DE60327442D1 - Antikörperkonstruktion unter verwendung einer mrl/lpr-maus - Google Patents

Antikörperkonstruktion unter verwendung einer mrl/lpr-maus

Info

Publication number
DE60327442D1
DE60327442D1 DE60327442T DE60327442T DE60327442D1 DE 60327442 D1 DE60327442 D1 DE 60327442D1 DE 60327442 T DE60327442 T DE 60327442T DE 60327442 T DE60327442 T DE 60327442T DE 60327442 D1 DE60327442 D1 DE 60327442D1
Authority
DE
Germany
Prior art keywords
mrl
lpr mouse
antibody
antibody construction
producing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60327442T
Other languages
English (en)
Inventor
Iwao Ohizumi
Mikiyoshi Saito
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Application granted granted Critical
Publication of DE60327442D1 publication Critical patent/DE60327442D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE60327442T 2002-09-04 2003-09-04 Antikörperkonstruktion unter verwendung einer mrl/lpr-maus Expired - Lifetime DE60327442D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/JP2002/008998 WO2004022595A1 (ja) 2002-09-04 2002-09-04 MRL/lprマウスを用いた抗体の作製
PCT/JP2003/011319 WO2004022754A1 (ja) 2002-09-04 2003-09-04 MRL/lprマウスを用いた抗体の作製

Publications (1)

Publication Number Publication Date
DE60327442D1 true DE60327442D1 (de) 2009-06-10

Family

ID=31972305

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60327442T Expired - Lifetime DE60327442D1 (de) 2002-09-04 2003-09-04 Antikörperkonstruktion unter verwendung einer mrl/lpr-maus

Country Status (7)

Country Link
US (1) US20060246550A1 (de)
EP (3) EP1849867A1 (de)
JP (1) JP4571496B2 (de)
AT (1) ATE430198T1 (de)
AU (2) AU2002328429A1 (de)
DE (1) DE60327442D1 (de)
WO (2) WO2004022595A1 (de)

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WO2006006693A1 (ja) 2004-07-09 2006-01-19 Chugai Seiyaku Kabushiki Kaisha 抗グリピカン３抗体
CN101014367B (zh) 2004-08-24 2012-07-04 中外制药株式会社 使用抗磷脂酰肌醇蛋白聚糖-3抗体的辅助疗法
CA2585196C (en) 2004-10-26 2015-01-06 Chugai Seiyaku Kabushiki Kaisha Anti-glypican 3 antibody having modified sugar chain
US20070087005A1 (en) 2005-10-14 2007-04-19 Lazar Gregory A Anti-glypican-3 antibody
JP2008110943A (ja) * 2006-10-31 2008-05-15 Niigata Univ モノクローナル抗体の作成方法
ES2562790T3 (es) 2007-07-17 2016-03-08 E. R. Squibb & Sons, L.L.C. Anticuerpos monoclonales contra Glipicano-3
CN107973851A (zh) 2010-11-30 2018-05-01 中外制药株式会社 与多分子的抗原重复结合的抗原结合分子
WO2012073985A1 (ja) 2010-11-30 2012-06-07 中外製薬株式会社 細胞傷害誘導治療剤
WO2012133782A1 (ja) 2011-03-30 2012-10-04 中外製薬株式会社 抗原結合分子の血漿中滞留性と免疫原性を改変する方法
CN103974721A (zh) 2011-09-30 2014-08-06 中外制药株式会社 促进抗原消除的抗原结合分子
KR102239138B1 (ko) 2011-09-30 2021-04-12 추가이 세이야쿠 가부시키가이샤 표적 항원에 대한 면역응답을 유도하는 항원 결합 분자
JP6271251B2 (ja) 2011-10-05 2018-01-31 中外製薬株式会社 糖鎖受容体結合ドメインを含む抗原の血漿中からの消失を促進する抗原結合分子
US20160046693A1 (en) 2012-02-24 2016-02-18 Chugai Seiyaku Kabushiki Kaisha Antigen-Binding Molecule for Promoting Disappearance of Antigen via Fc gamma RIIB
KR20150016579A (ko) 2012-05-30 2015-02-12 추가이 세이야쿠 가부시키가이샤 표적 조직 특이적 항원 결합 분자
TWI693073B (zh) 2012-12-21 2020-05-11 日商中外製藥股份有限公司 對ｇｐｃ３標的治療劑療法為有效之患者投與的ｇｐｃ３標的治療劑
WO2014144170A1 (en) * 2013-03-15 2014-09-18 The Cleveland Clinic Foundation In-vitro method for monoclonal antibody production using non-human act1 -deficient mice
AU2014358191B2 (en) 2013-12-04 2020-12-24 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecules, the antigen-binding activity of which varies according to the concentration of compounds, and libraries of said molecules
EP3141603A4 (de) 2014-05-08 2017-12-27 Chugai Seiyaku Kabushiki Kaisha Gpc3-anzielendes therapeutikum für die verabreichung an einen mittels einer therapie mit dem gpc3-anzielenden therapeutikum behandelten patienten
MA40764A (fr) 2014-09-26 2017-08-01 Chugai Pharmaceutical Co Ltd Agent thérapeutique induisant une cytotoxicité
EP3318879B1 (de) 2015-07-01 2020-10-21 Chugai Seiyaku Kabushiki Kaisha Verabreichung eines gegen gpc3 gerichteten therapeutikums an einen patienten mit bestätigter wirksamkeit des gegen gpc3 gerichteten therapeutikums
SG11201807936VA (en) 2016-03-14 2018-10-30 Chugai Pharmaceutical Co Ltd Cell injury inducing therapeutic drug for use in cancer therapy
TW202235438A (zh) 2016-11-28 2022-09-16 日商中外製藥股份有限公司 能夠調節配體結合活性的配體結合分子
AU2018376309A1 (en) 2017-11-28 2020-06-25 Chugai Seiyaku Kabushiki Kaisha Ligand-binding molecule having adjustable ligand-binding activity
WO2019230868A1 (ja) 2018-05-30 2019-12-05 中外製薬株式会社 単ドメイン抗体含有リガンド結合分子
EP3943108A4 (de) 2019-03-19 2023-01-04 Chugai Seiyaku Kabushiki Kaisha Antigen-bindendes molekül mit antigen-bindender domäne mit veränderlicher bindungsaktivität gegenüber antigen in abhängigkeit von mta und bibliothek zur gewinnung der antigen-bindenden domäne
CN114127277A (zh) 2019-06-05 2022-03-01 中外制药株式会社 蛋白酶底物和包含蛋白酶切割序列的多肽
AU2020288499A1 (en) 2019-06-05 2022-01-27 Chugai Seiyaku Kabushiki Kaisha Antibody cleavage site-binding molecule
WO2021100715A1 (ja) * 2019-11-18 2021-05-27 住友化学株式会社 抗体の作製方法
EP4197545A1 (de) 2020-07-31 2023-06-21 Chugai Seiyaku Kabushiki Kaisha Pharmazeutische zusammensetzung mit einer zelle zur expression eines chimären rezeptors

