DE60223496T2 - Endgruppenverzweigte polymere verbindungsgruppen und diese enthaltende polymere konjugate - Google Patents
Endgruppenverzweigte polymere verbindungsgruppen und diese enthaltende polymere konjugate Download PDFInfo
- Publication number
- DE60223496T2 DE60223496T2 DE60223496T DE60223496T DE60223496T2 DE 60223496 T2 DE60223496 T2 DE 60223496T2 DE 60223496 T DE60223496 T DE 60223496T DE 60223496 T DE60223496 T DE 60223496T DE 60223496 T2 DE60223496 T2 DE 60223496T2
- Authority
- DE
- Germany
- Prior art keywords
- substituted
- group
- alkyl
- independently
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 0 CN(*)C(*)(*)* Chemical compound CN(*)C(*)(*)* 0.000 description 7
- QUNSEFMCEPPZSZ-UHFFFAOYSA-N CC(C)(CC(S)=O)c(c(C)cc(C)c1)c1OC(NCCOCCOCCN)=O Chemical compound CC(C)(CC(S)=O)c(c(C)cc(C)c1)c1OC(NCCOCCOCCN)=O QUNSEFMCEPPZSZ-UHFFFAOYSA-N 0.000 description 1
- PXHHIBMOFPCBJQ-UHFFFAOYSA-N CC1N(C)CCC1 Chemical compound CC1N(C)CCC1 PXHHIBMOFPCBJQ-UHFFFAOYSA-N 0.000 description 1
- NKXLTPYNROKYPL-JUVXEPFKSA-N COc(cc([C@@H](C([C@H](CO1)[C@H](c2c3)O)C1=O)c2cc1c3O[IH]O1)cc1OC)c1OC Chemical compound COc(cc([C@@H](C([C@H](CO1)[C@H](c2c3)O)C1=O)c2cc1c3O[IH]O1)cc1OC)c1OC NKXLTPYNROKYPL-JUVXEPFKSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
- Peptides Or Proteins (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Polyethers (AREA)
- Materials For Medical Uses (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27251101P | 2001-02-20 | 2001-02-20 | |
| US272511P | 2001-02-20 | ||
| PCT/US2002/004780 WO2002066066A1 (en) | 2001-02-20 | 2002-02-19 | Terminally-branched polymeric linkers and polymeric conjugates containing the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60223496D1 DE60223496D1 (de) | 2007-12-27 |
| DE60223496T2 true DE60223496T2 (de) | 2008-10-02 |
Family
ID=23040108
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60223496T Expired - Lifetime DE60223496T2 (de) | 2001-02-20 | 2002-02-19 | Endgruppenverzweigte polymere verbindungsgruppen und diese enthaltende polymere konjugate |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20020161052A1 (enExample) |
| EP (1) | EP1361895B1 (enExample) |
| JP (1) | JP2004530736A (enExample) |
| AT (1) | ATE378071T1 (enExample) |
| CA (1) | CA2437986A1 (enExample) |
| DE (1) | DE60223496T2 (enExample) |
| DK (1) | DK1361895T3 (enExample) |
| MX (1) | MXPA03007391A (enExample) |
| WO (1) | WO2002066066A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6624142B2 (en) * | 1997-12-30 | 2003-09-23 | Enzon, Inc. | Trimethyl lock based tetrapartate prodrugs |
| US7332164B2 (en) * | 2003-03-21 | 2008-02-19 | Enzon Pharmaceuticals, Inc. | Heterobifunctional polymeric bioconjugates |
| EP1533385A1 (en) * | 2003-09-05 | 2005-05-25 | Nuevolution A/S | Templated compounds for generation of encoded molecules and directional methods using such compounds |
| CN101023119B (zh) | 2004-09-22 | 2010-05-05 | 日本化药株式会社 | 新型嵌段共聚物，胶束制剂以及含胶束制剂为活性组分的抗癌剂 |
| CA2611823C (en) | 2005-06-16 | 2013-07-30 | Nektar Therapeutics Al, Corporation | Conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates |
| KR20080106254A (ko) | 2006-03-28 | 2008-12-04 | 니폰 가야꾸 가부시끼가이샤 | 탁산류의 고분자 결합체 |
| CA2652656A1 (en) | 2006-05-18 | 2007-11-29 | Nippon Kayaku Kabushiki Kaisha | High-molecular weight conjugate of podophyllotoxins |
