DE597811C - Process for the preparation of crystallized derivatives of the gonad hormones - Google Patents

Process for the preparation of crystallized derivatives of the gonad hormones

Info

Publication number
DE597811C
DE597811C DESCH99034D DESC099034D DE597811C DE 597811 C DE597811 C DE 597811C DE SCH99034 D DESCH99034 D DE SCH99034D DE SC099034 D DESC099034 D DE SC099034D DE 597811 C DE597811 C DE 597811C
Authority
DE
Germany
Prior art keywords
preparation
hormones
crystallized
gonad
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DESCH99034D
Other languages
German (de)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Schering Kahlbaum AG
Original Assignee
Schering Kahlbaum AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Kahlbaum AG filed Critical Schering Kahlbaum AG
Priority to DESCH99034D priority Critical patent/DE597811C/en
Application granted granted Critical
Publication of DE597811C publication Critical patent/DE597811C/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Extraction Or Liquid Replacement (AREA)

Description

Es wurde die. Beobachtung gemacht, daß sich die Keimdrüsenhormone, wie beispielsweise das Follikelhormon, leicht mit Chinolin vereinigen, wobei schön kristallisierte, in Wasser unlösliche Verbindungen entstehen. Diese Verbindungen können zur Reinigung der Keimdrüsenhormone verwendet werden, da sie sich durch Behandlung mit verdünnten Säuren unter Abspaltung der unveränderten ίο Keimdrüsenhormone · spalten lassen. Besonders geeignet erscheinen diese Verbindungen zur Abscheidung der Keimdrüsenhormone aus vorgereinigten, noch nicht völlig reinen Präparaten.It became the. Observation made that the gonadal hormones, such as the follicular hormone, easily combine with quinoline, whereby nicely crystallized, in Water-insoluble compounds are formed. These compounds can be used for cleaning of the gonad hormones are used as they are diluted by treatment with Allow acids to split off, with the unaltered ίο gonadal hormones · split off. Particularly These compounds appear to be suitable for separating the gonadal hormones from pre-purified, not yet completely pure Preparations.

Beispielexample

ι Teil des Follikelhormons der Formel C18 H22O2 wird mit der gleichen Gewichtsmenge Chinolin vorsichtig erwärmt, so daß vollständige Lösung eintritt. Beim Abkühlen erstarrt das Ganze zu einem Kristallbrei, der auf Ton abgepreßt wird. Die erhaltene Molekülverbindung schmilzt bei 2100 und entspricht der Formel C18H22O2 · C9H7N. Sie läßt sich aus ätherischer Lösung und aus reinem Alkohol Umkristallisieren. In mit Wasser verdünnten Lösungen (z. B. verdünntem Alkohol) zersetzt sich die Verbindung leicht in ihre Komponenten. Part of the follicle hormone of the formula C 18 H 22 O 2 is carefully heated with the same amount by weight of quinoline so that complete solution occurs. When it cools down, the whole thing solidifies to a crystal pulp that is pressed onto clay. The molecular compound obtained melts at 210 ° and corresponds to the formula C 18 H 22 O 2 · C 9 H 7 N. It can be recrystallized from ethereal solution and from pure alcohol. In solutions diluted with water (e.g. dilute alcohol), the compound easily decomposes into its components.

In analoger Weise können andere Keimdrüsenhormone behandelt werden.Other gonadal hormones can be treated in an analogous manner.

Claims (1)

Patentanspruch :Claim: Verfahren zur Darstellung von kristallisierten Derivaten der Keimdrüsenhormone, dadurch gekennzeichnet, daß man diese mit Chinolin vereinigt.Process for the preparation of crystallized derivatives of the gonadal hormones, characterized in that this is combined with quinoline.
DESCH99034D 1932-09-28 1932-09-28 Process for the preparation of crystallized derivatives of the gonad hormones Expired DE597811C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DESCH99034D DE597811C (en) 1932-09-28 1932-09-28 Process for the preparation of crystallized derivatives of the gonad hormones

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DESCH99034D DE597811C (en) 1932-09-28 1932-09-28 Process for the preparation of crystallized derivatives of the gonad hormones

Publications (1)

Publication Number Publication Date
DE597811C true DE597811C (en) 1934-05-31

Family

ID=7446502

Family Applications (1)

Application Number Title Priority Date Filing Date
DESCH99034D Expired DE597811C (en) 1932-09-28 1932-09-28 Process for the preparation of crystallized derivatives of the gonad hormones

Country Status (1)

Country Link
DE (1) DE597811C (en)

Similar Documents

Publication Publication Date Title
DE597811C (en) Process for the preparation of crystallized derivatives of the gonad hormones
DE1964959A1 (en) Clear, concentrated single phase mixture
AT138176B (en) Process for the preparation of crystallized derivatives of the gonadal hormones.
DE591808C (en) Process for the preparation of a solution of salicylic acid piperazine suitable for injections
CH172508A (en) Procedure for purifying the gonad hormones.
DE540842C (en) Process for the preparation of 8-acetyloxyquinoline-7-carboxylic acid
US2467859A (en) Preparation of pyrethrin concentrate
US2207385A (en) Preparation of vitamin concentrate
DE895504C (en) Disinfectant supply form
DE899294C (en) Process for the preparation of a spray composition containing dinitroorthocresol
DE566784C (en) Method for the visualization of clots of the follicular hormone CHO
DE878491C (en) Process for the production of N-chlorinated fatty acid amides
DE661384C (en) Process for the preparation of esters of saturated or unsaturated oxyketones of the androstan-3-one-17-ol type
AT158148B (en) Process for the preparation of esters of androstanone- (3) -ols- (17) or androsten- (4) -one- (3) -ols- (17) or their 17-methyl derivatives.
DE464527C (en) Process for the preparation of alkyl and aralkyl derivatives of diphenolisatins
DE624899C (en) Combating plant pests
DE552447C (en) Process for the preparation of lipoid-soluble antimony compounds
DE584349C (en) Process for obtaining the sex hormones excreted in the urine
AT143320B (en) Process for the extraction of therapeutically effective components from essential oils.
DE578040C (en) Process for the preparation of derivatives of the male glandular hormone
DE562392C (en) Process for the preparation of a 2,4-diaminoazobenzene compound
AT135448B (en) Process for the production of preparations containing sulfur, which produce colloidal solutions with water.
CH183066A (en) Method for preparing a salicylic acid compound.
DE442358C (en) Process for the solidification of liquids
DE430770C (en) Process for the preparation of physiologically active substances