CH112496A - Process for the preparation of sodium tribismutyl tartrate. - Google Patents
Process for the preparation of sodium tribismutyl tartrate.Info
- Publication number
- CH112496A CH112496A CH112496DA CH112496A CH 112496 A CH112496 A CH 112496A CH 112496D A CH112496D A CH 112496DA CH 112496 A CH112496 A CH 112496A
- Authority
- CH
- Switzerland
- Prior art keywords
- tartrate
- sodium
- tribismutyl
- preparation
- cho
- Prior art date
Links
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 title claims description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 title claims description 4
- 229910052708 sodium Inorganic materials 0.000 title claims description 4
- 239000011734 sodium Substances 0.000 title claims description 4
- 229940095064 tartrate Drugs 0.000 title claims description 4
- 238000000034 method Methods 0.000 title claims description 3
- 238000002360 preparation method Methods 0.000 title claims description 3
- HELHAJAZNSDZJO-OLXYHTOASA-L sodium L-tartrate Chemical compound [Na+].[Na+].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O HELHAJAZNSDZJO-OLXYHTOASA-L 0.000 claims description 5
- 239000001433 sodium tartrate Substances 0.000 claims description 5
- 229940049676 bismuth hydroxide Drugs 0.000 claims description 4
- TZSXPYWRDWEXHG-UHFFFAOYSA-K bismuth;trihydroxide Chemical compound [OH-].[OH-].[OH-].[Bi+3] TZSXPYWRDWEXHG-UHFFFAOYSA-K 0.000 claims description 4
- 235000019524 disodium tartrate Nutrition 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- 238000006243 chemical reaction Methods 0.000 claims description 2
- 230000001427 coherent effect Effects 0.000 claims description 2
- 238000001035 drying Methods 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 239000003960 organic solvent Substances 0.000 claims description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- SULICOHAQXOMED-UHFFFAOYSA-H bis(5,6-dihydroxy-4,7-dioxo-1,3,2-dioxabismepan-2-yl) 2,3-dihydroxybutanedioate Chemical class [Bi+3].[Bi+3].[O-]C(=O)C(O)C(O)C([O-])=O.[O-]C(=O)C(O)C(O)C([O-])=O.[O-]C(=O)C(O)C(O)C([O-])=O SULICOHAQXOMED-UHFFFAOYSA-H 0.000 description 1
- 229910052797 bismuth Inorganic materials 0.000 description 1
- JCXGWMGPZLAOME-UHFFFAOYSA-N bismuth atom Chemical compound [Bi] JCXGWMGPZLAOME-UHFFFAOYSA-N 0.000 description 1
- HLOXFOXDYOIBDU-UHFFFAOYSA-N bismuth;2,3-dihydroxybutanedioic acid Chemical class [Bi].OC(=O)C(O)C(O)C(O)=O HLOXFOXDYOIBDU-UHFFFAOYSA-N 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 229960002167 sodium tartrate Drugs 0.000 description 1
- 235000011004 sodium tartrates Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/94—Bismuth compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
verfahren zur Darstellung von Natrium-Tribismutyltartrat. Im Gegensatz zu den komplexen Kafium- wismuttartraten sind Natriumsalze der Wis mutweinsäure in reinem Zustand und in fester Form bisher nicht erhalten worden. (Zeitschrift für anorganische Chemie 48 [1906], Seite 212, vorletzter Absatz; Archiv der Pharmazie 246 1908], Seite 501, letzter Absatz.) Wie nun gefunden wurde, kann man leicht zu einem Natrium-Tribismutyltartrat gelangen, wenn man reines Wismuthydroxyd im Überschuss auf Dinatriumtartrat zur Ein wirkung bringt.
Die auf diese Weise erhält liche Komplexverbindung ist ausgezeichnet durch ausserordentlich leichte Löslichkeit und durch einen hohen Wismutgehalt (71,14 %), Eigenschaften, die ihr besondere Eignung für die Anwendung in der Therapie, vor allem zu Injektionszwecken, verleihen.
Zur Darstellung der neuen Doppelverbin dung verfährt man zweckmässig wie folgt: Eine molare Lösung von Dinatriumtartrat wird auf dem Wasserbad zwei Stunden lang mit überschüssigem, reinem Wismuthydroxyd erhitzt. Ein geeignetes Wismuthydroxyd kann man zum Beispiel nach der Vorschrift von Vanino und Zumbusch (Archiv der Phar mazie 248 1910], Seite 665) gewinnen. Bei der Behandlung auf dem Wasserbad gehen auf je 5 Mol. Dinatriumtartrat 2 Mol. Wis muthydroxyd in Lösung. Nach dem Ab kühlen des Reaktionsgemisches versetzt man mit dem gleichen Volumen 50 %igen Alko hols. Es fällt dabei ein sehr feinkristallini scher Niederschlag aus, den man auf der Nutsche abfiltriert und einigemal mit 50 %igem Alkohol nachwäscht. Auf diese Weise wird ein gleichzeitiges Ausfallen von Natriumtartrat vermieden.
Nach dem Trock nen bildet das neue Produkt eine weisse zu sammenhängende mikrokristallinische Masse, die leicht mit alkalischer Reaktion in Was ser löslich ist. Sie ist unlöslich in organi schen Lösungsmitteln. Die Zusammensetzung enstpricht der Formel COONa . CHO . Bi0 . CFIO . Bi0 . C00 . Bi0 -f- 2 H20.
process for the preparation of sodium tribismutyl tartrate. In contrast to the complex cafium bismuth tartrates, sodium salts of bismuth tartaric acid have not yet been obtained in the pure state or in solid form. (Zeitschrift für inorganic Chemie 48 [1906], page 212, penultimate paragraph; Archiv der Pharmazie 246 1908], page 501, last paragraph.) As has now been found, a sodium tribismuthyl tartrate can easily be obtained if pure bismuth hydroxide is used Excess of disodium tartrate takes effect.
The complex compound obtained in this way is distinguished by its extremely easy solubility and a high bismuth content (71.14%), properties which make it particularly suitable for use in therapy, especially for injection purposes.
Proceed as follows to prepare the new double compound: A molar solution of disodium tartrate is heated on a water bath for two hours with excess, pure bismuth hydroxide. A suitable bismuth hydroxide can be obtained, for example, according to the instructions of Vanino and Zumbusch (Archiv der Pharmacy 248 1910], page 665). During the treatment on a water bath, 2 mol of bisodium hydroxide go into solution for every 5 mol of disodium tartrate. After the reaction mixture has cooled, the same volume of 50% alcohol is added. It turns out a very fine crystalline precipitate, which is filtered off on the suction filter and washed several times with 50% alcohol. In this way, a simultaneous precipitation of sodium tartrate is avoided.
After drying, the new product forms a white, coherent microcrystalline mass that is easily soluble in water with an alkaline reaction. It is insoluble in organic solvents. The composition corresponds to the formula COONa. CHO. Bi0. CFIO. Bi0. C00. Bi0 -f- 2 H20.
Claims (1)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH112496T | 1924-08-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH112496A true CH112496A (en) | 1925-11-02 |
Family
ID=4371621
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH112496D CH112496A (en) | 1924-08-21 | 1924-08-21 | Process for the preparation of sodium tribismutyl tartrate. |
Country Status (1)
| Country | Link |
|---|---|
| CH (1) | CH112496A (en) |
-
1924
- 1924-08-21 CH CH112496D patent/CH112496A/en unknown
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