ATE484514T1 - Derivate von isoindigo, indigo und indirubin und deren verwendung bei der behandlung von krebs - Google Patents
Derivate von isoindigo, indigo und indirubin und deren verwendung bei der behandlung von krebsInfo
- Publication number
- ATE484514T1 ATE484514T1 AT02805123T AT02805123T ATE484514T1 AT E484514 T1 ATE484514 T1 AT E484514T1 AT 02805123 T AT02805123 T AT 02805123T AT 02805123 T AT02805123 T AT 02805123T AT E484514 T1 ATE484514 T1 AT E484514T1
- Authority
- AT
- Austria
- Prior art keywords
- derivatives
- compound
- isoindigo
- indigo
- cancer
- Prior art date
Links
- MLCPSWPIYHDOKG-BUHFOSPRSA-N (3e)-3-(2-oxo-1h-indol-3-ylidene)-1h-indol-2-one Chemical class O=C\1NC2=CC=CC=C2C/1=C1/C2=CC=CC=C2NC1=O MLCPSWPIYHDOKG-BUHFOSPRSA-N 0.000 title abstract 4
- 206010028980 Neoplasm Diseases 0.000 title abstract 4
- 201000011510 cancer Diseases 0.000 title abstract 3
- 235000000177 Indigofera tinctoria Nutrition 0.000 title abstract 2
- CRDNMYFJWFXOCH-YPKPFQOOSA-N Indirubin Natural products N/1C2=CC=CC=C2C(=O)C\1=C1/C2=CC=CC=C2NC1=O CRDNMYFJWFXOCH-YPKPFQOOSA-N 0.000 title abstract 2
- 229940097275 indigo Drugs 0.000 title abstract 2
- COHYTHOBJLSHDF-UHFFFAOYSA-N indigo powder Natural products N1C2=CC=CC=C2C(=O)C1=C1C(=O)C2=CC=CC=C2N1 COHYTHOBJLSHDF-UHFFFAOYSA-N 0.000 title abstract 2
- CRDNMYFJWFXOCH-BUHFOSPRSA-N Couroupitine B Natural products N\1C2=CC=CC=C2C(=O)C/1=C1/C2=CC=CC=C2NC1=O CRDNMYFJWFXOCH-BUHFOSPRSA-N 0.000 title 1
- JNLNPCNGMHKCKO-UHFFFAOYSA-N chembl35349 Chemical compound C1=CC=C2C(=O)C(C=3C4=CC=CC=C4NC=3O)=NC2=C1 JNLNPCNGMHKCKO-UHFFFAOYSA-N 0.000 title 1
- CRDNMYFJWFXOCH-UHFFFAOYSA-N isoindigotin Natural products N1C2=CC=CC=C2C(=O)C1=C1C2=CC=CC=C2NC1=O CRDNMYFJWFXOCH-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 239000008194 pharmaceutical composition Substances 0.000 abstract 3
- 230000009286 beneficial effect Effects 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 230000002194 synthesizing effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/021,589 US6566341B1 (en) | 2001-12-13 | 2001-12-13 | Derivative of isoindigo, indigo and indirubin for the treatment of cancer |
| US40726702P | 2002-09-03 | 2002-09-03 | |
| PCT/US2002/039866 WO2003051900A1 (en) | 2001-12-13 | 2002-12-13 | Derivatives of isoindigo, indigo and indirubin and use in treating cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE484514T1 true ATE484514T1 (de) | 2010-10-15 |
Family
ID=26694875
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02805123T ATE484514T1 (de) | 2001-12-13 | 2002-12-13 | Derivate von isoindigo, indigo und indirubin und deren verwendung bei der behandlung von krebs |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6933315B2 (de) |
| EP (1) | EP1458734B1 (de) |
| JP (1) | JP2005516938A (de) |
| AT (1) | ATE484514T1 (de) |
| AU (1) | AU2002357191A1 (de) |
| CA (1) | CA2469649C (de) |
| DE (1) | DE60237993D1 (de) |
| WO (1) | WO2003051900A1 (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100098702A1 (en) * | 2008-09-16 | 2010-04-22 | Longgui Wang | Method of treating androgen independent prostate cancer |
| US8748475B2 (en) | 2004-01-12 | 2014-06-10 | Natrogen Therapeutics International, Inc. | Methods and compositions for treating lupus |
| US7582670B2 (en) | 2001-12-13 | 2009-09-01 | Natrogen Therapeutics, Inc. | Methods of treating an inflammatory-related disease |
| US8563525B2 (en) | 2004-01-12 | 2013-10-22 | Natrogen Therapeutics International, Inc. | Methods of treating an inflammatory-related disease |
| US20050154046A1 (en) * | 2004-01-12 | 2005-07-14 | Longgui Wang | Methods of treating an inflammatory-related disease |
