DE60318013T2 - N-oxid von n-phenyl-2-pyrimidinaminderivaten - Google Patents
N-oxid von n-phenyl-2-pyrimidinaminderivaten Download PDFInfo
- Publication number
- DE60318013T2 DE60318013T2 DE60318013T DE60318013T DE60318013T2 DE 60318013 T2 DE60318013 T2 DE 60318013T2 DE 60318013 T DE60318013 T DE 60318013T DE 60318013 T DE60318013 T DE 60318013T DE 60318013 T2 DE60318013 T2 DE 60318013T2
- Authority
- DE
- Germany
- Prior art keywords
- methyl
- phenyl
- pyridinyl
- piperazinyl
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P17/06—Antipsoriatics
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
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- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Transplantation (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Communicable Diseases (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Liquid Crystal Substances (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0201508 | 2002-01-23 | ||
| GBGB0201508.9A GB0201508D0 (en) | 2002-01-23 | 2002-01-23 | Organic compounds |
| PCT/EP2003/000613 WO2003062220A1 (en) | 2002-01-23 | 2003-01-22 | N-oxyde of n-phenyl-2-pyrimidine-amine derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60318013D1 DE60318013D1 (de) | 2008-01-24 |
| DE60318013T2 true DE60318013T2 (de) | 2008-11-13 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60318013T Expired - Lifetime DE60318013T2 (de) | 2002-01-23 | 2003-01-22 | N-oxid von n-phenyl-2-pyrimidinaminderivaten |
Country Status (15)
| Country | Link |
|---|---|
| US (5) | US7557105B2 (OSRAM) |
| EP (3) | EP2194049B1 (OSRAM) |
| JP (2) | JP4213595B2 (OSRAM) |
| KR (2) | KR100778163B1 (OSRAM) |
| CN (2) | CN100467461C (OSRAM) |
| AT (1) | ATE380807T1 (OSRAM) |
| BR (1) | BR0307058A (OSRAM) |
| CA (1) | CA2474104C (OSRAM) |
| DE (1) | DE60318013T2 (OSRAM) |
| ES (2) | ES2294293T3 (OSRAM) |
| GB (1) | GB0201508D0 (OSRAM) |
| IL (2) | IL162979A (OSRAM) |
| MX (1) | MXPA04007130A (OSRAM) |
| PT (2) | PT2194049E (OSRAM) |
| WO (1) | WO2003062220A1 (OSRAM) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| EP1506962B1 (en) * | 2000-10-20 | 2008-07-02 | Eisai R&D Management Co., Ltd. | Nitrogen-containing aromatic heterocycles |
| GB0201508D0 (en) * | 2002-01-23 | 2002-03-13 | Novartis Ag | Organic compounds |
| PT1635835E (pt) * | 2003-06-13 | 2010-03-17 | Novartis Ag | Derivados de 2-aminopiridina como inibidores da raf-quinase |
| US8969379B2 (en) * | 2004-09-17 | 2015-03-03 | Eisai R&D Management Co., Ltd. | Pharmaceutical compositions of 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7=methoxy-6-quinolinecarboxide |
| GB0512091D0 (en) * | 2005-06-14 | 2005-07-20 | Novartis Ag | Organic compounds |
| JP5066446B2 (ja) * | 2005-08-01 | 2012-11-07 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 血管新生阻害物質の効果を予測する方法 |
| WO2007015578A1 (ja) | 2005-08-02 | 2007-02-08 | Eisai R & D Management Co., Ltd. | 血管新生阻害物質の効果を検定する方法 |
| US20090053236A1 (en) * | 2005-11-07 | 2009-02-26 | Eisai R & D Management Co., Ltd. | USE OF COMBINATION OF ANTI-ANGIOGENIC SUBSTANCE AND c-kit KINASE INHIBITOR |
| WO2007071752A2 (en) * | 2005-12-21 | 2007-06-28 | Novartis Ag | Pyrimidinyl aryl urea derivatives being fgf inhibitors |
| CA2652442C (en) * | 2006-05-18 | 2014-12-09 | Eisai R & D Management Co., Ltd. | Antitumor agent for thyroid cancer |
| WO2008027600A2 (en) * | 2006-09-01 | 2008-03-06 | Teva Pharmaceutical Industries Ltd. | Imatinib compositions |
| MX2008008447A (es) * | 2006-10-26 | 2008-09-15 | Sicor Inc | Proceso para la preparacion de imatinib. |
