ATE479769T1 - Glycoprotein sowie verfahren zu dessen herstellung - Google Patents
Glycoprotein sowie verfahren zu dessen herstellungInfo
- Publication number
- ATE479769T1 ATE479769T1 AT02736110T AT02736110T ATE479769T1 AT E479769 T1 ATE479769 T1 AT E479769T1 AT 02736110 T AT02736110 T AT 02736110T AT 02736110 T AT02736110 T AT 02736110T AT E479769 T1 ATE479769 T1 AT E479769T1
- Authority
- AT
- Austria
- Prior art keywords
- mannose
- phosphate
- glycoproteins
- reducing terminal
- yeast
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
- A61K36/064—Saccharomycetales, e.g. baker's yeast
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Wood Science & Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Mycology (AREA)
- Cardiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Medical Informatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Heart & Thoracic Surgery (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2001180907A JP4742191B2 (ja) | 2001-06-14 | 2001-06-14 | 糖蛋白質およびその製造方法 |
PCT/JP2002/005965 WO2002103027A1 (fr) | 2001-06-14 | 2002-06-14 | Glycoprotéine et procédé de production |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE479769T1 true ATE479769T1 (de) | 2010-09-15 |
Family
ID=19021250
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02736110T ATE479769T1 (de) | 2001-06-14 | 2002-06-14 | Glycoprotein sowie verfahren zu dessen herstellung |
Country Status (8)
Country | Link |
---|---|
US (1) | US7579166B2 (de) |
EP (1) | EP1408117B1 (de) |
JP (1) | JP4742191B2 (de) |
KR (1) | KR100888316B1 (de) |
CN (1) | CN1298862C (de) |
AT (1) | ATE479769T1 (de) |
DE (1) | DE60237520D1 (de) |
WO (1) | WO2002103027A1 (de) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7449308B2 (en) * | 2000-06-28 | 2008-11-11 | Glycofi, Inc. | Combinatorial DNA library for producing modified N-glycans in lower eukaryotes |
JP4931332B2 (ja) * | 2004-03-31 | 2012-05-16 | 株式会社日立ハイテクノロジーズ | 糖の除去方法 |
CA2623197A1 (en) * | 2005-09-22 | 2007-03-29 | Prosci Incorporated | Glycosylated polypeptides produced in yeast mutants and methods of use thereof |
KR100757544B1 (ko) * | 2005-11-08 | 2007-09-10 | 엘지전자 주식회사 | 플라즈마 디스플레이 패널의 화상처리 장치 및 화상처리방법 |
CA2626092A1 (en) | 2005-11-18 | 2007-05-24 | Tokyo Metropolitan Organization For Medical Research | Novel highly functional enzyme having modified substrate-specificity |
DK2508612T3 (en) | 2007-04-03 | 2018-01-22 | Oxyrane Uk Ltd | Glycosylation of molecules |
JP5507242B2 (ja) | 2007-05-18 | 2014-05-28 | 公益財団法人東京都医学総合研究所 | 酵素補充療法用医薬組成物 |
CN102712914A (zh) * | 2009-09-29 | 2012-10-03 | 根特大学 | 水解甘露糖-1-磷酸-6-甘露糖连接为磷酸-6-甘露糖 |
CA2781240A1 (en) | 2009-11-19 | 2011-05-26 | Oxyrane Uk Limited | Yeast strains producing mammalian-like complex n-glycans |
EA022220B1 (ru) * | 2010-02-24 | 2015-11-30 | Сюменекс А/С | Способ получения и очистки рекомбинантной лизосомальной альфа-маннозидазы |
CA2812872C (en) | 2010-09-29 | 2021-08-03 | Oxyrane Uk Limited | De-mannosylation of phosphorylated n-glycans |
CN103328646B (zh) * | 2010-09-29 | 2021-06-18 | 奥克西雷恩英国有限公司 | 能够使甘露糖-1-磷酸-6-甘露糖连接脱帽并使磷酸化的n-聚糖脱甘露糖基化的甘露糖苷酶及促进糖蛋白的哺乳动物细胞摄取的方法 |
EP2633065A4 (de) * | 2010-10-29 | 2014-05-07 | Shire Human Genetic Therapies | Assays und kits zur bestimmung einer galactocerebrosidasewirkung auf einem festen träger |
EP2699676A1 (de) * | 2011-04-22 | 2014-02-26 | Genzyme Corporation | Modifizierte saure alpha-glukosidase mit beschleunigter verarbeitung |
