DE872246C - Production of readily water-soluble compounds and concentrated aqueous solutions of theophylline or caffeine - Google Patents
Production of readily water-soluble compounds and concentrated aqueous solutions of theophylline or caffeineInfo
- Publication number
- DE872246C DE872246C DEC1110D DEC0001110D DE872246C DE 872246 C DE872246 C DE 872246C DE C1110 D DEC1110 D DE C1110D DE C0001110 D DEC0001110 D DE C0001110D DE 872246 C DE872246 C DE 872246C
- Authority
- DE
- Germany
- Prior art keywords
- theophylline
- caffeine
- aqueous solutions
- concentrated aqueous
- production
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
Herstellung von leichtwasserlöslichen Verbindungen und konzentrierten wäßrigen Lösungen des Theophyllins bzw. Koffeins Es sind bereits verschiedene Verfahren bekannt, um Theophyllin oder Koffein, die an sich schwer löslich sind, in wäßrige Lösungen zu überführen.Production of readily water-soluble compounds and concentrated aqueous solutions of theophylline or caffeine There are already different procedures known to be theophylline or caffeine, which in themselves are sparingly soluble in aqueous Convict solutions.
Hier hat man als Lösungsvermittler leichtwasserlösliche aliphatische Amine verwendet.Here one has readily water-soluble aliphatic as a solubilizer Amines used.
Nach den Patenten 690 488 und 69I 339 werden Koffein bzw. Theophyllin dadurch in wäßrige Lösungen übergeführt, daß an sich ebenfalls schwerlösliche araliphatische Amine, nämlich Beta-Phenylisopropylamin oder seine Derivate, mit ephedrinartiger Wirkung als Lösungsvermittler verwendet werden. According to patents 690 488 and 69I 339, caffeine and theophylline, respectively converted into aqueous solutions by the fact that araliphatic ones are also sparingly soluble Amines, namely beta-phenylisopropylamine or its derivatives, with ephedrine-like Effect can be used as a solubilizer.
Es wurde nun gefunden, daß man zur Herstellung von wasserlöslichen Verbindungen und konzentrierten wäßrigen Lösungen des Theophyllins oder Koffeins an Stelle von Beta-Phenylisopropylamin oder seiner Derivate mit ephedrinartiger Wirkung andere Phenylalkylamine und ihre Derivate, insbesondere ihre N-Alkylderivate, als Lösungsvermittler verwendet. It has now been found that one can produce water-soluble Compounds and concentrated aqueous solutions of theophylline or caffeine instead of beta-phenylisopropylamine or its derivatives with ephedrine-like Effect of other phenylalkylamines and their derivatives, especially their N-alkyl derivatives, used as a solubilizer.
In Ausübung 4es Verfahrens kann man den zu lösenden Ausgangsstoff in Gegenwart von Wasser mit einem Phenylalkylamin, z. B. Phenyläthylamin, 1 -Phenyl-3-Aminobutan oder 1 -Phenyl-3-Methylaminobutan, behandeln und die wäßrige Lösung gegebenenfalls unter schonen den Bedingungen eindampfen. Sofern man die festen Verbindungen gewinnen will, wird nur sehr wenig Wasser ange- wandt bzw. werden die Reaktionskomponenten unter Erwärmen aufeinander einwirken gelassen. In the exercise of 4es the process can be used to dissolve the starting material in the presence of water with a phenylalkylamine, e.g. B. phenylethylamine, 1-phenyl-3-aminobutane or 1-phenyl-3-methylaminobutane, treat and optionally the aqueous solution evaporate under gentle conditions. Unless you win the solid connections very little water is turns or becomes the reaction components allowed to act on each other while being heated.
Die erfindungsgemäß hergestellten Verbindurigen zeichnen sich durch besonders starke und - anhattende Steigerung des Blutdrucks vorteilhaft vor den Verbindungen der Adrenalin- und Ephedrinreihe saums. The compounds produced according to the invention are distinguished by particularly strong and persistent increase in blood pressure beneficial before the Connections of the adrenaline and ephedrine series hem.
Beispiele I. I8 g bzw. 33 g Theophyllin werden mit I2,I g bzw. 24,2 g Phenyläthylamin ad 100 ccm zu einer stabilen konzentrierten wäßrigen Lösung gelöst. Examples I. 18 g and 33 g of theophylline are assigned I2, I g and 24.2, respectively g phenylethylamine ad 100 ccm dissolved to a stable concentrated aqueous solution.
2. 19 g Theophyllin (O,I Mol) werden mit I5 g I-Phenyl-3-Aminobutan innigst' verrieben. 2. 19 g of theophylline (0.1 mol) are mixed with 15 g of I-phenyl-3-aminobutane deeply rubbed in.
Unter schwachem Erwärmen entsteht eine feste zerreibliche Verbindung mit einem Schmelzpunkt von etwa 2OO C. Die Verbindung ist zu 300/0 in der Kälte wasserlöslich. Eine 300/oige wäßrige Lösung weist einen Gehalt von 16,76 0/o Theophyllin und I3,23 O/o Amin auf. A firm, friable connection is created under gentle heating with a melting point of about 2OO C. The compound is 300/0 in the cold water soluble. A 300% aqueous solution has a theophylline content of 16.76% and I3.23 O / o amine.
