DE60309899D1 - Verfahren zur synthese von hochreinem 3,5-diamino 6-(2, 3-dichlorophenyl)-1,2,4-triazin - Google Patents
Verfahren zur synthese von hochreinem 3,5-diamino 6-(2, 3-dichlorophenyl)-1,2,4-triazinInfo
- Publication number
- DE60309899D1 DE60309899D1 DE60309899T DE60309899T DE60309899D1 DE 60309899 D1 DE60309899 D1 DE 60309899D1 DE 60309899 T DE60309899 T DE 60309899T DE 60309899 T DE60309899 T DE 60309899T DE 60309899 D1 DE60309899 D1 DE 60309899D1
- Authority
- DE
- Germany
- Prior art keywords
- dichlorophenyl
- diamino
- triazine
- synthesis
- purity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- PYZRQGJRPPTADH-UHFFFAOYSA-N lamotrigine Chemical compound NC1=NC(N)=NN=C1C1=CC=CC(Cl)=C1Cl PYZRQGJRPPTADH-UHFFFAOYSA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- FIBBFBXFASKAON-UHFFFAOYSA-N 2,3-dichlorobenzoyl cyanide Chemical compound ClC1=CC=CC(C(=O)C#N)=C1Cl FIBBFBXFASKAON-UHFFFAOYSA-N 0.000 abstract 2
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 abstract 2
- HAMNKKUPIHEESI-UHFFFAOYSA-N aminoguanidine Chemical class NNC(N)=N HAMNKKUPIHEESI-UHFFFAOYSA-N 0.000 abstract 2
- 239000012043 crude product Substances 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 abstract 1
- 239000000395 magnesium oxide Substances 0.000 abstract 1
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 abstract 1
- 229940098779 methanesulfonic acid Drugs 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 239000000047 product Substances 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D253/075—Two hetero atoms, in positions 3 and 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
- C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU0203114 | 2002-09-20 | ||
| HU0203114A HU225667B1 (en) | 2002-09-20 | 2002-09-20 | Method for producing high-purity 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine |
| PCT/HU2003/000072 WO2004026845A1 (en) | 2002-09-20 | 2003-09-18 | New process for the synthesis of high purity 3,5-diamino-6-(2, 3-dichlorophenyl)-1,2,4-triazine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60309899D1 true DE60309899D1 (de) | 2007-01-04 |
| DE60309899T2 DE60309899T2 (de) | 2007-10-18 |
Family
ID=89980802
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60309899T Expired - Lifetime DE60309899T2 (de) | 2002-09-20 | 2003-09-18 | Verfahren zur synthese von hochreinem 3,5-diamino-6-(2,3-dichlorphenyl)-1,2,4-triazin |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7390899B2 (de) |
| EP (1) | EP1539720B8 (de) |
| AT (1) | ATE346051T1 (de) |
| AU (1) | AU2003267676A1 (de) |
| CA (1) | CA2498761A1 (de) |
| DE (1) | DE60309899T2 (de) |
| ES (1) | ES2277104T3 (de) |
| HU (1) | HU225667B1 (de) |
| IL (1) | IL166953A (de) |
| PL (1) | PL374724A1 (de) |
| RU (1) | RU2335497C2 (de) |
| WO (1) | WO2004026845A1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2209639B1 (es) * | 2002-10-31 | 2005-08-01 | Vita Cientifica, S.L. | Procedimiento para la obtencion de un compuesto farmaceuticamente activo y obtencion de su intermedio. |
| WO2007138075A1 (en) * | 2006-05-31 | 2007-12-06 | Calaire Chimie Sas | Method for preparing lamotrigine and its intermediate 2,3-dichlorobenzoyl chloride |
| CN101506178A (zh) * | 2006-08-14 | 2009-08-12 | 隆沙有限公司 | 制备拉莫三嗪的方法 |
| GB0800741D0 (en) | 2008-01-16 | 2008-02-20 | Univ Greenwich | Cyclic triazo and diazo sodium channel blockers |
| GB2471729A (en) | 2009-07-08 | 2011-01-12 | Univ Greenwich | 1,2,4-triazine derivatives and their use as sodium channel blockers |
| WO2018229517A1 (en) | 2017-06-15 | 2018-12-20 | GYURCSÁNSZKY, László György | Pallet for supporting and suspending loads |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0059987B1 (de) | 1979-06-01 | 1985-08-14 | The Wellcome Foundation Limited | Alpha-Cyano-alpha-((N-guanidino)-imino)toluene |
| GB8613183D0 (en) | 1986-05-30 | 1986-07-02 | Wellcome Found | Triazine salt |
| WO1996020934A1 (en) | 1994-12-30 | 1996-07-11 | The Wellcome Foundation Limited | Process for the preparation of lamotrigine |
| GB9426448D0 (en) | 1994-12-30 | 1995-03-01 | Wellcome Found | Process |
| GB9812413D0 (en) | 1998-06-10 | 1998-08-05 | Glaxo Group Ltd | Compound and its use |
| US6639072B1 (en) * | 2000-01-03 | 2003-10-28 | Rpg Life Sciences Limited | Process for the preparation of 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine, commonly known as lamotrigine |
| CA2366521C (en) * | 2001-12-24 | 2007-03-06 | Brantford Chemicals Inc. | A new and efficient process for the preparation of lamotrigine and related 3,5-diamino-6-substituted-1,2,4-triazines |
-
2002
- 2002-09-20 HU HU0203114A patent/HU225667B1/hu not_active IP Right Cessation
-
2003
- 2003-09-18 US US10/528,379 patent/US7390899B2/en not_active Expired - Fee Related
- 2003-09-18 DE DE60309899T patent/DE60309899T2/de not_active Expired - Lifetime
- 2003-09-18 RU RU2005111751/04A patent/RU2335497C2/ru not_active IP Right Cessation
- 2003-09-18 ES ES03748368T patent/ES2277104T3/es not_active Expired - Lifetime
- 2003-09-18 PL PL03374724A patent/PL374724A1/xx not_active IP Right Cessation
- 2003-09-18 AU AU2003267676A patent/AU2003267676A1/en not_active Abandoned
- 2003-09-18 CA CA002498761A patent/CA2498761A1/en not_active Abandoned
- 2003-09-18 WO PCT/HU2003/000072 patent/WO2004026845A1/en active IP Right Grant
- 2003-09-18 AT AT03748368T patent/ATE346051T1/de not_active IP Right Cessation
- 2003-09-18 EP EP03748368A patent/EP1539720B8/de not_active Expired - Lifetime
-
2005
- 2005-02-17 IL IL166953A patent/IL166953A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1539720B8 (de) | 2007-01-03 |
| US20060178511A1 (en) | 2006-08-10 |
| EP1539720B1 (de) | 2006-11-22 |
| DE60309899T2 (de) | 2007-10-18 |
| WO2004026845A1 (en) | 2004-04-01 |
| HUP0203114A2 (hu) | 2004-05-28 |
| HU0203114D0 (de) | 2002-11-28 |
| PL374724A1 (en) | 2005-10-31 |
| CA2498761A1 (en) | 2004-04-01 |
| ES2277104T3 (es) | 2007-07-01 |
| ATE346051T1 (de) | 2006-12-15 |
| EP1539720A1 (de) | 2005-06-15 |
| HU225667B1 (en) | 2007-05-29 |
| IL166953A (en) | 2009-09-01 |
| RU2335497C2 (ru) | 2008-10-10 |
| RU2005111751A (ru) | 2006-10-27 |
| AU2003267676A1 (en) | 2004-04-08 |
| US7390899B2 (en) | 2008-06-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |