ATE430198T1 - Antikörperkonstruktion unter verwendung einer mrl/lpr-maus - Google Patents

Antikörperkonstruktion unter verwendung einer mrl/lpr-maus

Info

Publication number
ATE430198T1
ATE430198T1 AT03794237T AT03794237T ATE430198T1 AT E430198 T1 ATE430198 T1 AT E430198T1 AT 03794237 T AT03794237 T AT 03794237T AT 03794237 T AT03794237 T AT 03794237T AT E430198 T1 ATE430198 T1 AT E430198T1
Authority
AT
Austria
Prior art keywords
mrl
lpr mouse
antibodies construction
producing
relates
Prior art date
Application number
AT03794237T
Other languages
English (en)
Inventor
Iwao Ohizumi
Mikiyoshi Saito
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ATE430198T1 publication Critical patent/ATE430198T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT03794237T 2002-09-04 2003-09-04 Antikörperkonstruktion unter verwendung einer mrl/lpr-maus ATE430198T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/JP2002/008998 WO2004022595A1 (ja) 2002-09-04 2002-09-04 MRL/lprマウスを用いた抗体の作製
PCT/JP2003/011319 WO2004022754A1 (ja) 2002-09-04 2003-09-04 MRL/lprマウスを用いた抗体の作製

Publications (1)

Publication Number Publication Date
ATE430198T1 true ATE430198T1 (de) 2009-05-15

Family

ID=31972305

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03794237T ATE430198T1 (de) 2002-09-04 2003-09-04 Antikörperkonstruktion unter verwendung einer mrl/lpr-maus

Country Status (7)

Country Link
US (1) US20060246550A1 (de)
EP (3) EP1849867A1 (de)
JP (1) JP4571496B2 (de)
AT (1) ATE430198T1 (de)
AU (2) AU2002328429A1 (de)
DE (1) DE60327442D1 (de)
WO (2) WO2004022595A1 (de)

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EP2898897A3 (de) * 2004-07-09 2015-10-14 Chugai Seiyaku Kabushiki Kaisha Anti-Glypican-3-Antikörper
CN102698267B (zh) 2004-08-24 2017-07-21 中外制药株式会社 使用抗磷脂酰肌醇蛋白聚糖‑3抗体的辅助疗法
BRPI0518279A2 (pt) 2004-10-26 2008-11-11 Chugai Pharmaceutical Co Ltd anticorpo antiglipicam 3 tendo cadeia de aÇécar modificada
US20070087005A1 (en) 2005-10-14 2007-04-19 Lazar Gregory A Anti-glypican-3 antibody
JP2008110943A (ja) * 2006-10-31 2008-05-15 Niigata Univ モノクローナル抗体の作成方法
RS54624B1 (en) 2007-07-17 2016-08-31 E. R. Squibb & Sons, L.L.C. MONOCLONIC ANTIBODIES AGAINST GLIPICAN-3
EP2647706B1 (de) 2010-11-30 2023-05-17 Chugai Seiyaku Kabushiki Kaisha Antigenbindende moleküle zur wiederholten bindung an mehrere antigenmoleküle
TWI638833B (zh) 2010-11-30 2018-10-21 中外製藥股份有限公司 細胞傷害誘導治療劑
EP2698431B1 (de) 2011-03-30 2020-09-09 Chugai Seiyaku Kabushiki Kaisha Aufrechterhaltung antigenbindender moleküle im blutplasma und verfahren zur modifizierung einer immunogenität
CN110655578A (zh) 2011-09-30 2020-01-07 中外制药株式会社 诱导针对靶抗原的免疫应答的抗原结合分子
US20140335089A1 (en) 2011-09-30 2014-11-13 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule for promoting elimination of antigens
EP2765192A4 (de) 2011-10-05 2015-04-15 Chugai Pharmaceutical Co Ltd Antigenbindendes molekül zur herstellung eines abstands zwischen einem plasma und einem antigen mit einer saccharidkettenrezeptor-bindenden domäne
CN107266564A (zh) 2012-02-24 2017-10-20 中外制药株式会社 经由FcγIIB促进抗原消除的抗原结合分子
CA2874721A1 (en) 2012-05-30 2013-12-05 Tomoyuki Igawa Target tissue-specific antigen-binding molecule
TWI693073B (zh) 2012-12-21 2020-05-11 日商中外製藥股份有限公司 對ｇｐｃ３標的治療劑療法為有效之患者投與的ｇｐｃ３標的治療劑
WO2014144170A1 (en) * 2013-03-15 2014-09-18 The Cleveland Clinic Foundation In-vitro method for monoclonal antibody production using non-human act1 -deficient mice
KR20220142539A (ko) 2013-12-04 2022-10-21 추가이 세이야쿠 가부시키가이샤 화합물의 농도에 따라 항원 결합능이 변화되는 항원 결합 분자 및 그의 라이브러리
EP3141603A4 (de) 2014-05-08 2017-12-27 Chugai Seiyaku Kabushiki Kaisha Gpc3-anzielendes therapeutikum für die verabreichung an einen mittels einer therapie mit dem gpc3-anzielenden therapeutikum behandelten patienten
MA40764A (fr) 2014-09-26 2017-08-01 Chugai Pharmaceutical Co Ltd Agent thérapeutique induisant une cytotoxicité
WO2017002934A1 (ja) 2015-07-01 2017-01-05 中外製薬株式会社 Ｇｐｃ３標的治療剤が有効である患者に投与されるｇｐｃ３標的治療剤
RU2746754C2 (ru) 2016-03-14 2021-04-20 Чугаи Сейяку Кабусики Кайся Индуцирующее повреждение клеток терапевтическое лекарственное средство, предназначенное для противораковой терапии
KR102533814B1 (ko) 2016-11-28 2023-05-19 추가이 세이야쿠 가부시키가이샤 리간드 결합 활성을 조정 가능한 리간드 결합 분자
US20210206845A1 (en) 2017-11-28 2021-07-08 Chugai Seiyaku Kabushiki Kaisha Ligand-binding molecule having adjustable ligand-binding activity
EP3816182A4 (de) 2018-05-30 2022-07-13 Chugai Seiyaku Kabushiki Kaisha Ligandbindungsmolekül mit einzeldomänen-antikörper
CN113613676A (zh) 2019-03-19 2021-11-05 中外制药株式会社 包含对抗原的结合活性因mta而变化的抗原结合结构域的抗原结合分子及用于获得该抗原结合结构域的文库
US20220315909A1 (en) 2019-06-05 2022-10-06 Chugai Seiyaku Kabushiki Kaisha Protease substrate, and polypeptide including protease cleavage sequence
MX2021014433A (es) 2019-06-05 2022-03-11 Chugai Pharmaceutical Co Ltd Molecula de union a sitio de escision de anticuerpo.
WO2021100715A1 (ja) * 2019-11-18 2021-05-27 住友化学株式会社 抗体の作製方法
KR20230048059A (ko) 2020-07-31 2023-04-10 추가이 세이야쿠 가부시키가이샤 키메라 수용체를 발현하는 세포를 포함하는 의약 조성물

