DE60334202D1 - Modulatoren des östrogenrezeptors - Google Patents
Modulatoren des östrogenrezeptorsInfo
- Publication number
- DE60334202D1 DE60334202D1 DE60334202T DE60334202T DE60334202D1 DE 60334202 D1 DE60334202 D1 DE 60334202D1 DE 60334202 T DE60334202 T DE 60334202T DE 60334202 T DE60334202 T DE 60334202T DE 60334202 D1 DE60334202 D1 DE 60334202D1
- Authority
- DE
- Germany
- Prior art keywords
- estrogen
- compounds
- estrogen receptor
- modulators
- functioning
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
- C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
- C07D327/06—Six-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Obesity (AREA)
- Reproductive Health (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Psychiatry (AREA)
- Child & Adolescent Psychology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37523702P | 2002-04-24 | 2002-04-24 | |
PCT/US2003/012103 WO2003091239A1 (en) | 2002-04-24 | 2003-04-18 | Estrogen receptor modulators |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60334202D1 true DE60334202D1 (de) | 2010-10-28 |
Family
ID=29270611
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60334202T Expired - Lifetime DE60334202D1 (de) | 2002-04-24 | 2003-04-18 | Modulatoren des östrogenrezeptors |
Country Status (13)
Country | Link |
---|---|
US (1) | US7138426B2 (de) |
EP (1) | EP1501819B1 (de) |
JP (1) | JP4554219B2 (de) |
AT (1) | ATE481397T1 (de) |
AU (1) | AU2003237084C1 (de) |
CA (1) | CA2484038C (de) |
CY (1) | CY1111195T1 (de) |
DE (1) | DE60334202D1 (de) |
DK (1) | DK1501819T3 (de) |
ES (1) | ES2350446T3 (de) |
PT (1) | PT1501819E (de) |
SI (1) | SI1501819T1 (de) |
WO (1) | WO2003091239A1 (de) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1824340A4 (de) * | 2004-12-17 | 2009-08-05 | Bionovo Inc | Verfahren zur verwendung von extrakten von epimediumspezies |
US8163770B2 (en) * | 2005-10-27 | 2012-04-24 | Msd. K. K. | Benzoxathiin derivative |
US20120115865A1 (en) * | 2006-02-28 | 2012-05-10 | Anna-Lena Berg | New Salts of an Indole Derivative and Their Use in Medicine |
US8933130B2 (en) | 2006-06-23 | 2015-01-13 | Radius Health, Inc. | Treatment of vasomotor symptoms with selective estrogen receptor modulators |
US20080119444A1 (en) * | 2006-11-16 | 2008-05-22 | Steven Lehrer | Methods and compositions for the treatment of cancer |
CN101641013B (zh) | 2007-01-22 | 2014-07-30 | Gtx公司 | 核受体结合剂 |
US9623021B2 (en) * | 2007-01-22 | 2017-04-18 | Gtx, Inc. | Nuclear receptor binding agents |
US9604931B2 (en) | 2007-01-22 | 2017-03-28 | Gtx, Inc. | Nuclear receptor binding agents |
ME00996B (me) | 2007-10-16 | 2012-10-20 | Repros Therapeutics Inc | Trans-klomifen za liječenje metaboličkog sindroma |
US7902147B2 (en) * | 2007-11-05 | 2011-03-08 | Duke University | Chronic lymphocytic leukemia prognosis and treatment |
US8354446B2 (en) | 2007-12-21 | 2013-01-15 | Ligand Pharmaceuticals Incorporated | Selective androgen receptor modulators (SARMs) and uses thereof |
US20100087402A1 (en) * | 2008-09-29 | 2010-04-08 | Vivus, Inc. | Methods and compositions for the treatment of estrogen-dependent hyperproliferative uterine disorders |
LT2568806T (lt) | 2010-05-12 | 2016-09-26 | Radius Health, Inc. | Terapiniai režimai |
PL2580210T3 (pl) | 2010-06-10 | 2017-09-29 | Seragon Pharmaceuticals, Inc. | Modulatory receptora estrogenowego i ich zastosowania |
WO2011159769A2 (en) | 2010-06-17 | 2011-12-22 | Aragon Pharmaceuticals, Inc. | Indane estrogen receptor modulators and uses thereof |
JP5965909B2 (ja) | 2010-09-28 | 2016-08-10 | ラジウス ヘルス,インコーポレイテッド | 選択的アンドロゲン受容体モジュレーター |
US9540361B2 (en) | 2010-12-24 | 2017-01-10 | Merck Sharp & Dohme B.V. | N-substituted azetidine derivatives |
BR112014014124A2 (pt) | 2011-12-14 | 2017-08-22 | Seragon Pharmaceutical Inc | Moduladores do receptor de estrogênio fluorados e usos dos mesmos |
CN104169266A (zh) | 2011-12-16 | 2014-11-26 | 奥乐玛药物股份有限公司 | 新的苯并吡喃化合物、其组合物和用途 |
CA2865234A1 (en) | 2012-02-29 | 2013-09-06 | Repros Therapeutics Inc. | Combination therapy for treating androgen deficiency |
RU2015140066A (ru) | 2013-02-22 | 2017-03-30 | Мерк Шарп И Доум Корп. | Противодиабетические бициклические соединения |
US9421264B2 (en) | 2014-03-28 | 2016-08-23 | Duke University | Method of treating cancer using selective estrogen receptor modulators |
EP3834824A1 (de) | 2014-03-28 | 2021-06-16 | Duke University | Verfahren zur behandlung von krebs unter verwendung von selektiven östrogenrezeptormodulatoren |
AU2016352592B2 (en) | 2015-11-10 | 2023-04-27 | Paracrine Therapeutics Ab | Treatment of ER-negative breast cancer with an PDGF-CC inhibitor and an anti estrogen |
CN108884079B (zh) | 2016-02-15 | 2021-03-05 | 赛诺菲 | 作为雌激素受体调节剂的6,7-二氢-5h-苯并[7]轮烯衍生物 |
KR102397890B1 (ko) | 2016-06-22 | 2022-05-12 | 일립시스 파마 리미티드 | Ar+ 유방암 치료 방법 |
SG11201903908PA (en) * | 2016-11-17 | 2019-05-30 | Sanofi Sa | Novel substituted n-(3-fluoropropyl)-pyrrolidine compounds, processes for their preparation and therapeutic uses thereof |
WO2018129419A1 (en) | 2017-01-05 | 2018-07-12 | Radius Pharmaceuticals, Inc. | Polymorphic forms of rad1901-2hcl |
WO2018138739A1 (en) | 2017-01-27 | 2018-08-02 | Sun Pharma Advanced Research Company Limited | Novel antiestrogenic heterocyclic compounds |
EP3434272A1 (de) | 2017-07-25 | 2019-01-30 | Sanofi | Kombination aus palbociclib und 6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulen-2-carboxylsäure |
CA3089298A1 (en) | 2018-01-22 | 2019-07-25 | Radius Pharmaceuticals, Inc. | Estrogen receptor-modulating compounds |
SG11202013177WA (en) | 2018-07-04 | 2021-01-28 | Radius Pharmaceuticals Inc | Polymorphic forms of rad 1901-2hcl |
ES2924738T3 (es) | 2018-09-07 | 2022-10-10 | Sanofi Sa | Proceso para la preparación de 6-(2,4-diclorofenil)-5-[4-[(3S)-1-(3-fluoropropil)pirrolidin-3-il]oxifenil]-8,9-dihidro-7H-benzo[7]anuleno-2-carboxilato de metilo y una sal del mismo |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU728500B2 (en) | 1996-02-24 | 2001-01-11 | Basf Aktiengesellschaft | 2-hetaroylcyclohexane-1,3-diones |
