DE855897C - Process for the preparation of suppositories - Google Patents

Process for the preparation of suppositories

Info

Publication number
DE855897C
DE855897C DEW5319A DEW0005319A DE855897C DE 855897 C DE855897 C DE 855897C DE W5319 A DEW5319 A DE W5319A DE W0005319 A DEW0005319 A DE W0005319A DE 855897 C DE855897 C DE 855897C
Authority
DE
Germany
Prior art keywords
calcium salt
suppositories
preparation
calcium
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DEW5319A
Other languages
German (de)
Inventor
Richard Dr Fleischmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
JOHANN A WUELFING CHEM FAB
Original Assignee
JOHANN A WUELFING CHEM FAB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by JOHANN A WUELFING CHEM FAB filed Critical JOHANN A WUELFING CHEM FAB
Priority to DEW5319A priority Critical patent/DE855897C/en
Application granted granted Critical
Publication of DE855897C publication Critical patent/DE855897C/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/02—Suppositories; Bougies; Bases therefor; Ovules

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

Verfahren zur Herstellung von Suppositorien Nach dem verfahren des Patents 849 170 wird ein in Wasser leicht lösliches anorganisches Calciumsalz, nämlich das Calciumthiosulfat, bis auf einen niederen Hydratwassergehalt entwässert und dann in der Schwingmühle zu einem hochvoluminösen Produkt gemalllen. das in einer geschmolzenen Suppositoriengrundmasse homogen verteilt werden kann.Method of making suppositories According to the procedure of the Patent 849 170 is an inorganic calcium salt readily soluble in water, viz the calcium thiosulphate, dehydrated to a low hydration water content and then crushed in the vibrating mill to a high-volume product. that in one melted suppository base can be distributed homogeneously.

Es wurde nun gefunden daß auch ein anderes in Wasser leicht lösliches anorganisches Calciumsalz, nämlich das Calciumsalz der Amidosulfonsäure, nach nahezu vollständiger Entwässerung in der Schwingmühle gemahlen und das im feinsten Zerteilungsgrad erhaltene Produkt in üblicher Weise mit Suppositoriengrundmassen homogen vermengt werden kann. Beispielsweise werden I9,5 Gewichts teile des nahezu vollständig entwässerten und in der Schxvingmühle his zum feinsten Zerteilungsgrad gemahlenen Calciumsalzes der Amidosulfonsäure in 80,5 Gewichtsteile Kakaobutter oder einer anderen Suppositoriengrundmasse hei etwa 400 homogen verrührt. Die so erhaltenen Suppositorien sind trotz ihres relativ hohen Calciumgebaltes bei rektaler Verabfolgung gut verträglich, beständig und zeigen eine gute therapeutische Wirkung. It has now been found that another one which is also readily soluble in water inorganic calcium salt, namely the calcium salt of sulfamic acid, after almost complete dehydration in the vibrating mill and ground in the finest degree of division product obtained homogeneously mixed with suppository bases in the usual way can be. For example, I9.5 parts by weight of the almost completely dehydrated and in the Schxvingmühle up to the finest degree of division of ground calcium salt of sulfamic acid in 80.5 parts by weight of cocoa butter or another suppository base about 400 homogeneously stirred. The suppositories thus obtained are in spite of theirs Relatively high calcium content when administered rectally, well tolerated, stable and show a good therapeutic effect.

Der Schmelze können auch noch andere Arzneimittel zugesetzt werden. Other drugs can also be added to the melt.

Claims (2)

PATENTANSPRÜCHE: 1. Verfahren zur Herstellung von Calcium enthaltenden Suppositorien, dadurch gekennzeichnet, daß man ein in Wasser leicht lösliches anorganisches Calciumsalz, wie das Calciumsalz der Amidosulfonsäure, nahezu völlig entwässert, eier Mahlung in der Schwingmühle unterwirft und dana in an sich üblicher Welse mit einer Suppositoriengrundmasse homogen vermengt. PATENT CLAIMS: 1. Process for the preparation of calcium containing Suppositories, characterized in that an inorganic one which is readily soluble in water is used Calcium salt, like the calcium salt of sulfamic acid, is almost completely dehydrated, Eggs are subjected to grinding in the vibrating mill and then in the usual catfish with a suppository base mixed homogeneously. 2. Verfahren nach Anspruch 1, dadurch gekennzeichnet, daß man der Schmelze noch andere Arzneimittel inkorporiert. 2. The method according to claim 1, characterized in that one of the Melt also incorporated other drugs.
DEW5319A 1951-03-08 1951-03-08 Process for the preparation of suppositories Expired DE855897C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DEW5319A DE855897C (en) 1951-03-08 1951-03-08 Process for the preparation of suppositories

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEW5319A DE855897C (en) 1951-03-08 1951-03-08 Process for the preparation of suppositories

Publications (1)

Publication Number Publication Date
DE855897C true DE855897C (en) 1952-11-17

Family

ID=7592686

Family Applications (1)

Application Number Title Priority Date Filing Date
DEW5319A Expired DE855897C (en) 1951-03-08 1951-03-08 Process for the preparation of suppositories

Country Status (1)

Country Link
DE (1) DE855897C (en)

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