ATE479769T1 - Glycoprotein sowie verfahren zu dessen herstellung - Google Patents

Glycoprotein sowie verfahren zu dessen herstellung

Info

Publication number
ATE479769T1
ATE479769T1 AT02736110T AT02736110T ATE479769T1 AT E479769 T1 ATE479769 T1 AT E479769T1 AT 02736110 T AT02736110 T AT 02736110T AT 02736110 T AT02736110 T AT 02736110T AT E479769 T1 ATE479769 T1 AT E479769T1
Authority
AT
Austria
Prior art keywords
mannose
phosphate
glycoproteins
reducing terminal
yeast
Prior art date
Application number
AT02736110T
Other languages
English (en)
Inventor
Yasunori Chiba
Yoshifumi Jigami
Hitoshi Sakuraba
Kazuo Kobayashi
Makoto Takeuchi
Original Assignee
Nat Inst Of Advanced Ind Scien
Tokyo Metropolitan Org Med Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nat Inst Of Advanced Ind Scien, Tokyo Metropolitan Org Med Res filed Critical Nat Inst Of Advanced Ind Scien
Application granted granted Critical
Publication of ATE479769T1 publication Critical patent/ATE479769T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/062—Ascomycota
    • A61K36/064—Saccharomycetales, e.g. baker's yeast
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Biomedical Technology (AREA)
  • Botany (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medical Informatics (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
AT02736110T 2001-06-14 2002-06-14 Glycoprotein sowie verfahren zu dessen herstellung ATE479769T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001180907A JP4742191B2 (ja) 2001-06-14 2001-06-14 糖蛋白質およびその製造方法
PCT/JP2002/005965 WO2002103027A1 (en) 2001-06-14 2002-06-14 Glycoprotein and process for producing the same

Publications (1)

Publication Number Publication Date
ATE479769T1 true ATE479769T1 (de) 2010-09-15

Family

ID=19021250

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02736110T ATE479769T1 (de) 2001-06-14 2002-06-14 Glycoprotein sowie verfahren zu dessen herstellung

Country Status (8)

Country Link
US (1) US7579166B2 (de)
EP (1) EP1408117B1 (de)
JP (1) JP4742191B2 (de)
KR (1) KR100888316B1 (de)
CN (1) CN1298862C (de)
AT (1) ATE479769T1 (de)
DE (1) DE60237520D1 (de)
WO (1) WO2002103027A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7449308B2 (en) * 2000-06-28 2008-11-11 Glycofi, Inc. Combinatorial DNA library for producing modified N-glycans in lower eukaryotes
JP4931332B2 (ja) * 2004-03-31 2012-05-16 株式会社日立ハイテクノロジーズ 糖の除去方法
CA2623197A1 (en) * 2005-09-22 2007-03-29 Prosci Incorporated Glycosylated polypeptides produced in yeast mutants and methods of use thereof
KR100757544B1 (ko) * 2005-11-08 2007-09-10 엘지전자 주식회사 플라즈마 디스플레이 패널의 화상처리 장치 및 화상처리방법
BRPI0618583A2 (pt) 2005-11-18 2011-09-06 Tokyo Metropolitan Org Med Res enzima altamente funcional tendo especifidade ao substrato modificada
WO2008120107A2 (en) 2007-04-03 2008-10-09 Oxyrane (Uk) Limited Glycosylation of molecules
EP2166093B1 (de) 2007-05-18 2015-09-16 Tokyo Metropolitan Institute of Medical Science Pharmazeutische zusammensetzungen für die enzymersatztherapie
US9598682B2 (en) 2009-09-29 2017-03-21 Vib Vzw Hydrolysis of mannose-1-phospho-6-mannose linkage to phospho-6-mannose
US20130053550A1 (en) 2009-11-19 2013-02-28 Oxyrane Uk Limited Yeast strains producing mammalian-like complex n-glycans
DK2538968T3 (en) * 2010-02-24 2017-12-11 Chiesi Farm Spa PROCEDURE FOR THE PREPARATION AND PURIFICATION OF RECOMBINANT LYSOSOMAL ALFA MANNOSIDASE
US9347050B2 (en) 2010-09-29 2016-05-24 Oxyrane Uk Limited Mannosidases capable of uncapping mannose-1-phospho-6-mannose linkages and demannosylating phosphorylated N-glycans and methods of facilitating mammalian cellular uptake of glycoproteins
WO2012042387A2 (en) 2010-09-29 2012-04-05 Oxyrane Uk Limited De-mannosylation of phosphorylated n-glycans
WO2012058625A2 (en) * 2010-10-29 2012-05-03 Shire Human Genetic Therapies, Inc. Assays and kits to determine galactocerebrosidase activity on solid support
MX2013012345A (es) * 2011-04-22 2015-05-07 Genzyme Corp Alfa glucosidasa acida modificada con procesamiento acelerado.
JP5665065B2 (ja) * 2011-04-28 2015-02-04 国立大学法人大阪大学 リソソーム病治療用医薬組成物
JP5959114B2 (ja) * 2011-05-19 2016-08-02 学校法人 明治薬科大学 リン酸化糖鎖を含有する組換えヒトサポシンｂタンパク質及びその用途
EP3628326B1 (de) 2012-03-15 2024-02-28 Oxyrane UK Limited Verfahren und materialien zur behandlung von morbus pompe
RU2015118580A (ru) 2012-10-19 2016-12-10 Токусима Юниверсити НОВЫЙ ВЫСОКО ФУНКЦИОНАЛЬНЫЙ ФЕРМЕНТ, ИМЕЮЩИЙ МОДИФИЦИРОВАННУЮ СУБСТРАТНУЮ СПЕЦИФИЧНОСТЬ β-ГЕКСОЗАМИНИДАЗЫ ЧЕЛОВЕКА И ПРОЯВЛЯЮЩИЙ УСТОЙЧИВОСТЬ К ПРОТЕАЗЕ
JP6169552B2 (ja) * 2013-10-01 2017-07-26 Ｊｃｒファーマ株式会社 ２−アミノピリジンによる糖鎖の標識法
KR101750888B1 (ko) 2014-09-23 2017-06-26 한국생명공학연구원 YlMpo1 과발현을 이용한 만노스인산화 증대 방법
GB201508025D0 (en) 2015-05-11 2015-06-24 Ucl Business Plc Fabry disease gene therapy
KR101847536B1 (ko) * 2015-06-02 2018-04-11 한국생명공학연구원 효모 세포벽 만노단백질 유래의 당사슬을 이용한 만노스-6-인산 당사슬이 부가된 당단백질의 제조방법
JP6996676B2 (ja) * 2016-03-30 2022-02-04 国立研究開発法人農業・食品産業技術総合研究機構 マンノース－６－リン酸基含有糖蛋白質の製造方法、及び蛍光基結合型マンノース－６－リン酸基含有糖蛋白質の細胞内分布を検出する方法
CN108795871B (zh) * 2017-04-28 2021-12-03 江南大学 用于生产糖蛋白的动物细胞株及方法、糖蛋白及其用途
JP7134444B2 (ja) 2018-01-26 2022-09-12 国立大学法人徳島大学 テイ－サックス病及びザンドホッフ病治療用の新規アデノ随伴ウイルスビリオン

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5401650A (en) * 1990-10-24 1995-03-28 The Mount Sinai School Of Medicine Of The City University Of New York Cloning and expression of biologically active α-galactosidase A
JP3091851B2 (ja) * 1992-11-06 2000-09-25 工業技術院長 哺乳類の高マンノース型糖蛋白質糖鎖の酵母による製造法
JP2767401B2 (ja) 1995-11-17 1998-06-18 工業技術院長 酵母のマンノース−１−リン酸転移酵素遺伝子およびこれを利用するマンノース−１−リン酸含有酸性糖鎖の製造方法
JP2826636B2 (ja) * 1997-10-30 1998-11-18 工業技術院長 酵母のマンノース−１−リン酸転移酵素遺伝子を利用するリン酸含有酸性糖鎖の製造方法
CA2382184A1 (en) * 1999-08-19 2001-03-01 Kirin Beer Kabushiki Kaisha Novel yeast mutants and process for producing glycoprotein containing mammalian type sugar chain
US6537785B1 (en) * 1999-09-14 2003-03-25 Genzyme Glycobiology Research Institute, Inc. Methods of treating lysosomal storage diseases

