DE60237520D1 - Glycoprotein sowie verfahren zu dessen herstellung - Google Patents

Glycoprotein sowie verfahren zu dessen herstellung

Info

Publication number
DE60237520D1
DE60237520D1 DE60237520T DE60237520T DE60237520D1 DE 60237520 D1 DE60237520 D1 DE 60237520D1 DE 60237520 T DE60237520 T DE 60237520T DE 60237520 T DE60237520 T DE 60237520T DE 60237520 D1 DE60237520 D1 DE 60237520D1
Authority
DE
Germany
Prior art keywords
mannose
phosphate
glycoproteins
reducing terminal
yeast
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60237520T
Other languages
English (en)
Inventor
Yasunori Chiba
Yoshifumi Jigami
Hitoshi Sakuraba
Kazuo Kobayashi
Makoto Takeuchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National Institute of Advanced Industrial Science and Technology AIST
Tokyo Metropolitan Organization for Medical Research
Original Assignee
National Institute of Advanced Industrial Science and Technology AIST
Tokyo Metropolitan Organization for Medical Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National Institute of Advanced Industrial Science and Technology AIST, Tokyo Metropolitan Organization for Medical Research filed Critical National Institute of Advanced Industrial Science and Technology AIST
Application granted granted Critical
Publication of DE60237520D1 publication Critical patent/DE60237520D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/062—Ascomycota
    • A61K36/064—Saccharomycetales, e.g. baker's yeast
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medical Informatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Botany (AREA)
  • Biomedical Technology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
DE60237520T 2001-06-14 2002-06-14 Glycoprotein sowie verfahren zu dessen herstellung Expired - Lifetime DE60237520D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001180907A JP4742191B2 (ja) 2001-06-14 2001-06-14 糖蛋白質およびその製造方法
PCT/JP2002/005965 WO2002103027A1 (fr) 2001-06-14 2002-06-14 Glycoprotéine et procédé de production

Publications (1)

Publication Number Publication Date
DE60237520D1 true DE60237520D1 (de) 2010-10-14

Family

ID=19021250

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60237520T Expired - Lifetime DE60237520D1 (de) 2001-06-14 2002-06-14 Glycoprotein sowie verfahren zu dessen herstellung

Country Status (8)

Country Link
US (1) US7579166B2 (de)
EP (1) EP1408117B1 (de)
JP (1) JP4742191B2 (de)
KR (1) KR100888316B1 (de)
CN (1) CN1298862C (de)
AT (1) ATE479769T1 (de)
DE (1) DE60237520D1 (de)
WO (1) WO2002103027A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7449308B2 (en) * 2000-06-28 2008-11-11 Glycofi, Inc. Combinatorial DNA library for producing modified N-glycans in lower eukaryotes
JP4931332B2 (ja) * 2004-03-31 2012-05-16 株式会社日立ハイテクノロジーズ 糖の除去方法
CN101313216A (zh) * 2005-09-22 2008-11-26 普洛茨股份有限公司 酵母突变体中产生的糖基化多肽及其使用方法
KR100757544B1 (ko) * 2005-11-08 2007-09-10 엘지전자 주식회사 플라즈마 디스플레이 패널의 화상처리 장치 및 화상처리방법
WO2007058381A1 (ja) 2005-11-18 2007-05-24 Tokyo Metropolitan Organization For Medical Research 基質特異性を変換した新規高機能酵素
SG177941A1 (en) 2007-04-03 2012-02-28 Oxyrane Uk Ltd Glycosylation of molecules
EP2166093B1 (de) 2007-05-18 2015-09-16 Tokyo Metropolitan Institute of Medical Science Pharmazeutische zusammensetzungen für die enzymersatztherapie
CA2775938C (en) * 2009-09-29 2021-08-10 Oxyrane Uk Limited Hydrolysis of mannose-1-phospho-6-mannose linkage to phospho-6-mannose
CN102834509A (zh) 2009-11-19 2012-12-19 奥克西雷恩英国有限公司 生成哺乳动物样复合n-聚糖的酵母菌株
US8974780B2 (en) 2010-02-24 2015-03-10 Zymenex A/S Process for production and purification of recombinant lysosomal alpha-mannosidase
BR112013007263A2 (pt) * 2010-09-29 2016-06-14 Oxyrane Uk Ltd desmanosilação de n-glicanos fosforilados
US9347050B2 (en) 2010-09-29 2016-05-24 Oxyrane Uk Limited Mannosidases capable of uncapping mannose-1-phospho-6-mannose linkages and demannosylating phosphorylated N-glycans and methods of facilitating mammalian cellular uptake of glycoproteins
US20130337482A1 (en) * 2010-10-29 2013-12-19 Shire Human Genetic Therapies, Inc. Assays and kits to determine galactocerebrosidase activity on solid support
BR112013026976A2 (pt) * 2011-04-22 2019-09-24 Genzyme Corp alfa glucosidade ácida modificada com processamento acelerado
JP5665065B2 (ja) * 2011-04-28 2015-02-04 国立大学法人大阪大学 リソソーム病治療用医薬組成物
JP5959114B2 (ja) * 2011-05-19 2016-08-02 学校法人 明治薬科大学 リン酸化糖鎖を含有する組換えヒトサポシンｂタンパク質及びその用途
US9249399B2 (en) 2012-03-15 2016-02-02 Oxyrane Uk Limited Methods and materials for treatment of pompe's disease
JP6230158B2 (ja) 2012-10-19 2017-11-15 国立大学法人徳島大学 ヒトβ−ヘキソサミニダーゼＢの基質特異性を変換し、且つ、プロテアーゼ抵抗性を付与した新規高機能酵素
JP6169552B2 (ja) * 2013-10-01 2017-07-26 Ｊｃｒファーマ株式会社 ２−アミノピリジンによる糖鎖の標識法
KR101750888B1 (ko) * 2014-09-23 2017-06-26 한국생명공학연구원 YlMpo1 과발현을 이용한 만노스인산화 증대 방법
GB201508025D0 (en) 2015-05-11 2015-06-24 Ucl Business Plc Fabry disease gene therapy
WO2016195394A1 (ko) * 2015-06-02 2016-12-08 한국생명공학연구원 효모 세포벽 만노단백질 유래의 당사슬을 이용한 만노스-6-인산 당사슬이 부가된 당단백질의 제조방법
WO2017170896A1 (ja) * 2016-03-30 2017-10-05 国立大学法人徳島大学 マンノース－６－リン酸基含有糖蛋白質の製造方法、及び蛍光基結合型マンノース－６－リン酸基含有糖蛋白質の細胞内分布を検出する方法
CN108795871B (zh) * 2017-04-28 2021-12-03 江南大学 用于生产糖蛋白的动物细胞株及方法、糖蛋白及其用途
JP7134444B2 (ja) 2018-01-26 2022-09-12 国立大学法人徳島大学 テイ－サックス病及びザンドホッフ病治療用の新規アデノ随伴ウイルスビリオン