US5985306A (en) * | 1996-10-28 | 1999-11-16 | Novo Nordisk A/S | (+)-enantiomers of cis-3,4-chroman derivatives useful in prevention or treatment of estrogen diseases or syndromes |
FR2762598A1 (fr) | 1997-04-25 | 1998-10-30 | Adir | Nouveaux composes heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennnent |
US6465445B1 (en) * | 1998-06-11 | 2002-10-15 | Endorecherche, Inc. | Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors |
US6750213B2 (en) * | 2000-10-19 | 2004-06-15 | Merck & Co., Inc. | Estrogen receptor modulators |
JP2004511501A (ja) | 2000-10-19 | 2004-04-15 | メルク エンド カムパニー インコーポレーテッド | エストロゲン受容体モジュレーター |
PL361053A1 (en) | 2000-10-19 | 2004-09-20 | Merck & Co,Inc. | Estrogen receptor modulators |
US20030225132A1 (en) * | 2002-04-11 | 2003-12-04 | Dininno Frank P. | Estrogen receptor modulators |
-
2003
- 2003-04-18 PT PT03736470T patent/PT1501819E/pt unknown
- 2003-04-18 AT AT03736470T patent/ATE481397T1/de active
- 2003-04-18 ES ES03736470T patent/ES2350446T3/es not_active Expired - Lifetime
- 2003-04-18 JP JP2003587798A patent/JP4554219B2/ja not_active Expired - Fee Related
- 2003-04-18 EP EP03736470A patent/EP1501819B1/de not_active Expired - Lifetime
- 2003-04-18 AU AU2003237084A patent/AU2003237084C1/en not_active Ceased
- 2003-04-18 US US10/512,172 patent/US7138426B2/en not_active Expired - Lifetime
- 2003-04-18 CA CA2484038A patent/CA2484038C/en not_active Expired - Fee Related
- 2003-04-18 SI SI200331909T patent/SI1501819T1/sl unknown
- 2003-04-18 WO PCT/US2003/012103 patent/WO2003091239A1/en active Application Filing
- 2003-04-18 DE DE60334202T patent/DE60334202D1/de not_active Expired - Lifetime
- 2003-04-18 DK DK03736470.0T patent/DK1501819T3/da active
-
2010
- 2010-12-13 CY CY20101101150T patent/CY1111195T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
AU2003237084B2 (en) | 2008-11-20 |
EP1501819B1 (de) | 2010-09-15 |
ES2350446T3 (es) | 2011-01-24 |
JP2005529136A (ja) | 2005-09-29 |
ATE481397T1 (de) | 2010-10-15 |
EP1501819A1 (de) | 2005-02-02 |
AU2003237084C1 (en) | 2009-03-26 |
SI1501819T1 (sl) | 2011-01-31 |
JP4554219B2 (ja) | 2010-09-29 |
EP1501819A4 (de) | 2006-06-21 |
US7138426B2 (en) | 2006-11-21 |
WO2003091239A1 (en) | 2003-11-06 |
DK1501819T3 (da) | 2011-01-10 |
US20050234245A1 (en) | 2005-10-20 |
CA2484038C (en) | 2011-10-18 |
AU2003237084A1 (en) | 2003-11-10 |
CA2484038A1 (en) | 2003-11-06 |
PT1501819E (pt) | 2010-11-11 |
CY1111195T1 (el) | 2015-06-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
R081 | Change of applicant/patentee |
Ref document number: 1501819 Country of ref document: EP Owner name: SCHERING CORPORATION, US Free format text: FORMER OWNER: MERCK SHARP & DOHME CORP., RAHWAY, US Effective date: 20121213 |
|
R082 | Change of representative |
Ref document number: 1501819 Country of ref document: EP Representative=s name: ABITZ & PARTNER, DE Effective date: 20121213 |