CH235505A - Process for the preparation of a concentrated aqueous solution of the dipotassium salt of diiodotyrosine. - Google Patents
Process for the preparation of a concentrated aqueous solution of the dipotassium salt of diiodotyrosine.Info
- Publication number
- CH235505A CH235505A CH235505DA CH235505A CH 235505 A CH235505 A CH 235505A CH 235505D A CH235505D A CH 235505DA CH 235505 A CH235505 A CH 235505A
- Authority
- CH
- Switzerland
- Prior art keywords
- diiodotyrosine
- aqueous solution
- preparation
- concentrated aqueous
- dipotassium salt
- Prior art date
Links
- 239000007864 aqueous solution Substances 0.000 title claims description 5
- 238000000034 method Methods 0.000 title claims description 5
- KCIDZIIHRGYJAE-YGFYJFDDSA-L dipotassium;[(2r,3r,4s,5r,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] phosphate Chemical class [K+].[K+].OC[C@H]1O[C@H](OP([O-])([O-])=O)[C@H](O)[C@@H](O)[C@H]1O KCIDZIIHRGYJAE-YGFYJFDDSA-L 0.000 title claims description 4
- NYPYHUZRZVSYKL-UHFFFAOYSA-N -3,5-Diiodotyrosine Natural products OC(=O)C(N)CC1=CC(I)=C(O)C(I)=C1 NYPYHUZRZVSYKL-UHFFFAOYSA-N 0.000 title description 10
- NYPYHUZRZVSYKL-ZETCQYMHSA-N 3,5-diiodo-L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC(I)=C(O)C(I)=C1 NYPYHUZRZVSYKL-ZETCQYMHSA-N 0.000 title description 10
- 229960000415 diiodotyrosine Drugs 0.000 title description 10
- 238000002360 preparation method Methods 0.000 title description 3
- 239000000243 solution Substances 0.000 description 8
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 150000003112 potassium compounds Chemical class 0.000 description 2
- 150000007514 bases Chemical class 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 235000011118 potassium hydroxide Nutrition 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Description
Verfahren zur Herstellung einer konzentrierten wässerigen Lösung des Dikaliumsalzes des ijodtyrosins. . Gegenstand des Hauptpatentes ist ein Ver fahren zur Herstellung einer konzentrierten. wässrigen Lösung von Mono- und Disalz des Dijodtyrosins, das dadurch gekennzeichnet ist, dass man auf Dijodtyrosin mehr als ein Äquivalent und weniger als zwei Äqui valente eines basischen Stoffes in Gegenwart von Wasser einwirken lässt.
Solche Lösungen sind gegen die Zersetzung beim Erhitzen be ständiger als solche, die nur das Salz der Carboxylgruppe des Dijodtyrosins enthalten und lassen sich deshalb gut sterilisieren.
Es wurde nun gefunden, dass man die Be ständigkeit solcher Lösungen noch erhöhen kann, wenn man zur Herstellung derselben mindestens zwei Äquivalente Base verwendet, so dass, also in der Lösung ein Disalz des Dijodtyrosins gegebenenfalls neben einem Überschuss an Base vorhanden ist. Letzteres ist besonders erwünscht bei schwach basi schen Verbindungen, um das Gleichgewicht aufrecht zu erhalten.
Gegenstand des vorliegenden Patentes ist nun ein Verfahren zur Herstellung -einer kon zentrierten wässrigen Lösung des Dikalium- salzes des Dijodtyrösins, das dadurch ge kennzeichnet ist, dass man auf Dijodtyrosin mindestens zwei Äquivalente einer basischen Kaliumverbindung in Gegenwart von Wasser einwirken lässt.
Die Lösung soll als Arzneimittel für In jektionen Verwendung finden. <I>Beispiele:</I> 1. 0,2165g Dijodtyrosin (1/200o Mol) wer den mit 10 cm'
EMI0001.0032
Kalilauge (2 X 112uoo Mol) übergossen, worauf sich .sogleich eine farb lose Lösung bildet, welche sterilisiert wird.
2. 1,0g Dijodtyrosin <B>(11433</B> Mol) wird durch Übergiessen mit 4,63 cm3 n Kalilauge (2<B>X</B> 11433 Mol) in Lösung gebracht und die Lösung mit Wasser auf ein Gesamtvolumen zes des Dijodtyrosins, dadurch gekennzeich net,
dass man auf Dijodtyrosin mindestens zwei Äquivalente einer basischen Kaliumver- bindung in Gegenwart von Wassereinwirken lässt. von 10 cm' aufgefüllt. Die farblose 10%ige Lösung wird sterilisiert.
Process for the preparation of a concentrated aqueous solution of the dipotassium salt of ijodtyrosine. . The subject of the main patent is a process for producing a concentrated. aqueous solution of the mono- and disalt of diiodotyrosine, which is characterized in that more than one equivalent and less than two equivalents of a basic substance are allowed to act on diiodotyrosine in the presence of water.
Such solutions are more resistant to decomposition when heated than those which only contain the salt of the carboxyl group of diiodotyrosine and can therefore be easily sterilized.
It has now been found that the stability of such solutions can be increased if at least two equivalents of base are used to prepare them, so that a disalt of diiodotyrosine is optionally present in the solution in addition to an excess of base. The latter is particularly desirable for weakly basic compounds in order to maintain equilibrium.
The present patent now relates to a process for the preparation of a concentrated aqueous solution of the dipotassium salt of diiodotyrösin, which is characterized in that at least two equivalents of a basic potassium compound are allowed to act on diiodotyrosine in the presence of water.
The solution is to be used as a medicine for injections. <I> Examples: </I> 1. 0.2165g diiodotyrosine (1 / 200o mol) with 10 cm '
EMI0001.0032
Potash lye (2 X 112uoo mol) is poured over it, whereupon a colorless solution immediately forms, which is sterilized.
2. 1.0 g of diiodotyrosine (11433 mol) is brought into solution by pouring 4.63 cm3 of n potassium hydroxide solution (2 X 11433 mol) over it and the solution is made up with water Total volume of diiodotyrosine, characterized by
that at least two equivalents of a basic potassium compound are allowed to act on diiodotyrosine in the presence of water. of 10 cm 'padded. The colorless 10% solution is sterilized.
Claims (1)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE235505X | 1939-03-13 | ||
| CH231604T | 1940-03-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH235505A true CH235505A (en) | 1944-11-30 |
Family
ID=25727613
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH235505D CH235505A (en) | 1939-03-13 | 1940-03-12 | Process for the preparation of a concentrated aqueous solution of the dipotassium salt of diiodotyrosine. |
Country Status (1)
| Country | Link |
|---|---|
| CH (1) | CH235505A (en) |
-
1940
- 1940-03-12 CH CH235505D patent/CH235505A/en unknown
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