HUP0203114A2 - Új eljárás nagy tisztaságú 3,5-diamino-6-(2,3-diklór-fenil)-triazin előállítására - Google Patents

Új eljárás nagy tisztaságú 3,5-diamino-6-(2,3-diklór-fenil)-triazin előállítására

Info

Publication number
HUP0203114A2
HUP0203114A2 HU0203114A HUP0203114A HUP0203114A2 HU P0203114 A2 HUP0203114 A2 HU P0203114A2 HU 0203114 A HU0203114 A HU 0203114A HU P0203114 A HUP0203114 A HU P0203114A HU P0203114 A2 HUP0203114 A2 HU P0203114A2
Authority
HU
Hungary
Prior art keywords
dichlorophenyl
diamino
triazine
purity
producing high
Prior art date
Application number
HU0203114A
Other languages
English (en)
Inventor
József Neu
Tibor Gizur
József Törley
János Csabai
Ferenc Végh
Péter Kálvin
Gábor Tárkányi
Original Assignee
Richter Gedeon Vegyészeti Gyár Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyészeti Gyár Rt. filed Critical Richter Gedeon Vegyészeti Gyár Rt.
Priority to HU0203114A priority Critical patent/HU225667B1/hu
Publication of HU0203114D0 publication Critical patent/HU0203114D0/hu
Priority to EP03748368A priority patent/EP1539720B8/en
Priority to DE60309899T priority patent/DE60309899T2/de
Priority to ES03748368T priority patent/ES2277104T3/es
Priority to RU2005111751/04A priority patent/RU2335497C2/ru
Priority to PL03374724A priority patent/PL374724A1/xx
Priority to CA002498761A priority patent/CA2498761A1/en
Priority to AU2003267676A priority patent/AU2003267676A1/en
Priority to US10/528,379 priority patent/US7390899B2/en
Priority to PCT/HU2003/000072 priority patent/WO2004026845A1/en
Priority to AT03748368T priority patent/ATE346051T1/de
Publication of HUP0203114A2 publication Critical patent/HUP0203114A2/hu
Priority to IL166953A priority patent/IL166953A/en
Publication of HU225667B1 publication Critical patent/HU225667B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
HU0203114A 2002-09-20 2002-09-20 Method for producing high-purity 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine HU225667B1 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
HU0203114A HU225667B1 (en) 2002-09-20 2002-09-20 Method for producing high-purity 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine
AT03748368T ATE346051T1 (de) 2002-09-20 2003-09-18 Verfahren zur synthese von hochreinem 3,5-diamino 6-(2, 3-dichlorophenyl)-1,2,4-triazin
CA002498761A CA2498761A1 (en) 2002-09-20 2003-09-18 New process for the synthesis of high purity 3,5-diamino-6-(2, 3-dichlorophenyl)-1,2,4-triazine
DE60309899T DE60309899T2 (de) 2002-09-20 2003-09-18 Verfahren zur synthese von hochreinem 3,5-diamino-6-(2,3-dichlorphenyl)-1,2,4-triazin
ES03748368T ES2277104T3 (es) 2002-09-20 2003-09-18 Nuevo procedimiento para la sintesis de 3,5-diamino-6-(2,3-diclorofenil)-1,2,4-triazina de alta pureza.
RU2005111751/04A RU2335497C2 (ru) 2002-09-20 2003-09-18 Способ получения высокочистого 3,5-диамино-6-(2,3-дихлорфенил)-1,2,4-триазина
PL03374724A PL374724A1 (en) 2002-09-20 2003-09-18 New process for the synthesis of high purity 3,5-diamino-6-(2, 3-dichlorophenyl)-1,2,4-triazine
EP03748368A EP1539720B8 (en) 2002-09-20 2003-09-18 New process for the synthesis of high purity 3,5-diamino-6-(2, 3-dichlorophenyl)-1,2,4-triazine
AU2003267676A AU2003267676A1 (en) 2002-09-20 2003-09-18 New process for the synthesis of high purity 3,5-diamino-6-(2, 3-dichlorophenyl)-1,2,4-triazine
US10/528,379 US7390899B2 (en) 2002-09-20 2003-09-18 Process for the synthesis of high purity 3,5-diamino-6-(2,3-dichlorophenyl) (1,2,4-triazine)
PCT/HU2003/000072 WO2004026845A1 (en) 2002-09-20 2003-09-18 New process for the synthesis of high purity 3,5-diamino-6-(2, 3-dichlorophenyl)-1,2,4-triazine
IL166953A IL166953A (en) 2002-09-20 2005-02-17 Process for the synthesis of high purity 3,5 - diamino - 6 - (2,3 - dichlorophenyl) - 1,2,4 - triazine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU0203114A HU225667B1 (en) 2002-09-20 2002-09-20 Method for producing high-purity 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine

Publications (3)

Publication Number Publication Date
HU0203114D0 HU0203114D0 (hu) 2002-11-28
HUP0203114A2 true HUP0203114A2 (hu) 2004-05-28
HU225667B1 HU225667B1 (en) 2007-05-29

Family

ID=89980802

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0203114A HU225667B1 (en) 2002-09-20 2002-09-20 Method for producing high-purity 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine

Country Status (12)

Country Link
US (1) US7390899B2 (hu)
EP (1) EP1539720B8 (hu)
AT (1) ATE346051T1 (hu)
AU (1) AU2003267676A1 (hu)
CA (1) CA2498761A1 (hu)
DE (1) DE60309899T2 (hu)
ES (1) ES2277104T3 (hu)
HU (1) HU225667B1 (hu)
IL (1) IL166953A (hu)
PL (1) PL374724A1 (hu)
RU (1) RU2335497C2 (hu)
WO (1) WO2004026845A1 (hu)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2209639B1 (es) * 2002-10-31 2005-08-01 Vita Cientifica, S.L. Procedimiento para la obtencion de un compuesto farmaceuticamente activo y obtencion de su intermedio.
US20090312544A1 (en) * 2006-05-31 2009-12-17 Calaire Chimie Sas Method for preparing lamortrigine and its intermediate 2,3-dichlorobenzoyl chloride
EP2054396A1 (en) * 2006-08-14 2009-05-06 Lonza Ag A process for the preparation of lamotrigine
GB0800741D0 (en) 2008-01-16 2008-02-20 Univ Greenwich Cyclic triazo and diazo sodium channel blockers
GB2471729A (en) 2009-07-08 2011-01-12 Univ Greenwich 1,2,4-triazine derivatives and their use as sodium channel blockers
WO2018229517A1 (en) 2017-06-15 2018-12-20 GYURCSÁNSZKY, László György Pallet for supporting and suspending loads

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR227521A1 (es) 1979-06-01 1982-11-15 Wellcome Found Procedimiento para la preparacion de derivados de 3,5-diamino-6-(fenil substituido)-1,2,4-triazinas e intermediario para realizar el procedimiento
GB8613183D0 (en) 1986-05-30 1986-07-02 Wellcome Found Triazine salt
JPH11501007A (ja) 1994-12-30 1999-01-26 ザ、ウェルカム、ファンデーション、リミテッド ラモトリジンの製造法
GB9426448D0 (en) 1994-12-30 1995-03-01 Wellcome Found Process
GB9812413D0 (en) * 1998-06-10 1998-08-05 Glaxo Group Ltd Compound and its use
GB2372988B (en) * 2000-01-03 2004-04-07 Rpg Life Sciences Ltd A process for the preparation of 6-(2,3-Dichlorophenyl)-1,2,4- Triazine-3,5-Diamine, commonly known as Lamotrigine
CA2366521C (en) * 2001-12-24 2007-03-06 Brantford Chemicals Inc. A new and efficient process for the preparation of lamotrigine and related 3,5-diamino-6-substituted-1,2,4-triazines

Also Published As

Publication number Publication date
ES2277104T3 (es) 2007-07-01
HU0203114D0 (hu) 2002-11-28
EP1539720B1 (en) 2006-11-22
ATE346051T1 (de) 2006-12-15
AU2003267676A1 (en) 2004-04-08
HU225667B1 (en) 2007-05-29
RU2005111751A (ru) 2006-10-27
US20060178511A1 (en) 2006-08-10
RU2335497C2 (ru) 2008-10-10
DE60309899T2 (de) 2007-10-18
WO2004026845A1 (en) 2004-04-01
DE60309899D1 (de) 2007-01-04
EP1539720A1 (en) 2005-06-15
US7390899B2 (en) 2008-06-24
IL166953A (en) 2009-09-01
CA2498761A1 (en) 2004-04-01
EP1539720B8 (en) 2007-01-03
PL374724A1 (en) 2005-10-31

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Legal Events

Date Code Title Description
HC9A Change of name, address

Owner name: RICHTER GEDEON NYRT., HU

Free format text: FORMER OWNER(S): RICHTER GEDEON VEGYESZETI GYAR RT., HU

MM4A Lapse of definitive patent protection due to non-payment of fees