WO2012147933A1 (ja) * | 2011-04-28 | 2012-11-01 | 国立大学法人大阪大学 | リソソーム病治療用医薬組成物 |
US20140219988A1 (en) * | 2011-05-19 | 2014-08-07 | Tokyo Metropolitan Institute Of Medical Science | Rrecombinant human saposin b protein containing phosphorylated glucose ring and use thereof |
CN104379162B (zh) | 2012-03-15 | 2017-03-15 | 奥克西雷恩英国有限公司 | 用于治疗蓬佩氏病的方法和材料 |
CA2888628A1 (en) | 2012-10-19 | 2014-04-24 | Tokushima University | Novel high functional enzyme having modified substrate specificity of human beta-hexosaminidase b and exhibiting protease resistance |
JP6169552B2 (ja) * | 2013-10-01 | 2017-07-26 | Jcrファーマ株式会社 | 2−アミノピリジンによる糖鎖の標識法 |
KR101750888B1 (ko) | 2014-09-23 | 2017-06-26 | 한국생명공학연구원 | YlMpo1 과발현을 이용한 만노스인산화 증대 방법 |
GB201508025D0 (en) | 2015-05-11 | 2015-06-24 | Ucl Business Plc | Fabry disease gene therapy |
WO2016195394A1 (ko) * | 2015-06-02 | 2016-12-08 | 한국생명공학연구원 | 효모 세포벽 만노단백질 유래의 당사슬을 이용한 만노스-6-인산 당사슬이 부가된 당단백질의 제조방법 |
WO2017170896A1 (ja) | 2016-03-30 | 2017-10-05 | 国立大学法人徳島大学 | マンノース-6-リン酸基含有糖蛋白質の製造方法、及び蛍光基結合型マンノース-6-リン酸基含有糖蛋白質の細胞内分布を検出する方法 |
CN108795871B (zh) * | 2017-04-28 | 2021-12-03 | 江南大学 | 用于生产糖蛋白的动物细胞株及方法、糖蛋白及其用途 |
JP7134444B2 (ja) | 2018-01-26 | 2022-09-12 | 国立大学法人徳島大学 | テイ-サックス病及びザンドホッフ病治療用の新規アデノ随伴ウイルスビリオン |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5401650A (en) * | 1990-10-24 | 1995-03-28 | The Mount Sinai School Of Medicine Of The City University Of New York | Cloning and expression of biologically active α-galactosidase A |
JP3091851B2 (ja) * | 1992-11-06 | 2000-09-25 | 工業技術院長 | 哺乳類の高マンノース型糖蛋白質糖鎖の酵母による製造法 |
JP2767401B2 (ja) * | 1995-11-17 | 1998-06-18 | 工業技術院長 | 酵母のマンノース−1−リン酸転移酵素遺伝子およびこれを利用するマンノース−1−リン酸含有酸性糖鎖の製造方法 |
JP2826636B2 (ja) * | 1997-10-30 | 1998-11-18 | 工業技術院長 | 酵母のマンノース−1−リン酸転移酵素遺伝子を利用するリン酸含有酸性糖鎖の製造方法 |
WO2001014522A1 (fr) * | 1999-08-19 | 2001-03-01 | Kirin Beer Kabushiki Kaisha | Nouvelles variantes de levure et procede de production de glycoproteine |
US6642038B1 (en) | 1999-09-14 | 2003-11-04 | Genzyme Glycobiology Research Institute, Inc. | GlcNAc phosphotransferase of the lysosomal targeting pathway |
-
2001
- 2001-06-14 JP JP2001180907A patent/JP4742191B2/ja not_active Expired - Lifetime
-
2002
- 2002-06-14 CN CNB028158032A patent/CN1298862C/zh not_active Expired - Fee Related
- 2002-06-14 AT AT02736110T patent/ATE479769T1/de not_active IP Right Cessation
- 2002-06-14 WO PCT/JP2002/005965 patent/WO2002103027A1/ja active Application Filing
- 2002-06-14 US US10/480,790 patent/US7579166B2/en not_active Expired - Fee Related
- 2002-06-14 EP EP02736110A patent/EP1408117B1/de not_active Expired - Lifetime
- 2002-06-14 KR KR1020037016258A patent/KR100888316B1/ko not_active IP Right Cessation
- 2002-06-14 DE DE60237520T patent/DE60237520D1/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
CN1298862C (zh) | 2007-02-07 |
JP4742191B2 (ja) | 2011-08-10 |
KR20040026663A (ko) | 2004-03-31 |
EP1408117A1 (de) | 2004-04-14 |
EP1408117B1 (de) | 2010-09-01 |
WO2002103027A1 (fr) | 2002-12-27 |
DE60237520D1 (de) | 2010-10-14 |
US20050064539A1 (en) | 2005-03-24 |
CN1541275A (zh) | 2004-10-27 |
JP2002369692A (ja) | 2002-12-24 |
EP1408117A4 (de) | 2005-01-26 |
US7579166B2 (en) | 2009-08-25 |
KR100888316B1 (ko) | 2009-03-11 |
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Legal Events
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RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |