DE60327628D1 - Amid substituierte xanthin derivate mit gluconeogenesis modulierender wirkung - Google Patents

Amid substituierte xanthin derivate mit gluconeogenesis modulierender wirkung

Info

Publication number
DE60327628D1
DE60327628D1 DE60327628T DE60327628T DE60327628D1 DE 60327628 D1 DE60327628 D1 DE 60327628D1 DE 60327628 T DE60327628 T DE 60327628T DE 60327628 T DE60327628 T DE 60327628T DE 60327628 D1 DE60327628 D1 DE 60327628D1
Authority
DE
Germany
Prior art keywords
gluconeogenesis
amid
xanthine derivatives
modulating effect
substituted xanthine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60327628T
Other languages
English (en)
Inventor
Pete William Dunten
Louise Helen Foley
Nicholas John Huby
Sherrie Lynn Pietranico-Cole
Weiya Yun
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of DE60327628D1 publication Critical patent/DE60327628D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE60327628T 2002-06-12 2003-06-05 Amid substituierte xanthin derivate mit gluconeogenesis modulierender wirkung Expired - Lifetime DE60327628D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38816402P 2002-06-12 2002-06-12
PCT/EP2003/005922 WO2003106459A1 (en) 2002-06-12 2003-06-05 Amide substituted xanthine derivatives with gluconeogenesis modulating activity

Publications (1)

Publication Number Publication Date
DE60327628D1 true DE60327628D1 (de) 2009-06-25

Family

ID=29736437

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60327628T Expired - Lifetime DE60327628D1 (de) 2002-06-12 2003-06-05 Amid substituierte xanthin derivate mit gluconeogenesis modulierender wirkung

Country Status (16)

Country Link
US (1) US7135475B2 (de)
EP (1) EP1515972B1 (de)
JP (1) JP4294582B2 (de)
KR (1) KR100657118B1 (de)
CN (1) CN100522961C (de)
AR (1) AR040260A1 (de)
AT (1) ATE431350T1 (de)
AU (1) AU2003236702B2 (de)
BR (1) BR0311760A (de)
CA (1) CA2487033C (de)
DE (1) DE60327628D1 (de)
ES (1) ES2324215T3 (de)
MX (1) MXPA04012057A (de)
PL (1) PL374552A1 (de)
RU (1) RU2295525C2 (de)
WO (1) WO2003106459A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7148229B2 (en) 2003-02-19 2006-12-12 Hoffman-La Roche Inc. Sulfonamide substituted xanthine derivatives
US7202252B2 (en) * 2003-02-19 2007-04-10 Endacea, Inc. A1 adenosine receptor antagonists
WO2004074288A1 (en) * 2003-02-19 2004-09-02 F. Hoffmann-La Roche Ag Sulfonamide substituted xanthine derivatives for use as pepck inhibitors
WO2005009343A2 (en) * 2003-06-06 2005-02-03 Endacea, Inc. A1 adenosine receptor antogonists
US20090068101A9 (en) * 2003-06-09 2009-03-12 Endacea, Inc. A1 Adenosine Receptor Antagonists
AU2005214135B2 (en) 2004-02-17 2008-10-30 The University Of York Desaturase enzymes
WO2010039289A2 (en) 2008-05-14 2010-04-08 Hydra Biosciences, Inc. Compounds and compositions for treating chemical warfare agent-induced injuries
WO2009140517A1 (en) 2008-05-14 2009-11-19 Hydra Biosciences, Inc. Compounds and compositions for treating chemical warfare agent-induced injuries
EP2336104A4 (de) * 2008-09-02 2012-01-25 Nissan Chemical Ind Ltd Orthosubstituiertes haloalkylsulfonanilidderivat und herbizid
WO2010132838A1 (en) * 2009-05-14 2010-11-18 Hydra Biosciences, Inc. Compounds useful for treating disorders related to trpa1
EP2617722B1 (de) 2010-09-10 2016-03-23 Shionogi & Co., Ltd. Heteroring-annelliertes imidazolderivat mit ampk-aktivierender wirkung
KR20230061860A (ko) * 2021-10-29 2023-05-09 부산대학교 산학협력단 크산틴 유도체를 유효성분으로 포함하는 죽상동맥경화증 예방 또는 치료용 약학적 조성물

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2729642A (en) * 1954-08-13 1956-01-03 Chattanooga Medicine Co Water soluble salts of 8-(para-aminobenzyl) caffeine and method for their preparation
GB0008694D0 (en) * 2000-04-07 2000-05-31 Novartis Ag Organic compounds
US7148229B2 (en) * 2003-02-19 2006-12-12 Hoffman-La Roche Inc. Sulfonamide substituted xanthine derivatives
US7202252B2 (en) * 2003-02-19 2007-04-10 Endacea, Inc. A1 adenosine receptor antagonists
WO2005009343A2 (en) * 2003-06-06 2005-02-03 Endacea, Inc. A1 adenosine receptor antogonists

Also Published As

Publication number Publication date
US7135475B2 (en) 2006-11-14
RU2005100761A (ru) 2005-09-10
CA2487033C (en) 2009-08-11
WO2003106459A1 (en) 2003-12-24
EP1515972B1 (de) 2009-05-13
CN100522961C (zh) 2009-08-05
AU2003236702A1 (en) 2003-12-31
KR20050016548A (ko) 2005-02-21
JP4294582B2 (ja) 2009-07-15
PL374552A1 (en) 2005-10-31
CA2487033A1 (en) 2003-12-24
MXPA04012057A (es) 2005-03-07
AR040260A1 (es) 2005-03-23
ES2324215T3 (es) 2009-08-03
BR0311760A (pt) 2005-03-29
JP2005533067A (ja) 2005-11-04
RU2295525C2 (ru) 2007-03-20
ATE431350T1 (de) 2009-05-15
AU2003236702B2 (en) 2007-03-08
KR100657118B1 (ko) 2007-02-28
EP1515972A1 (de) 2005-03-23
CN1659168A (zh) 2005-08-24
US20040014766A1 (en) 2004-01-22

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Legal Events

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