DE60333392D1 - Verwendung von endoperoxiden zur behandlungvon infektionen durch flaviviridae, einschliesslich hepatinefieber-virus - Google Patents
Verwendung von endoperoxiden zur behandlungvon infektionen durch flaviviridae, einschliesslich hepatinefieber-virusInfo
- Publication number
- DE60333392D1 DE60333392D1 DE60333392T DE60333392T DE60333392D1 DE 60333392 D1 DE60333392 D1 DE 60333392D1 DE 60333392 T DE60333392 T DE 60333392T DE 60333392 T DE60333392 T DE 60333392T DE 60333392 D1 DE60333392 D1 DE 60333392D1
- Authority
- DE
- Germany
- Prior art keywords
- virus
- artemisinin
- endoperoxides
- infections
- hepatitis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000011282 treatment Methods 0.000 title abstract 3
- 241000710781 Flaviviridae Species 0.000 title 1
- 241000700605 Viruses Species 0.000 title 1
- 208000015181 infectious disease Diseases 0.000 title 1
- BLUAFEHZUWYNDE-NNWCWBAJSA-N artemisinin Chemical compound C([C@](OO1)(C)O2)C[C@H]3[C@H](C)CC[C@@H]4[C@@]31[C@@H]2OC(=O)[C@@H]4C BLUAFEHZUWYNDE-NNWCWBAJSA-N 0.000 abstract 4
- 229960004191 artemisinin Drugs 0.000 abstract 4
- 229930101531 artemisinin Natural products 0.000 abstract 4
- 241000710780 Bovine viral diarrhea virus 1 Species 0.000 abstract 3
- 241000711549 Hepacivirus C Species 0.000 abstract 2
- 235000003826 Artemisia Nutrition 0.000 abstract 1
- 240000006891 Artemisia vulgaris Species 0.000 abstract 1
- 235000003261 Artemisia vulgaris Nutrition 0.000 abstract 1
- 241000450599 DNA viruses Species 0.000 abstract 1
- 208000005176 Hepatitis C Diseases 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 241000710778 Pestivirus Species 0.000 abstract 1
- HATRDXDCPOXQJX-UHFFFAOYSA-N Thapsigargin Natural products CCCCCCCC(=O)OC1C(OC(O)C(=C/C)C)C(=C2C3OC(=O)C(C)(O)C3(O)C(CC(C)(OC(=O)C)C12)OC(=O)CCC)C HATRDXDCPOXQJX-UHFFFAOYSA-N 0.000 abstract 1
- 208000036142 Viral infection Diseases 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 235000009052 artemisia Nutrition 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000000284 extract Substances 0.000 abstract 1
- 208000010710 hepatitis C virus infection Diseases 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 244000052769 pathogen Species 0.000 abstract 1
- 229930004725 sesquiterpene Natural products 0.000 abstract 1
- 150000004354 sesquiterpene derivatives Chemical class 0.000 abstract 1
- 229930009674 sesquiterpene lactone Natural products 0.000 abstract 1
- 150000002107 sesquiterpene lactone derivatives Chemical class 0.000 abstract 1
- 241001430294 unidentified retrovirus Species 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Mycology (AREA)
- Alternative & Traditional Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42268302P | 2002-10-31 | 2002-10-31 | |
| PCT/US2003/034431 WO2004041176A2 (en) | 2002-10-31 | 2003-10-29 | The use of endoperoxides for the treatment of infections caused by flaviviridae, including hepatitis c, bovine viral diarrhea and classical swine fever virus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60333392D1 true DE60333392D1 (de) | 2010-08-26 |
Family
ID=32312544
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60333392T Expired - Lifetime DE60333392D1 (de) | 2002-10-31 | 2003-10-29 | Verwendung von endoperoxiden zur behandlungvon infektionen durch flaviviridae, einschliesslich hepatinefieber-virus |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7842719B2 (enExample) |
| EP (1) | EP1585524B1 (enExample) |
| JP (1) | JP4594734B2 (enExample) |
| CN (1) | CN100430061C (enExample) |
| AT (1) | ATE473745T1 (enExample) |
| AU (1) | AU2003287259A1 (enExample) |
| CA (1) | CA2501584C (enExample) |
| DE (1) | DE60333392D1 (enExample) |
| ES (1) | ES2348536T3 (enExample) |
| PT (1) | PT1585524E (enExample) |
| WO (1) | WO2004041176A2 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2353384T3 (es) | 2003-02-12 | 2011-03-01 | Georgetown University | Uso de artemisinina para tratar tumores inducidos por virus oncogénicos y para tratar infecciones víricas. |
| ES2245248B1 (es) * | 2004-06-09 | 2007-02-16 | Universidad De Salamanca | Uso de la artemisinina y sus derivados en la fabricacion de medicamentos utiles como agentes antiviricos. |
| KR100824106B1 (ko) * | 2006-05-30 | 2008-04-21 | 주식회사 씨티씨바이오 | 흰반점바이러스를 치료 또는 예방하기 위한 조성물 및 방법 |
| WO2008010620A1 (en) * | 2006-07-21 | 2008-01-24 | Ben's Lab Co., Ltd. | Composition comprising the crude drug extracts for improving liver function |
| AU2007286754A1 (en) * | 2006-08-25 | 2008-02-28 | Viropharma Incorporated | Identification and characterization of HCV replicon variants with reduced susceptibility to HCV-796, and methods related thereto |
| EP2310393A4 (en) * | 2008-06-17 | 2011-06-22 | Hhv 6 Foundation | ARTEMISININE AND DERIVATIVES THEREOF AS ANTIVIRAL AGENTS |
| CN102731464B (zh) * | 2011-04-12 | 2014-07-23 | 沈阳药科大学 | 一个倍半萜内酯化合物、制备方法及其应用 |
| WO2013006795A2 (en) | 2011-07-07 | 2013-01-10 | Humanitas International Foundation | Antiviral compositions and methods of their use |
| US20130012470A1 (en) * | 2011-07-07 | 2013-01-10 | Humanitas Technology, LLC | Antiviral compositions and methods of their use |
| US9616067B2 (en) | 2012-04-18 | 2017-04-11 | Hadasit Medical Research Services And Development Ltd. | Methods and compositions for treating viral infections |
| FR2989588A1 (fr) * | 2012-04-19 | 2013-10-25 | Centre Nat Rech Scient | Composes pour la prevention ou le traitement des infections par des virus de la famille des flaviviridae |
| CN102755316A (zh) * | 2012-07-16 | 2012-10-31 | 中国科学院武汉病毒研究所 | 青蒿素及其衍生物在制备治疗丙型肝炎病毒药物中的应用 |
| WO2018068060A1 (en) | 2016-10-07 | 2018-04-12 | Navidea Biopharmaceuticals, Inc. | Compounds and methods for diagnosis and treatment of viral infections |
| GB201805665D0 (en) * | 2018-04-05 | 2018-05-23 | Univ Nottingham | Antiviral Compounds And Methods |
| WO2019232129A1 (en) * | 2018-05-30 | 2019-12-05 | The Board Of Regents Of The University Of Texas System | Treatment of viral infections and virally associated lesions with sequiterpene lactones |
| CA3179317A1 (en) * | 2020-04-20 | 2021-10-28 | Lloyd Hung Loi TRAN | Methods for the prophylaxis and treatment of covid and covid-19 |