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US4965198A (en) * 1985-12-24 1990-10-23 Konica Corporation Monoclonal antibody and method of manufacturing hybridoma producing the same
JPH0787798B2 (ja) * 1987-04-27 1995-09-27 コニカ株式会社 モノクロ−ナル抗体の製造方法
JPH0722518B2 (ja) * 1987-06-04 1995-03-15 コニカ株式会社 モノクローナル抗体
JPH0776600B2 (ja) 1991-01-28 1995-08-16 未来工業株式会社 流体管の二重配管における消音構造及びそれに使用する介在材
US5976835A (en) * 1992-03-19 1999-11-02 The Rockefeller University Nucleic acids encoding receptor recognition factor Stat1α and Stat1β, and methods of use thereof
US5648267A (en) 1992-11-13 1997-07-15 Idec Pharmaceuticals Corporation Impaired dominant selectable marker sequence and intronic insertion strategies for enhancement of expression of gene product and expression vector systems comprising same
US5756361A (en) * 1992-12-17 1998-05-26 Metra Biosystems, Inc. Screening method for periodontal disease
US5641488A (en) * 1993-04-01 1997-06-24 National Jewish Center For Immunology And Respiratory Medicine Method for producing an antibody to a chosen antigen
JPH0776600A (ja) * 1993-07-14 1995-03-20 Kao Corp モノクローナル抗体及びこれを産生するハイブリドーマ
CA2194907A1 (en) 1994-07-13 1996-02-01 Kouji Matsushima Reshaped human antibody against human interleukin-8
CA2215905A1 (en) * 1995-03-20 1996-09-26 Sumitomo Electric Industries, Ltd. Monoclonal antibody reacting specifically with fas ligand and process for producing the same
KR100847441B1 (ko) 1996-09-26 2008-07-21 츄가이 세이야꾸 가부시키가이샤 인간의 부갑상선 호르몬 관련 펩티드에 대한 항체
WO1999037764A2 (en) * 1998-01-27 1999-07-29 Vlaams Interuniversitair Instituut Voor Biotechnologie New members of the glypican gene family
RU2319969C2 (ru) * 2002-05-23 2008-03-20 Саннибрук Энд Вуменз Колледж Хелс Сайнсиз Сентре Способ диагностики гепатоцеллюлярной карциномы

Also Published As

Publication number Publication date
AU2002328429A1 (en) 2004-03-29
WO2004022754A1 (ja) 2004-03-18
US20060246550A1 (en) 2006-11-02
EP2075257B1 (de) 2012-08-08
EP1849867A1 (de) 2007-10-31
EP1541686B1 (de) 2009-04-29
EP1541686A4 (de) 2005-12-21
JPWO2004022754A1 (ja) 2005-12-22
EP1541686A1 (de) 2005-06-15
WO2004022595A1 (ja) 2004-03-18
ATE430198T1 (de) 2009-05-15
EP2075257A1 (de) 2009-07-01
JP4571496B2 (ja) 2010-10-27
AU2003261942A1 (en) 2004-03-29

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