EA200000746A1 - ТРЕХМЕРНЫЕ СТРУКТУРЫ И МОДЕЛИ Fc РЕЦЕПТОРОВ И ИХ ПРИМЕНЕНИЕ - Google Patents

ТРЕХМЕРНЫЕ СТРУКТУРЫ И МОДЕЛИ Fc РЕЦЕПТОРОВ И ИХ ПРИМЕНЕНИЕ

Info

Publication number
EA200000746A1
EA200000746A1 EA200000746A EA200000746A EA200000746A1 EA 200000746 A1 EA200000746 A1 EA 200000746A1 EA 200000746 A EA200000746 A EA 200000746A EA 200000746 A EA200000746 A EA 200000746A EA 200000746 A1 EA200000746 A1 EA 200000746A1
Authority
EA
Eurasian Patent Office
Prior art keywords
models
protein
crystals
disclosed
fcγriia
Prior art date
Application number
EA200000746A
Other languages
English (en)
Inventor
Марк П. Хогарт
Мари С. Пауэлл
Ян Ф.С. Маккензи
Келли Ф. Максвелл
Томас П.Дж. Гаррет
Видана Эпа
Джонатан Б. Баэлл
Барри Р. Мэттьюс
Томас Д. Маккарти
Жоффрей А. Петерш
Original Assignee
Айлексус Пти. Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Айлексус Пти. Лимитед filed Critical Айлексус Пти. Лимитед
Publication of EA200000746A1 publication Critical patent/EA200000746A1/ru

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • C07K14/70535Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2299/00Coordinates from 3D structures of peptides, e.g. proteins or enzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00Uses of viruses
    • C12N2799/02Uses of viruses as vector
    • C12N2799/021Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Abstract

Раскрыты кристаллы, кристаллическая структура белка FcγRIIa, трехмерные координаты белка FcγRIIa и структуры и модели, полученные из структуры FcγRIIa. Также раскрыты кристаллы белка FcεRI и трехмерные координаты мономеров и димеров белка FcεRI, полученных из структуры FcεRI. Также раскрыты трехмерные координаты белков FcγRIIIb и моделей белка FcγRIIIb, полученных из структуры белка FcγRIIa. Данное изобретение также включает способы получения таких кристаллов, кристаллических структур и моделей. Также раскрыто применение таких кристаллов, кристаллических структур и моделей, включая конструирование лекарств и терапевтических составов на основе знания структуры.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200000746A 1998-02-06 1999-02-04 ТРЕХМЕРНЫЕ СТРУКТУРЫ И МОДЕЛИ Fc РЕЦЕПТОРОВ И ИХ ПРИМЕНЕНИЕ EA200000746A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7397298P 1998-02-06 1998-02-06
US9999498P 1998-09-11 1998-09-11
PCT/IB1999/000367 WO1999040117A1 (en) 1998-02-06 1999-02-04 THREE-DIMENSIONAL STRUCTURES AND MODELS OF Fc RECEPTORS AND USES THEREOF

Publications (1)

Publication Number Publication Date
EA200000746A1 true EA200000746A1 (ru) 2001-04-23

Family

ID=26755120

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200000746A EA200000746A1 (ru) 1998-02-06 1999-02-04 ТРЕХМЕРНЫЕ СТРУКТУРЫ И МОДЕЛИ Fc РЕЦЕПТОРОВ И ИХ ПРИМЕНЕНИЕ

Country Status (16)

Country Link
US (2) US6675105B2 (ru)
EP (1) EP1053255A4 (ru)
JP (1) JP2004510681A (ru)
KR (1) KR20010024899A (ru)
CN (1) CN1291198A (ru)
AP (1) AP2000001876A0 (ru)
AU (1) AU759378B2 (ru)
BR (1) BR9907964A (ru)
CA (1) CA2316860A1 (ru)
EA (1) EA200000746A1 (ru)
IL (1) IL137583A0 (ru)
NO (1) NO20003964L (ru)
NZ (1) NZ505914A (ru)
PL (1) PL342297A1 (ru)
TR (1) TR200002271T2 (ru)
WO (1) WO1999040117A1 (ru)

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Also Published As

Publication number Publication date
EP1053255A4 (en) 2003-01-02
US20040054480A1 (en) 2004-03-18
TR200002271T2 (tr) 2000-11-21
US6675105B2 (en) 2004-01-06
EP1053255A1 (en) 2000-11-22
PL342297A1 (en) 2001-06-04
BR9907964A (pt) 2000-10-17
NO20003964D0 (no) 2000-08-04
KR20010024899A (ko) 2001-03-26
AU2438299A (en) 1999-08-23
CN1291198A (zh) 2001-04-11
CA2316860A1 (en) 1999-08-12
US20020107359A1 (en) 2002-08-08
WO1999040117A1 (en) 1999-08-12
AP2000001876A0 (en) 2000-09-30
NO20003964L (no) 2000-10-04
NZ505914A (en) 2004-03-26
IL137583A0 (en) 2001-07-24
AU759378B2 (en) 2003-04-10
JP2004510681A (ja) 2004-04-08

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