DE60224346D1 - Monoklonales Antikörper gegen das HCV Kernantigen - Google Patents

Monoklonales Antikörper gegen das HCV Kernantigen

Info

Publication number
DE60224346D1
DE60224346D1 DE60224346T DE60224346T DE60224346D1 DE 60224346 D1 DE60224346 D1 DE 60224346D1 DE 60224346 T DE60224346 T DE 60224346T DE 60224346 T DE60224346 T DE 60224346T DE 60224346 D1 DE60224346 D1 DE 60224346D1
Authority
DE
Germany
Prior art keywords
core antigen
hcv core
monoclonal antibody
antibody against
antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60224346T
Other languages
English (en)
Other versions
DE60224346T2 (de
Inventor
Chander Bahl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ortho Clinical Diagnostics Inc
Original Assignee
Ortho Clinical Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Clinical Diagnostics Inc filed Critical Ortho Clinical Diagnostics Inc
Application granted granted Critical
Publication of DE60224346D1 publication Critical patent/DE60224346D1/de
Publication of DE60224346T2 publication Critical patent/DE60224346T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1081—Togaviridae, e.g. flavivirus, rubella virus, hog cholera virus
    • C07K16/109—Hepatitis C virus; Hepatitis G virus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE60224346T 2001-11-05 2002-11-04 Monoklonales Antikörper gegen das HCV Kernantigen Expired - Lifetime DE60224346T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US33745301P 2001-11-05 2001-11-05
US337453P 2001-11-05
US268561 2002-10-10
US10/268,561 US7049060B2 (en) 2001-11-05 2002-10-10 HCV anti-core monoclonal antibodies

Publications (2)

Publication Number Publication Date
DE60224346D1 true DE60224346D1 (de) 2008-02-14
DE60224346T2 DE60224346T2 (de) 2008-12-24

Family

ID=26953173

Family Applications (2)

Application Number Title Priority Date Filing Date
DE60235588T Expired - Lifetime DE60235588D1 (de) 2001-11-05 2002-11-04 Monoklonales Antikörper gegen das HCV Kernantigen
DE60224346T Expired - Lifetime DE60224346T2 (de) 2001-11-05 2002-11-04 Monoklonales Antikörper gegen das HCV Kernantigen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE60235588T Expired - Lifetime DE60235588D1 (de) 2001-11-05 2002-11-04 Monoklonales Antikörper gegen das HCV Kernantigen

Country Status (9)

Country Link
US (1) US7049060B2 (de)
EP (3) EP1881064B1 (de)
JP (1) JP2004035534A (de)
AT (2) ATE459706T1 (de)
CA (1) CA2406240C (de)
DE (2) DE60235588D1 (de)
DK (2) DK1308507T3 (de)
ES (2) ES2339709T3 (de)
PT (2) PT1881064E (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7902338B2 (en) 2003-07-31 2011-03-08 Immunomedics, Inc. Anti-CD19 antibodies
JP2009018990A (ja) * 2005-10-25 2009-01-29 Univ Kurume Ｃ型肝炎ウイルス由来ペプチド
US7858752B2 (en) * 2006-12-05 2010-12-28 Abbott Laboratories Recombinant antibodies against hepatitis C virus and methods of obtaining and using same
DK3903829T3 (da) 2009-02-13 2023-06-26 Immunomedics Inc Immunkonjugater med en intracellulær spaltelig binding
EP3009455A1 (de) 2009-09-16 2016-04-20 Immunomedics Inc. Klasse-i-anti-cea-antikörper und verwendungen davon
IN2012DN03354A (de) 2009-12-02 2015-10-23 Immunomedics Inc
WO2012006500A2 (en) * 2010-07-08 2012-01-12 Abbott Laboratories Monoclonal antibodies against hepatitis c virus core protein
EP2704751B1 (de) 2011-05-02 2019-04-17 Immunomedics, Inc. Ultrafiltrationskonzentration ausgewählter allotypen-antikörper für kleinvolumige verabreichung
FR2984328B1 (fr) 2011-12-20 2016-12-30 Bio-Rad Innovations Procede de detection d'une infection par le virus de l'hepatite c
EP2885002A4 (de) 2012-08-14 2016-04-20 Ibc Pharmaceuticals Inc Umleitung t-zell-bispezifischer antikörper zur behandlung von krankheiten
CA3177936A1 (en) 2012-12-13 2014-06-19 Immunomedics, Inc. Dosages of immunoconjugates of antibodies and sn-38 for improved efficacy and decreased toxicity
MX362075B (es) 2013-03-14 2019-01-07 Abbott Lab Ensayo de combinación de antígeno-anticuerpo del virus de la hepatitis c (vhc) y métodos y composiciones para usarlo.
CA2906417C (en) 2013-03-14 2022-06-21 Robert Ziemann Hcv core lipid binding domain monoclonal antibodies
CN105209616A (zh) 2013-03-14 2015-12-30 雅培制药有限公司 用于改进的抗体检测的hcv ns3重组抗原及其突变体
CN106132436B (zh) 2014-02-21 2021-06-15 Ibc药品公司 通过诱导对trop-2表达细胞的免疫应答的疾病疗法
US9139649B2 (en) 2014-02-25 2015-09-22 Immunomedics, Inc. Humanized anti-CD22 antibody
US9580495B2 (en) 2014-06-24 2017-02-28 Immunomedics, Inc. Anti-histone therapy for vascular necrosis in severe glomerulonephritis
CN106999517A (zh) 2014-10-07 2017-08-01 免疫医疗公司 抗体‑药物缀合物的新辅助剂用途
EP3286224A4 (de) 2015-04-22 2018-11-14 Immunomedics, Inc. Isolierung, detektion, diagnose und/oder charakterisierung von zirkulierenden trop-2-positiven krebszellen
PL3313443T3 (pl) 2015-06-25 2023-11-06 Immunomedics, Inc. Łączenie przeciwciał anty-hla-dr lub anty-trop-2 z inhibitorami mikrotubuli, inhibitorami parp, 5 inhibitorami kinazy brutona lub inhibitorami 3-kinazy fosfoinozytydu istotnie poprawia wynik terapeutyczny nowotworu
SI3316885T1 (sl) 2015-07-01 2021-09-30 Immunomedics, Inc. Imunokonjugati protitelo-SN-38 z linkerjem CL2A
EP3465217A1 (de) 2016-05-31 2019-04-10 Roche Diagnostics GmbH Verfahren zum serologischen nachweis von virusantigenen
BR112018074527A2 (pt) 2016-05-31 2019-03-19 F. Hoffmann-La Roche Ag métodos de detecção de polipeptídeo central e de processamento prévio de amostras de pacientes, uso de reagente de processamento prévio, dispositivo analítico de detecção de polipeptídeo central e sistema analítico
WO2018141768A1 (en) 2017-02-02 2018-08-09 Roche Diagnostics Gmbh Immunoassay using at least two pegylated analyte-specific binding agents
KR20200032695A (ko) 2017-07-27 2020-03-26 에프. 호프만-라 로슈 아게 Hcv 항원의 다중-에피토프 융합 단백질 및 이의 용도
CN109738648B (zh) * 2018-12-29 2021-09-17 山东莱博生物科技有限公司 稳定高效表达丙型肝炎病毒核心抗原抗体的工程细胞株及其应用
WO2022239720A1 (ja) 2021-05-10 2022-11-17 公益財団法人川崎市産業振興財団 抗原への結合親和性を低減させた抗体

