DE416327C - Process for the preparation of sodium tribismutyl tartrate - Google Patents

Process for the preparation of sodium tribismutyl tartrate

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Publication number
DE416327C
DE416327C DEB107104D DEB0107104D DE416327C DE 416327 C DE416327 C DE 416327C DE B107104 D DEB107104 D DE B107104D DE B0107104 D DEB0107104 D DE B0107104D DE 416327 C DE416327 C DE 416327C
Authority
DE
Germany
Prior art keywords
tartrate
sodium
tribismutyl
preparation
bismuth
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DEB107104D
Other languages
German (de)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Priority to DEB107104D priority Critical patent/DE416327C/en
Application granted granted Critical
Publication of DE416327C publication Critical patent/DE416327C/en
Expired legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/94—Bismuth compounds

Description

Verfahren zur Darstellung von Natrium-Tribismutyltartrat. Im Gegensatz zu den komplexen Kaliumwismuttartraten sind Natriumsalze der Wismutweinsäure in reinem Zustand und in fester Form bisher nicht erhalten worden (Zeitschrift für anorganische Chemie 48 (19o6}, Seite 212, vorletzter Absatz; Archiv der Pharmazie 2,16 [rgo8], Seite 5o1, letzter Absatz).Process for the preparation of sodium tribismutyl tartrate. In contrast In addition to the complex potassium bismuth tartrates, sodium salts of bismuth tartaric acid are in pure state and in solid form has not yet been preserved (magazine for inorganic chemistry 48 (19o6}, page 212, penultimate paragraph; Archives of Pharmacy 2.16 [rgo8], page 5o1, last paragraph).

Wie nun gefunden wurde, kann man leicht zu einem Natrium-Tribismutyltartrat gelangen, wenn man reines Wismuthydroxyd im Überschuß auf Dinatriumtartrat zur Einwirkung bringt. Die auf diese Weise erhältliche Komplexverbindung ist ausgezeichnet durch außerordentlich leichte Löslichkeit und durch einen hohen Wismutgehalt (7r,1,1 Prozent), Eigenschaften, die ihr besondere Eignung für die Anwendung in der Therapie, vor allem zu Injektionszwecken, verleihen.As has now been found, one can easily add a sodium tribismutyl tartrate come into effect when pure bismuth hydroxide is used in excess on disodium tartrate brings. The complex compound thus obtainable is excellent in extremely easy solubility and a high bismuth content (7r, 1.1 percent), Properties that make it particularly suitable for use in therapy all for injections.

Zur Darstellung der neuen Doppelverbindung verfährt man wie folgt: Eine molare Lösung von Dinatriumtartrat wird auf dem Wasserbad 2 Stunden lang mit überschüssigem -reinem Wismuthydroxyd erhitzt. Ein geeignetes Wismuthydroxyd kann man z. B. nach der Vorschrift von V a n i n o und Z u m -b u s c h (Archiv der Pharmazie 248 [19101i Seite 665) gewinnen. Bei der Behandlung auf dem Wasserbad gehen auf je 5 Mol. Dinatriumtartrat 2 MOI. Wismuthydroxyd in Lösung. Nach dem Abkühlen des Reaktionsgemisches versetzt man mit dem gleichen Volumen 5oprozentigen Alkohols. Es fällt dabei ein sehr feinkristallinischer Niederschlag aus, den man auf der Nutsche abfiltriert und einigemal mit 5oprozentigem Alkohol nachwäscht. Auf diese Weise wird ein gleichzeitiges Ausfallen von Natriumtartrat vermieden Nach dem Trocknen bildet das neue Produkt eine weiße zusammenhängende mikrokristallinische Masse, die leicht mit alkalischer Reaktion in Wasser löslich ist. Die Zusammensetzung entspricht der Formel COON a. CHO.BiO. CHO #BiO # COO.Bi0.2H20.To display the new double connection, proceed as follows: A molar solution of disodium tartrate is used on the water bath for 2 hours Excess -pure bismuth hydroxide heated. A suitable bismuth hydroxide can one z. B. according to the regulation of V a n i n o and Z u m -b u s c h (Archive of Pharmacy 248 [19101i page 665) win. When treating on the water bath go on 5 moles each. Disodium tartrate 2 MOI. Bismuth hydroxide in solution. After the The same volume of 5% alcohol is added to the reaction mixture. It turns out a very fine crystalline precipitate, which one on the suction filter filtered off and washed several times with 5% alcohol. In this way a simultaneous precipitation of sodium tartrate is avoided after drying the new product forms a white coherent microcrystalline mass, which is easily soluble in water with an alkaline reaction. The composition corresponds of the formula COON a. CHO.BiO. CHO #BiO # COO.Bi0.2H20.

Bekannt ist die Darstellung eines dem Brechweinstein entsprechend zusammengesetzten Wismutkaliumtartrats durch Einwirkung von Wismuthydroxyd auf saures Kaliumtartrat (Annalen der Chemie. Band 61 [18q.7], Seite 24q.). Das auf- diesem Wege erhältliche Produkt wird durch Wasser zersetzt und ist daher zur therapeutischen Verwendung ungeeignet. Erwähnt sei noch, daß in den Comptes rendus de 1'Academie des sciences, Band 172 (1921), Seite 1391, über die Anwendung eines Kalium-Natriumbismutyltartrats bei experimenteller Kaninchensyphilis berichtet wird.The representation of an emetic tartar is known compound bismuth potassium tartrate by the action of bismuth hydroxide on acid Potassium tartrate (Annalen der Chemie. Volume 61 [18q.7], page 24q.). That on this one Ways available product is decomposed by water and is therefore intended for therapeutic use Use unsuitable. It should also be mentioned that in the Comptes rendus de 1'Academie des sciences, Volume 172 (1921), page 1391, on the use of a potassium sodium bismuth tartrate reported in experimental rabbit syphilis.

Claims (1)

PATENTANSPRUCH: Verfahren zur Darstellung von Natrium-Tribismutyltartrat, dadurch gekennzeichnet, daß man Wismuthydroxyd auf Dinatriumtartrat einwirken läßt. PATENT CLAIM: Process for the preparation of sodium tribismutyl tartrate, characterized in that bismuth hydroxide is allowed to act on disodium tartrate.
DEB107104D 1922-11-03 1922-11-03 Process for the preparation of sodium tribismutyl tartrate Expired DE416327C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DEB107104D DE416327C (en) 1922-11-03 1922-11-03 Process for the preparation of sodium tribismutyl tartrate

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEB107104D DE416327C (en) 1922-11-03 1922-11-03 Process for the preparation of sodium tribismutyl tartrate

Publications (1)

Publication Number Publication Date
DE416327C true DE416327C (en) 1925-07-15

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Family Applications (1)

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DEB107104D Expired DE416327C (en) 1922-11-03 1922-11-03 Process for the preparation of sodium tribismutyl tartrate

Country Status (1)

Country Link
DE (1) DE416327C (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6783554B2 (en) 2001-02-20 2004-08-31 Atrium Medical Corporation Pile mesh prosthesis

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6783554B2 (en) 2001-02-20 2004-08-31 Atrium Medical Corporation Pile mesh prosthesis

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