| EP2009008A1 (en) * | 2006-10-26 | 2008-12-31 | Sicor, Inc. | Imatinib base, and imatinib mesylate and processes for preparation thereof |
| CN101225085B (zh) * | 2007-01-17 | 2011-09-21 | 天津天士力集团有限公司 | 苯基呋咱氮类一氧化氮供体型2-苯胺嘧啶衍生物、其制备方法、含有该化合物的组合物及其用途 |
| US8962655B2 (en) | 2007-01-29 | 2015-02-24 | Eisai R&D Management Co., Ltd. | Composition for treatment of undifferentiated gastric cancer |
| CN101245061B (zh) * | 2007-02-13 | 2012-09-19 | 天津天士力集团有限公司 | N-(5-氨基-2-甲基苯基)-4-(3-吡啶基)-2-嘧啶胺类一氧化氮供体型衍生物，制备方法及其用途 |
| US7550591B2 (en) * | 2007-05-02 | 2009-06-23 | Chemagis Ltd. | Imatinib production process |
| EP2152079A4 (en) * | 2007-06-04 | 2011-03-09 | Avila Therapeutics Inc | HETEROCYCLIC COMPOUNDS AND USES THEREOF |
| US9062023B2 (en) | 2007-06-07 | 2015-06-23 | Intra-Cellular Therapies, Inc. | Heterocycle compounds and uses thereof |
| US8367686B2 (en) | 2007-06-07 | 2013-02-05 | Intra-Cellular Therapies, Inc. | Heterocycle compounds and uses thereof |
| US8414918B2 (en) * | 2007-09-25 | 2013-04-09 | Teva Pharmaceutical Industries Ltd. | Stable imatinib compositions |
| CN101848895B (zh) * | 2007-11-09 | 2013-10-23 | 卫材R&D管理有限公司 | 血管新生抑制物质和抗肿瘤性铂络合物的组合使用 |
| BRPI0906576A2 (pt) * | 2008-01-29 | 2015-07-07 | Eisai R&D Man Co Ltd | Composição farmacêutica, kit, uso de um composto, e, agente terapêutico para câncer |
| WO2009118108A1 (en) * | 2008-03-26 | 2009-10-01 | Merck Patent Gmbh | Method of long term storage of substrate-coupled beads |
| CN101417995B (zh) * | 2008-11-21 | 2012-06-06 | 陈依军 | 苯氧基嘧啶衍生物及其制备方法和用途 |
| ES2573515T3 (es) | 2010-06-25 | 2016-06-08 | Eisai R&D Management Co., Ltd. | Agente antitumoral que emplea compuestos con efecto inhibitorio de cinasas combinados |
| MX2013009931A (es) | 2011-04-18 | 2013-10-01 | Eisai R&D Man Co Ltd | Agentes terapeuticos contra tumores. |
| EP2714937B1 (en) | 2011-06-03 | 2018-11-14 | Eisai R&D Management Co., Ltd. | Biomarkers for predicting and assessing responsiveness of thyroid and kidney cancer subjects to lenvatinib compounds |
| MX2015004979A (es) | 2012-12-21 | 2015-07-17 | Eisai R&D Man Co Ltd | Forma amorfa de derivado de quinolina y metodo para su produccion. |
| NZ714049A (en) | 2013-05-14 | 2020-05-29 | Eisai R&D Man Co Ltd | Biomarkers for predicting and assessing responsiveness of endometrial cancer subjects to lenvatinib compounds |
| CN103588754B (zh) * | 2013-11-04 | 2015-05-27 | 遵义医学院 | 伊马替尼的制备方法 |
| CN113683564A (zh) | 2014-08-28 | 2021-11-23 | 卫材R&D管理有限公司 | 高纯度喹啉衍生物及其生产方法 |
| LT3263106T (lt) | 2015-02-25 | 2024-01-10 | Eisai R&D Management Co., Ltd. | Chinolino darinių kartumo sumažinimo būdas |
| CA2978226C (en) | 2015-03-04 | 2025-02-18 | Eisai R&D Management Co., Ltd. | COMBINATION OF A PD-1 ANTAGONIST AND A VEGFR/FGFR/RET TYROSINE KINASE INHIBITOR TO TREAT CANCER |
| CN107801379B (zh) | 2015-06-16 | 2021-05-25 | 卫材R&D管理有限公司 | 抗癌剂 |
| RU2718048C2 (ru) | 2015-08-20 | 2020-03-30 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Противоопухолевое терапевтическое средство |
| WO2018147275A1 (ja) | 2017-02-08 | 2018-08-16 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 腫瘍治療用医薬組成物 |
| RU2019134940A (ru) | 2017-05-16 | 2021-06-16 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Лечение гепатоцеллюлярной карциномы |
| CN107573322A (zh) * | 2017-09-06 | 2018-01-12 | 南京优科生物医药研究有限公司 | 伊马替尼双氮氧化物、其制备方法和用途 |
| CN109761970B (zh) * | 2019-01-26 | 2020-06-09 | 中国药科大学 | 一种蛋白靶向降解嵌合分子、制备方法及应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4607041A (en) * | 1983-04-27 | 1986-08-19 | Fisons Plc | Antihypertensive 2-phenyl Hantzsch dihydropyridines |
