic acid using calcium hypophosphite. These solutions you can add a magnesium content that is desirable for medical purposes of magnesium hypophosphite.

Es wurde gefunden, daß die Haltbarkeit der Calciurnsalzlösiingen auch dann aufrechterhalten bleibt, wenn diese das Magnesium nicht nur in Form des Hypophosphits, sondern auch in Form anderer löslicher Magnesiumsalze enthalten. Jedoch müssen solche löslichen Magnesiumsalze vermieden werden, deren Säureion bereits als Calciumsalz vorliegt. Magnesiumgluconat hat somit als Zusatz auszuscheiden, wenn man eine Calciumgluconatlösung herzustellen beabsichtigt; das gleiche gilt für Magnesiulmlactat, wenn man von Calciumlactatlö:sungen ausgeht. Solche Lösungen kristallisieren leicht aus. Diese Regel war nicht ohne weiteres zu vermuten, da sie für die unterphosphorige Säure als Säureion nach den Angaben des Patents 726 635 nicht zutriftt. It has been found that the shelf life of the calcium salt solutions is maintained even if this is not just the magnesium in the form of the Hypophosphite, but also in the form of other soluble magnesium salts. However, such soluble magnesium salts must be avoided, their acid ion already is present as a calcium salt. Magnesium gluconate has to be excreted as an additive, if one intends to prepare a calcium gluconate solution; the same goes for for magnesium lactate, assuming calcium lactate solutions. Such solutions easily crystallize. This rule was not to be suspected without further ado they for hypophosphorous acid as acid ion according to the information in patent 726 635 does not drift.

Der Zusatz anderer Magnesiumsalze als Magnesiumhypophosphit hat unter anderem den Vorteil, in der Menge der eingebrachten unterphosphorigen Säure nicht von derjenigen des eingeführten Magnesiums abhängig zu sein, was für therapeutische Zwecke von Bedeutung ist. The addition of magnesium salts other than magnesium hypophosphite has under among other things, the advantage is not in the amount of hypophosphorous acid introduced depends on that of the imported magnesium to be what is of importance for therapeutic purposes.

Claims (1)

Die Herstellung der Lösungen erfolgt wie im Patent 726 635 angegeben in der Weise, daß man die Komponenten unter Erwärmen in Wasser löst und die Lösung auf das gel; wünschte Volumen bringt. Löst man die in der nachstehenden Tabelle in g angegebenen Sälzmengen in so viel Wasser, daß man 100 ccm Flüssigkeit erhält, dann gelangt man zu Lösungen, die in 1 ccm ungefähr 40 mg Calcium und 9,2 mg Magnesium enthalten. Diese Lösungen halten sich unter den üblichen sterilen Bedingungen auch bei monatelanger Beobachtung unverändert. The solutions are prepared as indicated in patent 726,635 in such a way that the components are dissolved in water with heating and the solution on the gel; brings the desired volume. Solve the in the table below The amount of salt given in g in so much water that 100 ccm of liquid is obtained, Then one arrives at solutions which in 1 ccm approximately 40 mg calcium and 9.2 mg magnesium contain. These solutions also hold up under the usual sterile conditions unchanged after months of observation. Die Angaben in den Spalten beziehen sich auf g in 100 ccm Lösung. Calcium- Magnesium- gluconat lactat hypophosphit chlorid acetat lactat gluconat 13,96 - 11,4 7,9 - - - 13,96 - 11,4 - 8,2 - - 13,96 - 11,4 - - 10 - 15,40 - 10,7 - 8,2 - - - 10 11,4 - 8,2 - - - 10 11,4 7,9 - - - - 10 11,4 - - - 18
In ähnlicher Weise kann man mit anderen Mengenverhältnissen oder Konzentrationen zu Calcium-Magnesium-Lösungen von guter Stabilität gelangen. Calcium- -- Magnesium- gluconat hypophosphit lactat thiosulfat 10 3,8 4,6 5 1,9 2,3 I4 11,4 10 7 I,5 2.5 7 1,5 2,5
PATEXTAXSPRUCH: Abänderung des Verfahrens nach Patent 726 635, dadurch gekennzeichnet, daß man Lösungen des Calciumgluconats oder -lactats, die Magnesium in Form anderer löslicher Magnesiumsalze enthalten, deren Säureion nicht bereits als Calciumsalz vorliegt, unter Zusatz von Calciumhypophosphit herstellt.The information in the columns relates to g in 100 ccm solution. Calcium magnesium gluconate lactate hypophosphite chloride acetate lactate gluconate 13.96 - 11.4 7.9 - - - 13.96 - 11.4 - 8.2 - - 13.96 - 11.4 - - 10 - 15.40 - 10.7 - 8.2 - - - 10 11.4 - 8.2 - - - 10 11.4 7.9 - - - - 10 11.4 - - - 18th
In a similar way, calcium-magnesium solutions of good stability can be obtained with other proportions or concentrations. Calcium - magnesium gluconate hypophosphite lactate thiosulphate 10 3.8 4.6 5 1.9 2.3 I4 11.4 10 7 I, 5 2.5 7 1.5 2.5
PATEX TAX CLAIM: Modification of the process according to patent 726 635, characterized in that solutions of calcium gluconate or lactate containing magnesium in the form of other soluble magnesium salts, the acid ion of which is not already present as calcium salt, are prepared with the addition of calcium hypophosphite.
DEI64233D 1939-03-30 1939-03-30 Process for the preparation of durable solutions of calcium gluconate or lactate Expired DE731086C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DEI64233D DE731086C (en) 1939-03-30 1939-03-30 Process for the preparation of durable solutions of calcium gluconate or lactate

