DE665601C - Process for the production of durable, aqueous colloidal solutions of carotene - Google Patents
Process for the production of durable, aqueous colloidal solutions of caroteneInfo
- Publication number
- DE665601C DE665601C DEH153633D DEH0153633D DE665601C DE 665601 C DE665601 C DE 665601C DE H153633 D DEH153633 D DE H153633D DE H0153633 D DEH0153633 D DE H0153633D DE 665601 C DE665601 C DE 665601C
- Authority
- DE
- Germany
- Prior art keywords
- carotene
- durable
- colloidal solutions
- production
- aqueous colloidal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Jellies, Jams, And Syrups (AREA)
- Fodder In General (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Description
Verfahren zur Herstellung von haltbaren, wässerigen kolloidalen Lösungen von Carotin Die bis jetzt bekannten kolloidalen Lösungen von Carotin in Wasser weisen den Nachteil auf, daß das Carotin nach verhältnismäßig kurzer Zeit wieder ausflockt.Process for the preparation of durable, aqueous colloidal solutions of carotene The colloidal solutions of carotene in water known up to now show the disadvantage that the carotene flocculates again after a relatively short time.
Es wurde nun gefunden, daß man zu haltbaren kolloidalen Lösungen von Carotin in Wasser gelangen kann, wenn man den Lösungen Pektin als Schutzkolloid zusetzt.It has now been found that stable colloidal solutions of Carotene can get into water if you use pectin as a protective colloid in the solutions clogs.
Pektin ist bereits zur Einulgierung von Fetten und zur Erhöhung der Löslichkeit von Arzneistoffen in Wasser verwendet worden. Auch hat man schon Pektin zur Herstellung von kolloidalen Kupfer- oder Silberlösungen benutzt. Daraus konnte indessen nicht geschlossen werden, daß mit Hilfe von Pektin haltbare wässerige kolloidale Lösungen von Carotin gewonnen werden können. Diese Wirkung des Pektins war um so weniger zu erwarten, als kolloidale Lösungen anderer Kohlenwasserstoffe, wie z. B. Benzpyren, durch Pektin ausgeflockt werden.Pectin is already used to emulsify fats and increase the Solubility of Drugs in Water has been used. You also have pectin used for the production of colloidal copper or silver solutions. From this could however, it should not be concluded that with the help of pectin durable aqueous colloidal Solutions of carotene can be obtained. This effect of the pectin was all the more so less to be expected than colloidal solutions of other hydrocarbons, such as. B. Benzpyrene, be flocculated by pectin.
Zur Herstellung von haltbaren wässerigen kolloidalen Lösungen des Carotins wird dieses zunächst in einem geeigneten Lösungsmittel gelöst und die Lösung in eine wässerige Lösung von Pektin fbergeführt. Man gelangt auf diese Weise zu haltbaren kolloidalen Lösungen von Carotin in Wasser, die leicht sterilisiert werden können und in bezug auf die C arotinkonzentration den Anforderungen der Praxis genügen.For the preparation of durable aqueous colloidal solutions of the Carotene this is first dissolved in a suitable solvent and the solution transferred into an aqueous solution of pectin. This is how you get to durable colloidal solutions of carotene in water that are easily sterilized can and with regard to the carotene concentration meet the requirements of practice.
Die haltbaren wässeri-en kolloidalen Lösungen von Carotin sollen als Arzneimittel verwendet werden.The durable aqueous colloidal solutions of carotene are said to be used as Medicines are used.
Beispiel i o,2 Teile Carotin werden in der nötigen Menge :Uher oder einem anderen geeigneten Lösungsmittel gelöst und darauf finit Zoo Teilen Aceton versetzt. Man destilliert die Lösung so lange, bis der Äther oder das mit Wasser nicht mischbare Lösungstriittel entfernt ist und bis eine Probe finit Wasser eine orange gefärbte Milch ergibt. Jetzt gießt man die Carotinlösung in eine Lösung von 5 Teilen Apfelpektin in aoo Teilen Wasser und entfernt das Aceton durch Einblasen von Dampf oder durch Destillation im Vakuum. Beispiel 0,2 Teile Carotin «-erden in 4.o Teilen Schwefelkohlenstoff gelöst und mit Zoo Teilen absolutem Alkohol versetzt. Die Lösung wird darauf so lange destilliert, bis der Schwefelkohlenstoff entfernt ist. Nun gießt man zur alkoholischen Carotinlösung 25o Teile Wasser, die i Teil Citruspektin gelöst enthalten, und destilliert so lange im Vakuum, bis der :Alkohol vollständig entfernt ist. Es hinterbleibt eine kolloidale Carotinlösung von leuchtender Orangefarbe; die in der Durchsicht in dünner Schicht weinrot erscheint und mit Wasser in jedem Verhältnis verdiinnf werden kann.Example i o, 2 parts of carotene are in the necessary amount: Uher or Dissolve another suitable solvent and then add finite zoo parts of acetone offset. The solution is distilled until the ether or that with water immiscible solution particles are removed and until a sample is finitely water orange colored milk results. Now you pour the carotene solution into a solution of 5 parts of apple pectin in 100 parts of water and the acetone is removed by blowing in by steam or by distillation in vacuo. Example 0.2 part of carotene earth Dissolved in 4.o parts of carbon disulfide and mixed with zoo parts of absolute alcohol. The solution is then distilled until the carbon disulfide is removed is. Now one pours 25o parts of water, the i part, to the alcoholic carotene solution Citrus pectin contained dissolved and distilled in vacuo until the :Alcohol is completely removed. What remains is a colloidal carotene solution that is more luminous Orange color; which appears burgundy in a thin layer when viewed through and with water can be diluted in any proportion.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEH153633D DE665601C (en) | 1937-11-13 | 1937-11-13 | Process for the production of durable, aqueous colloidal solutions of carotene |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEH153633D DE665601C (en) | 1937-11-13 | 1937-11-13 | Process for the production of durable, aqueous colloidal solutions of carotene |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE665601C true DE665601C (en) | 1938-09-29 |
Family
ID=7181708
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DEH153633D Expired DE665601C (en) | 1937-11-13 | 1937-11-13 | Process for the production of durable, aqueous colloidal solutions of carotene |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE665601C (en) |
-
1937
- 1937-11-13 DE DEH153633D patent/DE665601C/en not_active Expired
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