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US5648267A (en) 1992-11-13 1997-07-15 Idec Pharmaceuticals Corporation Impaired dominant selectable marker sequence and intronic insertion strategies for enhancement of expression of gene product and expression vector systems comprising same
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US5641488A (en) * 1993-04-01 1997-06-24 National Jewish Center For Immunology And Respiratory Medicine Method for producing an antibody to a chosen antigen
JPH0776600A (ja) * 1993-07-14 1995-03-20 Kao Corp モノクローナル抗体及びこれを産生するハイブリドーマ
WO1996002576A1 (fr) 1994-07-13 1996-02-01 Chugai Seiyaku Kabushiki Kaisha Anticorps humain reconstitue contre l'interleukine-8 humaine
AU716731B2 (en) * 1995-03-20 2000-03-02 Ko Okumura Monoclonal antibody reacting specifically with Fas ligand and process for producing the same
RU2198220C2 (ru) 1996-09-26 2003-02-10 Чугаи Сейяку Кабусики Кайся Антитело против белка, родственного паращитовидному гормону человека, днк, вектор, способ получения и использование антитела
AU2422999A (en) * 1998-01-27 1999-08-09 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw New members of the glypican gene family
DE60326567D1 (de) * 2002-05-23 2009-04-23 Sunnybrook & Womens College Diagnose von hepatozellulärem karzinom

Also Published As

Publication number Publication date
DE60327442D1 (de) 2009-06-10
JPWO2004022754A1 (ja) 2005-12-22
EP1541686A1 (de) 2005-06-15
WO2004022595A1 (ja) 2004-03-18
EP1541686A4 (de) 2005-12-21
US20060246550A1 (en) 2006-11-02
EP1849867A1 (de) 2007-10-31
EP2075257B1 (de) 2012-08-08
EP2075257A1 (de) 2009-07-01
AU2003261942A1 (en) 2004-03-29
AU2002328429A1 (en) 2004-03-29
WO2004022754A1 (ja) 2004-03-18
JP4571496B2 (ja) 2010-10-27
EP1541686B1 (de) 2009-04-29

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