AT153199B - Process for the preparation of amino alcohols. - Google Patents

Process for the preparation of amino alcohols.

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Publication number
AT153199B
AT153199B AT153199DA AT153199B AT 153199 B AT153199 B AT 153199B AT 153199D A AT153199D A AT 153199DA AT 153199 B AT153199 B AT 153199B
Authority
AT
Austria
Prior art keywords
preparation
amino alcohols
phenyl
aminopropanol
acyloxybenzyl
Prior art date
Application number
Other languages
German (de)
Original Assignee
Ig Farbenindustrie Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE153199T external-priority
Application filed by Ig Farbenindustrie Ag filed Critical Ig Farbenindustrie Ag
Application granted granted Critical
Publication of AT153199B publication Critical patent/AT153199B/en

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Description

  

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  Verfahren zur Darstellung von Aminoalkoholen. 
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   Des weiteren können in ähnlicher Weise nachstehende Verbindungen erhalten werden : 1-Phenyl-   2-methyl- [4'-methoxy-3'-carbäthoxybenzyl]-aminopropanol- (l)-Chlorhydrat,   aus Alkohol umkristallisiert F   = 1780   ;   1-Phenyl-2-methyl- [4'-methoxy-3'-benzyloxybenzyl]-aminopropanol- (l)-Chlorhydrat,   aus   96% igem   Alkohol umkristallisiert F = 188  ; 1-Phenyl-2-methyl-[3'-äthoxybenzyl]-aminopropanol- (l)-Chlorhydrat, aus Essigester umkristallisiert F =   168-170 .   Ferner lässt sich in gleicher Weise auch die   3'-Acetoxybenzyl-Verbindung   herstellen. 



   Beispiel 4 : 30 g 1-Phenyl-2-aminopropanol-(1) und 17 g 2-Methoxy-5-methylbenzylchlorid werden in 200 cm3 Benzol gelöst und einige Stunden unter   Rückfluss   gekocht. Das ausgeschiedene salzsaure 1-Phenyl-2-aminop"opanol- (1) wird abfiltriert, die Benzollösung mit alkoholischer Salzsäure neutralisiert und das auskristallisierende   1-Phenyl-2- [2'-methoxy-5'-methylbenzyl]-aminopropanol- (l)-   Chlorhydrat abgesaugt. Nach dem Umkristallisieren aus Wasser schmilzt die Verbindung bei   187 .  



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  Process for the preparation of amino alcohols.
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   In addition, the following compounds can be obtained in a similar manner: 1-phenyl-2-methyl- [4'-methoxy-3'-carbethoxybenzyl] -aminopropanol- (1) -chlorohydrate, recrystallized from alcohol, F = 1780; 1-phenyl-2-methyl- [4'-methoxy-3'-benzyloxybenzyl] -aminopropanol- (l) -chlorohydrate, recrystallized from 96% alcohol. F = 188; 1-Phenyl-2-methyl- [3'-ethoxybenzyl] -aminopropanol- (l) -chlorohydrate, recrystallized from ethyl acetate, F = 168-170. Furthermore, the 3'-acetoxybenzyl compound can also be prepared in the same way.



   Example 4: 30 g of 1-phenyl-2-aminopropanol- (1) and 17 g of 2-methoxy-5-methylbenzyl chloride are dissolved in 200 cm3 of benzene and refluxed for a few hours. The precipitated hydrochloric acid 1-phenyl-2-aminop "opanol- (1) is filtered off, the benzene solution is neutralized with alcoholic hydrochloric acid and the 1-phenyl-2- [2'-methoxy-5'-methylbenzyl] aminopropanol (l After recrystallization from water, the compound melts at 187.

Claims (1)

PATENT-ANSPRUCH : Verfahren zur Darstellung von Aminoalkoholen der allgemeinen Formel C6Hs. CH (OH). CH (CHa). PATENT CLAIM: Process for the preparation of amino alcohols of the general formula C6Hs. CH (OH). CH (CHa). NYZ (worin Y Wasserstoff oder einen Alkylrest, Z einen Alkoxy-, Aralkoxy-oder Acyloxybenzylrest bedeutet), dadurch gekennzeichnet, dass man in 1-Phenyl-2-aminopropanol- (1) bzw. dessen N-Alkyl- derivate einen allenfalls substituierten Alkoxy-, Aralkoxy- oder Acyloxybenzylrest einführt und gegebenenfalls die entstandenen N-Monosubstitutionsprodukte alkyliert. NYZ (in which Y denotes hydrogen or an alkyl radical, Z denotes an alkoxy, aralkoxy or acyloxybenzyl radical), characterized in that 1-phenyl-2-aminopropanol- (1) or its N-alkyl derivatives are an optionally substituted alkoxy - Introduces aralkoxy or acyloxybenzyl radicals and optionally alkylates the N-monosubstitution products formed.
AT153199D 1934-07-05 1935-07-01 Process for the preparation of amino alcohols. AT153199B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE153199T 1934-07-05

Publications (1)

Publication Number Publication Date
AT153199B true AT153199B (en) 1938-04-25

Family

ID=29412237

Family Applications (1)

Application Number Title Priority Date Filing Date
AT153199D AT153199B (en) 1934-07-05 1935-07-01 Process for the preparation of amino alcohols.

Country Status (1)

Country Link
AT (1) AT153199B (en)

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