AT124745B - Process for the preparation of the mono- or di [β-oxyäthylamine] salt of 3-acetylamino-4-oxybenzolaric acid (1). - Google Patents

Process for the preparation of the mono- or di [β-oxyäthylamine] salt of 3-acetylamino-4-oxybenzolaric acid (1).

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Publication number
AT124745B
AT124745B AT124745DA AT124745B AT 124745 B AT124745 B AT 124745B AT 124745D A AT124745D A AT 124745DA AT 124745 B AT124745 B AT 124745B
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Austria
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salt
acetylamino
mono
acid
preparation
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German (de)
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Ig Farbenindustrie Ag
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Publication of AT124745B publication Critical patent/AT124745B/en

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Description

  

   <Desc/Clms Page number 1> 
 



  Verfahren zur Darstellung des Mono- oder Di-[ss-oxyäthylamin]-Salzes der 3-Acetyl-   amino-4-oxybenzolarsinsäure-(1).   
 EMI1.1 
 Salze bildet, die gegenüber den bislang bekannten Salzen dieser Säure den   Vorzug grösserer Bekömmlich-   keit und Haltbarkeit in Lösung zeigen und daher für die medizinische Praxis, vor allem bei der Behandlung von Kindern, Vorteile bieten. Je nachdem, ob man ein oder zwei Mol. Äthanolamin je Mol. Arsinsäure verwendet, bilden sich Mono-oder Di-[ss-oxyäthylamin]-Salze. Es ist nicht erforderlich, die entstandenen Salze erst zu isolieren, man kann vielmehr auch die durch Zusammengeben der Komponenten in wässerigem Medium erhaltenen Lösungen unmittelbar zum Gebrauch verwenden. Um die Stabilität der Lösungen zu erhöhen, ist es zweckmässig, den Lösungen geringe Mengen Natriumsulfit zuzusetzen. 



   Beispiel : 275   3-Acetylamino-4-oxybenzolarsinsäure- (1)   werden mit 220 em3 Wasser angeteigt und 61 g   ss-Oxyäthylamin,   in 20   cm3     Wasser gelöst, zugesetzt. Nachdem durch Aufkochen   gelöst wurde, setzt man 9 g Entfärbungskohle zu und filtriert. Das Filtrat (350   ein3)   wird mit 70   ein3 Aceton   versetzt und dann unter Rühren 350 cm Alkohol zugegeben. Das entstandene Salz kristallisiert nach kurzer Zeit aus ; nach dem Absaugen und Waschen mit Alkohol und Äther wird es im Vakuum getrocknet. Das Produkt bildet ein weisses kristallinisches Pulver, welches in 1, 5-2 Teilen Wasser von   350 C leicht,   in Aceton, Äther und Benzin schwer löslich ist. 



   Verwendet man unter Einhaltung der gleichen Bedingungen 122 g ss-Oxyäthylamin, so erhält man das entsprechende Di-[ss-oxyäthylamin]-Salz. 

**WARNUNG** Ende DESC Feld kannt Anfang CLMS uberlappen**.



   <Desc / Clms Page number 1>
 



  Process for the preparation of the mono- or di- [ss-oxyethylamine] salt of 3-acetylamino-4-oxybenzolaric acid (1).
 EMI1.1
 Forms salts which, compared to the previously known salts of this acid, have the advantage of greater digestibility and shelf life in solution and therefore offer advantages for medical practice, especially in the treatment of children. Depending on whether one or two moles of ethanolamine is used per mole of arsic acid, mono- or di- [β-oxyethylamine] salts are formed. It is not necessary first to isolate the resulting salts; rather, the solutions obtained by combining the components in an aqueous medium can also be used directly for use. To increase the stability of the solutions, it is advisable to add small amounts of sodium sulfite to the solutions.



   Example: 275 3-acetylamino-4-oxybenzolaric acid- (1) are made into a paste with 220 cubic meters of water and 61 g of β-oxyethylamine, dissolved in 20 cm3 of water, are added. After it has been dissolved by boiling, 9 g of decolorizing charcoal are added and the mixture is filtered. The filtrate (350 in3) is treated with 70 in3 acetone and then 350 cm of alcohol is added with stirring. The resulting salt crystallizes out after a short time; after suctioning off and washing with alcohol and ether, it is dried in vacuo. The product forms a white crystalline powder, which is easily soluble in 1.5-2 parts of water at 350 C, and sparingly soluble in acetone, ether and petrol.



   If 122 g of β-oxyethylamine are used while maintaining the same conditions, the corresponding di- [β-oxyethylamine] salt is obtained.

** WARNING ** End of DESC field may overlap beginning of CLMS **.

Claims (1)

PATENT-ANSPRUCH : Verfahren zur Darstellung des Mono- oder Di-[ss-oxyäthylamin]-Salzes der 3-Acetylamino-4-oxybenzolarsinsäure-(1), dadurch gekennzeichnet, dass man diese mit der einfach-oder doppeltmolekularen Menge ss-Oxyäthylamin in Gegenwart von Wasser umsetzt und gegebenenfalls aus der hiebei erhaltenen Lösung das Salz durch Zusatz von Lösungsmitteln, in denen es unlöslich ist, zur Abscheidung bringt. **WARNUNG** Ende CLMS Feld Kannt Anfang DESC uberlappen**. PATENT CLAIM: Process for the preparation of the mono- or di- [ß-oxyäthylamine] salt of 3-acetylamino-4-oxybenzolarsinsäure- (1), characterized in that this is reacted with the single or double molecular amount of ß-oxyethylamine in the presence of water and optionally causes the salt to separate out from the solution obtained by adding solvents in which it is insoluble. ** WARNING ** End of CLMS field may overlap beginning of DESC **.
AT124745D 1929-06-14 1930-05-14 Process for the preparation of the mono- or di [β-oxyäthylamine] salt of 3-acetylamino-4-oxybenzolaric acid (1). AT124745B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE124745X 1929-06-14

Publications (1)

Publication Number Publication Date
AT124745B true AT124745B (en) 1931-10-10

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AT124745D AT124745B (en) 1929-06-14 1930-05-14 Process for the preparation of the mono- or di [β-oxyäthylamine] salt of 3-acetylamino-4-oxybenzolaric acid (1).

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AT (1) AT124745B (en)

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