DE60326833D1 - Vitamin-mitomycin-konjugate - Google Patents
Vitamin-mitomycin-konjugateInfo
- Publication number
- DE60326833D1 DE60326833D1 DE60326833T DE60326833T DE60326833D1 DE 60326833 D1 DE60326833 D1 DE 60326833D1 DE 60326833 T DE60326833 T DE 60326833T DE 60326833 T DE60326833 T DE 60326833T DE 60326833 D1 DE60326833 D1 DE 60326833D1
- Authority
- DE
- Germany
- Prior art keywords
- conjugates
- group
- folate
- mitomycin
- pathogenic cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
- C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug
- A61K47/551—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug one of the codrug's components being a vitamin, e.g. niacinamide, vitamin B3, cobalamin, vitamin B12, folate, vitamin A or retinoic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38057902P | 2002-05-15 | 2002-05-15 | |
| US42591802P | 2002-11-13 | 2002-11-13 | |
| PCT/US2003/014969 WO2003097647A1 (en) | 2002-05-15 | 2003-05-13 | Vitamin-mitomycin conjugates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60326833D1 true DE60326833D1 (de) | 2009-05-07 |
Family
ID=29553501
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60326833T Expired - Lifetime DE60326833D1 (de) | 2002-05-15 | 2003-05-13 | Vitamin-mitomycin-konjugate |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7910594B2 (https=) |
| EP (2) | EP1504010B1 (https=) |
| JP (1) | JP4814520B2 (https=) |
| KR (1) | KR20040106547A (https=) |
| AT (1) | ATE426414T1 (https=) |
| AU (1) | AU2003243226A1 (https=) |
| CA (1) | CA2484640C (https=) |
| DE (1) | DE60326833D1 (https=) |
| ES (1) | ES2324708T3 (https=) |
| WO (1) | WO2003097647A1 (https=) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE427948T1 (de) | 2001-04-24 | 2009-04-15 | Purdue Research Foundation | Folat-mimetika und deren folatrezeptorbindende konjugate |
| CA2484640C (en) | 2002-05-15 | 2012-01-17 | Endocyte, Inc. | Vitamin-mitomycin conjugates |
| CN101239190B (zh) * | 2003-01-27 | 2013-09-25 | 恩多塞特公司 | 维生素受体结合递药缀合物 |
| WO2004069159A2 (en) * | 2003-01-27 | 2004-08-19 | Endocyte, Inc. | Vitamin receptor binding drug delivery conjugates |
| CN101098854B (zh) * | 2004-07-23 | 2012-12-05 | 恩多塞特公司 | 二价连接体及其轭合物 |
| HUE056941T2 (hu) | 2004-12-22 | 2022-04-28 | Nitto Denko Corp | Gyógyszerhordozó és gyógyszerhordozó kit fibrózis gátlására |
| JP2009221164A (ja) | 2008-03-17 | 2009-10-01 | Nitto Denko Corp | 肺線維症処置剤 |
| US20120269886A1 (en) | 2004-12-22 | 2012-10-25 | Nitto Denko Corporation | Therapeutic agent for pulmonary fibrosis |
| CN101175757B (zh) * | 2005-03-16 | 2012-11-14 | 恩多塞特公司 | 蝶酸及其缀合物的合成和纯化 |
| ATE460668T1 (de) | 2005-03-30 | 2010-03-15 | Purdue Research Foundation | Verfahren zur prognose von brustkrebs mittels quantifizierung von zellulären folat vitamin rezeptoren |
| BRPI0615354A2 (pt) * | 2005-08-19 | 2011-05-17 | Endocyte, Inc. | conjugado de liberação de fármaco de ligação de receptor, composição farmacêutica que o compreende, bem como seu uso |
| EP2382995A3 (en) * | 2005-08-19 | 2013-09-25 | Endocyte, Inc. | Ligand conjugates of Vinca alkaloids, analogs and derivatives |
| US9572886B2 (en) | 2005-12-22 | 2017-02-21 | Nitto Denko Corporation | Agent for treating myelofibrosis |
| EP1832575A1 (en) * | 2006-03-06 | 2007-09-12 | Sulfidris S.r.l. | Anti-inflammatory agents |
| US20100104626A1 (en) * | 2007-02-16 | 2010-04-29 | Endocyte, Inc. | Methods and compositions for treating and diagnosing kidney disease |
| AU2008224988A1 (en) | 2007-03-14 | 2008-09-18 | Endocyte, Inc. | Binding ligand linked drug delivery conjugates of tubulysins |
| TWI407971B (zh) | 2007-03-30 | 2013-09-11 | 日東電工股份有限公司 | Cancer cells and tumor-related fibroblasts |
| US9877965B2 (en) | 2007-06-25 | 2018-01-30 | Endocyte, Inc. | Vitamin receptor drug delivery conjugates for treating inflammation |
| CN101784565B (zh) | 2007-06-25 | 2014-12-10 | 恩多塞特公司 | 含有亲水性间隔区接头的共轭物 |
| PL2187965T3 (pl) | 2007-08-17 | 2020-05-18 | Purdue Research Foundation | Koniugaty wiążący psma ligand-łącznik i sposoby ich zastosowania |
| CN101970012A (zh) | 2007-09-14 | 2011-02-09 | 日东电工株式会社 | 药物载体 |
| CN101909441B (zh) | 2007-10-25 | 2015-05-13 | 恩多塞特公司 | 微管蛋白抑制剂及其制备方法 |
| US9951324B2 (en) | 2010-02-25 | 2018-04-24 | Purdue Research Foundation | PSMA binding ligand-linker conjugates and methods for using |
| JP5950428B2 (ja) | 2010-08-05 | 2016-07-13 | 日東電工株式会社 | 線維化組織から正常組織を再生するための組成物 |
| KR20130140032A (ko) * | 2010-11-12 | 2013-12-23 | 엔도사이트, 인코포레이티드 | 암을 치료하는 방법들 |
| US10080805B2 (en) | 2012-02-24 | 2018-09-25 | Purdue Research Foundation | Cholecystokinin B receptor targeting for imaging and therapy |
| WO2013130776A1 (en) | 2012-02-29 | 2013-09-06 | Purdue Research Foundation | Folate receptor alpha binding ligands |
| US20140080175A1 (en) | 2012-03-29 | 2014-03-20 | Endocyte, Inc. | Processes for preparing tubulysin derivatives and conjugates thereof |
| BR112015008365A2 (pt) | 2012-10-16 | 2017-07-04 | Endocyte Inc | composto da fórmula b-l(d)x, ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, uso de um composto, composição de forma de dosagem unitária ou dose unitária, composição para tratar um câncer em um paciente, e método para tratar um câncer em um paciente |
| EA201590783A1 (ru) | 2012-11-15 | 2015-11-30 | Эндосайт, Инк. | Конъюгаты для доставки лекарственных средств и способы лечения заболеваний, вызванных клетками, экспрессирующими psma |
| CA2891280C (en) | 2012-11-24 | 2018-03-20 | Hangzhou Dac Biotech Co., Ltd. | Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules |
| JP6340162B2 (ja) | 2012-12-20 | 2018-06-06 | 日東電工株式会社 | アポトーシス誘導剤 |
| EP3456700A1 (en) | 2013-10-18 | 2019-03-20 | Deutsches Krebsforschungszentrum | Labeled inhibitors of prostate specific membrane antigen (psma), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer |
| EP3533473A3 (en) | 2013-11-14 | 2019-12-18 | Endocyte, Inc. | Compounds for positron emission tomography |
| US10464955B2 (en) | 2014-02-28 | 2019-11-05 | Hangzhou Dac Biotech Co., Ltd. | Charged linkers and their uses for conjugation |
| US9976142B2 (en) | 2014-04-02 | 2018-05-22 | Nitto Denko Corporation | Targeting molecule and a use thereof |
| AU2014390729B2 (en) | 2014-04-07 | 2018-11-29 | Nitto Denko Corporation | Novel polymer-based hydrotropes for hydrophobic drug delivery |
| US10188759B2 (en) | 2015-01-07 | 2019-01-29 | Endocyte, Inc. | Conjugates for imaging |
| WO2016149516A1 (en) * | 2015-03-17 | 2016-09-22 | Lipomedix Pharmaceuticals Ltd. | Methods for the treatment of bladder cancer |
| JP6869187B2 (ja) | 2015-04-07 | 2021-05-12 | メモリアル スローン ケタリング キャンサー センター | ナノ粒子イムノコンジュゲート |