| CA2658100A1 (en) * | 2006-07-19 | 2008-01-24 | Nippon Kayaku Kabushiki Kaisha | High-molecular weight conjugate of combretastatins |
| EP2080779B1 (en) | 2006-11-06 | 2016-05-18 | Nippon Kayaku Kabushiki Kaisha | Polymeric derivative of nucleic acid metabolic antagonist |
| EP2090607B1 (en) | 2006-11-08 | 2015-05-20 | Nippon Kayaku Kabushiki Kaisha | Polymeric derivative of nucleic acid metabolic antagonist |
| US8703878B2 (en) | 2007-09-28 | 2014-04-22 | Nippon Kayaku Kabushiki Kaisha | High-molecular weight conjugate of steroids |
| KR101589582B1 (ko) | 2008-03-18 | 2016-01-28 | 니폰 가야꾸 가부시끼가이샤 | 생리활성물질의 고분자량 결합체 |
| JP5366940B2 (ja) | 2008-05-08 | 2013-12-11 | 日本化薬株式会社 | 葉酸若しくは葉酸誘導体の高分子結合体 |
| JP5544357B2 (ja) | 2009-05-15 | 2014-07-09 | 日本化薬株式会社 | 水酸基を有する生理活性物質の高分子結合体 |
| JP5856069B2 (ja) | 2010-11-17 | 2016-02-09 | 日本化薬株式会社 | 新規なシチジン系代謝拮抗剤の高分子誘導体 |
| JP5711378B2 (ja) | 2011-09-11 | 2015-04-30 | 日本化薬株式会社 | ブロック共重合体の製造方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5552391A (en) * | 1990-01-16 | 1996-09-03 | La Jolla Pharmaceutical Company | Chemically-defined non-polymeric valency platform molecules and conjugates thereof |
| AU4406793A (en) * | 1992-06-04 | 1993-12-30 | Clover Consolidated, Limited | Water-soluble polymeric carriers for drug delivery |
| US5840900A (en) * | 1993-10-20 | 1998-11-24 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
| US5880131A (en) * | 1993-10-20 | 1999-03-09 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
| US5965566A (en) * | 1993-10-20 | 1999-10-12 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
| US6011042A (en) * | 1997-10-10 | 2000-01-04 | Enzon, Inc. | Acyl polymeric derivatives of aromatic hydroxyl-containing compounds |
| US6180095B1 (en) * | 1997-12-17 | 2001-01-30 | Enzon, Inc. | Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents |
| US5965119A (en) * | 1997-12-30 | 1999-10-12 | Enzon, Inc. | Trialkyl-lock-facilitated polymeric prodrugs of amino-containing bioactive agents |
| US6153655A (en) * | 1998-04-17 | 2000-11-28 | Enzon, Inc. | Terminally-branched polymeric linkers and polymeric conjugates containing the same |
-
2002
- 2002-02-19 AT AT02709573T patent/ATE378071T1/de not_active IP Right Cessation
- 2002-02-19 JP JP2002565624A patent/JP2004530736A/ja active Pending
- 2002-02-19 EP EP02709573A patent/EP1361895B1/en not_active Expired - Lifetime
- 2002-02-19 WO PCT/US2002/004780 patent/WO2002066066A1/en not_active Ceased
- 2002-02-19 US US10/078,649 patent/US20020161052A1/en not_active Abandoned
- 2002-02-19 DK DK02709573T patent/DK1361895T3/da active
- 2002-02-19 CA CA002437986A patent/CA2437986A1/en not_active Abandoned
- 2002-02-19 MX MXPA03007391A patent/MXPA03007391A/es active IP Right Grant
- 2002-02-19 DE DE60223496T patent/DE60223496T2/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP2004530736A (ja) | 2004-10-07 |
| EP1361895B1 (en) | 2007-11-14 |
| EP1361895A1 (en) | 2003-11-19 |
| EP1361895A4 (en) | 2005-01-19 |
| DE60223496D1 (de) | 2007-12-27 |
| MXPA03007391A (es) | 2003-12-04 |
| ATE378071T1 (de) | 2007-11-15 |
| WO2002066066A9 (en) | 2003-10-16 |
| US20020161052A1 (en) | 2002-10-31 |
| CA2437986A1 (en) | 2002-08-29 |
| DK1361895T3 (da) | 2008-02-18 |
| WO2002066066A1 (en) | 2002-08-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |