DE60307998D1 - Zur behandlung hyperproliferativer erkrankungen geeignete benzofuran- und benzothiophenderivate - Google Patents

Zur behandlung hyperproliferativer erkrankungen geeignete benzofuran- und benzothiophenderivate

Info

Publication number
DE60307998D1
DE60307998D1 DE60307998T DE60307998T DE60307998D1 DE 60307998 D1 DE60307998 D1 DE 60307998D1 DE 60307998 T DE60307998 T DE 60307998T DE 60307998 T DE60307998 T DE 60307998T DE 60307998 D1 DE60307998 D1 DE 60307998D1
Authority
DE
Germany
Prior art keywords
treatment
benzofurane
hyperproliferative diseases
benzothiophene derivatives
derivatives suitable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60307998T
Other languages
English (en)
Other versions
DE60307998T2 (de
Inventor
Chengzhi Zhang
Michael Burke
Zhi Chen
Jacques Dumas
Dongping Fan
Jianmei Fan
Holia Hatoum-Mokdad
D Jones
Gaetan Ladouceur
Wendy Lee
Barton Phillips
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharmaceuticals Corp
Original Assignee
Bayer Pharmaceuticals Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharmaceuticals Corp filed Critical Bayer Pharmaceuticals Corp
Application granted granted Critical
Publication of DE60307998D1 publication Critical patent/DE60307998D1/de
Publication of DE60307998T2 publication Critical patent/DE60307998T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/92—Naphthofurans; Hydrogenated naphthofurans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/66—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/74—Naphthothiophenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE60307998T 2002-02-22 2003-02-21 Zur behandlung hyperproliferativer erkrankungen geeignete benzofuran- und benzothiophenderivate Expired - Lifetime DE60307998T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US35901102P 2002-02-22 2002-02-22
US359011P 2002-02-22
US39988602P 2002-07-31 2002-07-31
US399886P 2002-07-31
PCT/US2003/005396 WO2003072561A1 (en) 2002-02-22 2003-02-21 Benzofuran and benzothiophene derivatives useful in the treatment of hyper-proliferative disorders

Publications (2)

Publication Number Publication Date
DE60307998D1 true DE60307998D1 (de) 2006-10-12
DE60307998T2 DE60307998T2 (de) 2007-04-05

Family

ID=27767558

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60307998T Expired - Lifetime DE60307998T2 (de) 2002-02-22 2003-02-21 Zur behandlung hyperproliferativer erkrankungen geeignete benzofuran- und benzothiophenderivate

Country Status (23)

Country Link
US (2) US7351735B2 (de)
EP (2) EP1478639A1 (de)
JP (3) JP2006507215A (de)
KR (3) KR20100029280A (de)
CN (2) CN1319961C (de)
AT (1) ATE338036T1 (de)
AU (2) AU2003215380B2 (de)
BR (2) BR0307905A (de)
CA (2) CA2474510C (de)
CO (1) CO5611124A2 (de)
DE (1) DE60307998T2 (de)
ES (1) ES2271537T3 (de)
HK (2) HK1080467B (de)
HR (1) HRP20040874A2 (de)
HU (1) HUP0600156A2 (de)
IL (2) IL163027A (de)
MA (1) MA27111A1 (de)
MX (2) MXPA04007391A (de)
NO (1) NO329185B1 (de)
NZ (1) NZ534255A (de)
PL (2) PL372179A1 (de)
RU (1) RU2350609C2 (de)
WO (2) WO2003072561A1 (de)

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CA2534127A1 (en) 2003-07-31 2005-02-10 Boehringer Ingelheim Pharmaceuticals, Inc. Substituted benzothiophene compounds and uses thereof
US7420066B2 (en) 2003-08-07 2008-09-02 Bayer Pharmaceuticals Corporation Benzofuran derivatives useful for treating hyper-proliferative disorders
JP4557984B2 (ja) * 2003-12-05 2010-10-06 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド Ｉｋｋインヒビターとしての置換３−アミノ−チエノ−［２，３−ｂ］ピリジン−２−カルボン酸アミド化合物
JP4805166B2 (ja) * 2003-12-22 2011-11-02 バジリア ファルマスーチカ アーゲー アロイルフランおよびアロイルチオフェン
WO2005087778A1 (en) * 2004-02-16 2005-09-22 Bayer Pharmaceuticals Corporation Tricyclic furopyridine derivatives useful in the treatment of hyper-proliferative disorders
US7449481B2 (en) 2004-04-13 2008-11-11 Cephalon, Inc. Thio-substituted biaryl-methanesulfinyl derivatives
US7652029B2 (en) 2004-07-09 2010-01-26 Medisyn Technologies, Inc. Therapeutic compound and treatments
WO2006036031A1 (ja) * 2004-09-30 2006-04-06 Takeda Pharmaceutical Company Limited 縮合フラン誘導体およびその用途
US7592353B2 (en) 2006-06-06 2009-09-22 Boehringer Ingelheim International Gmbh Substituted 3-amino-thieno[2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses
WO2008025509A1 (en) * 2006-09-01 2008-03-06 Bayer Schering Pharma Aktiengesellschaft Benzofuran and benzothiophene derivatives useful in the treatment of cancers of the central nervous system
US10512644B2 (en) 2007-03-12 2019-12-24 Inheris Pharmaceuticals, Inc. Oligomer-opioid agonist conjugates
US8173666B2 (en) 2007-03-12 2012-05-08 Nektar Therapeutics Oligomer-opioid agonist conjugates
MX2009009851A (es) * 2007-03-12 2009-09-24 Nektar Therapeutics Conjugados de agonistas de oligomeros-opioides.
AU2011202542A1 (en) 2010-07-14 2012-02-02 Indian Institute Of Science Benzothiophene carboxamide compounds, composition and applications thereof
KR101734868B1 (ko) 2010-07-22 2017-05-12 후소 야쿠힝 고교 가부시끼가이샤 벤조푸라논 화합물 및 그것을 포함하는 의약 조성물
JP7499698B2 (ja) 2017-11-03 2024-06-14 ウニヴェルシテ ド モントリオール 化合物及び幹細胞及び／又は前駆細胞の増殖におけるその使用
CN113614182A (zh) 2018-12-20 2021-11-05 生命技术公司 经修饰的罗丹明染料和其在生物测定中的用途
CN113173928B (zh) * 2021-04-25 2022-05-27 武汉国粹医药科技有限公司 萜类化合物、其制备方法和其应用以及抗菌剂
AU2022325367A1 (en) * 2021-08-10 2024-02-08 Jiangsu Hengrui Pharmaceuticals Co., Ltd. Sulfonamide derivative, preparation method therefor and medical use thereof

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JPS6072880A (ja) * 1983-09-29 1985-04-24 Kaken Pharmaceut Co Ltd ベンゾフラン誘導体およびその製造法
GB9200623D0 (en) 1992-01-13 1992-03-11 Bayer Ag Benzofuranyl and thiophenyl-methylthio-alkanecarboxylic acid derivatives
GB9309324D0 (en) * 1993-05-06 1993-06-16 Bayer Ag Venzofuranyl-and-thiophenyl-alkanecarboxyclic acids derivatives
HRP950288A2 (en) * 1994-05-31 1997-08-31 Bayer Ag Oxalylamino-benzofuran- and benzothienyl-derivatives
EP0685475B1 (de) * 1994-05-31 1999-01-13 Bayer Ag Aminobenzofuryl- und -thienylderivate
GB9410877D0 (en) * 1994-05-31 1994-07-20 Bayer Ag Heterocyclycarbonyl substituted benzoduranyl-and-thiophenyl-alkanecarboxyclic acid derivatives
US5466810A (en) * 1994-06-10 1995-11-14 Eli Lilly And Company 2-amino-3-aroyl-benzo[β]thiophenes and methods for preparing and using same to produce 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-aminoethoxy)-benzoyl]benzo[β]thiophenes
GB9504460D0 (en) 1995-03-06 1995-04-26 Bayer Ag N-(3-Benzofuranyl)urea-derivatives
DE19527568A1 (de) * 1995-07-28 1997-01-30 Merck Patent Gmbh Endothelin-Rezeptor-Antagonisten
GB9525262D0 (en) * 1995-12-11 1996-02-07 Bayer Ag Heterocyclylcarbonyl substituted benzofuranyl-ureas
ID18405A (id) * 1996-02-19 1998-04-02 Meiji Seika Co Turunan tetrahidronaftofuranon baru dan proses produksinya
EP0801066A1 (de) * 1996-03-12 1997-10-15 Eli Lilly And Company Heterozyklisch substituierte Benzothiophene und pharmazeutische Zusammensetzungen
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GB9614718D0 (en) 1996-07-12 1996-09-04 Bayer Ag 3-ureido-pyridofurans and -pyridothiophenes
GB2350111A (en) 1999-05-17 2000-11-22 Bayer Ag Oligohydroxyl substituted 3-urea-benzofuran and pyridofuran derivatives
GB2350109A (en) 1999-05-17 2000-11-22 Bayer Ag Pharmaceutically active benzofuranyl sulfonates
GB2350110A (en) 1999-05-17 2000-11-22 Bayer Ag Pharmaceutically active benzofurans
GB2350112A (en) 1999-05-17 2000-11-22 Bayer Ag Pharmaceutically active cycloalkyl ketones

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ES2271537T3 (es) 2007-04-16
AU2003213219A1 (en) 2003-09-09
CO5611124A2 (es) 2006-02-28
EP1478639A1 (de) 2004-11-24
WO2003072566A1 (en) 2003-09-04
IL163026A (en) 2009-09-01
DE60307998T2 (de) 2007-04-05
AU2003213219B2 (en) 2009-02-26
US7585888B2 (en) 2009-09-08
WO2003072561A1 (en) 2003-09-04
NO329185B1 (no) 2010-09-06
KR20100029280A (ko) 2010-03-16
NZ534255A (en) 2007-06-29
MXPA04007391A (es) 2004-10-11
JP2006507215A (ja) 2006-03-02
RU2004128393A (ru) 2005-05-10
US20090054514A1 (en) 2009-02-26
HK1080467B (zh) 2008-02-01
EP1487813A1 (de) 2004-12-22
KR100965021B1 (ko) 2010-06-21
CA2474510C (en) 2009-11-03
HK1080466A1 (zh) 2006-04-28
HRP20040874A2 (en) 2006-05-31
BR0307894A (pt) 2004-12-07
IL163027A (en) 2009-07-20
CA2474510A1 (en) 2003-09-04
MA27111A1 (fr) 2004-12-20
KR20040096600A (ko) 2004-11-16
US7351735B2 (en) 2008-04-01
JP2010229152A (ja) 2010-10-14
MXPA04007031A (es) 2004-10-11
EP1487813B1 (de) 2006-08-30
ATE338036T1 (de) 2006-09-15
PL372179A1 (en) 2005-07-11
KR20040094720A (ko) 2004-11-10
HK1080467A1 (en) 2006-04-28
CN1639145A (zh) 2005-07-13
PL373373A1 (en) 2005-08-22
JP5153830B2 (ja) 2013-02-27
AU2003215380A1 (en) 2003-09-09
CA2474511C (en) 2008-07-22
HUP0600156A2 (en) 2006-06-28
RU2350609C2 (ru) 2009-03-27
JP2005518446A (ja) 2005-06-23
BR0307905A (pt) 2006-04-04
CA2474511A1 (en) 2003-09-04
CN1319961C (zh) 2007-06-06
CN1639146A (zh) 2005-07-13
US20050139814A1 (en) 2005-06-30
AU2003215380B2 (en) 2008-10-02
NO20043952L (no) 2004-10-22

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