DE431847C - Process for the production of intravenous injectable preparations against bilharzia - Google Patents

Process for the production of intravenous injectable preparations against bilharzia

Info

Publication number
DE431847C
DE431847C DESCH68962D DESC068962D DE431847C DE 431847 C DE431847 C DE 431847C DE SCH68962 D DESCH68962 D DE SCH68962D DE SC068962 D DESC068962 D DE SC068962D DE 431847 C DE431847 C DE 431847C
Authority
DE
Germany
Prior art keywords
bilharzia
production
injectable preparations
preparations against
intravenous injectable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DESCH68962D
Other languages
German (de)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
HANS SCHIROKAUER DR
Original Assignee
HANS SCHIROKAUER DR
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by HANS SCHIROKAUER DR filed Critical HANS SCHIROKAUER DR
Priority to DESCH68962D priority Critical patent/DE431847C/en
Application granted granted Critical
Publication of DE431847C publication Critical patent/DE431847C/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

Verfahren zur Herstellung intravenös injizierbarer Präparate gegen Bilharzia. Die Bilharzia wird bisher fast ausschließlich mit intravenösen Injektionen von Antimonpräparaten, insbesondere Brechweinstein, behandelt. Diese Therapie ist aber wenig befriedigend, denn sie führt nur nach langer, durch häufige Rückfälle unterbrochener Dauer zu Besserungen.Process for the preparation of intravenous injectable preparations against Bilharzia. The bilharzia is so far almost exclusively with intravenous injections treated by antimony preparations, especially emetic tartar. This therapy is but not very satisfactory, because it only leads to frequent relapses after a long period of time interrupted duration for improvement.

Die Wirkung des Antimons kann durch Kombination mit Alkalisalzen der z-Phenylchinolin-q.-carbonsäure oder deren Derivaten gesteigert werden. Es hat sich aber gezeigt, daß Lösungen, die Brechweinstein und das Natriumsalz der 2-Phenylchinolin-¢-carbonsäure oder der 6-Methylchinolin-¢-carbonsäure enthalten, nach einiger Zeit Ausfällungen zeigen und daher für den beabsichtigten Zweck nicht geeignet sind. Dagegen lassen sich, wie gefunden wurde, haltbare injizierbare Lösungen herstellen, wenn man von den betreffenden Carbonsäuren selbst ausgeht und zu deren Kombination mit Brechweinstein eine organische Base, vorzugsweise Hexamethylentetram.in, im überschuß zufügt. Man nimmt z. B. auf 0,5g 2 Phenylchinolin-q.-carbonsäure und o,o3 bis o,o6 g Brechweinstein etwa I,5 g Hexamethylentetramin und löst das Gemisch in Wasser.The effect of antimony can be increased by combining it with alkali salts of z-phenylquinoline-q.-carboxylic acid or its derivatives. However, it has been shown that solutions containing emetic tartar and the sodium salt of 2-phenylquinoline [carboxylic acid or 6-methylquinoline [carboxylic acid] show precipitates after some time and are therefore unsuitable for the intended purpose. On the other hand, as has been found, stable injectable solutions can be produced if the carboxylic acids in question are used as a starting point and an organic base, preferably hexamethylenetetramine, is added in excess to their combination with emetic tartar. One takes z. B. to 0.5 g of 2-phenylquinoline-q.-carboxylic acid and o, o3 to o, o6 g of tartar emetic about 1.5 g of hexamethylenetetramine and dissolve the mixture in water.

Claims (1)

PATENT-ANSPRUCII: Verfahren zur Herstellung intravenös injizierbarer Präparate gegen Bilharzia, dadurch gekennzeichnet, daß man Brechweinstein mit 2-Phenylchünolin-q.-carbonsäure oder deren Derivaten und mit einer im L'berschuß zugegebenen organischen Base, vorzugsweise Hexamethylentetramin, kombiniert.PATENT-ANSPRUCII: Process for the preparation of intravenous injectables Preparations against bilharzia, characterized in that emetic tartar is treated with 2-phenylchünoline-q.-carboxylic acid or their derivatives and with an organic base added in excess, preferably Hexamethylenetetramine, combined.
DESCH68962D 1923-11-14 1923-11-14 Process for the production of intravenous injectable preparations against bilharzia Expired DE431847C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DESCH68962D DE431847C (en) 1923-11-14 1923-11-14 Process for the production of intravenous injectable preparations against bilharzia

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DESCH68962D DE431847C (en) 1923-11-14 1923-11-14 Process for the production of intravenous injectable preparations against bilharzia

Publications (1)

Publication Number Publication Date
DE431847C true DE431847C (en) 1926-07-16

Family

ID=7439545

Family Applications (1)

Application Number Title Priority Date Filing Date
DESCH68962D Expired DE431847C (en) 1923-11-14 1923-11-14 Process for the production of intravenous injectable preparations against bilharzia

Country Status (1)

Country Link
DE (1) DE431847C (en)

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