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEI64233D DE731086C (en) 1939-03-30 1939-03-30 Process for the preparation of durable solutions of calcium gluconate or lactate

Publications (1)

Publication Number Publication Date
DE731086C true DE731086C (en) 1943-02-08

Family

ID=7196083

Family Applications (1)

Application Number Title Priority Date Filing Date
DEI64233D Expired DE731086C (en) 1939-03-30 1939-03-30 Process for the preparation of durable solutions of calcium gluconate or lactate

Country Status (1)

Country Link
DE (1) DE731086C (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1012031B (en) * 1955-12-23 1957-07-11 Merck Ag E Process for stabilizing solutions of ascorbic acid and calcium salts, preferably calcium gluconate
DE1030515B (en) * 1954-11-29 1958-05-22 Alpine Chemische A G Process for the production of stable injectable solutions of an easily water-soluble magnesium double salt of ascorbic acid and salicylic acid

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1030515B (en) * 1954-11-29 1958-05-22 Alpine Chemische A G Process for the production of stable injectable solutions of an easily water-soluble magnesium double salt of ascorbic acid and salicylic acid
DE1012031B (en) * 1955-12-23 1957-07-11 Merck Ag E Process for stabilizing solutions of ascorbic acid and calcium salts, preferably calcium gluconate

Similar Documents

Publication Publication Date Title
DE731086C (en) Process for the preparation of durable solutions of calcium gluconate or lactate
DE1212679B (en) Process for the preparation of insulin solutions
DE726635C (en) Process for the production of rich, durable solutions of calcium gluconate or lactate
DE977478C (en) Process for the manufacture of injectable insulin preparations with delayed action
CH241111A (en) Process for the production of an easily soluble, durable product containing calcium and the gluconic acid residue.
DE714141C (en) Process for the production of long-lasting, saturated solutions of calcium glucoheptonate
DE688962C (en) Process for the production of durable calcium salt solutions
DE855894C (en) Process for the production of durable, aqueous solutions of gluconates
DE589519C (en) Process for the production of durable solutions of aminobenzoic acid alcohol esters
DE711635C (en) Process for stabilizing solutions of the circulatory hormone kallikrein from pancreas
DE636308C (en) Process for the production of praseodymium salts or their aqueous solutions
DE557519C (en) Process for the preparation of easily soluble alkali salts of acylaminophenolar acids
AT136741B (en) Process for the preparation of durable solutions of aminobenzoic acid alkamine esters.
DE372246C (en) Process for the production of long-lasting alkaline alumina salt solutions
DE682955C (en) Process for the representation of solutions of anesthetizing substances
DE873087C (en) Process for the production of easily soluble halopyridone compounds
DE1026046B (en) Process for the production of concentrated stable aqueous Mg-solutions
DE519053C (en) Process for the preparation of salts of camphoric acid with scopolamine, hyoscyamine and atropine
CH233509A (en) Process for increasing the shelf life of cut flowers.
DE668590C (en) Process for the preservation of skins, hides and bare
DE472346C (en) Process for the preparation of a concentrated calcium solution which remains clear for a long time and which can be injected intramuscularly without tissue irritation
DE694902C (en) Process for the production of high-content solutions of calcium sodium lactate
DE964632C (en) Process for the production of colourfast, durable streptomycin solutions of high effectiveness
DE831882C (en) Process for the production of concentrated, injectable and undecomposed sterilizable solutions of iron (3) polyoxycarboxylic acid complex compounds
DE903624C (en) Process for the preparation of durable, injectable solutions of 1-phenyl-2, 3-dialkyl-4-dialkylamino-5-pyrazolones