DE60316124T3 - Hybride and einzelkettige meganukleasen und deren anwendungen - Google Patents

Hybride and einzelkettige meganukleasen und deren anwendungen Download PDF

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Publication number
DE60316124T3
DE60316124T3 DE60316124.3T DE60316124T DE60316124T3 DE 60316124 T3 DE60316124 T3 DE 60316124T3 DE 60316124 T DE60316124 T DE 60316124T DE 60316124 T3 DE60316124 T3 DE 60316124T3
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Prior art keywords
meganuclease
domain
hybrid
dodecapeptide
crei
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Expired - Lifetime
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DE60316124.3T
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German (de)
English (en)
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DE60316124D1 (de
DE60316124T2 (de
Inventor
Sylvain Arnould
Patrick Chames
Andre Choulika
Jean-Charles Epinat
Emmanuel Lacroix
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Cellectis SA
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Cellectis SA
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Publication of DE60316124T2 publication Critical patent/DE60316124T2/de
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/16Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Detergent Compositions (AREA)
DE60316124.3T 2002-03-15 2003-03-14 Hybride and einzelkettige meganukleasen und deren anwendungen Expired - Lifetime DE60316124T3 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US36411302P 2002-03-15 2002-03-15
US364113P 2002-03-15
PCT/IB2003/001352 WO2003078619A1 (en) 2002-03-15 2003-03-14 Hybrid and single chain meganucleases and use thereof
EP03744485.8A EP1485475B2 (en) 2002-03-15 2003-03-14 Hybrid and single chain meganucleases and use thereof

Publications (3)

Publication Number Publication Date
DE60316124D1 DE60316124D1 (de) 2007-10-18
DE60316124T2 DE60316124T2 (de) 2008-06-05
DE60316124T3 true DE60316124T3 (de) 2018-03-22

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ID=28041871

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DE60316124.3T Expired - Lifetime DE60316124T3 (de) 2002-03-15 2003-03-14 Hybride and einzelkettige meganukleasen und deren anwendungen

Country Status (10)

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US (2) US8206965B2 (https=)
EP (1) EP1485475B2 (https=)
JP (3) JP2005520519A (https=)
AT (1) ATE372379T1 (https=)
AU (1) AU2003215869B2 (https=)
CA (1) CA2479153C (https=)
DE (1) DE60316124T3 (https=)
DK (1) DK1485475T3 (https=)
ES (1) ES2292994T3 (https=)
WO (1) WO2003078619A1 (https=)

Families Citing this family (160)

* Cited by examiner, † Cited by third party
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US20040002092A1 (en) 2004-01-01
EP1485475B1 (en) 2007-09-05
EP1485475A1 (en) 2004-12-15
DE60316124D1 (de) 2007-10-18
WO2003078619A1 (en) 2003-09-25
AU2003215869A1 (en) 2003-09-29
US8206965B2 (en) 2012-06-26
EP1485475B2 (en) 2017-09-20
CA2479153A1 (en) 2003-09-25
CA2479153C (en) 2015-06-02
ES2292994T3 (es) 2008-03-16
JP2010207234A (ja) 2010-09-24
JP2005520519A (ja) 2005-07-14
US20060078552A1 (en) 2006-04-13
AU2003215869B2 (en) 2008-04-24
DK1485475T3 (da) 2008-01-21
DE60316124T2 (de) 2008-06-05
ATE372379T1 (de) 2007-09-15

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