DE682955C - Process for the representation of solutions of anesthetizing substances - Google Patents
Process for the representation of solutions of anesthetizing substancesInfo
- Publication number
- DE682955C DE682955C DEI50159D DEI0050159D DE682955C DE 682955 C DE682955 C DE 682955C DE I50159 D DEI50159 D DE I50159D DE I0050159 D DEI0050159 D DE I0050159D DE 682955 C DE682955 C DE 682955C
- Authority
- DE
- Germany
- Prior art keywords
- solutions
- chloride
- blood
- substances
- representation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
Landscapes
- Health & Medical Sciences (AREA)
- Emergency Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
Verfahren zur Darstellung von Lösungen anästhesierend wirkender Stoffe Die im Handel befindlichen Lösungen von anästhesierend wirkenden Substanzen enthalten meistens außer dem Anästhetikum und einem gefäßverengenden Mittel in wechselnden Mengen noch anorganische oder organische Salze. Obgleich diese Salze im menschlichen und tierischen Blutserum vorkommen können, ist es bis heute nicht geglückt, beständige Lösungen herzustellen, welche sämtliche im Blut ,enthaltenen Salze, nämlich Kaliumsulfat, Kaliumchlorid, Natriumchlorid, Natriumbicarbonat, Calciumchlorid, Magnesiumchlorid und sekundäres Natriumphosphat enthalten. Der Grund hierfür ist in dem Umstand zu suchen, daß .es bisher nicht gelang, haltbare Lösungen der Blutsalze ohne Zuhilfenahme kolloider Substanzen darzustellen, da die Calciumionen mit den Carbonat- und Phosphationen bald unter Bildung von Fällungen oder Trübungen reagieren.Process for the preparation of solutions of substances with anesthetic effect The commercially available solutions contain substances with anesthetic effect mostly besides the anesthetic and a vasoconstrictor in alternate Amounts of inorganic or organic salts. Although these salts are in the human and animal blood serum can occur, it has not been successful to this day To prepare solutions that contain all salts contained in the blood, namely potassium sulfate, Potassium chloride, sodium chloride, sodium bicarbonate, calcium chloride, magnesium chloride and secondary sodium phosphate. The reason for this is in the circumstance too seek that it has not yet been possible to obtain stable solutions of the blood salts without assistance represent colloidal substances, since the calcium ions with the carbonate and phosphate ions soon react with the formation of precipitates or opacities.
Es wurde nun gefunden, daß man stabile wäßrige Lösungen aller. im Blut enthaltender Salze dadurch herstellen kann, daß man den Lösungen eine anästhesierend wirkende Verbindung aus der Klasse der Aminobenzoes.äurealkaminester hinzufügt. Führt man das Verfahren so aus, daß man -die Blutsalze zunächst in Wasser löst, bis zur Entstehung der Niederschläge wartet und ,darauf das Anästhetikum zugibt, so lösen sich die Niederschläge völlig auf. Offenbar geben die Anästhetika mit den Calciumsalzen Molekülverbindungen, welche gegen Carbonat- und Phosphationen lösungsbeständig sind.It has now been found that stable aqueous solutions of all. in the Blood containing salts can be prepared by giving the solutions an anesthetic active compound from the class of aminobenzoes.äurealkaminester adds. If the procedure is carried out in such a way that -the blood salts are first dissolved in water, waits until the precipitation occurs and then adds the anesthetic, so the precipitates dissolve completely. Apparently the anesthetics give with the Calcium salts Molecular compounds which are resistant to carbonate and phosphate ions are.
Mit Hilfe des neuen Verfahrens ist ein Weg geschaffen, Lösungen ,anästhesierend wirkender Substanzen zu gewinnen, welche die gleichen Ionen wie das Blutserum haben. Durch Verwendung geeigneter Mengen der einzelnen Komponenten gelingt es, die nach dem Verfahren der Erfindung darstellbaren isoionischen Lösungen von anästhesierend wirkenden Stoffen dem osmotischen Druck der Blutflüssigkeit anzugleichen, wobei die Wasserstoffionenkonzentration schwanken kann. Ddn Lösungen können ,gefäßverengende Mittel, wie z. B. Dioxyphenyläthanolmethylamin, ferner Glucose sowie Stoffe, die wie Oxäthylmethylcellulose die Viscosität erhöhen, zugesetzt werden.With the help of the new procedure a way is created, solutions, anesthetizing to gain active substances which have the same ions as the blood serum. By using suitable amounts of the individual components it is possible to achieve the isoionic solutions of anesthetizing which can be prepared using the method of the invention acting substances to adjust to the osmotic pressure of the blood fluid, whereby the hydrogen ion concentration can fluctuate. Ddn solutions can, vasoconstrictive Means such as B. Dioxyphenyläthanolmethylamin, also glucose and substances that as Oxäthylmethylcellulose increase the viscosity, are added.
Beispiele i. 2 g p-Aminobenzoesäurediäthylanvnoäthylesterchlorhydrat, 7 mg Kaliumsulfat, 3 z mg Kaliumchlorid, q.oo mg Natriumchlorid, i oo mg Glucose, 23 ¢ mg Natriumbicarbonat, 30 mg Calciumchlorid, i i mg Magnesiumchlorid und 7,5m9 sekundäres Natriumphosphat werden mit Wasser zu i oo g gelöst. Die Lösung ist in bezug auf Blutserum isoionisch und isotonisch.Examples i. 2 g of p-aminobenzoic acid diethylanvnoäthylesterchlorhydrat, 7 mg of potassium sulfate, 3 mg of potassium chloride, q.oo mg of sodium chloride, 10 mg of glucose, 23 mg of sodium bicarbonate, 30 mg of calcium chloride, 11 mg of magnesium chloride and 7.5 mg of secondary sodium phosphate are mixed with water to 100 mg g solved. The solution is isoionic and isotonic with respect to blood serum.
2. 2 g p-Anvnobenzoesäurediäthylami4ap; äthylesterchlorhydrat, 2o mg o-Dioxypheripropanolaminchlorhydrat, 25o mg Oxäty= methylcellulose, 32 mg Kaliumchlorid, 280:@i# Natriumchlorid, roomg Glucose, 3omg Cal= ciumc hlorid, i i mg Magnesiumchlorid, 230 mg Natriumbicarbonat, 7,5 mg sekundäres Natriumphosphat und 7 mg Kaliumsulfat werden mit Wasser zu iooccm gelöst. Die Lösung ist in bezug auf Blutserum isoionisch, isotonisch und zeigt die gleiche Viscosität wie Blutserum.2. 2 g of p-annobenzoic acid diethylami4ap; ethyl ester chlorohydrate, 20 mg o-dioxypheripropanolamine chlorohydrate, 25o mg oxäty = methylcellulose, 32 mg potassium chloride, 280: @ i # sodium chloride, roomg glucose, 3omg calcium chloride, ii mg magnesium chloride, 230 mg sodium bicarbonate, 7.5 mg secondary sodium phosphate and 7 mg of potassium sulphate are dissolved in water to give 10 ounces. The solution is isoionic, isotonic with respect to blood serum, and exhibits the same viscosity as blood serum.
3. 2 g p-Aminobenzoesäurediäthylaminoäthylesterchlorhydrat, 20 mg
o-Dioxyphenylpropanolaminchlorhydrat, 250 mg Oxäthylmethylcellulose, 32 mg
Kaliumchlorid, 28o mg Natriumchlorid, i oo mg Glucose, 3o mg Calciumchlorid, i i
mg Magnesiumchlorid, 23o mg Natriumbicarbonat, 7,5 mg sekundäres Natriumphosphat,
7 mg Kaliumsulfat und i oo Y Stearolsäure werden mit Wasser zu i oo g
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEI50159D DE682955C (en) | 1934-07-15 | 1934-07-15 | Process for the representation of solutions of anesthetizing substances |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEI50159D DE682955C (en) | 1934-07-15 | 1934-07-15 | Process for the representation of solutions of anesthetizing substances |
Publications (1)
Publication Number | Publication Date |
---|---|
DE682955C true DE682955C (en) | 1939-10-25 |
Family
ID=7192753
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DEI50159D Expired DE682955C (en) | 1934-07-15 | 1934-07-15 | Process for the representation of solutions of anesthetizing substances |
Country Status (1)
Country | Link |
---|---|
DE (1) | DE682955C (en) |
-
1934
- 1934-07-15 DE DEI50159D patent/DE682955C/en not_active Expired
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