EA200000746A1 - ТРЕХМЕРНЫЕ СТРУКТУРЫ И МОДЕЛИ Fc РЕЦЕПТОРОВ И ИХ ПРИМЕНЕНИЕ - Google Patents
ТРЕХМЕРНЫЕ СТРУКТУРЫ И МОДЕЛИ Fc РЕЦЕПТОРОВ И ИХ ПРИМЕНЕНИЕInfo
- Publication number
- EA200000746A1 EA200000746A1 EA200000746A EA200000746A EA200000746A1 EA 200000746 A1 EA200000746 A1 EA 200000746A1 EA 200000746 A EA200000746 A EA 200000746A EA 200000746 A EA200000746 A EA 200000746A EA 200000746 A1 EA200000746 A1 EA 200000746A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- models
- protein
- crystals
- disclosed
- fcγriia
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
- Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation
Abstract
Раскрыты кристаллы, кристаллическая структура белка FcγRIIa, трехмерные координаты белка FcγRIIa и структуры и модели, полученные из структуры FcγRIIa. Также раскрыты кристаллы белка FcεRI и трехмерные координаты мономеров и димеров белка FcεRI, полученных из структуры FcεRI. Также раскрыты трехмерные координаты белков FcγRIIIb и моделей белка FcγRIIIb, полученных из структуры белка FcγRIIa. Данное изобретение также включает способы получения таких кристаллов, кристаллических структур и моделей. Также раскрыто применение таких кристаллов, кристаллических структур и моделей, включая конструирование лекарств и терапевтических составов на основе знания структуры.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7397298P | 1998-02-06 | 1998-02-06 | |
US9999498P | 1998-09-11 | 1998-09-11 | |
PCT/IB1999/000367 WO1999040117A1 (en) | 1998-02-06 | 1999-02-04 | THREE-DIMENSIONAL STRUCTURES AND MODELS OF Fc RECEPTORS AND USES THEREOF |
Publications (1)
Publication Number | Publication Date |
---|---|
EA200000746A1 true EA200000746A1 (ru) | 2001-04-23 |
Family
ID=26755120
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200000746A EA200000746A1 (ru) | 1998-02-06 | 1999-02-04 | ТРЕХМЕРНЫЕ СТРУКТУРЫ И МОДЕЛИ Fc РЕЦЕПТОРОВ И ИХ ПРИМЕНЕНИЕ |
Country Status (16)
Country | Link |
---|---|
US (2) | US6675105B2 (ru) |
EP (1) | EP1053255A4 (ru) |
JP (1) | JP2004510681A (ru) |
KR (1) | KR20010024899A (ru) |
CN (1) | CN1291198A (ru) |
AP (1) | AP2000001876A0 (ru) |
AU (1) | AU759378B2 (ru) |
BR (1) | BR9907964A (ru) |
CA (1) | CA2316860A1 (ru) |
EA (1) | EA200000746A1 (ru) |
IL (1) | IL137583A0 (ru) |
NO (1) | NO20003964L (ru) |
NZ (1) | NZ505914A (ru) |
PL (1) | PL342297A1 (ru) |
TR (1) | TR200002271T2 (ru) |
WO (1) | WO1999040117A1 (ru) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
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US7553809B2 (en) | 1998-02-06 | 2009-06-30 | Ilexus Pty Limited | Fc receptor modulators and uses thereof |
CN1189166C (zh) | 1998-09-11 | 2005-02-16 | 伊来克萨斯独资有限公司 | Fc受体调节剂及其应用 |
JP2002533060A (ja) * | 1998-11-05 | 2002-10-08 | ヘスカ コーポレイション | 結晶化型のFcイプシロンレセプタアルファ鎖、その3−Dモデル、及びそれらの利用法 |
EP1006183A1 (en) * | 1998-12-03 | 2000-06-07 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Recombinant soluble Fc receptors |
US7912689B1 (en) | 1999-02-11 | 2011-03-22 | Cambridgesoft Corporation | Enhancing structure diagram generation through use of symmetry |
US7295931B1 (en) * | 1999-02-18 | 2007-11-13 | Cambridgesoft Corporation | Deriving fixed bond information |
US6850876B1 (en) * | 1999-05-04 | 2005-02-01 | Smithkline Beecham Corporation | Cell based binning methods and cell coverage system for molecule selection |
US6889145B1 (en) | 2000-03-15 | 2005-05-03 | Northwestern University | Three-dimensional model of a Fc region of an IgE antibody and uses thereof |
US7356419B1 (en) | 2000-05-05 | 2008-04-08 | Cambridgesoft Corporation | Deriving product information |
US7272509B1 (en) * | 2000-05-05 | 2007-09-18 | Cambridgesoft Corporation | Managing product information |
GB0029871D0 (en) * | 2000-07-14 | 2001-01-24 | Medical Res Council | Crystal structure (V) |
IL144082A0 (en) * | 2000-07-14 | 2002-05-23 | Medical Res Council | Crystal structure of antibiotics bound to the 30s ribosome and its use |
EP1201681A1 (en) | 2000-10-30 | 2002-05-02 | Millennium Pharmaceuticals, Inc. | "Fail" molecules and uses thereof |
CN1245215C (zh) | 2001-02-28 | 2006-03-15 | 四川省生物工程研究中心 | 重组高效复合干扰素用作乙型肝炎表面抗原和e抗原抑制剂 |
US7803982B2 (en) | 2001-04-20 | 2010-09-28 | The Mount Sinai School Of Medicine Of New York University | T1R3 transgenic animals, cells and related methods |
MXPA03009580A (es) * | 2001-04-20 | 2004-12-06 | Sinai School Medicine | Tir3, un receptor de sabor novedoso. |
EP2335728A1 (en) * | 2001-05-11 | 2011-06-22 | Ludwig Institute for Cancer Research Ltd. | Specific binding proteins and uses thereof |
US20100056762A1 (en) | 2001-05-11 | 2010-03-04 | Old Lloyd J | Specific binding proteins and uses thereof |
DE10157290A1 (de) * | 2001-11-22 | 2003-06-05 | Max Planck Gesellschaft | Pharmazeutische Zusammensetzung enthaltend sFcRgamma IIb oder sFcRgamma III |
CA2480202A1 (en) * | 2002-04-10 | 2003-10-23 | Transtech Pharma, Inc. | System and method for data analysis, manipulation, and visualization |
AU2002953533A0 (en) | 2002-12-24 | 2003-01-16 | Arthron Limited | Fc receptor modulating compounds and compositions |
EP2272533A1 (en) | 2003-01-13 | 2011-01-12 | MacroGenics, Inc. | Soluble FcyR fusion proteins and methods of use thereof |
AU2004241060B2 (en) * | 2003-05-26 | 2009-07-23 | Biotie Therapies Corp. | Crystalline VAP-1 and uses thereof |
US7585647B2 (en) | 2003-08-28 | 2009-09-08 | Guangwen Wei | Nucleic acid encoding recombinant interferon |
JP2008512083A (ja) * | 2004-02-10 | 2008-04-24 | ジ・オースティン・リサーチ・インスティテュート | Fc受容体の結晶構造およびモデルならびにFc受容体モジュレーター化合物の設計および同定におけるそれらの使用 |
WO2006133486A1 (en) * | 2005-06-14 | 2006-12-21 | The Macfarlane Burnet Institute For Medical Research And Public Health Limited | CRYSTAL STRUCTURES AND MODELS FOR Fc RECEPTOR:Fc COMPLEXES AND USES THEREOF |
WO2008103474A1 (en) | 2007-02-20 | 2008-08-28 | Anaptysbio, Inc. | Methods of generating libraries and uses thereof |
CA2798294C (en) * | 2010-05-03 | 2019-05-28 | Cambridgesoft Corporation | Method and apparatus for processing documents to identify chemical structures |
RU2641256C2 (ru) | 2011-06-30 | 2018-01-16 | Чугаи Сейяку Кабусики Кайся | Гетеродимеризованный полипептид |
US9977876B2 (en) | 2012-02-24 | 2018-05-22 | Perkinelmer Informatics, Inc. | Systems, methods, and apparatus for drawing chemical structures using touch and gestures |
JP6628966B2 (ja) | 2012-06-14 | 2020-01-15 | 中外製薬株式会社 | 改変されたFc領域を含む抗原結合分子 |
RU2729831C2 (ru) | 2012-08-24 | 2020-08-12 | Чугаи Сейяку Кабусики Кайся | ВАРИАНТЫ FcγRIIB-СПЕЦИФИЧЕСКОЙ Fc-ОБЛАСТИ |
US9535583B2 (en) | 2012-12-13 | 2017-01-03 | Perkinelmer Informatics, Inc. | Draw-ahead feature for chemical structure drawing applications |
US10766960B2 (en) | 2012-12-27 | 2020-09-08 | Chugai Seiyaku Kabushiki Kaisha | Heterodimerized polypeptide |
WO2014163749A1 (en) | 2013-03-13 | 2014-10-09 | Cambridgesoft Corporation | Systems and methods for gesture-based sharing of data between separate electronic devices |
US8854361B1 (en) | 2013-03-13 | 2014-10-07 | Cambridgesoft Corporation | Visually augmenting a graphical rendering of a chemical structure representation or biological sequence representation with multi-dimensional information |
EP3783017A1 (en) | 2013-04-02 | 2021-02-24 | Chugai Seiyaku Kabushiki Kaisha | Fc region variant |
US9430127B2 (en) | 2013-05-08 | 2016-08-30 | Cambridgesoft Corporation | Systems and methods for providing feedback cues for touch screen interface interaction with chemical and biological structure drawing applications |
US9751294B2 (en) | 2013-05-09 | 2017-09-05 | Perkinelmer Informatics, Inc. | Systems and methods for translating three dimensional graphic molecular models to computer aided design format |
CA3041717A1 (en) | 2016-11-09 | 2018-05-17 | North Carolina State University | Treatment of allergic diseases with chimeric protein |
CA3055172C (en) | 2017-03-03 | 2022-03-01 | Perkinelmer Informatics, Inc. | Systems and methods for searching and indexing documents comprising chemical information |
KR101986250B1 (ko) * | 2017-09-15 | 2019-06-05 | 국민대학교 산학협력단 | Fc 감마 수용체 변이체 SH2A40 |
KR101987279B1 (ko) * | 2017-10-12 | 2019-06-10 | 국민대학교 산학협력단 | Fc 감마 수용체 변이체 MG2A45.1 |
KR101987268B1 (ko) * | 2017-10-12 | 2019-06-10 | 국민대학교 산학협력단 | Fc 감마 수용체 변이체 MG2A45 |
KR101987272B1 (ko) * | 2017-09-15 | 2019-06-10 | 국민대학교 산학협력단 | Fc 감마 수용체 변이체 MG2A28.1 |
KR101987292B1 (ko) * | 2017-10-12 | 2019-06-10 | 국민대학교 산학협력단 | Fc 감마 수용체 변이체 MG2B45.1 |
KR101986252B1 (ko) * | 2017-09-15 | 2019-06-05 | 국민대학교 산학협력단 | Fc 감마 수용체 변이체 MG2A28 |
BR112020000098A2 (pt) * | 2017-09-15 | 2020-07-14 | Kookmin University Industry Academy Cooperation Foundation | mutantes de receptor fc-gama |
WO2019183437A1 (en) * | 2018-03-23 | 2019-09-26 | North Carolina State University | Methods and compositions for antibody to high affinity receptor for ige |
CN115035947B (zh) * | 2022-06-10 | 2023-03-10 | 水木未来(北京)科技有限公司 | 蛋白质结构建模方法及装置、电子设备和存储介质 |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5858981A (en) * | 1993-09-30 | 1999-01-12 | University Of Pennsylvania | Method of inhibiting phagocytosis |
CN1189166C (zh) * | 1998-09-11 | 2005-02-16 | 伊来克萨斯独资有限公司 | Fc受体调节剂及其应用 |
AU2001278771A1 (en) * | 2000-08-22 | 2002-03-04 | Ono Pharmaceutical Co. Ltd. | Carboxylic acid derivatives, process for producing the same and drugs containingthe same as the active ingredient |
-
1999
- 1999-02-04 CN CN99802768A patent/CN1291198A/zh active Pending
- 1999-02-04 BR BR9907964-0A patent/BR9907964A/pt not_active IP Right Cessation
- 1999-02-04 TR TR2000/02271T patent/TR200002271T2/xx unknown
- 1999-02-04 PL PL99342297A patent/PL342297A1/xx not_active Application Discontinuation
- 1999-02-04 NZ NZ505914A patent/NZ505914A/xx unknown
- 1999-02-04 AU AU24382/99A patent/AU759378B2/en not_active Ceased
- 1999-02-04 IL IL13758399A patent/IL137583A0/xx unknown
- 1999-02-04 EP EP99903878A patent/EP1053255A4/en not_active Withdrawn
- 1999-02-04 CA CA002316860A patent/CA2316860A1/en not_active Abandoned
- 1999-02-04 JP JP2000530545A patent/JP2004510681A/ja active Pending
- 1999-02-04 WO PCT/IB1999/000367 patent/WO1999040117A1/en not_active Application Discontinuation
- 1999-02-04 AP APAP/P/2000/001876A patent/AP2000001876A0/en unknown
- 1999-02-04 EA EA200000746A patent/EA200000746A1/ru unknown
- 1999-02-04 KR KR1020007008582A patent/KR20010024899A/ko not_active Application Discontinuation
- 1999-02-05 US US09/245,764 patent/US6675105B2/en not_active Expired - Fee Related
-
2000
- 2000-08-04 NO NO20003964A patent/NO20003964L/no not_active Application Discontinuation
-
2003
- 2003-10-15 US US10/687,109 patent/US20040054480A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1053255A4 (en) | 2003-01-02 |
US20040054480A1 (en) | 2004-03-18 |
TR200002271T2 (tr) | 2000-11-21 |
US6675105B2 (en) | 2004-01-06 |
EP1053255A1 (en) | 2000-11-22 |
PL342297A1 (en) | 2001-06-04 |
BR9907964A (pt) | 2000-10-17 |
NO20003964D0 (no) | 2000-08-04 |
KR20010024899A (ko) | 2001-03-26 |
AU2438299A (en) | 1999-08-23 |
CN1291198A (zh) | 2001-04-11 |
CA2316860A1 (en) | 1999-08-12 |
US20020107359A1 (en) | 2002-08-08 |
WO1999040117A1 (en) | 1999-08-12 |
AP2000001876A0 (en) | 2000-09-30 |
NO20003964L (no) | 2000-10-04 |
NZ505914A (en) | 2004-03-26 |
IL137583A0 (en) | 2001-07-24 |
AU759378B2 (en) | 2003-04-10 |
JP2004510681A (ja) | 2004-04-08 |
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