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA50829C2 (uk) 1989-03-17 2002-11-15 Чірон Корпорейшн Очищений поліпептид, що містить антиген вірусу гепатиту с, полінуклеотид, вектор, клітини, система експресії, моноклональне антитіло, препарат поліклональних антитіл, нуклеотидна проба, аналітичні набори, спосіб виявлення нуклеїнових кислот, способи імуноаналізу, вакцина, спосіб одержання антитіл
DE4209215A1 (de) * 1991-07-04 1993-01-07 Boehringer Mannheim Gmbh Hcv peptidantigene und verfahren zur bestimmung von hcv
ZA927837B (en) 1991-10-15 1994-03-11 Akzo Nv Monoclonal antibodiesto hepatitis C virus
JP3217600B2 (ja) * 1994-07-12 2001-10-09 株式会社先端生命科学研究所 非ａ非ｂ型肝炎ウイルス関連抗原のイムノアッセイ、それに使用するモノクローナル抗体、およびこの抗体を産生するハイブリドーマ
FR2775690B1 (fr) 1998-03-09 2001-12-14 Bio Merieux Anticorps monoclonal et utilisations pour detecter des antigenes de la proteine core de vhc
WO2000063444A2 (en) 1999-04-14 2000-10-26 Institut Pasteur Method for detecting hepatitis c virus with hybridomas
MXPA02012424A (es) * 2000-06-15 2003-04-25 Chiron Corp Ensayo de combinacion de antigenos/anticuerpos para el virus de hepatitis c.
JP4353793B2 (ja) * 2001-06-26 2009-10-28 アボット・ラボラトリーズ Ｈｃｖ抗原とｈｃｖ抗体との同時検出のための方法

Also Published As

Publication number Publication date
ATE382683T1 (de) 2008-01-15
DE60224346T2 (de) 2008-12-24
EP2186884A3 (de) 2010-09-08
JP2004035534A (ja) 2004-02-05
US20030148333A1 (en) 2003-08-07
EP1308507A2 (de) 2003-05-07
CA2406240A1 (en) 2003-05-05
ATE459706T1 (de) 2010-03-15
ES2339709T3 (es) 2010-05-24
DK1881064T3 (da) 2010-06-07
EP2186884A2 (de) 2010-05-19
EP1308507B1 (de) 2008-01-02
ES2295292T3 (es) 2008-04-16
EP1881064A2 (de) 2008-01-23
EP1881064A3 (de) 2008-04-09
EP1308507A3 (de) 2003-10-22
EP1881064B1 (de) 2010-03-03
US7049060B2 (en) 2006-05-23
DK1308507T3 (da) 2008-05-19
PT1308507E (pt) 2008-03-31
CA2406240C (en) 2011-01-04
DE60235588D1 (de) 2010-04-15
PT1881064E (pt) 2010-03-31

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