DE60331870D1 - Enantioselektive Alkylierung von trizyklischen Verbindungen - Google Patents

Enantioselektive Alkylierung von trizyklischen Verbindungen

Info

Publication number
DE60331870D1
DE60331870D1 DE60331870T DE60331870T DE60331870D1 DE 60331870 D1 DE60331870 D1 DE 60331870D1 DE 60331870 T DE60331870 T DE 60331870T DE 60331870 T DE60331870 T DE 60331870T DE 60331870 D1 DE60331870 D1 DE 60331870D1
Authority
DE
Germany
Prior art keywords
tricyclic compounds
enantioselective alkylation
enantioselective
alkylation
tricyclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60331870T
Other languages
English (en)
Inventor
Frank X Chen
Yee-Shing Wong
Jeffrey M Eckert
Nanfei Zou
Feng Liang
Agnes S Kim-Meade
Marc Poirier
Tiruvettipuram K Thiruvengadam
George G Wu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of DE60331870D1 publication Critical patent/DE60331870D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D221/00Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04Ortho- or peri-condensed ring systems
    • C07D221/06Ring systems of three rings
    • C07D221/16Ring systems of three rings containing carbocyclic rings other than six-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE60331870T 2002-10-03 2003-10-01 Enantioselektive Alkylierung von trizyklischen Verbindungen Expired - Lifetime DE60331870D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41567302P 2002-10-03 2002-10-03
US41880602P 2002-10-15 2002-10-15

Publications (1)

Publication Number Publication Date
DE60331870D1 true DE60331870D1 (de) 2010-05-06

Family

ID=32073383

Family Applications (2)

Application Number Title Priority Date Filing Date
DE60314535T Expired - Lifetime DE60314535T2 (de) 2002-10-03 2003-10-01 Enantioselective alkylierung von trizyklischen verbindungen
DE60331870T Expired - Lifetime DE60331870D1 (de) 2002-10-03 2003-10-01 Enantioselektive Alkylierung von trizyklischen Verbindungen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE60314535T Expired - Lifetime DE60314535T2 (de) 2002-10-03 2003-10-01 Enantioselective alkylierung von trizyklischen verbindungen

Country Status (18)

Country Link
US (2) US7049440B2 (de)
EP (3) EP1780203B1 (de)
JP (2) JP4679150B2 (de)
CN (2) CN101289425B (de)
AR (1) AR041466A1 (de)
AT (3) ATE461921T1 (de)
AU (1) AU2003277194A1 (de)
CA (1) CA2501292A1 (de)
CY (1) CY1107481T1 (de)
DE (2) DE60314535T2 (de)
DK (1) DK1556358T3 (de)
ES (3) ES2374705T3 (de)
HK (2) HK1072773A1 (de)
MX (1) MXPA05003518A (de)
PT (1) PT1556358E (de)
SI (1) SI1556358T1 (de)
WO (1) WO2004031153A2 (de)
ZA (1) ZA200502581B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060205810A1 (en) * 2004-11-24 2006-09-14 Schering Corporation Platinum therapeutic combinations
US8784618B2 (en) 2010-08-19 2014-07-22 International Business Machines Corporation Working electrode design for electrochemical processing of electronic components
CN107021925B (zh) * 2017-05-23 2020-05-29 中节能万润股份有限公司 一种以氮杂二苯并环庚酮为核心的化合物及其在oled上的应用
EP3741745B1 (de) 2018-01-19 2023-04-26 Yuki Gosei Kogyo Co., Ltd. Verfahren zur herstellung eines n-alkoxycarbonylpiperidinderivats und zwischenprodukt dafür
EP3741743A4 (de) * 2018-01-19 2021-10-20 Yuki Gosei Kogyo Co., Ltd. Verfahren zur herstellung von 1-(1-tert-butoxycarbonyl-4-piperidylacetyl)-4-mesyloxypiperidin und 1-(1-tert-butoxycarbonyl-4-piperidylacetyl)-4-mesyloxypiperidin

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5719148A (en) * 1993-10-15 1998-02-17 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
US5874442A (en) 1995-12-22 1999-02-23 Schering-Plough Corporation Tricyclic amides useful for inhibition of G-protein function and for treatment of proliferative disease
KR100295224B1 (ko) * 1995-12-22 2001-09-17 둘락 노먼 씨. G-단백질기능의억제및증식성질환의치료에유용한트리사이클릭아미드
IL128931A0 (en) * 1996-09-13 2000-02-17 Schering Corp Tricylic antitumor compounds being farnesyl protein transferase inhibitors
US5962741A (en) * 1996-11-19 1999-10-05 Novartis Ag Process for the production of aromatic halogen-amino compounds
US5998620A (en) * 1997-03-25 1999-12-07 Schering Corporation Synthesis of intermediates useful in preparing tricyclic compounds
US5760232A (en) * 1997-06-16 1998-06-02 Schering Corporation Synthesis of intermediates useful in preparing bromo-substituted tricyclic compounds
US6426352B1 (en) * 1997-06-17 2002-07-30 Schering Corporation Sulfonamide inhibitors of farnesyl-protein transferase
US6576639B1 (en) * 1997-06-17 2003-06-10 Schering Corporation Compounds for the inhibition of farnesyl protein transferase
US6372909B1 (en) * 1998-11-20 2002-04-16 Schering Corporation Synthesis of intermediates useful in preparing tricyclic compounds
US6307048B1 (en) * 1998-11-20 2001-10-23 Schering Corporation Enantioselective alkylation of tricyclic compounds
EP1131313B1 (de) * 1998-11-20 2003-02-26 Schering Corporation Enantioselective alkylierung von trizyklischen verbindungen

Also Published As

Publication number Publication date
US20040122232A1 (en) 2004-06-24
CN101289425B (zh) 2011-04-13
AU2003277194A1 (en) 2004-04-23
AU2003277194A8 (en) 2004-04-23
WO2004031153A2 (en) 2004-04-15
JP2006511481A (ja) 2006-04-06
ES2340806T3 (es) 2010-06-09
ATE461921T1 (de) 2010-04-15
EP1556358B1 (de) 2007-06-20
CN101289425A (zh) 2008-10-22
DE60314535T2 (de) 2008-02-21
US7049440B2 (en) 2006-05-23
CN100404510C (zh) 2008-07-23
EP2189447B1 (de) 2011-11-16
HK1101910A1 (en) 2007-11-02
ATE533748T1 (de) 2011-12-15
EP1556358A2 (de) 2005-07-27
ES2374705T3 (es) 2012-02-21
EP1780203B1 (de) 2010-03-24
DK1556358T3 (da) 2007-09-10
WO2004031153A3 (en) 2004-07-15
HK1072773A1 (en) 2005-09-09
US7582763B2 (en) 2009-09-01
EP1780203A3 (de) 2007-07-11
US20060074241A1 (en) 2006-04-06
MXPA05003518A (es) 2005-06-03
PT1556358E (pt) 2007-09-25
ATE365157T1 (de) 2007-07-15
EP2189447A1 (de) 2010-05-26
JP2010202656A (ja) 2010-09-16
DE60314535D1 (de) 2007-08-02
CY1107481T1 (el) 2013-04-18
EP1780203A2 (de) 2007-05-02
AR041466A1 (es) 2005-05-18
JP4679150B2 (ja) 2011-04-27
CN1717392A (zh) 2006-01-04
ZA200502581B (en) 2006-02-20
SI1556358T1 (sl) 2007-10-31
CA2501292A1 (en) 2004-04-15
ES2285252T3 (es) 2007-11-16

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition