AT138176B - Process for the preparation of crystallized derivatives of the gonadal hormones. - Google Patents
Process for the preparation of crystallized derivatives of the gonadal hormones.Info
- Publication number
- AT138176B AT138176B AT138176DA AT138176B AT 138176 B AT138176 B AT 138176B AT 138176D A AT138176D A AT 138176DA AT 138176 B AT138176 B AT 138176B
- Authority
- AT
- Austria
- Prior art keywords
- preparation
- hormones
- gonadal hormones
- crystallized
- derivatives
- Prior art date
Links
- 239000000745 gonadal hormone Substances 0.000 title claims description 5
- 238000002360 preparation method Methods 0.000 title claims description 4
- 238000000034 method Methods 0.000 title claims description 3
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 claims description 6
- 150000001875 compounds Chemical class 0.000 description 5
- 239000005556 hormone Substances 0.000 description 4
- 229940088597 hormone Drugs 0.000 description 4
- 210000002149 gonad Anatomy 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- DNXHEGUUPJUMQT-CBZIJGRNSA-N Estrone Chemical compound OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 DNXHEGUUPJUMQT-CBZIJGRNSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000004927 clay Substances 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
<Desc/Clms Page number 1>
Verfahren zur Darstellung von kristallisierten Derivaten der Keimdrüsenhormone.
Es wurde die Beobachtung gemacht, dass sich die Keimdrüsenhormone, wie beispielsweise das Follikelhormon, leicht mit Chinolin vereinigen, wobei schön kristallisierte, in Wasser unlösliche Verbindungen entstehen. Diese Verbindungen können zur Reinigung der Keimdrüsenhormone verwendet werden, da sie sich durch Behandlung mit verdünnten Säuren unter Abspaltung der unveränderten Keimdrüsenhormone spalten lassen. Besonders geeignet erscheinen diese Verbindungen zur Abscheidung der Keimdrüsenhormone aus vorgereinigten, noch nicht völlig reinen Präparaten.
Beispiel : 1 Teil des Follikelhormons der Formel C1sH2202 wird mit der gleichen Gewichtsmenge Chinolin vorsichtig erwärmt, so dass vollständige Lösung eintritt. Beim Abkühlen erstarrt das Ganze zu einem Kristallbrei, der auf Ton abgepresst wird. Die erhaltene Molekülverbindung schmilzt bei 210 und entspricht der Formel C1sH22C2, C9H7N. Sie lässt sich aus ätherischer Lösung und aus reinem Alkohol umkristallisieren. In mit Wasser verdünnten Lösungen (z. B. verdünntem Alkohol) zersetzt sich die Verbindung leicht in ihre Komponenten.
In analoger Weise können andere Keimdrüsenhormone behandelt werden.
**WARNUNG** Ende DESC Feld kannt Anfang CLMS uberlappen**.
<Desc / Clms Page number 1>
Process for the preparation of crystallized derivatives of the gonadal hormones.
It has been observed that gonadal hormones such as follicular hormone easily combine with quinoline to produce nicely crystallized water-insoluble compounds. These compounds can be used to purify the gonad hormones, as they can be broken down by treatment with dilute acids with the cleavage of the unchanged gonad hormones. These compounds appear to be particularly suitable for separating the gonad hormones from prepurified, not yet completely pure preparations.
Example: 1 part of the follicle hormone of the formula C1sH2202 is carefully heated with the same amount by weight of quinoline so that complete solution occurs. When it cools down, the whole thing solidifies into a crystal pulp that is pressed onto clay. The resulting molecular compound melts at 210 and corresponds to the formula C1sH22C2, C9H7N. It can be recrystallized from an ethereal solution and from pure alcohol. In solutions diluted with water (e.g. diluted alcohol), the compound easily decomposes into its components.
Other gonadal hormones can be treated in an analogous manner.
** WARNING ** End of DESC field may overlap beginning of CLMS **.
Claims (1)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE138176T | 1932-09-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AT138176B true AT138176B (en) | 1934-07-10 |
Family
ID=34257061
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT138176D AT138176B (en) | 1932-09-27 | 1933-08-04 | Process for the preparation of crystallized derivatives of the gonadal hormones. |
Country Status (1)
| Country | Link |
|---|---|
| AT (1) | AT138176B (en) |
-
1933
- 1933-08-04 AT AT138176D patent/AT138176B/en active
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