DE60222244T2 - Verfahren zur herstellung von zwischenverbindungen in der herstellung von discodermolid und discodermolid-analoga - Google Patents
Verfahren zur herstellung von zwischenverbindungen in der herstellung von discodermolid und discodermolid-analoga Download PDFInfo
- Publication number
- DE60222244T2 DE60222244T2 DE60222244T DE60222244T DE60222244T2 DE 60222244 T2 DE60222244 T2 DE 60222244T2 DE 60222244 T DE60222244 T DE 60222244T DE 60222244 T DE60222244 T DE 60222244T DE 60222244 T2 DE60222244 T2 DE 60222244T2
- Authority
- DE
- Germany
- Prior art keywords
- formula
- alkyl
- unsubstituted
- phenyl
- monosubstituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 *C(C(OCc1ccccc1)=*)(N)N Chemical compound *C(C(OCc1ccccc1)=*)(N)N 0.000 description 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/26—Oxygen atoms attached in position 2 with hetero atoms or acyl radicals directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Steroid Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyrane Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Polyoxymethylene Polymers And Polymers With Carbon-To-Carbon Bonds (AREA)
- Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0101599 | 2001-01-22 | ||
| GBGB0101599.9A GB0101599D0 (en) | 2001-01-22 | 2001-01-22 | Organic compounds |
| PCT/EP2002/000570 WO2002057251A2 (en) | 2001-01-22 | 2002-01-21 | Process for preparing intermediates for the manufacture of discodermolide and discodermolide analogues |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60222244D1 DE60222244D1 (de) | 2007-10-18 |
| DE60222244T2 true DE60222244T2 (de) | 2008-05-29 |
Family
ID=9907244
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60222244T Expired - Fee Related DE60222244T2 (de) | 2001-01-22 | 2002-01-21 | Verfahren zur herstellung von zwischenverbindungen in der herstellung von discodermolid und discodermolid-analoga |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6974875B2 (https=) |
| EP (1) | EP1368334B1 (https=) |
| JP (1) | JP4301810B2 (https=) |
| CN (2) | CN1261428C (https=) |
| AT (1) | ATE372332T1 (https=) |
| AU (1) | AU2002228057A1 (https=) |
| BR (1) | BR0206585A (https=) |
| CA (1) | CA2435371A1 (https=) |
| DE (1) | DE60222244T2 (https=) |
| ES (1) | ES2292726T3 (https=) |
| GB (1) | GB0101599D0 (https=) |
| WO (1) | WO2002057251A2 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY127609A (en) * | 2000-08-07 | 2006-12-29 | Novartis Ag | Process for preparing discodermolide and analogues thereof |
| WO2004009574A1 (en) * | 2002-07-22 | 2004-01-29 | Novartis Ag | Synthesis of discodermolide |
| AU2003263090A1 (en) | 2002-09-06 | 2004-03-29 | University Of Pittsburgh | Analogs of discodermolide and dictyostatin-1, intermediates therefor and methods of synthesis thereof |
| US7321046B2 (en) | 2002-09-06 | 2008-01-22 | University Of Pittsburgh | Analogs of dictyostatin, intermediates therefor and methods of synthesis thereof |
| GB0226434D0 (en) * | 2002-11-13 | 2002-12-18 | Astrazeneca Ab | Combination product |
| US7348436B2 (en) * | 2004-03-02 | 2008-03-25 | Kosan Biosciences Incorporated | Compounds useful for the synthesis of (+)-discodermolide and methods thereof |
| US7214708B2 (en) * | 2004-11-18 | 2007-05-08 | Kosan Biosciences Incorporated | Synthetic discodermolide analogs |
| EP1873141A4 (en) * | 2005-04-19 | 2010-09-22 | Eisai R&D Man Co Ltd | CALCIUM-BIS [2S] -3- [3- (2S) -3- (4-CHLORO-2-CYANOPHENOXY) -2-FLUORO-PROPOXYPHENYL] -2-ISOPROPOXYPROPIONATE] AND INTERMEDIATE PRODUCTS THEREOF |
| US7816405B2 (en) | 2005-04-19 | 2010-10-19 | Eisai R&D Management Co., Ltd. | Calcium bis [(2S)-3-[3-[(2S)-3-(4-chloro-2-cyanophenoxy)-2-fluoropropoxy]phenyl ]-2-isopropoxypropionate] and intermediate thereof |
| US7297807B1 (en) | 2006-05-31 | 2007-11-20 | The Research Foundation Of State University Of New York | Intermediates for the synthesis of polypropionate antibiotics |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9315802D0 (en) | 1993-07-30 | 1993-09-15 | Roussel Lab Ltd | Chemical compounds |
| US5789605A (en) | 1996-12-03 | 1998-08-04 | Trustees Of The University Of Pennsylvania | Synthetic techniques and intermediates for polyhydroxy, dienyl lactones and mimics thereof |
| US6096904A (en) | 1996-12-03 | 2000-08-01 | The Trustees Of The University Of Pennsylvania | Synthetic techniques and intermediates for polyhydroxy, dienyl lactone derivatives |
| WO1998048791A1 (en) | 1997-04-30 | 1998-11-05 | The Regents Of The University Of California | Synthesis of discodermolide and analogs |
-
2001
- 2001-01-22 GB GBGB0101599.9A patent/GB0101599D0/en not_active Ceased
-
2002
- 2002-01-21 ES ES02710021T patent/ES2292726T3/es not_active Expired - Lifetime
- 2002-01-21 EP EP02710021A patent/EP1368334B1/en not_active Expired - Lifetime
- 2002-01-21 DE DE60222244T patent/DE60222244T2/de not_active Expired - Fee Related
- 2002-01-21 BR BR0206585-1A patent/BR0206585A/pt not_active IP Right Cessation
- 2002-01-21 US US10/466,728 patent/US6974875B2/en not_active Expired - Fee Related
- 2002-01-21 AT AT02710021T patent/ATE372332T1/de not_active IP Right Cessation
- 2002-01-21 AU AU2002228057A patent/AU2002228057A1/en not_active Abandoned
- 2002-01-21 WO PCT/EP2002/000570 patent/WO2002057251A2/en not_active Ceased
- 2002-01-21 CN CNB028039920A patent/CN1261428C/zh not_active Expired - Fee Related
- 2002-01-21 CN CNA2005101126328A patent/CN1775774A/zh active Pending
- 2002-01-21 JP JP2002557932A patent/JP4301810B2/ja not_active Expired - Fee Related
- 2002-01-21 CA CA002435371A patent/CA2435371A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| GB0101599D0 (en) | 2001-03-07 |
| HK1060882A1 (en) | 2004-08-27 |
| AU2002228057A1 (en) | 2002-07-30 |
| CA2435371A1 (en) | 2002-07-25 |
| US6974875B2 (en) | 2005-12-13 |
| ATE372332T1 (de) | 2007-09-15 |
| CN1261428C (zh) | 2006-06-28 |
| WO2002057251A2 (en) | 2002-07-25 |
| EP1368334B1 (en) | 2007-09-05 |
| CN1775774A (zh) | 2006-05-24 |
| JP4301810B2 (ja) | 2009-07-22 |
| EP1368334A2 (en) | 2003-12-10 |
| WO2002057251A3 (en) | 2002-10-10 |
| ES2292726T3 (es) | 2008-03-16 |
| DE60222244D1 (de) | 2007-10-18 |
| CN1487929A (zh) | 2004-04-07 |
| US20040073049A1 (en) | 2004-04-15 |
| BR0206585A (pt) | 2003-12-16 |
| JP2004517891A (ja) | 2004-06-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8328 | Change in the person/name/address of the agent |
Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336 |
|
| R119 | Application deemed withdrawn, or ip right lapsed, due to non-payment of renewal fee |
Ref document number: 1368334 Country of ref document: EP Effective date: 20110802 |
|
| R082 | Change of representative |
Ref document number: 1368334 Country of ref document: EP Representative=s name: DR. SCHOEN & PARTNER, 80336 MUENCHEN, DE |