DE60237993D1 - Derivate von isoindigo, indigo und indirubin und deren verwendung bei der behandlung von krebs - Google Patents
Derivate von isoindigo, indigo und indirubin und deren verwendung bei der behandlung von krebsInfo
- Publication number
- DE60237993D1 DE60237993D1 DE60237993T DE60237993T DE60237993D1 DE 60237993 D1 DE60237993 D1 DE 60237993D1 DE 60237993 T DE60237993 T DE 60237993T DE 60237993 T DE60237993 T DE 60237993T DE 60237993 D1 DE60237993 D1 DE 60237993D1
- Authority
- DE
- Germany
- Prior art keywords
- derivatives
- compound
- isoindigo
- indigo
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/021,589 US6566341B1 (en) | 2001-12-13 | 2001-12-13 | Derivative of isoindigo, indigo and indirubin for the treatment of cancer |
US40726702P | 2002-09-03 | 2002-09-03 | |
PCT/US2002/039866 WO2003051900A1 (en) | 2001-12-13 | 2002-12-13 | Derivatives of isoindigo, indigo and indirubin and use in treating cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60237993D1 true DE60237993D1 (de) | 2010-11-25 |
Family
ID=26694875
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60237993T Expired - Lifetime DE60237993D1 (de) | 2001-12-13 | 2002-12-13 | Derivate von isoindigo, indigo und indirubin und deren verwendung bei der behandlung von krebs |
Country Status (8)
Country | Link |
---|---|
US (1) | US6933315B2 (de) |
EP (1) | EP1458734B1 (de) |
JP (1) | JP2005516938A (de) |
AT (1) | ATE484514T1 (de) |
AU (1) | AU2002357191A1 (de) |
CA (1) | CA2469649C (de) |
DE (1) | DE60237993D1 (de) |
WO (1) | WO2003051900A1 (de) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7582670B2 (en) | 2001-12-13 | 2009-09-01 | Natrogen Therapeutics, Inc. | Methods of treating an inflammatory-related disease |
US8748475B2 (en) | 2004-01-12 | 2014-06-10 | Natrogen Therapeutics International, Inc. | Methods and compositions for treating lupus |
US20100098702A1 (en) * | 2008-09-16 | 2010-04-22 | Longgui Wang | Method of treating androgen independent prostate cancer |
US8563525B2 (en) | 2004-01-12 | 2013-10-22 | Natrogen Therapeutics International, Inc. | Methods of treating an inflammatory-related disease |
US20050154046A1 (en) * | 2004-01-12 | 2005-07-14 | Longgui Wang | Methods of treating an inflammatory-related disease |
CN101074229B (zh) * | 2007-06-08 | 2010-09-01 | 无锡杰西医药科技有限公司 | 7-氮杂靛玉红和7-氮杂异靛蓝衍生物制备及其药学用途 |
CN101426268B (zh) * | 2007-11-02 | 2010-08-25 | 大唐移动通信设备有限公司 | 导频资源分配方法、系统和设备 |
US8563595B2 (en) * | 2008-11-14 | 2013-10-22 | Board Of Regents, The University Of Texas System | Treatment of cancer with complex organic-inorganic pigment compositions |
US20150087687A1 (en) * | 2012-03-23 | 2015-03-26 | Dennis Brown | Compositions and methods to improve the therapeutic benefit of indirubin and analogs thereof, including meisoindigo |
WO2013192493A1 (en) * | 2012-06-21 | 2013-12-27 | Phosphorex, Inc. | Nanoparticles of indirubin, derivatives thereof and methods of making and using same |
CN103333161B (zh) * | 2013-05-28 | 2015-09-30 | 滁州市洛达生物科技有限公司 | 1’-氧代靛玉红的制备和用途 |
FI3632443T3 (fi) * | 2017-05-26 | 2023-08-23 | Taiho Pharmaceutical Co Ltd | Kasvainkasvua ehkäisevän vaikutuksen tehostaja, jossa käytetään bifenyyliyhdistettä |
MX2019014104A (es) | 2017-05-26 | 2020-02-07 | Taiho Pharmaceutical Co Ltd | Compuesto novedoso de bifenilo o sal del mismo. |
EP3891141A4 (de) * | 2018-12-07 | 2022-10-12 | Natrogen Therapeutics International, Inc. | Polymorphe form von mesoindigo und modifizierte formulierung von mesoindigo |
US11345818B1 (en) | 2020-12-29 | 2022-05-31 | Industrial Technology Research Institute | Dye for fiber and dyeing method |
WO2022232243A1 (en) * | 2021-04-27 | 2022-11-03 | Curapep Llc | Compositions for wound relief and inhibiting a phd protein and methods of treatment |
CN114920728B (zh) * | 2022-05-27 | 2023-10-20 | 中南大学 | 一种甲异靛衍生物及其制备方法与应用 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS617254A (ja) * | 1984-06-20 | 1986-01-13 | Isukura Sangyo Kk | ビスインドリノンおよびそれを主成分とする制癌剤 |
US5696092A (en) | 1995-03-07 | 1997-12-09 | George Washington University | Methods and compositions for inhibiting metastasis of epithelial cell-derived cancers |
ES2194468T3 (es) * | 1998-05-29 | 2003-11-16 | Centre Nat Rech Scient | Uso de derivados del bisindol indigoide para la fabricacion de un medicamento para inhibir quinasas dependientes de ciclinas. |
US6664285B1 (en) * | 1999-04-12 | 2003-12-16 | Gerhard Eisenbrand | Use of cell membrane penetrating indigoid bisindole derivatives |
HUP0200724A3 (en) * | 1999-04-12 | 2002-10-28 | Eisenbrand Gerhard | Indigoid bisindole derivatives and pharmaceurical compositions containing them |
-
2002
- 2002-12-13 DE DE60237993T patent/DE60237993D1/de not_active Expired - Lifetime
- 2002-12-13 AT AT02805123T patent/ATE484514T1/de not_active IP Right Cessation
- 2002-12-13 EP EP02805123A patent/EP1458734B1/de not_active Expired - Lifetime
- 2002-12-13 AU AU2002357191A patent/AU2002357191A1/en not_active Abandoned
- 2002-12-13 JP JP2003552781A patent/JP2005516938A/ja active Pending
- 2002-12-13 WO PCT/US2002/039866 patent/WO2003051900A1/en active Search and Examination
- 2002-12-13 CA CA2469649A patent/CA2469649C/en not_active Expired - Lifetime
-
2004
- 2004-06-10 US US10/864,458 patent/US6933315B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US6933315B2 (en) | 2005-08-23 |
AU2002357191A1 (en) | 2003-06-30 |
EP1458734B1 (de) | 2010-10-13 |
US20040225002A1 (en) | 2004-11-11 |
CA2469649C (en) | 2011-05-03 |
WO2003051900A1 (en) | 2003-06-26 |
EP1458734A1 (de) | 2004-09-22 |
EP1458734A4 (de) | 2007-12-19 |
CA2469649A1 (en) | 2003-06-26 |
JP2005516938A (ja) | 2005-06-09 |
ATE484514T1 (de) | 2010-10-15 |
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