DE868493C - Process for the production of aqueous solutions of p-aminobenzene sulfonamide or of decoctions of the same - Google Patents
Process for the production of aqueous solutions of p-aminobenzene sulfonamide or of decoctions of the sameInfo
- Publication number
- DE868493C DE868493C DEV1852D DEV0001852D DE868493C DE 868493 C DE868493 C DE 868493C DE V1852 D DEV1852 D DE V1852D DE V0001852 D DEV0001852 D DE V0001852D DE 868493 C DE868493 C DE 868493C
- Authority
- DE
- Germany
- Prior art keywords
- aqueous solutions
- decoctions
- production
- same
- aminobenzene sulfonamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
Verfahren zur Herstellung von wäßrigen Lösungen des p-Aminobenzolsulfonamids bzw. von Abkömmlingen desselben Nach den Patentschriften «676 436 und 718 707 liat man bereits Lösungen der p-Aminobenzolsulfonamids bzw. des p-Aminobenzolsulfonamidopyridins hergestellt. Es gelingt danach jedoch höchstens, eine Konzentration von 5 % zu erreichen.Process for the preparation of aqueous solutions of p-aminobenzenesulfonamide or of derivatives thereof According to patents 676 436 and 71 8 707 , solutions of p-aminobenzenesulfonamide or p-aminobenzenesulfonamidopyridine have already been prepared. However, it then succeeds at most to achieve a concentration of 5%.
Nach den Patentschriften 683 866 und 695 034 wird Hexamethylentetramin neben anderen Lösungsvermittlern verwendet; dabei erzielt man jedoch nur Konzentrationen von etwa 21/2°/o.According to patents 683 866 and 695 034, hexamethylenetetramine is used used alongside other solubilizers; however, only concentrations are achieved here of about 21/2 ° / o.
Es wurde nun gefunden, saß durch Verwendung von Natriumsalicylat bzw. Natriumsulfosalicylat neben Urethan und Phenyldimethylpyrazolon als Lösungsvermittler haltbare- Lösungen mit einem Gehalt von roo/o und darüber erreicht werden können.It has now been found that by using sodium salicylate or Sodium sulfosalicylate in addition to urethane and phenyldimethylpyrazolone as a solubilizer Durable solutions with a content of roo / o and above can be achieved.
Es war nicht vorauszusehen, saß mit geringen Wassermengen, wie sie zur Erreichung der hohen Konzentration an Sulfonamid zur Verfügung stehen, derartig große Mengen an Lösungsvermittler in Lösung gebracht werden können. Die Verwendung von salicylsauren Salzen hat auch bedeutende therapeutische Vorteile. Besonders hohe Konzentrationen sind erzielbar, wenn man neben Phenyldimethylpyrazolon noch Phenyldimethyldimethylaminopyrazolon verwendet.It was unforeseeable, sat with small amounts of water like them to achieve the high concentration of sulfonamide available such large amounts of solubilizer can be brought into solution. The usage of salicylic acid salts also has significant therapeutic benefits. Particularly high concentrations can be achieved if one also uses phenyldimethylpyrazolone Phenyldimethyldimethylaminopyrazolone is used.
Beispiel zog p-Aminobenzolsulfonamid lösen sich mit 2o g Phenyldimethylpyrazolon, 2o g Äthylurethan und 30 ccm Wasser nicht, gehen aber nach Zusatz von 2o g Natriumsalicylät glatt in Lösung. In dieser können noch anders Sulfonamidpräparate gelöst werden. Die Lösung ist injizierbar.Example p-aminobenzenesulfonamide does not dissolve with 20 g of phenyldimethylpyrazolone, 20 g of ethyl urethane and 30 cc of water, but dissolves smoothly after the addition of 20 g of sodium salicylate. Sulphonamide preparations can also be dissolved in this. The solution is injectable.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEV1852D DE868493C (en) | 1943-04-08 | 1943-04-08 | Process for the production of aqueous solutions of p-aminobenzene sulfonamide or of decoctions of the same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEV1852D DE868493C (en) | 1943-04-08 | 1943-04-08 | Process for the production of aqueous solutions of p-aminobenzene sulfonamide or of decoctions of the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE868493C true DE868493C (en) | 1953-02-26 |
Family
ID=7569829
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DEV1852D Expired DE868493C (en) | 1943-04-08 | 1943-04-08 | Process for the production of aqueous solutions of p-aminobenzene sulfonamide or of decoctions of the same |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE868493C (en) |
-
1943
- 1943-04-08 DE DEV1852D patent/DE868493C/en not_active Expired
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