| CN112245424B (zh) * | 2020-10-19 | 2021-09-21 | 中国医学科学院医药生物技术研究所 | 一种没药烷倍半萜结构类似物在制备抗冠状病毒药物中的用途 |
| CN112294795B (zh) * | 2020-11-17 | 2022-03-29 | 北京化工大学 | 蒿甲醚在治疗和预防柯萨奇病毒感染中的应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW198722B (enExample) | 1990-05-07 | 1993-01-21 | Hoechst Ag | |
| CN1058717A (zh) | 1990-08-08 | 1992-02-19 | 中国人民解放军军事医学科学院微生物流行病研究所 | 抗疟新药—复方蒿甲醚及其制备方法 |
| CN1035767C (zh) * | 1992-11-10 | 1997-09-03 | 罗宣德 | 新的青蒿素衍生物及其用途 |
| CN1105238A (zh) * | 1992-11-10 | 1995-07-19 | 中国预防医学科学院病毒学研究所 | 抗aids病毒的药物组合物 |
| EP0713877A1 (en) | 1993-07-19 | 1996-05-29 | LUO, Xuande | Qinghaosu derivatives against aids |
| DE4447588C2 (de) | 1994-05-03 | 1997-11-20 | Omer Osama Dr Dr Med | Pflanzliches Arzneimittel zur Behandlung von chronischen und allergischen Rhino-Sino-Bronchitiden |
| CN1049435C (zh) * | 1994-11-09 | 2000-02-16 | 中国科学院上海药物研究所 | 含苯基和杂环基的青蒿素衍生物及其制备方法 |
| DE19902924A1 (de) | 1999-01-26 | 2000-08-03 | Hassan Jomaa | Verwendung von phosphororganischen Verbindungen zur prophylaktischen und therapeutischen Behandlung von Infektionen |
| CN1135974C (zh) | 2000-08-23 | 2004-01-28 | 重庆健桥医药开发有限公司 | 抗疟药新药复方双氢青蒿素 |
| JPWO2002032905A1 (ja) | 2000-10-20 | 2004-02-26 | 味の素株式会社 | マラリア治療のための医薬組成物、ドーズおよび方法 |
| ES2353384T3 (es) * | 2003-02-12 | 2011-03-01 | Georgetown University | Uso de artemisinina para tratar tumores inducidos por virus oncogénicos y para tratar infecciones víricas. |
-
2003
- 2003-09-16 US US10/664,008 patent/US7842719B2/en not_active Expired - Fee Related
- 2003-10-29 AT AT03781492T patent/ATE473745T1/de active
- 2003-10-29 JP JP2004550230A patent/JP4594734B2/ja not_active Expired - Fee Related
- 2003-10-29 DE DE60333392T patent/DE60333392D1/de not_active Expired - Lifetime
- 2003-10-29 AU AU2003287259A patent/AU2003287259A1/en not_active Abandoned
- 2003-10-29 PT PT03781492T patent/PT1585524E/pt unknown
- 2003-10-29 ES ES03781492T patent/ES2348536T3/es not_active Expired - Lifetime
- 2003-10-29 CA CA002501584A patent/CA2501584C/en not_active Expired - Fee Related
- 2003-10-29 CN CNB2003801026935A patent/CN100430061C/zh not_active Expired - Fee Related
- 2003-10-29 EP EP03781492A patent/EP1585524B1/en not_active Expired - Lifetime
- 2003-10-29 WO PCT/US2003/034431 patent/WO2004041176A2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| ES2348536T3 (es) | 2010-12-09 |
| US7842719B2 (en) | 2010-11-30 |
| AU2003287259A8 (en) | 2004-06-07 |
| EP1585524B1 (en) | 2010-07-14 |
| CA2501584C (en) | 2009-03-10 |
| JP2006504787A (ja) | 2006-02-09 |
| WO2004041176A2 (en) | 2004-05-21 |
| CN100430061C (zh) | 2008-11-05 |
| AU2003287259A1 (en) | 2004-06-07 |
| CA2501584A1 (en) | 2004-05-21 |
| CN1711091A (zh) | 2005-12-21 |
| JP4594734B2 (ja) | 2010-12-08 |
| EP1585524A2 (en) | 2005-10-19 |
| PT1585524E (pt) | 2010-10-19 |
| ATE473745T1 (de) | 2010-07-15 |
| WO2004041176A3 (en) | 2004-10-07 |
| US20050059647A1 (en) | 2005-03-17 |
| EP1585524A4 (en) | 2007-10-10 |
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