| US5521184A (en) * | 1992-04-03 | 1996-05-28 | Ciba-Geigy Corporation | Pyrimidine derivatives and processes for the preparation thereof |
| TW225528B (OSRAM) * | 1992-04-03 | 1994-06-21 | Ciba Geigy Ag | |
| DE4444288A1 (de) * | 1994-12-13 | 1996-06-20 | Rainer Dr Med Etzel | Verwendung von Weihrauch zur Behandlung der Alzheimer-Krankheit |
| AU701042B2 (en) * | 1995-02-28 | 1999-01-21 | Aventisub Llc | Pharmaceutical composition for piperidinoalkanol compounds |
| CO4940418A1 (es) | 1997-07-18 | 2000-07-24 | Novartis Ag | Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso |
| GB9914258D0 (en) | 1999-06-18 | 1999-08-18 | Celltech Therapeutics Ltd | Chemical compounds |
| ITMI992711A1 (it) | 1999-12-27 | 2001-06-27 | Novartis Ag | Composti organici |
| GB0022438D0 (en) * | 2000-09-13 | 2000-11-01 | Novartis Ag | Organic Compounds |
| GB0201508D0 (en) * | 2002-01-23 | 2002-03-13 | Novartis Ag | Organic compounds |
| US7279576B2 (en) * | 2002-12-31 | 2007-10-09 | Deciphera Pharmaceuticals, Llc | Anti-cancer medicaments |
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2002
- 2002-01-23 GB GBGB0201508.9A patent/GB0201508D0/en not_active Ceased
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2003
- 2003-01-22 EP EP10150442.1A patent/EP2194049B1/en not_active Expired - Lifetime
- 2003-01-22 WO PCT/EP2003/000613 patent/WO2003062220A1/en not_active Ceased
- 2003-01-22 PT PT101504421T patent/PT2194049E/pt unknown
- 2003-01-22 ES ES03731700T patent/ES2294293T3/es not_active Expired - Lifetime
- 2003-01-22 CN CNB038027089A patent/CN100467461C/zh not_active Expired - Fee Related
- 2003-01-22 EP EP07101787A patent/EP1783126A3/en not_active Withdrawn
- 2003-01-22 ES ES10150442.1T patent/ES2503734T3/es not_active Expired - Lifetime
- 2003-01-22 JP JP2003562099A patent/JP4213595B2/ja not_active Expired - Fee Related
- 2003-01-22 EP EP03731700A patent/EP1470120B1/en not_active Expired - Lifetime
- 2003-01-22 MX MXPA04007130A patent/MXPA04007130A/es active IP Right Grant
- 2003-01-22 PT PT03731700T patent/PT1470120E/pt unknown
- 2003-01-22 US US10/502,291 patent/US7557105B2/en not_active Expired - Fee Related
- 2003-01-22 KR KR1020047011382A patent/KR100778163B1/ko not_active Expired - Fee Related
- 2003-01-22 CN CNA200910002666XA patent/CN101468984A/zh active Pending
- 2003-01-22 CA CA2474104A patent/CA2474104C/en not_active Expired - Fee Related
- 2003-01-22 DE DE60318013T patent/DE60318013T2/de not_active Expired - Lifetime
- 2003-01-22 BR BR0307058-1A patent/BR0307058A/pt not_active IP Right Cessation
- 2003-01-22 AT AT03731700T patent/ATE380807T1/de active
- 2003-01-22 KR KR1020077011065A patent/KR20070058019A/ko not_active Withdrawn
-
2004
- 2004-07-12 IL IL162979A patent/IL162979A/en unknown
-
2008
- 2008-08-13 JP JP2008208640A patent/JP5027076B2/ja not_active Expired - Fee Related
-
2009
- 2009-06-04 US US12/478,082 patent/US20090239879A1/en not_active Abandoned
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2010
- 2010-05-17 US US12/781,430 patent/US20100222362A1/en not_active Abandoned
- 2010-10-03 IL IL208399A patent/IL208399A/en unknown
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2011
- 2011-07-05 US US13/176,289 patent/US20110294820A1/en not_active Abandoned
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2014
- 2014-07-14 US US14/330,404 patent/US20140323494A1/en not_active Abandoned
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