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5401650A (en) * 1990-10-24 1995-03-28 The Mount Sinai School Of Medicine Of The City University Of New York Cloning and expression of biologically active α-galactosidase A
JP3091851B2 (ja) * 1992-11-06 2000-09-25 工業技術院長 哺乳類の高マンノース型糖蛋白質糖鎖の酵母による製造法
JP2767401B2 (ja) 1995-11-17 1998-06-18 工業技術院長 酵母のマンノース−１−リン酸転移酵素遺伝子およびこれを利用するマンノース−１−リン酸含有酸性糖鎖の製造方法
JP2826636B2 (ja) * 1997-10-30 1998-11-18 工業技術院長 酵母のマンノース−１−リン酸転移酵素遺伝子を利用するリン酸含有酸性糖鎖の製造方法
WO2001014522A1 (fr) * 1999-08-19 2001-03-01 Kirin Beer Kabushiki Kaisha Nouvelles variantes de levure et procede de production de glycoproteine
US6642038B1 (en) * 1999-09-14 2003-11-04 Genzyme Glycobiology Research Institute, Inc. GlcNAc phosphotransferase of the lysosomal targeting pathway

Also Published As

Publication number Publication date
CN1298862C (zh) 2007-02-07
KR20040026663A (ko) 2004-03-31
JP4742191B2 (ja) 2011-08-10
EP1408117A1 (de) 2004-04-14
JP2002369692A (ja) 2002-12-24
US7579166B2 (en) 2009-08-25
CN1541275A (zh) 2004-10-27
EP1408117A4 (de) 2005-01-26
WO2002103027A1 (fr) 2002-12-27
US20050064539A1 (en) 2005-03-24
KR100888316B1 (ko) 2009-03-11
ATE479769T1 (de) 2010-09-15
EP1408117B1 (de) 2010-09-01

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Legal Events

Date Code Title Description
8381 Inventor (new situation)

Inventor name: CHIBA, YASUNORI C/O TSUKUBA CENTER, CHIYODA-KU, JP

Inventor name: JIGAMI, YOSHIFUMI, C/O TSUKUBA CENTER, CHIYODA, JP

Inventor name: SAKURABA, HITOSHI, CHIBA, 270-1164, JP

Inventor name: KOBAYASHI, KAZUO, C/O BIO PROCESS R&D LAB., TA, JP

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