3. -32g Theophyllin werden mit I6,4 g I-Phenyl-3-Methylaminobutan ad 100 ccm in wäßrige Lösung übergeführt. 3. -32 g of theophylline are mixed with 16.4 g of I-phenyl-3-methylaminobutane transferred to 100 cc in aqueous solution.
4. II g Koffein werden mit I2,I g Phenyläthylamin ad 100 ccm in wäßrige Lösung übergeführt. 4. II g of caffeine are mixed with I2.1 g of phenylethylamine to 100 cc in aqueous Solution transferred.
Bei Anwendung von 24,2 g Phenyläthylamin gelingt es, den Koffeingehalt auf I80/o zu steigern.When using 24.2 g of phenylethylamine it is possible to reduce the caffeine content to increase to I80 / o.
Claims (1)
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL119341D NL119341B (en) | 1943-03-12 | ||
NL64616D NL64616C (en) | 1943-03-12 | ||
DEC1110D DE872246C (en) | 1943-03-12 | 1943-03-12 | Production of readily water-soluble compounds and concentrated aqueous solutions of theophylline or caffeine |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEC1110D DE872246C (en) | 1943-03-12 | 1943-03-12 | Production of readily water-soluble compounds and concentrated aqueous solutions of theophylline or caffeine |
Publications (1)
Publication Number | Publication Date |
---|---|
DE872246C true DE872246C (en) | 1953-03-30 |
Family
ID=7012522
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DEC1110D Expired DE872246C (en) | 1943-03-12 | 1943-03-12 | Production of readily water-soluble compounds and concentrated aqueous solutions of theophylline or caffeine |
Country Status (2)
Country | Link |
---|---|
DE (1) | DE872246C (en) |
NL (2) | NL119341B (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3209429A1 (en) * | 1982-03-16 | 1983-10-06 | Boehringer Ingelheim Vetmed | AGENT FOR IMPROVING THE RESORPTION OF INJECTED ANTIBACTERIAL EFFECTIVE SUBSTANCES AND COMBINATIONS CONTAINING A BENZYAMINE DERIVATIVE |
-
0
- NL NL64616D patent/NL64616C/xx active
- NL NL119341D patent/NL119341B/xx unknown
-
1943
- 1943-03-12 DE DEC1110D patent/DE872246C/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
NL64616C (en) | 1900-01-01 |
NL119341B (en) |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE872246C (en) | Production of readily water-soluble compounds and concentrated aqueous solutions of theophylline or caffeine | |
DE691339C (en) | Process for the preparation of concentrated aqueous theophylline solutions | |
DE156901C (en) | ||
AT157575B (en) | Process for the production of undecomposed, sterilizable drug solutions from the double compound theophylline-piperazine. | |
DE490012C (en) | Process for the production of urea-formaldehyde condensation products | |
DE748005C (en) | Process for the production of readily water-soluble compounds of theophylline or caffeine | |
DE844299C (en) | Process for the preparation of a new condensation product of 2- (p-aminobenzenesulfonamido) pyrimidine | |
AT149825B (en) | Process for the production of alkali or alkaline earth double compounds of dimethylxanthines with organic acids. | |
DE612536C (en) | Process for the preparation of aminodisulfonic acids | |
AT140431B (en) | Process for the preparation of solutions of organic substances which are poorly soluble or insoluble in water, with the exception of substances similar to proteins and fats. | |
AT218532B (en) | Process for the preparation of N-arylsulfonyl-N'-alkyl ureas | |
DE432420C (en) | Process for the preparation of N-methylsulphurous acid salts of secondary amines | |
DE721746C (en) | Process for the preparation of concentrated sterilizable solutions of diiodotyrosine | |
DE828101C (en) | Process for the preparation of nicotinic aeurethioamide | |
DE512880C (en) | Process for the preparation of reaction products of cyanamide with salts of higher aliphatic amines | |
DE663688C (en) | Improvement of the adhesion of pesticides to be dusted or suspended in spray boilers | |
DE574564C (en) | Process for the preparation of salts of dibasic organic acids | |
DE577107C (en) | Process for the conversion of diacetyl monoxime into diacetyl | |
DE372071C (en) | Process for the preparation of thionine series dyes | |
DE486659C (en) | Process for transferring water-insoluble or poorly soluble drugs into drip and injectable form | |
DE600412C (en) | Process for the preparation of a blue-violet dye | |
DE903574C (en) | Process for the preparation of Pentaerythritdiiodohydrinphosphoric acid | |
DE570860C (en) | Process for the production of easily soluble derivatives of pyridine derivatives | |
CH235505A (en) | Process for the preparation of a concentrated aqueous solution of the dipotassium salt of diiodotyrosine. | |
CH170617A (en) | Process for obtaining a therapeutically valuable compound of the heterocyclic series. |