| US10406238B2 (en) | 2015-05-11 | 2019-09-10 | Purdue Research Foundation | Ligand ionophore conjugates |
| CN112368024A (zh) | 2018-04-17 | 2021-02-12 | 恩多塞特公司 | 治疗癌症的方法 |
| CN114096264B (zh) | 2019-05-20 | 2025-03-14 | 因多塞特股份有限公司 | 制备psma缀合物的方法 |
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| WO2004069159A2 (en) * | 2003-01-27 | 2004-08-19 | Endocyte, Inc. | Vitamin receptor binding drug delivery conjugates |
| AR042938A1 (es) * | 2003-02-06 | 2005-07-06 | Wyeth Corp | Uso del cci-779 en el tratamiento de la fibrosis hepatica |
| ES2702942T3 (es) * | 2003-04-17 | 2019-03-06 | Alnylam Pharmaceuticals Inc | Agentes de ARNi modificados |
| WO2004101803A2 (en) * | 2003-05-12 | 2004-11-25 | Wyeth Holdings Corporation | Process for producing anticancer agent ll-d45042 |
| EP1646635A1 (en) * | 2003-07-16 | 2006-04-19 | Wyeth | Cci-779 isomer c |
| JP4227649B2 (ja) * | 2003-08-07 | 2009-02-18 | ワイス | Ｃｃｉ−７７９の位置選択的合成 |
| EP1791567B1 (en) * | 2004-08-10 | 2015-07-29 | Alnylam Pharmaceuticals Inc. | Chemically modified oligonucleotides |
| US7290958B2 (en) * | 2004-12-03 | 2007-11-06 | Airfield Systems, Llc | Subsurface drainage system and drain structure therefor |
| ATE460668T1 (de) | 2005-03-30 | 2010-03-15 | Purdue Research Foundation | Verfahren zur prognose von brustkrebs mittels quantifizierung von zellulären folat vitamin rezeptoren |
| EP1904183B1 (en) * | 2005-07-05 | 2014-10-15 | Purdue Research Foundation | Pharmaceutical composition for the treatment of osteoarthritis |
| AR062448A1 (es) * | 2006-05-25 | 2008-11-12 | Endocyte Inc | Conjugados de analogos de aziridinil-epotilona y composiciones farmaceuticas que comprenden los mismos |
| US20100104626A1 (en) * | 2007-02-16 | 2010-04-29 | Endocyte, Inc. | Methods and compositions for treating and diagnosing kidney disease |
-
2003
- 2003-05-13 CA CA2484640A patent/CA2484640C/en not_active Expired - Fee Related
- 2003-05-13 DE DE60326833T patent/DE60326833D1/de not_active Expired - Lifetime
- 2003-05-13 JP JP2004505379A patent/JP4814520B2/ja not_active Expired - Fee Related
- 2003-05-13 AT AT03752681T patent/ATE426414T1/de not_active IP Right Cessation
- 2003-05-13 ES ES03752681T patent/ES2324708T3/es not_active Expired - Lifetime
- 2003-05-13 US US10/513,372 patent/US7910594B2/en not_active Expired - Fee Related
- 2003-05-13 EP EP03752681A patent/EP1504010B1/en not_active Expired - Lifetime
- 2003-05-13 WO PCT/US2003/014969 patent/WO2003097647A1/en not_active Ceased
- 2003-05-13 KR KR10-2004-7018375A patent/KR20040106547A/ko not_active Ceased
- 2003-05-13 AU AU2003243226A patent/AU2003243226A1/en not_active Abandoned
- 2003-05-13 EP EP09002632A patent/EP2060272A3/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003097647A1 (en) | 2003-11-27 |
| JP4814520B2 (ja) | 2011-11-16 |
| US7910594B2 (en) | 2011-03-22 |
| ATE426414T1 (de) | 2009-04-15 |
| ES2324708T3 (es) | 2009-08-13 |
| AU2003243226A1 (en) | 2003-12-02 |
| JP2005531564A (ja) | 2005-10-20 |
| EP1504010B1 (en) | 2009-03-25 |
| EP1504010A1 (en) | 2005-02-09 |
| KR20040106547A (ko) | 2004-12-17 |
| CA2484640A1 (en) | 2003-11-27 |
| EP2060272A3 (en) | 2009-05-27 |
| CA2484640C (en) | 2012-01-17 |
| US20050165227A1 (en) | 2005-07-28 |
| EP1504010A4 (en) | 2007-03-28 |
| EP2060272A2 (en) | 2009-05-20 |
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