DE60313365T2 - 4-Aryl-4-(Naphth-1-ylmethylamino)methyl-Piperidin-Verbindungen und deren Verwendung - Google Patents
4-Aryl-4-(Naphth-1-ylmethylamino)methyl-Piperidin-Verbindungen und deren Verwendung Download PDFInfo
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- DE60313365T2 DE60313365T2 DE60313365T DE60313365T DE60313365T2 DE 60313365 T2 DE60313365 T2 DE 60313365T2 DE 60313365 T DE60313365 T DE 60313365T DE 60313365 T DE60313365 T DE 60313365T DE 60313365 T2 DE60313365 T2 DE 60313365T2
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- hydrogen
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- ADNPLDHMAVUMIW-CUZNLEPHSA-N substance P Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CCCN=C(N)N)C1=CC=CC=C1 ADNPLDHMAVUMIW-CUZNLEPHSA-N 0.000 description 1
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- RSTQKRVHGQXVQC-UHFFFAOYSA-N tert-butyl 4-[[(3-cyano-2,4-dimethoxynaphthalen-1-yl)methylamino]methyl]-4-(4-fluorophenyl)piperidine-1-carboxylate Chemical compound C12=CC=CC=C2C(OC)=C(C#N)C(OC)=C1CNCC1(C=2C=CC(F)=CC=2)CCN(C(=O)OC(C)(C)C)CC1 RSTQKRVHGQXVQC-UHFFFAOYSA-N 0.000 description 1
- LDEBDEMNJJWYHO-UHFFFAOYSA-N tert-butyl 4-[[(3-cyano-2-ethylnaphthalen-1-yl)methylamino]methyl]-4-(4-fluorophenyl)piperidine-1-carboxylate Chemical compound C12=CC=CC=C2C=C(C#N)C(CC)=C1CNCC1(C=2C=CC(F)=CC=2)CCN(C(=O)OC(C)(C)C)CC1 LDEBDEMNJJWYHO-UHFFFAOYSA-N 0.000 description 1
- WCXQZULBKBGQNO-UHFFFAOYSA-N tert-butyl 4-[[(3-cyano-2-methoxynaphthalen-1-yl)methylamino]methyl]-4-(4-fluorophenyl)piperidine-1-carboxylate Chemical compound C12=CC=CC=C2C=C(C#N)C(OC)=C1CNCC1(C=2C=CC(F)=CC=2)CCN(C(=O)OC(C)(C)C)CC1 WCXQZULBKBGQNO-UHFFFAOYSA-N 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
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- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
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- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
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- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Addiction (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43513002P | 2002-12-20 | 2002-12-20 | |
| US435130P | 2002-12-20 | ||
| PCT/SE2003/002004 WO2004056771A1 (en) | 2002-12-20 | 2003-12-18 | Piperidine amine compounds and their use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60313365D1 DE60313365D1 (de) | 2007-05-31 |
| DE60313365T2 true DE60313365T2 (de) | 2007-12-27 |
Family
ID=32682165
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60313365T Expired - Fee Related DE60313365T2 (de) | 2002-12-20 | 2003-12-18 | 4-Aryl-4-(Naphth-1-ylmethylamino)methyl-Piperidin-Verbindungen und deren Verwendung |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20060058352A1 (https=) |
| EP (1) | EP1581495B1 (https=) |
| JP (1) | JP2006512363A (https=) |
| AT (1) | ATE360001T1 (https=) |
| AU (1) | AU2003291589A1 (https=) |
| DE (1) | DE60313365T2 (https=) |
| ES (1) | ES2286470T3 (https=) |
| WO (1) | WO2004056771A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004022539A1 (en) * | 2002-09-09 | 2004-03-18 | Astrazeneca Ab | Naphthyl ether compounds and their use |
| EP1679069A4 (en) * | 2003-10-21 | 2009-05-13 | Dainippon Sumitomo Pharma Co | NEW PIPERIDINE DERIVATIVE |
| GB0412865D0 (en) | 2004-06-09 | 2004-07-14 | Glaxo Group Ltd | Chemical compounds |
| US7494986B2 (en) * | 2004-07-20 | 2009-02-24 | Bristol-Myers Squibb Company | Cycloalkylamine derivatives as NK-1/SSRI antagonists |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3693820A (en) * | 1971-06-03 | 1972-09-26 | Robert P Linkletter | Safety closure cap |
| US3931891A (en) * | 1974-10-11 | 1976-01-13 | Peppler Stanley R K | Pill container with pocket |
| FR2603871B1 (fr) * | 1986-09-16 | 1988-12-02 | Morel Simone | Capsule de securite formant bouchon pour flacons et objets analogues |
| GB9601960D0 (en) * | 1996-01-31 | 1996-04-03 | Galton Fenzi Miles D M | Containers |
| US5908125A (en) * | 1997-04-16 | 1999-06-01 | Weatherchem Corporation | Child-resistant screw-on cap and bottle |
| CN1309638A (zh) * | 1998-07-10 | 2001-08-22 | 阿斯特拉曾尼卡有限公司 | 作为神经激肽受体拮抗剂的n－取代的萘甲酰胺 |
| GB9907571D0 (en) * | 1999-04-06 | 1999-05-26 | Zeneca Ltd | Compounds |
| WO2004020411A1 (en) * | 2002-08-29 | 2004-03-11 | Astrazeneca Ab | Naphthamide derivatives and their use |
-
2003
- 2003-12-18 ES ES03768468T patent/ES2286470T3/es not_active Expired - Lifetime
- 2003-12-18 WO PCT/SE2003/002004 patent/WO2004056771A1/en not_active Ceased
- 2003-12-18 AU AU2003291589A patent/AU2003291589A1/en not_active Abandoned
- 2003-12-18 JP JP2004562205A patent/JP2006512363A/ja active Pending
- 2003-12-18 US US10/539,140 patent/US20060058352A1/en not_active Abandoned
- 2003-12-18 DE DE60313365T patent/DE60313365T2/de not_active Expired - Fee Related
- 2003-12-18 EP EP03768468A patent/EP1581495B1/en not_active Expired - Lifetime
- 2003-12-18 AT AT03768468T patent/ATE360001T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003291589A1 (en) | 2004-07-14 |
| WO2004056771A1 (en) | 2004-07-08 |
| EP1581495B1 (en) | 2007-04-18 |
| EP1581495A1 (en) | 2005-10-05 |
| US20060058352A1 (en) | 2006-03-16 |
| ATE360001T1 (de) | 2007-05-15 |
| DE60313365D1 (de) | 2007-05-31 |
| JP2006512363A (ja) | 2006-04-13 |
| ES2286470T3 (es) | 2007-12-01 |
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