DE688047C - Process for the production of stable aqueous, therapeutically usable solutions of the polyoxyalkylisoalloxazines - Google Patents

Process for the production of stable aqueous, therapeutically usable solutions of the polyoxyalkylisoalloxazines

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Publication number
DE688047C
DE688047C DE1938I0060332 DEI0060332D DE688047C DE 688047 C DE688047 C DE 688047C DE 1938I0060332 DE1938I0060332 DE 1938I0060332 DE I0060332 D DEI0060332 D DE I0060332D DE 688047 C DE688047 C DE 688047C
Authority
DE
Germany
Prior art keywords
polyoxyalkylisoalloxazines
production
solutions
stable aqueous
therapeutically usable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE1938I0060332
Other languages
German (de)
Inventor
Dr Ernst Auhagen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
IG Farbenindustrie AG
Original Assignee
IG Farbenindustrie AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by IG Farbenindustrie AG filed Critical IG Farbenindustrie AG
Priority to DE1938I0060332 priority Critical patent/DE688047C/en
Priority to DE1938I0062929 priority patent/DE698815C/en
Application granted granted Critical
Publication of DE688047C publication Critical patent/DE688047C/en
Expired legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

Verfahren zur Herstellung haltbarer wässeriger, therapeutisch verwendbarer Lösungen der Polyoxyalkylisoalloxazine Zusatz zum Patent 686 793 Das Patent 686 793 betrifft ein Verfahren, haltbare Lösungen der in Wasser nur schwer löslichen Polyoxyalkylisoalloxazine zu gewinnen durch die Verwendung von Mono-N-alkylderivaten der Amide niederer Fettsäuren als Lösungsmittel bzw. als Lösungsvermittler.Process for making durable aqueous, therapeutically useful Solutions of the polyoxyalkylisoalloxazines Addition to patent 686 793 The patent 686 793 relates to a method of preserving stable solutions that are only sparingly soluble in water Polyoxyalkylisoalloxazines can be obtained through the use of mono-N-alkyl derivatives of the amides of lower fatty acids as solvents or as solubilizers.

Bei der weiteren Bearbeitung hat sich gezeigt, daß man mit Vorteil auch die Salze von Phenol- bzw. Polyphenolsulfonsäuren als Lösungsvermittler verwenden kann. Schon bei verhältnismäßig geringen, z. B. 5 °/0 betragenden Konzentrationen der Salze von Phenol-bzw. Polyphenolsulfonsäuren lassen sich Lösungen erzielen, die im Vergleich zu wässerigen Lösungen einen mehrfachen Gehalt an Polyoxyalkylisoalloxazinen aufweisen. Die Lösungen können gleichzeitig mit anderen geeigneten Lösungsvermittlern, wie Fettsäurealkylamiden, Harnstoffen, Sarkosinanhydrid u. dgl., versetzt werden. Das beschriebene Verfahren eignet sich besonders zur Herstellung therapeutisch anwendbarer Lösungen des Lactoflavins. Further processing has shown that it is advantageous also use the salts of phenol or polyphenol sulfonic acids as solubilizers can. Even with relatively small, z. B. 5% concentrations the salts of phenol or. Polyphenolsulfonic acids can be used to achieve solutions which, compared to aqueous solutions, has a multiple content of polyoxyalkylisoalloxazines exhibit. The solutions can be used simultaneously with other suitable solubilizers, such as fatty acid alkylamides, ureas, sarcosine anhydride and the like. The method described is particularly suitable for producing therapeutically applicable ones Lactoflavin solutions.

Bei 20? löst beispielsweise eine 4%ige wässerige Lösung von phenolsulfonsaurein Natrium 0,05 °/0 Lactoflavin, eine 5 0/0ige wässerige Lösung von kresolsulfonsaurem Calcium o,o6 0!o Lactoflavin, eine 4°/0 wässerige Lösung von brenzkatechindisulfonsaurem Natrium 0,05010 Lactoflavin, eine 20 °/Oige wässerige Lösung des gleichen Salzes 0,4 01, Lactoflavin, eine 5 obige wässerige Lösung von phenolsulfonsaurem Natrium o,o6°/O 6, 7-Dimethyl-9-d-arabitylisoalloxazin, eine 50J0ige Lösung von brenzkatechindisulfonsaurem Natrium in Io°/Oiger wässeriger N°Methylacetamidlösung 0,08% Lactoflavin. At 20? dissolves, for example, a 4% aqueous solution of phenolsulfonic acid Sodium 0.05% lactoflavin, a 5% aqueous solution of cresol sulfonic acid Calcium o, o6 0! O Lactoflavin, a 4% aqueous solution of catechol disulphonic acid Sodium 0.05010 lactoflavin, a 20% aqueous solution of the same salt 0.4 01, lactoflavin, an aqueous solution of 5 above phenolsulfonic acid Sodium 0.06 / 0.67-Dimethyl-9-d-arabitylisoalloxazine, a 50% solution of Catechol disulphonic acid sodium in 10% aqueous N ° methylacetamide solution 0.08% lactoflavin.

PATENTANSPRÜCEE: I. Verfahren zur Herstellung haltbarer wässeriger, therapeutisch verwendbarer Lösungen der Polyoxyalkylisoalloxazine in Abänderung des Verfahrens nach Patent 686 793, dadurch gekennzeichnet, daß man phenol- bzw. polyphenolsulfonsaure Salze als Lösungsvermittler venvendet. PATENT CLAIMS: I. Process for the production of durable aqueous, therapeutically usable solutions of the polyoxyalkylisoalloxazines in modification of the process according to patent 686 793, characterized in that phenol or polyphenolsulfonic acid salts used as solubilizers.

Claims (1)

2. Verfahren nach Anspruch I, dadurch gekennzeichnet, daß man den wässerigen Lösungen der phenol- bzw. polyphenolsulfonsauren Salze andere Lösungsvermittler zusetzt. 2. The method according to claim I, characterized in that the aqueous solutions of the phenol or polyphenolsulfonic acid salts other solubilizers clogs. 3. Verfahren nach Ansprüchen I und 2, dadurch gekennzeichnet, daß als Polyoxyalkyli soalloxazin Lactoflavin verwendet wird. 3. Process according to Claims I and 2, characterized in that as Polyoxyalkyli soalloxazin Lactoflavin is used.
DE1938I0060332 1938-01-25 1938-01-25 Process for the production of stable aqueous, therapeutically usable solutions of the polyoxyalkylisoalloxazines Expired DE688047C (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DE1938I0060332 DE688047C (en) 1938-01-25 1938-01-25 Process for the production of stable aqueous, therapeutically usable solutions of the polyoxyalkylisoalloxazines
DE1938I0062929 DE698815C (en) 1938-01-25 1938-11-20 Process for the production of durable, high-content solutions of the polyoxyalkylisoalloxazines

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE1938I0060332 DE688047C (en) 1938-01-25 1938-01-25 Process for the production of stable aqueous, therapeutically usable solutions of the polyoxyalkylisoalloxazines

Publications (1)

Publication Number Publication Date
DE688047C true DE688047C (en) 1940-02-10

Family

ID=7195213

Family Applications (1)

Application Number Title Priority Date Filing Date
DE1938I0060332 Expired DE688047C (en) 1938-01-25 1938-01-25 Process for the production of stable aqueous, therapeutically usable solutions of the polyoxyalkylisoalloxazines

Country Status (1)

Country Link
DE (1) DE688047C (en)

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