| CN101074229B (zh) * | 2007-06-08 | 2010-09-01 | 无锡杰西医药科技有限公司 | 7-氮杂靛玉红和7-氮杂异靛蓝衍生物制备及其药学用途 |
| CN101426268B (zh) * | 2007-11-02 | 2010-08-25 | 大唐移动通信设备有限公司 | 导频资源分配方法、系统和设备 |
| US8563595B2 (en) * | 2008-11-14 | 2013-10-22 | Board Of Regents, The University Of Texas System | Treatment of cancer with complex organic-inorganic pigment compositions |
| WO2013142817A2 (en) * | 2012-03-23 | 2013-09-26 | Dennis Brown | Compositions and methods to improve the therapeutic benefit of indirubin and analogs thereof, including meisoindigo |
| EP3597178A1 (de) | 2012-06-21 | 2020-01-22 | Phosphorex Inc. | Nanopartikel aus indirubin, derivate davon sowie verfahren zur herstellung und verwendung davon |
| CN103333161B (zh) * | 2013-05-28 | 2015-09-30 | 滁州市洛达生物科技有限公司 | 1’-氧代靛玉红的制备和用途 |
| RU2765152C2 (ru) | 2017-05-26 | 2022-01-26 | Тайхо Фармасьютикал Ко., Лтд. | Новое соединение бифенила или его соль |
| TWI770925B (zh) * | 2017-05-26 | 2022-07-11 | 日商大鵬藥品工業股份有限公司 | 使用有新穎聯苯化合物之抗腫瘤效果增強劑 |
| JP6915056B2 (ja) | 2017-05-31 | 2021-08-04 | 大鵬薬品工業株式会社 | Ｉｎｓｍ１の発現に基づくｌｓｄ１阻害剤の治療効果の予測方法 |
| CN118515598A (zh) * | 2018-12-07 | 2024-08-20 | 斯塔蒂亚生物制药有限公司 | 甲异靛的多晶型和甲异靛的改进制剂 |
| EP4058018A4 (de) | 2019-11-13 | 2023-06-21 | Taiho Pharmaceutical Co., Ltd. | Verfahren zum behandeln von lsd1-verwandten krankheiten und störungen mit lsd1-inhibitoren |
| US11345818B1 (en) | 2020-12-29 | 2022-05-31 | Industrial Technology Research Institute | Dye for fiber and dyeing method |
| WO2022232243A1 (en) * | 2021-04-27 | 2022-11-03 | Curapep Llc | Compositions for wound relief and inhibiting a phd protein and methods of treatment |
| CN114920728B (zh) * | 2022-05-27 | 2023-10-20 | 中南大学 | 一种甲异靛衍生物及其制备方法与应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS617254A (ja) * | 1984-06-20 | 1986-01-13 | Isukura Sangyo Kk | ビスインドリノンおよびそれを主成分とする制癌剤 |
| US5696092A (en) | 1995-03-07 | 1997-12-09 | George Washington University | Methods and compositions for inhibiting metastasis of epithelial cell-derived cancers |
| CA2333661A1 (en) * | 1998-05-29 | 1999-12-09 | Cnrs (Centre National De Recherche Scientifique) France Innovation Scien Tifique Et Transfernt | Use of indigoid bisindole derivatives for the manufacture of a medicament to inhibit cyclin dependent kinases |
| JP2002541244A (ja) * | 1999-04-12 | 2002-12-03 | ゲルハルト アイゼンブランド | インジゴイドビスインドール誘導体 |
| WO2000061124A2 (en) * | 1999-04-12 | 2000-10-19 | Gerhard Eisenbrand | Use off cell membrane penetrating indigoid bisindole derivatives |
-
2002
- 2002-12-13 CA CA2469649A patent/CA2469649C/en not_active Expired - Lifetime
- 2002-12-13 AT AT02805123T patent/ATE484514T1/de not_active IP Right Cessation
- 2002-12-13 JP JP2003552781A patent/JP2005516938A/ja active Pending
- 2002-12-13 WO PCT/US2002/039866 patent/WO2003051900A1/en not_active Ceased
- 2002-12-13 EP EP02805123A patent/EP1458734B1/de not_active Expired - Lifetime
- 2002-12-13 DE DE60237993T patent/DE60237993D1/de not_active Expired - Lifetime
- 2002-12-13 AU AU2002357191A patent/AU2002357191A1/en not_active Abandoned
-
2004
- 2004-06-10 US US10/864,458 patent/US6933315B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1458734A1 (de) | 2004-09-22 |
| CA2469649C (en) | 2011-05-03 |
| WO2003051900A1 (en) | 2003-06-26 |
| EP1458734A4 (de) | 2007-12-19 |
| JP2005516938A (ja) | 2005-06-09 |
| US20040225002A1 (en) | 2004-11-11 |
| CA2469649A1 (en) | 2003-06-26 |
| DE60237993D1 (de) | 2010-11-25 |
| AU2002357191A1 (en) | 2003-06-30 |
| US6933315B2 (en) | 2005-08-23 |
| EP1458734B1 (de) | 2010-10-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |