DE60222378D1 - Fluoreszensanalyseelement mit der anwendung eines metallischen nanolochs und verfahren zur herstellung desselben - Google Patents
Fluoreszensanalyseelement mit der anwendung eines metallischen nanolochs und verfahren zur herstellung desselbenInfo
- Publication number
- DE60222378D1 DE60222378D1 DE60222378T DE60222378T DE60222378D1 DE 60222378 D1 DE60222378 D1 DE 60222378D1 DE 60222378 T DE60222378 T DE 60222378T DE 60222378 T DE60222378 T DE 60222378T DE 60222378 D1 DE60222378 D1 DE 60222378D1
- Authority
- DE
- Germany
- Prior art keywords
- fluorescence
- metallic
- nanoloch
- production
- fluorescence analysis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
- G01N33/553—Metal or metal coated
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Organic Chemistry (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Nanotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Medical Informatics (AREA)
- Inorganic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Crystallography & Structural Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Optical Measuring Cells (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2001005041A JP3525142B2 (ja) | 2001-01-12 | 2001-01-12 | 金属ナノウェルを用いた蛍光分析用素子及びその製造方法 |
JP2001005041 | 2001-01-12 | ||
PCT/JP2002/000026 WO2002056012A1 (fr) | 2001-01-12 | 2002-01-09 | Element d'analyse par fluorescence au moyen d'un nanopuits metallique et procede de production de cet element |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60222378D1 true DE60222378D1 (de) | 2007-10-25 |
DE60222378T2 DE60222378T2 (de) | 2008-06-12 |
Family
ID=18873135
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60222378T Expired - Lifetime DE60222378T2 (de) | 2001-01-12 | 2002-01-09 | Fluoreszenzanalseelement mit der Verwendung einer metallischen Nanovertiefung und Verfahren zur Herstellung desselben |
Country Status (6)
Country | Link |
---|---|
US (1) | US20040029152A1 (de) |
EP (1) | EP1353179B1 (de) |
JP (1) | JP3525142B2 (de) |
AT (1) | ATE373235T1 (de) |
DE (1) | DE60222378T2 (de) |
WO (1) | WO2002056012A1 (de) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL1027031C2 (nl) * | 2004-09-13 | 2006-03-14 | Univ Delft Tech | Titerplaat. |
US8535616B2 (en) * | 2005-08-02 | 2013-09-17 | Moxtek, Inc. | Sub-wavelength metallic apertures as light enhancement devices |
WO2007094817A2 (en) * | 2005-08-02 | 2007-08-23 | University Of Utah Research Foundation | Biosensors including metallic nanocavities |
US20070148677A1 (en) * | 2005-12-02 | 2007-06-28 | Chagovetz Alexander M | Methods and systems for acquiring real-time quantitative melt data |
US7618771B2 (en) | 2006-06-30 | 2009-11-17 | Searete Llc | Method of combing a nucleic acid |
US7858305B2 (en) * | 2006-06-30 | 2010-12-28 | The Invention Science Fund I, Llc | Method of combing a nucleic acid |
US7851028B2 (en) | 2006-06-30 | 2010-12-14 | The Invention Science Fund I, Llc | Method of combing an elongated molecule |
JP2008051512A (ja) * | 2006-08-22 | 2008-03-06 | Fujifilm Corp | 近接場光を用いたセンサおよびその作製方法 |
CA2677833C (en) * | 2007-01-22 | 2016-05-03 | Wafergen, Inc. | Apparatus for high throughput chemical reactions |
US8376013B2 (en) * | 2008-03-11 | 2013-02-19 | Duke University | Plasmonic assisted systems and methods for interior energy-activation from an exterior source |
JP5222599B2 (ja) * | 2007-07-20 | 2013-06-26 | 株式会社日立ハイテクノロジーズ | 核酸分析デバイス及びそれを用いた核酸分析装置 |
EP2100849B1 (de) | 2008-03-13 | 2010-09-22 | Institut de Ciències Fotòniques, Fundació Privada | Verfahren zur Herstellung von molekular plasmonischen Nanostrukturen |
US9518288B2 (en) | 2008-04-11 | 2016-12-13 | University Of Utah Research Foundation | Methods and compositions related to quantitative, array based methylation analysis |
JP4997181B2 (ja) * | 2008-06-13 | 2012-08-08 | 株式会社日立ハイテクノロジーズ | 核酸分析デバイス及び核酸分析装置 |
JP5066110B2 (ja) | 2009-01-30 | 2012-11-07 | 株式会社日立ハイテクノロジーズ | 蛍光分析装置、及び蛍光分析方法 |
JP5707030B2 (ja) * | 2009-04-02 | 2015-04-22 | 株式会社日立ハイテクノロジーズ | 核酸分析デバイス、及び核酸分析装置 |
FR2951271B1 (fr) * | 2009-10-13 | 2012-11-16 | Univ Troyes Technologie | Support d'echantillon, procede et systeme d'imagerie par fonctionnalisation du substrat |
EP2513630B1 (de) * | 2009-12-17 | 2016-05-25 | Chris Geddes | Detektionssystem umfassend mischmetallsubstrate zur metallverstärkten fluoreszenz |
KR20120010513A (ko) | 2010-07-26 | 2012-02-03 | 삼성전자주식회사 | 바이오 물질 수용소자와 그 제조 및 동작방법 |
KR101663183B1 (ko) | 2010-08-26 | 2016-10-06 | 삼성전자주식회사 | 열전재료, 이를 포함하는 열전모듈과 열전장치 |
JP5372876B2 (ja) * | 2010-09-10 | 2013-12-18 | 株式会社日立ハイテクノロジーズ | 核酸分析デバイス,核酸分析装置、及び核酸分析方法 |
CN102604140B (zh) * | 2012-03-21 | 2013-12-11 | 陕西师范大学 | 含胆固醇的聚合物荧光传感薄膜的制备方法 |
CN103980884B (zh) * | 2014-05-21 | 2016-09-21 | 南京理工大学 | Al3+荧光传感器、合成方法及应用 |
JP2016012114A (ja) * | 2014-06-02 | 2016-01-21 | オリンパス株式会社 | 照明装置、これを有する顕微鏡装置及び顕微鏡観察方法 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8423204D0 (en) * | 1984-09-14 | 1984-10-17 | Comtech Res Unit | Assay technique and equipment |
CA2076709A1 (en) * | 1992-08-24 | 1994-02-25 | Ulrich J. Krull | Amplified fluorescence emission for chemical transduction |
US5690894A (en) * | 1995-05-23 | 1997-11-25 | The Regents Of The University Of California | High density array fabrication and readout method for a fiber optic biosensor |
US5776785A (en) * | 1996-12-30 | 1998-07-07 | Diagnostic Products Corporation | Method and apparatus for immunoassay using fluorescent induced surface plasma emission |
DE19715483A1 (de) * | 1997-04-14 | 1998-10-15 | Boehringer Mannheim Gmbh | Methode zur gleichzeitigen Bestimmung von biomolekularen Wechselwirkungen mittels Plasmonenresonanz undFluoreszenzdetektion |
JPH11332595A (ja) * | 1997-07-09 | 1999-12-07 | Masao Karube | プローブpnaによるdnaの検出方法 |
US6210910B1 (en) * | 1998-03-02 | 2001-04-03 | Trustees Of Tufts College | Optical fiber biosensor array comprising cell populations confined to microcavities |
JP3647267B2 (ja) * | 1998-05-29 | 2005-05-11 | キヤノン株式会社 | 面発光レーザーを用いた表面プラズモン共鳴センサ装置 |
US6262216B1 (en) * | 1998-10-13 | 2001-07-17 | Affymetrix, Inc. | Functionalized silicon compounds and methods for their synthesis and use |
US6236033B1 (en) * | 1998-12-09 | 2001-05-22 | Nec Research Institute, Inc. | Enhanced optical transmission apparatus utilizing metal films having apertures and periodic surface topography |
US6429027B1 (en) * | 1998-12-28 | 2002-08-06 | Illumina, Inc. | Composite arrays utilizing microspheres |
JP3872227B2 (ja) * | 1999-02-26 | 2007-01-24 | 北斗科学産業株式会社 | 新規の生物学的チップ及び分析方法 |
US6489102B2 (en) * | 1999-08-05 | 2002-12-03 | Wisconsin Alumni Research Foundation | Biomolecule and/or cellular arrays on metal surfaces and product produced thereby |
JP3249954B2 (ja) * | 1999-07-07 | 2002-01-28 | 科学技術振興事業団 | 蛍光免疫分析方法及び装置 |
CA2381568A1 (en) * | 1999-07-30 | 2001-02-08 | The Penn State Research Foundation | Instruments, methods and reagents for surface plasmon resonance |
US6395483B1 (en) * | 1999-09-02 | 2002-05-28 | 3M Innovative Properties Company | Arrays with mask layers |
ATE284543T1 (de) * | 2000-07-21 | 2004-12-15 | Micro Managed Photons As | Bandlücken strukturen für oberflächenplasmonenpolariton |
CA2314398A1 (en) * | 2000-08-10 | 2002-02-10 | Edward Shipwash | Microarrays and microsystems for amino acid analysis and protein sequencing |
US6699665B1 (en) * | 2000-11-08 | 2004-03-02 | Surface Logix, Inc. | Multiple array system for integrating bioarrays |
-
2001
- 2001-01-12 JP JP2001005041A patent/JP3525142B2/ja not_active Expired - Fee Related
-
2002
- 2002-01-09 EP EP02715712A patent/EP1353179B1/de not_active Expired - Lifetime
- 2002-01-09 WO PCT/JP2002/000026 patent/WO2002056012A1/ja active IP Right Grant
- 2002-01-09 DE DE60222378T patent/DE60222378T2/de not_active Expired - Lifetime
- 2002-01-09 AT AT02715712T patent/ATE373235T1/de not_active IP Right Cessation
- 2002-01-09 US US10/415,246 patent/US20040029152A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1353179A1 (de) | 2003-10-15 |
EP1353179A4 (de) | 2004-05-19 |
EP1353179B1 (de) | 2007-09-12 |
JP2002214142A (ja) | 2002-07-31 |
ATE373235T1 (de) | 2007-09-15 |
DE60222378T2 (de) | 2008-06-12 |
JP3525142B2 (ja) | 2004-05-10 |
US20040029152A1 (en) | 2004-02-12 |
WO2002056012A1 (fr) | 2002-07-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE60222378D1 (de) | Fluoreszensanalyseelement mit der anwendung eines metallischen nanolochs und verfahren zur herstellung desselben | |
Michel et al. | Selective molecular assembly patterning: A new approach to micro-and nanochemical patterning of surfaces for biological applications | |
CN106691462B (zh) | 检测装置和相关使用方法 | |
DE60042738D1 (de) | Verfahren zum nachweis von analyten mit hilfe von halbleiternanokrystallen | |
WO2014144133A1 (en) | Analyte detection enhancement by targeted immobilization, surface amplification, and pixelated reading and analysis | |
ATE502117T1 (de) | Nanopartikel mit gebundenen oligonukleotiden und deren verwendungen | |
EP1256795A3 (de) | Biochipleser | |
ATE536406T1 (de) | Neuartiger zytokin-zcytor17-ligand | |
CN101346626A (zh) | 用于测定具有生物来源和复杂组成的样品中一种或多种分析物的方法及其用途 | |
ATE545460T1 (de) | Proteomanalyseverfahren für phosphoryliertes protein | |
ATE496298T1 (de) | Methode um die sensitivität einer luminesenz assay zu erhöhen | |
ATE390633T1 (de) | Reagens zum nachweis eines morbus-alzheimer- risikofaktors, nachweiskit dafür und verfahren zum nachweis eines morbus-alzheimer-risikofaktors unter verwendung davon | |
US20090311773A1 (en) | Novel apparatus and method for coating substrates for analyte detection by means of an affinity assay method | |
DE60209537D1 (de) | Neue kristalline formen von meloxicam, deren herstellung und verfahren zu deren umwandlung ineinander | |
ATE422671T1 (de) | Verfahren zur diagnose von morbus alzheimer | |
DE60207490D1 (de) | Verfahren zur Herstellung von (Meth)Acrylsäureanhydrid | |
DE60209634D1 (de) | Gelatine basiertes Substrat zur Herstellung von Protein-Biochips | |
DE602004026500D1 (de) | Verfahren zur Markierung phosphorylierten Peptiden, Komplexverbindunger, Verfahren zu deren Herstellung und Zwischenprodukte | |
DE69800312D1 (de) | Verfahren zur Herstellung von Acrylsäuren aus Acrolein durch Redox-Reaktion | |
ATE440968T1 (de) | Verfahren zur diagnostizierung von aspirinunverträglichkeit | |
KR101359268B1 (ko) | 바이오 필름 모니터링 장치 | |
EP1881471A3 (de) | Etikettband mit Identifizierungscode | |
EP1010764A3 (de) | Hybridisierungsnachweisverfahren unter Verwendung von Biochips | |
DK1567661T3 (da) | Fremgangsmåder, biosensorer og sæt til detektion og identificering af svampe | |
ATE292192T1 (de) | Verfahren zur herstellung und immobilisierung von nukleinsäure auf einem silan-modifizierten festträger |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |