DE69332718T2 - Enantiomere von carbazolderivaten als 5-ht1-ähnliche agonisten - Google Patents
Enantiomere von carbazolderivaten als 5-ht1-ähnliche agonistenInfo
- Publication number
- DE69332718T2 DE69332718T2 DE69332718T DE69332718T DE69332718T2 DE 69332718 T2 DE69332718 T2 DE 69332718T2 DE 69332718 T DE69332718 T DE 69332718T DE 69332718 T DE69332718 T DE 69332718T DE 69332718 T2 DE69332718 T2 DE 69332718T2
- Authority
- DE
- Germany
- Prior art keywords
- pct
- agonists
- enantiomers
- carbazole derivatives
- date jul
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000556 agonist Substances 0.000 title abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical compound C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 title 1
- UJOBWOGCFQCDNV-UHFFFAOYSA-N 9H-carbazole Chemical class C1=CC=C2C3=CC=CC=C3NC2=C1 UJOBWOGCFQCDNV-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical group 0.000 abstract 1
- 239000012453 solvate Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB929226530A GB9226530D0 (en) | 1992-12-21 | 1992-12-21 | Compounds |
| PCT/EP1993/003627 WO1994014772A1 (en) | 1992-12-21 | 1993-12-16 | Enantiomers of carbazole derivatives as 5-ht1-like agonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69332718D1 DE69332718D1 (de) | 2003-04-03 |
| DE69332718T2 true DE69332718T2 (de) | 2003-12-04 |
Family
ID=10726909
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69332718T Expired - Lifetime DE69332718T2 (de) | 1992-12-21 | 1993-12-16 | Enantiomere von carbazolderivaten als 5-ht1-ähnliche agonisten |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US5618947A (de) |
| EP (1) | EP0674621B1 (de) |
| JP (1) | JP3364222B2 (de) |
| KR (1) | KR100307001B1 (de) |
| CN (1) | CN1039491C (de) |
| AT (1) | ATE233239T1 (de) |
| AU (1) | AU688748B2 (de) |
| CA (1) | CA2152630C (de) |
| DE (1) | DE69332718T2 (de) |
| DK (1) | DK0674621T3 (de) |
| ES (1) | ES2193151T3 (de) |
| GB (1) | GB9226530D0 (de) |
| HK (1) | HK1012368A1 (de) |
| MX (1) | MX9400035A (de) |
| NZ (1) | NZ259363A (de) |
| PT (1) | PT674621E (de) |
| WO (1) | WO1994014772A1 (de) |
| ZA (1) | ZA939457B (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5616603A (en) * | 1995-05-26 | 1997-04-01 | Smithkline Beecham Plc | Enantiomers of carbazole derivatives as 5-HT1 -like agonists |
| US5917054A (en) * | 1995-07-18 | 1999-06-29 | Smithkline Beecham P.L.C. | Process for preparing enantiomers of carbazole derivatives as 5-HT1 -like agonists |
| GB9706089D0 (en) * | 1997-03-24 | 1997-05-14 | Scherer Ltd R P | Pharmaceutical composition |
| GB9723061D0 (en) * | 1997-10-31 | 1998-01-07 | Vanguard Medica Ltd | Medicaments |
| CA2310250A1 (en) * | 1997-11-14 | 1999-05-27 | August Masaru Watanabe | Treatment for alzheimer's disease |
| GB9808069D0 (en) * | 1998-04-16 | 1998-06-17 | Vanguard Medica Ltd | Novel processes |
| GB9817911D0 (en) * | 1998-08-17 | 1998-10-14 | Vanguard Medica Ltd | New use |
| FR2841899A1 (fr) * | 2002-07-05 | 2004-01-09 | Ppg Sipsy | Procede de resolution asymetrique d'un racemique faisant intervenir l'acide diprogulique et utilisation dudit acide comme agent de resolution asymetrique |
| CN101120002A (zh) * | 2005-02-17 | 2008-02-06 | 惠氏公司 | 环烷基稠合的吲哚、苯并噻吩、苯并呋喃和茚衍生物 |
| US20090069399A1 (en) * | 2007-09-12 | 2009-03-12 | Protia, Llc | Deuterium-enriched frovatriptan |
| WO2010073253A1 (en) * | 2008-12-22 | 2010-07-01 | Natco Pharma Limited | Method for preparing an optically active frovatriptan |
| WO2010122343A1 (en) * | 2009-04-23 | 2010-10-28 | Generics [Uk] Limited | A process for the preparation of frovatriptan and frovatriptan succinate and their synthetic intermediates |
| WO2011095803A1 (en) * | 2010-02-02 | 2011-08-11 | Generics [Uk] Limited | Hplc method for analyzing frovatriptan |
| WO2012147020A1 (en) * | 2011-04-25 | 2012-11-01 | Orchid Chemicals And Pharamceuticals Limited | An improved process for the preparation of frovatriptan |
| EP2816030A1 (de) * | 2013-06-20 | 2014-12-24 | Duke Chem, S. A. | Verfahren zur Herstellung von Frovatriptan und dessen Enantiomer |
| GB201312768D0 (en) * | 2013-07-17 | 2013-08-28 | Ge Healthcare Ltd | Work-up procedure |
| CN104402798B (zh) * | 2014-10-21 | 2016-09-14 | 杭州瑞德化工有限公司 | 一种3-氨基-1，2，3，4-四氢咔唑的拆分方法 |
| CN104529871A (zh) * | 2014-12-22 | 2015-04-22 | 青岛正大海尔制药有限公司 | 一种琥珀酸呋罗曲坦的制备方法 |
| US11405689B2 (en) * | 2020-12-09 | 2022-08-02 | Rovi Guides, Inc. | Systems and methods for providing recording of a blacked-out media content item |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4257952A (en) * | 1977-06-06 | 1981-03-24 | Sterling Drug Inc. | 3-Amino-tetrahydrocarbazoles |
| JPS6429699A (en) * | 1987-07-24 | 1989-01-31 | Mitsubishi Heavy Ind Ltd | Recovery method for adiabatic compression heat |
| US4874399A (en) * | 1988-01-25 | 1989-10-17 | Minnesota Mining And Manufacturing Company | Electret filter made of fibers containing polypropylene and poly(4-methyl-1-pentene) |
| JPH0247924A (ja) * | 1988-08-08 | 1990-02-16 | Nec Corp | 分周回路 |
| GB9113802D0 (en) * | 1991-06-26 | 1991-08-14 | Smithkline Beecham Plc | Medicaments |
-
1992
- 1992-12-21 GB GB929226530A patent/GB9226530D0/en active Pending
-
1993
- 1993-12-16 DE DE69332718T patent/DE69332718T2/de not_active Expired - Lifetime
- 1993-12-16 DK DK94903845T patent/DK0674621T3/da active
- 1993-12-16 AU AU58145/94A patent/AU688748B2/en not_active Expired
- 1993-12-16 PT PT94903845T patent/PT674621E/pt unknown
- 1993-12-16 JP JP51480694A patent/JP3364222B2/ja not_active Expired - Lifetime
- 1993-12-16 ES ES94903845T patent/ES2193151T3/es not_active Expired - Lifetime
- 1993-12-16 NZ NZ259363A patent/NZ259363A/en not_active IP Right Cessation
- 1993-12-16 CA CA002152630A patent/CA2152630C/en not_active Expired - Lifetime
- 1993-12-16 US US08/446,655 patent/US5618947A/en not_active Expired - Lifetime
- 1993-12-16 AT AT94903845T patent/ATE233239T1/de active
- 1993-12-16 EP EP94903845A patent/EP0674621B1/de not_active Expired - Lifetime
- 1993-12-16 KR KR1019950702522A patent/KR100307001B1/ko not_active IP Right Cessation
- 1993-12-16 WO PCT/EP1993/003627 patent/WO1994014772A1/en active IP Right Grant
- 1993-12-17 ZA ZA939457A patent/ZA939457B/xx unknown
- 1993-12-20 CN CN93120493A patent/CN1039491C/zh not_active Expired - Lifetime
-
1994
- 1994-01-03 MX MX9400035A patent/MX9400035A/es unknown
-
1995
- 1995-05-26 US US08/452,469 patent/US5650426A/en not_active Expired - Lifetime
-
1998
- 1998-12-15 HK HK98113524A patent/HK1012368A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| KR100307001B1 (ko) | 2001-12-28 |
| NZ259363A (en) | 1996-12-20 |
| JPH08504790A (ja) | 1996-05-21 |
| JP3364222B2 (ja) | 2003-01-08 |
| GB9226530D0 (en) | 1993-02-17 |
| ATE233239T1 (de) | 2003-03-15 |
| ES2193151T3 (es) | 2003-11-01 |
| CN1095712A (zh) | 1994-11-30 |
| PT674621E (pt) | 2003-07-31 |
| US5650426A (en) | 1997-07-22 |
| ZA939457B (en) | 1995-06-19 |
| DK0674621T3 (da) | 2003-06-10 |
| EP0674621B1 (de) | 2003-02-26 |
| EP0674621A1 (de) | 1995-10-04 |
| CA2152630A1 (en) | 1994-07-07 |
| US5618947A (en) | 1997-04-08 |
| CA2152630C (en) | 2005-07-26 |
| AU5814594A (en) | 1994-07-19 |
| KR950704253A (ko) | 1995-11-17 |
| CN1039491C (zh) | 1998-08-12 |
| DE69332718D1 (de) | 2003-04-03 |
| HK1012368A1 (en) | 1999-07-30 |
| MX9400035A (es) | 1994-07-29 |
| WO1994014772A1 (en) | 1994-07-07 |
| AU688748B2 (en) | 1998-03-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |