DE486659C - Process for transferring water-insoluble or poorly soluble drugs into drip and injectable form - Google Patents

Process for transferring water-insoluble or poorly soluble drugs into drip and injectable form

Info

Publication number
DE486659C
DE486659C DEG68124D DEG0068124D DE486659C DE 486659 C DE486659 C DE 486659C DE G68124 D DEG68124 D DE G68124D DE G0068124 D DEG0068124 D DE G0068124D DE 486659 C DE486659 C DE 486659C
Authority
DE
Germany
Prior art keywords
drip
insoluble
water
injectable form
poorly soluble
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DEG68124D
Other languages
German (de)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chemische Ind Ges
GESELLSCHAFT fur CHEMISCHE INDUSTRIE
BASF Schweiz AG
Original Assignee
Chemische Ind Ges
GESELLSCHAFT fur CHEMISCHE INDUSTRIE
Gesellschaft fuer Chemische Industrie in Basel CIBA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemische Ind Ges, GESELLSCHAFT fur CHEMISCHE INDUSTRIE, Gesellschaft fuer Chemische Industrie in Basel CIBA filed Critical Chemische Ind Ges
Priority to DEG68124D priority Critical patent/DE486659C/en
Application granted granted Critical
Publication of DE486659C publication Critical patent/DE486659C/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids

Description

Verfahren zur Überführung wasserunlöslicher bzw. schwerlöslicher Arzneimittel in tropfbare und injizierbare Form Gegenstand des Hauptpateuts 474 343 ist ein Verfahren zur flberführung wasserunlöslicher bzw. schwerlöslicher Arzneimittel in tropfbare und injizierbare Form, dadurch gekennzeichnet, daß man dieselben mit einem Gemisch von wasserlöslichen Alkyl- oder Alkylenharnstoffen mit wasserlöslichen Carbaminsäureestern, gegebenenfalls in Gegenwart von Wasser, in. Lösung bringt.Process for the transfer of water-insoluble or sparingly soluble drugs in drippable and injectable form The subject of main sponsor 474 343 is a method for transferring water-insoluble or sparingly soluble drugs into drip-drip and injectable form, characterized in that it is mixed with a mixture of water-soluble alkyl or alkylene ureas with water-soluble carbamic acid esters, optionally in the presence of water, in. Solution.

Es wurde nun gefunden, daß man bei der Herstellung solcher Lösungen. die wasserlöslichen Carbaminsäureester vorteilhaft durch wasserlösliche Fettsäureamide bzw. deren am Stickstoff substituierte Derivate ersetzen kann. So besitzt z. B. die Kombination Athylharn stoff-Acetamid oder Äthylbarnstoff-Acetdiäthylamid vorzügliches Lösungsvermögen, für die verschiedensten Arzneistoffe, insbesondere Barbitursäurederivate.It has now been found that in the preparation of such solutions. the water-soluble carbamic acid esters are advantageously replaced by water-soluble fatty acid amides or can replace their derivatives substituted on the nitrogen. So has z. B. the combination of Ethylurstoff-Acetamid or Äthylbarnstoff-Acetdiäthylamid is excellent Solvent power for a wide variety of drugs, especially barbituric acid derivatives.

Als vorteilhaft hat sich in der R@Zel die Kambination i + i der beiden Bestandteile des neuen Lösungsmittels erwiesen, jedach können auch andere Mischungsverhältnisse derselben mit Erfolg verwendet werden.. Ebenso kann man auch Gemische mehrerer Alkylharnstoffe bzw. mehrerer Fettsäureamide verwenden. Den neuen Lösungsmitteln können nach Wunsch ohne Beeinträchtigung des Lösungsvermögens 2o % und mehr Wasser zugefügt werden. -The combination i + i of the two has proven to be advantageous in the R @ Zel Components of the new solvent have been proven, but other mixing ratios can also be used the same can be used with success. Mixtures of several alkyl ureas can also be used or use several fatty acid amides. The new solvents can be used as desired 20% and more water can be added without impairing the dissolving power. -

Claims (1)

PATENTANSPRUCH: Abänderung des Verfahrens gemäß Hauptpatent, dadurch gekennzeichnet, daß in der dort verwendeten. Kombination der zur Herstellung der Lösungen verwendeten Stoffe die wasserlöslichen Carbaminsäureester durch - wasserlösliche Fettsäureamide bzw. deren am Stickstoff substituierte Derivate ersetzt werden. PATENT CLAIM: Modification of the method according to the main patent, characterized in that in the one used there. Combination of the substances used to produce the solutions, the water-soluble carbamic acid esters are replaced by water-soluble fatty acid amides or their nitrogen-substituted derivatives.
DEG68124D 1926-09-01 1926-09-02 Process for transferring water-insoluble or poorly soluble drugs into drip and injectable form Expired DE486659C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DEG68124D DE486659C (en) 1926-09-01 1926-09-02 Process for transferring water-insoluble or poorly soluble drugs into drip and injectable form

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE277003X 1926-09-01
DEG68124D DE486659C (en) 1926-09-01 1926-09-02 Process for transferring water-insoluble or poorly soluble drugs into drip and injectable form

Publications (1)

Publication Number Publication Date
DE486659C true DE486659C (en) 1929-11-22

Family

ID=25773502

Family Applications (1)

Application Number Title Priority Date Filing Date
DEG68124D Expired DE486659C (en) 1926-09-01 1926-09-02 Process for transferring water-insoluble or poorly soluble drugs into drip and injectable form

Country Status (1)

Country Link
DE (1) DE486659C (en)

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