Also Published As

Publication number Publication date
EP1408117A4 (de) 2005-01-26
JP2002369692A (ja) 2002-12-24
WO2002103027A1 (en) 2002-12-27
CN1541275A (zh) 2004-10-27
KR100888316B1 (ko) 2009-03-11
EP1408117B1 (de) 2010-09-01
EP1408117A1 (de) 2004-04-14
CN1298862C (zh) 2007-02-07
US20050064539A1 (en) 2005-03-24
KR20040026663A (ko) 2004-03-31
DE60237520D1 (de) 2010-10-14
JP4742191B2 (ja) 2011-08-10
US7579166B2 (en) 2009-08-25

Similar Documents

Publication Publication Date Title
ATE479769T1 (de) Glycoprotein sowie verfahren zu dessen herstellung
DE59410052D1 (de) Verwendung von nona- und dekapeptiden zur herstellung eines arzneimittels zur bekämpfung von aids
TW239144B (de)
ATE276769T1 (de) Verwendung eines acrylsäure-typ polymeres als desintegrationsmittel, vefahren zur herstellung von tabletten und hergestellte tabletten
MXPA04010311A (es) Composicion farmaceutica.
ATE221086T1 (de) Photovernetztes hyaluronsäuregel und verfahren zu dessen herstellung
ATE315050T2 (de) Verfahren zur herstellung von mehrfach vernetzten hyaluronsäurederivaten
EP1281722A4 (de) Hyaluronsäuregel, verfahren zu dessen herstellung sowie das gel enthaltendes medizinisches material
ATE278799T1 (de) Galactomannan-oligosaccharide und verfahren zu deren herstellung sowie deren verwendung
ATE151764T1 (de) Neue benzopyran-derivate, verfahren zu ihrer herstellung und ihre verwendung sowie die verbindungen enthaltenden zubereitungen
DE69429078D1 (de) Pharmacologisch wirksame pyridinderivate und verfahren zu deren herstellung
GEP20012414B (en) Semicarbazones Having CNS Activity and Pharmaceutical Preparations Containing the Same
ATE541583T1 (de) Enzym-enthaltendes präparat, verfahren zur herstellung und verwendung
DE50014164D1 (de) Verfahren zur herstellung einer wasserunlöslichen amorphen retardmatrix
ATE236191T1 (de) Substituierte phenyl-alkenoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikamente oder diagnostika sowie sie enthaltende medikamente
WO2005051331A3 (en) Chaperone-based therapy for niemann-pick disease
DK0520427T3 (da) Cyclopropenonderivater
DE69433012D1 (de) Verfahren zur herstellung von oralen dosierungsformulierungen enthaltend diclofenac
ATE309981T1 (de) Gallensäure-substituierte phenyl- alkenoylguanidine, verfahren zu ihrer herstellung,ihre verwendung als medikamente oder diagnostika sowie sie enthaltende medikamente
DE50301507D1 (de) 17a-FLUORALKYL-11BETA-BENZALDOXIM-STEROIDE, VERFAHREN ZU DEREN HERSTELLUNG, DIESE STEROIDE ENTHALTENDE PHARMAZEUTISCHE PRÄPARATE SOWIE DEREN VERWENDUNG ZUR HERSTELLUNG VON ARZNEIMITTELN
ATE208841T1 (de) Verfahren zur herstellung von cellulosischen formkörpern sowie cellulosische formkörper
ATE245974T1 (de) Pharmazeutische zusammensetzungen, bestimmt zur oralen verabreichung von phloroglucinol sowie deren herstellung
DE50301697D1 (de) Verfahren zur herstellung von polyetheralkoholen
WO1998011919A3 (en) Polyethyleneglycol conjugated nanoerythrosomes, method of making same and use thereof
ATE341630T1 (de) Verwendung von pankreatischer procarboxypeptidase b zur herstellung von insulin

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties