JP2004530736A - 末端分枝高分子リンカーおよびそれを含む高分子複合体 - Google Patents

末端分枝高分子リンカーおよびそれを含む高分子複合体 Download PDF

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Publication number
JP2004530736A
JP2004530736A JP2002565624A JP2002565624A JP2004530736A JP 2004530736 A JP2004530736 A JP 2004530736A JP 2002565624 A JP2002565624 A JP 2002565624A JP 2002565624 A JP2002565624 A JP 2002565624A JP 2004530736 A JP2004530736 A JP 2004530736A
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JP2004530736A5 (enExample
Inventor
チョウ，ユン，ファン
グリーンウォルド，リチャード，ビー．
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エンゾン ファーマシューティカルズ，インコーポレーテッド
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Publication of JP2004530736A publication Critical patent/JP2004530736A/ja
Publication of JP2004530736A5 publication Critical patent/JP2004530736A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Peptides Or Proteins (AREA)
  • Materials For Medical Uses (AREA)
  • Polyethers (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2002565624A 2001-02-20 2002-02-19 末端分枝高分子リンカーおよびそれを含む高分子複合体 Pending JP2004530736A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27251101P 2001-02-20 2001-02-20
PCT/US2002/004780 WO2002066066A1 (en) 2001-02-20 2002-02-19 Terminally-branched polymeric linkers and polymeric conjugates containing the same

Publications (2)

Publication Number Publication Date
JP2004530736A true JP2004530736A (ja) 2004-10-07
JP2004530736A5 JP2004530736A5 (enExample) 2005-12-22

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ID=23040108

Family Applications (1)

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JP2002565624A Pending JP2004530736A (ja) 2001-02-20 2002-02-19 末端分枝高分子リンカーおよびそれを含む高分子複合体

Country Status (9)

Country Link
US (1) US20020161052A1 (enExample)
EP (1) EP1361895B1 (enExample)
JP (1) JP2004530736A (enExample)
AT (1) ATE378071T1 (enExample)
CA (1) CA2437986A1 (enExample)
DE (1) DE60223496T2 (enExample)
DK (1) DK1361895T3 (enExample)
MX (1) MXPA03007391A (enExample)
WO (1) WO2002066066A1 (enExample)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008010463A1 (en) * 2006-07-19 2008-01-24 Nippon Kayaku Kabushiki Kaisha Polymer conjugate of combretastatin
US8188222B2 (en) 2006-11-08 2012-05-29 Nippon Kayaku Kabushiki Kaisha High molecular weight derivative of nucleic acid antimetabolite
US8323669B2 (en) 2006-03-28 2012-12-04 Nippon Kayaku Kabushiki Kaisha Polymer conjugate of taxane
US8334364B2 (en) 2006-11-06 2012-12-18 Nipon Kayaku Kabushiki Kaisha High-molecular weight derivative of nucleic acid antimetabolite
US8435505B2 (en) 2005-06-16 2013-05-07 Nektar Therapeutics Pharmaceutical compositions and methods for delivering such compositions
US8703878B2 (en) 2007-09-28 2014-04-22 Nippon Kayaku Kabushiki Kaisha High-molecular weight conjugate of steroids
US8808749B2 (en) 2009-05-15 2014-08-19 Nippon Kayaku Kabushiki Kaisha Polymer conjugate of bioactive substance having hydroxy group
US8920788B2 (en) 2008-03-18 2014-12-30 Nippon Kayaku Kabushiki Kaisha High-molecular weight conjugate of physiologically active substances
US8940332B2 (en) 2006-05-18 2015-01-27 Nippon Kayaku Kabushiki Kaisha High-molecular weight conjugate of podophyllotoxins
US9018323B2 (en) 2010-11-17 2015-04-28 Nippon Kayaku Kabushiki Kaisha Polymer derivative of cytidine metabolic antagonist
US9149540B2 (en) 2008-05-08 2015-10-06 Nippon Kayaku Kabushiki Kaisha Polymer conjugate of folic acid or folic acid derivative
US9346923B2 (en) 2011-09-11 2016-05-24 Nippon Kayaku Kabushiki Kaisha Method for manufacturing block copolymer
US9434822B2 (en) 2004-09-22 2016-09-06 Nippon Kayaku Kabushiki Kaisha Block copolymer, micelle preparation, and anticancer agent containing the same as active ingredient

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6624142B2 (en) * 1997-12-30 2003-09-23 Enzon, Inc. Trimethyl lock based tetrapartate prodrugs
US7332164B2 (en) * 2003-03-21 2008-02-19 Enzon Pharmaceuticals, Inc. Heterobifunctional polymeric bioconjugates
EP1533385A1 (en) * 2003-09-05 2005-05-25 Nuevolution A/S Templated compounds for generation of encoded molecules and directional methods using such compounds

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5552391A (en) * 1990-01-16 1996-09-03 La Jolla Pharmaceutical Company Chemically-defined non-polymeric valency platform molecules and conjugates thereof
WO1993024476A1 (en) * 1992-06-04 1993-12-09 Clover Consolidated, Limited Water-soluble polymeric carriers for drug delivery
US5840900A (en) * 1993-10-20 1998-11-24 Enzon, Inc. High molecular weight polymer-based prodrugs
US5880131A (en) * 1993-10-20 1999-03-09 Enzon, Inc. High molecular weight polymer-based prodrugs
US5965566A (en) * 1993-10-20 1999-10-12 Enzon, Inc. High molecular weight polymer-based prodrugs
US6011042A (en) * 1997-10-10 2000-01-04 Enzon, Inc. Acyl polymeric derivatives of aromatic hydroxyl-containing compounds
US6180095B1 (en) * 1997-12-17 2001-01-30 Enzon, Inc. Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents
US5965119A (en) * 1997-12-30 1999-10-12 Enzon, Inc. Trialkyl-lock-facilitated polymeric prodrugs of amino-containing bioactive agents
US6153655A (en) * 1998-04-17 2000-11-28 Enzon, Inc. Terminally-branched polymeric linkers and polymeric conjugates containing the same

Cited By (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9434822B2 (en) 2004-09-22 2016-09-06 Nippon Kayaku Kabushiki Kaisha Block copolymer, micelle preparation, and anticancer agent containing the same as active ingredient
US9381254B2 (en) 2005-06-16 2016-07-05 Nektar Therapeutics Methods for preparing polymeric reagents
US8911718B2 (en) 2005-06-16 2014-12-16 Nektar Therapeutics Methods for preparing polymeric reagents
US9775911B2 (en) 2005-06-16 2017-10-03 Nektar Therapeutics Composition comprising a polymeric reagent
US8435505B2 (en) 2005-06-16 2013-05-07 Nektar Therapeutics Pharmaceutical compositions and methods for delivering such compositions
US8703115B2 (en) 2005-06-16 2014-04-22 Nektar Therapeutics Methods for preparing conjugates
US11266742B2 (en) 2005-06-16 2022-03-08 Nektar Therapeutics Conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates
US10695435B2 (en) 2005-06-16 2020-06-30 Nektar Therapeutics Composition comprising a polymeric reagent
US9090740B2 (en) 2005-06-16 2015-07-28 Nektar Therapeutics Methods for preparing polymeric reagents
US10130720B2 (en) 2005-06-16 2018-11-20 Nektar Therapeutics Composition comprising a polymeric reagent
US8323669B2 (en) 2006-03-28 2012-12-04 Nippon Kayaku Kabushiki Kaisha Polymer conjugate of taxane
US8940332B2 (en) 2006-05-18 2015-01-27 Nippon Kayaku Kabushiki Kaisha High-molecular weight conjugate of podophyllotoxins
WO2008010463A1 (en) * 2006-07-19 2008-01-24 Nippon Kayaku Kabushiki Kaisha Polymer conjugate of combretastatin
US8334364B2 (en) 2006-11-06 2012-12-18 Nipon Kayaku Kabushiki Kaisha High-molecular weight derivative of nucleic acid antimetabolite
US8188222B2 (en) 2006-11-08 2012-05-29 Nippon Kayaku Kabushiki Kaisha High molecular weight derivative of nucleic acid antimetabolite
USRE46190E1 (en) 2007-09-28 2016-11-01 Nippon Kayaku Kabushiki Kaisha High-molecular weight conjugate of steroids
US8703878B2 (en) 2007-09-28 2014-04-22 Nippon Kayaku Kabushiki Kaisha High-molecular weight conjugate of steroids
US8920788B2 (en) 2008-03-18 2014-12-30 Nippon Kayaku Kabushiki Kaisha High-molecular weight conjugate of physiologically active substances
US9149540B2 (en) 2008-05-08 2015-10-06 Nippon Kayaku Kabushiki Kaisha Polymer conjugate of folic acid or folic acid derivative
US8808749B2 (en) 2009-05-15 2014-08-19 Nippon Kayaku Kabushiki Kaisha Polymer conjugate of bioactive substance having hydroxy group
US9018323B2 (en) 2010-11-17 2015-04-28 Nippon Kayaku Kabushiki Kaisha Polymer derivative of cytidine metabolic antagonist
US9346923B2 (en) 2011-09-11 2016-05-24 Nippon Kayaku Kabushiki Kaisha Method for manufacturing block copolymer

Also Published As

Publication number Publication date
ATE378071T1 (de) 2007-11-15
WO2002066066A9 (en) 2003-10-16
CA2437986A1 (en) 2002-08-29
DK1361895T3 (da) 2008-02-18
US20020161052A1 (en) 2002-10-31
EP1361895B1 (en) 2007-11-14
DE60223496T2 (de) 2008-10-02
WO2002066066A1 (en) 2002-08-29
MXPA03007391A (es) 2003-12-04
EP1361895A4 (en) 2005-01-19
DE60223496D1 (de) 2007-12-27
EP1361895A1 (en) 2003-11-19

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