DE60232903D1 - Stabilisierte zusammensetzungen einer wässrigen lösung von reduziertem coenzym q - Google Patents
Stabilisierte zusammensetzungen einer wässrigen lösung von reduziertem coenzym qInfo
- Publication number
- DE60232903D1 DE60232903D1 DE60232903T DE60232903T DE60232903D1 DE 60232903 D1 DE60232903 D1 DE 60232903D1 DE 60232903 T DE60232903 T DE 60232903T DE 60232903 T DE60232903 T DE 60232903T DE 60232903 D1 DE60232903 D1 DE 60232903D1
- Authority
- DE
- Germany
- Prior art keywords
- reduced coenzyme
- aqueous solution
- stabilized compositions
- present
- solution containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
- A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Nutrition Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2001312181A JP3822479B2 (ja) | 2001-10-10 | 2001-10-10 | 還元型補酵素q水溶液の安定化組成 |
PCT/JP2002/010516 WO2003033445A1 (fr) | 2001-10-10 | 2002-10-10 | Compositions stabilisees de solution de coenzyme q reduite aqueuse |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60232903D1 true DE60232903D1 (de) | 2009-08-20 |
Family
ID=19130880
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60232903T Expired - Lifetime DE60232903D1 (de) | 2001-10-10 | 2002-10-10 | Stabilisierte zusammensetzungen einer wässrigen lösung von reduziertem coenzym q |
Country Status (10)
Country | Link |
---|---|
US (1) | US7364751B2 (de) |
EP (1) | EP1440962B1 (de) |
JP (1) | JP3822479B2 (de) |
KR (1) | KR20050035127A (de) |
CN (2) | CN1899272A (de) |
AT (1) | ATE435848T1 (de) |
CA (1) | CA2461550A1 (de) |
DE (1) | DE60232903D1 (de) |
TW (1) | TWI245628B (de) |
WO (1) | WO2003033445A1 (de) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI329510B (en) | 2001-10-10 | 2010-09-01 | Kaneka Corp | Method of stabilizing reduced coenzyme q10 |
TWI305547B (en) | 2001-12-27 | 2009-01-21 | Kaneka Corp | Processes for producing coenzyme q10 |
TW200302056A (en) * | 2002-01-18 | 2003-08-01 | Kaneka Corp | Method for stabilizing reduced coenzyme Q10 and composition therefor |
TW200304372A (en) * | 2002-03-20 | 2003-10-01 | Kanegafuchi Chemical Ind | Compositions for diabetes |
CN1870982B (zh) * | 2003-10-31 | 2010-05-26 | 株式会社钟化 | 含还原型辅酶q的组合物 |
TW200524579A (en) * | 2003-11-28 | 2005-08-01 | Kaneka Corp | Composition for protecting liver functions |
WO2005097091A1 (ja) * | 2004-04-09 | 2005-10-20 | Kaneka Corporation | 還元型補酵素q10およびカロチノイド類を含有した組成物 |
ES2563929T3 (es) * | 2004-12-24 | 2016-03-16 | Kaneka Corporation | Preparación sólida que comprende coenzima Q10 reducida y proceso para la producción de la misma |
TW200722076A (en) * | 2005-03-29 | 2007-06-16 | Kaneka Corp | Composition for increasing anti-oxidation activity in blood |
WO2007105621A1 (ja) * | 2006-03-13 | 2007-09-20 | Kaneka Corporation | 心機能不良改善剤または心機能維持剤 |
WO2008029909A1 (en) * | 2006-09-08 | 2008-03-13 | Kaneka Corporation | Composition comprising reduced coenzyme q10 and lysolecithin |
DK200800040U3 (da) | 2008-03-06 | 2009-06-26 | Pharma Nord Aps | Lægemiddel og kosttilskud med indhold af stabiliseret ubiquinol i beskyttende pakning. |
CN101307338B (zh) * | 2008-07-17 | 2012-04-25 | 任雷 | 还原型辅酶q10的制备方法 |
JP4855551B2 (ja) * | 2009-10-16 | 2012-01-18 | 株式会社カネカ | 還元型補酵素q10の製造方法、安定化方法及びそれを含有する組成物 |
JP2011160746A (ja) * | 2010-02-12 | 2011-08-25 | Sanei Gen Ffi Inc | ユビキノール含有透明容器入り飲料 |
CN102247301A (zh) * | 2010-05-21 | 2011-11-23 | 上海新都生物科技有限公司 | 还原型辅酶q10的用途及在化妆品中的使用方法 |
CN101912371B (zh) * | 2010-08-30 | 2012-11-14 | 熊军 | 含有辅酶q10的注射剂组合物及其制备方法 |
CN104738620A (zh) * | 2015-03-06 | 2015-07-01 | 江南大学 | 一种还原型辅酶q10的纳米脂质体组合物及其制备方法 |
TWI754659B (zh) * | 2016-08-08 | 2022-02-11 | 台灣微脂體股份有限公司 | 用於製備含有弱酸性劑之微脂體組合物的傳輸載體、方法及套組 |
CN110496103B (zh) * | 2018-05-18 | 2022-05-10 | 上海维洱生物医药科技有限公司 | 一种多西他赛棕榈酸酯脂质体及其制备方法 |
US11471426B2 (en) | 2019-10-16 | 2022-10-18 | American River Nutrition, Llc | Compositions comprising quinone and/or quinol and methods of preparations and use thereof |
WO2021176264A1 (en) * | 2020-03-02 | 2021-09-10 | Yogesh Dound | Liposomal compositions and process for preparation thereof |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS54119424A (en) * | 1978-03-08 | 1979-09-17 | Ajinomoto Co Inc | Preparation of dihydrocoenzyme q analog |
IT1250672B (it) | 1991-07-11 | 1995-04-21 | Idb Holding Spa | Formulazioni orali di ubidecarenone in soluzione acquosa |
AU5355094A (en) | 1992-10-14 | 1994-05-09 | Sterling Winthrop Inc. | Therapeutic and diagnostic imaging compositions and methods |
IT1263840B (it) | 1993-03-30 | 1996-09-04 | Giuseppe Furiosi | Formulazioni orali di ubidecarenone in forma di capsule |
US5891465A (en) | 1996-05-14 | 1999-04-06 | Biozone Laboratories, Inc. | Delivery of biologically active material in a liposomal formulation for administration into the mouth |
JP3889481B2 (ja) | 1996-08-16 | 2007-03-07 | 株式会社カネカ | 医薬組成物 |
JP3926888B2 (ja) * | 1997-05-27 | 2007-06-06 | 株式会社カネカ | コレステロール低下剤 |
US6066327A (en) * | 1997-12-17 | 2000-05-23 | Color Access, Inc. | Antioxidant mixture |
JP3080162B2 (ja) | 1998-01-27 | 2000-08-21 | 日本パーカライジング株式会社 | 酸化チタンゾルおよびその製造方法 |
US6045826A (en) | 1999-04-02 | 2000-04-04 | National Research Council Of Canada | Water-soluble compositions of bioactive lipophilic compounds |
JP3542305B2 (ja) | 1999-07-07 | 2004-07-14 | 小林製薬株式会社 | 徐溶性ゲル状組成物 |
US6740338B1 (en) * | 2000-01-20 | 2004-05-25 | Raj K. Chopra | Reduced form of Cenzyme Q in high bioavailability stable oral dosage form |
US8753675B1 (en) | 2000-01-20 | 2014-06-17 | Raj K. Chopra | Reduced form of Coenzyme Q in high bioavailability stable dosage forms and related applications |
GB0017060D0 (en) * | 2000-07-11 | 2000-08-30 | Hunter Fleming Ltd | Production, stabilisation and use of reduced forms of pharmaceutical compounds |
US6441050B1 (en) | 2000-08-29 | 2002-08-27 | Raj K. Chopra | Palatable oral coenzyme Q liquid |
TWI310029B (de) | 2001-07-13 | 2009-05-21 | Kaneka Corp | |
TWI329510B (en) | 2001-10-10 | 2010-09-01 | Kaneka Corp | Method of stabilizing reduced coenzyme q10 |
-
2001
- 2001-10-10 JP JP2001312181A patent/JP3822479B2/ja not_active Expired - Fee Related
-
2002
- 2002-10-09 TW TW091123238A patent/TWI245628B/zh not_active IP Right Cessation
- 2002-10-10 CN CNA2006101084029A patent/CN1899272A/zh active Pending
- 2002-10-10 KR KR1020047005215A patent/KR20050035127A/ko not_active Application Discontinuation
- 2002-10-10 CA CA002461550A patent/CA2461550A1/en not_active Abandoned
- 2002-10-10 CN CNB028198840A patent/CN1297527C/zh not_active Expired - Fee Related
- 2002-10-10 DE DE60232903T patent/DE60232903D1/de not_active Expired - Lifetime
- 2002-10-10 EP EP02775312A patent/EP1440962B1/de not_active Expired - Lifetime
- 2002-10-10 AT AT02775312T patent/ATE435848T1/de not_active IP Right Cessation
- 2002-10-10 WO PCT/JP2002/010516 patent/WO2003033445A1/ja active Application Filing
- 2002-10-10 US US10/492,167 patent/US7364751B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
CN1899272A (zh) | 2007-01-24 |
ATE435848T1 (de) | 2009-07-15 |
CN1564796A (zh) | 2005-01-12 |
EP1440962A1 (de) | 2004-07-28 |
CN1297527C (zh) | 2007-01-31 |
US20050070481A1 (en) | 2005-03-31 |
TWI245628B (en) | 2005-12-21 |
JP3822479B2 (ja) | 2006-09-20 |
EP1440962A4 (de) | 2007-10-31 |
KR20050035127A (ko) | 2005-04-15 |
JP2003119126A (ja) | 2003-04-23 |
EP1440962B1 (de) | 2009-07-08 |
WO2003033445A1 (fr) | 2003-04-24 |
CA2461550A1 (en) | 2003-04-24 |
US7364751B2 (en) | 2008-04-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |